DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrrk and LRRK2

DIOPT Version :10

Sequence 1:NP_001262772.1 Gene:Lrrk / 42447 FlyBaseID:FBgn0038816 Length:2513 Species:Drosophila melanogaster
Sequence 2:NP_940980.4 Gene:LRRK2 / 120892 HGNCID:18618 Length:2527 Species:Homo sapiens


Alignment Length:2691 Identity:586/2691 - (21%)
Similarity:959/2691 - (35%) Gaps:926/2691 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    87 HKNVAIDFPQFNAREEVRQIKHGELRTAVISGDERTV--RVLLAALGTERQII------------ 137
            |:.|.:.....::.:||.|.....|.|.:    |:.|  |.:|.:.|....::            
Human   398 HREVMLSMLMHSSSKEVFQASANALSTLL----EQNVNFRKILLSKGIHLNVLELMQKHIHSPEV 458

  Fly   138 -------VNMAPSGANTLL---------FLACQSGYESITQRLLDA----------GADGRSHAV 176
                   :|....|:||.|         .|.....:|:.....|:|          |....|...
Human   459 AESGCKMLNHLFEGSNTSLDIMAAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESRED 523

  Fly   177 TKY-----------------SPLYAAVHS--GHLGIARLMLD------HFPELIQQPTVERWLPL 216
            |::                 ..:.||::.  |:.||.:..|.      |||:.::..::|     
Human   524 TEFHHKLNMVKKQCFKNDIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLE----- 583

  Fly   217 HAACINGHIKLLELLISYSYPDYLYQTYRDEEGQWEWRLPFDANAHDVTGQTSLYIASILGNKQL 281
              ..::..:..|::     |||       |:|.|.   |......:.:|.:........|..|.|
Human   584 --GAMDSVLHTLQM-----YPD-------DQEIQC---LGLSLIGYLITKKNVFIGTGHLLAKIL 631

  Fly   282 VGVLLKWQLHCRRTLGDSASSVSTPITPTRKRISFGIQAIMSKLHISGE---------------S 331
            |..|.:::         ..:.:.|.          |.|.|::.|.:|..               .
Human   632 VSSLYRFK---------DVAEIQTK----------GFQTILAILKLSASFSKLLVHHSFDLVIFH 677

  Fly   332 EGPDDLASQESTECQRCPINVNLLCGAARETALLAAVRGGHLD---------VVQSLLQHGANPN 387
            :...::..|:..:.      :||.|....:.|:...::...|:         :|:.||..||   
Human   678 QMSSNIMEQKDQQF------LNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVECLLLLGA--- 733

  Fly   388 IVAKPVEDHNDPKCCEEIYGLSNVPIAEAC-KQRSLAMLDLLLKHGARD-DNGTAIGMAITCGDE 450
                   |.|..|....:       |.:.| |:.|..:::|||..|:|: |...|:.::|..||.
Human   734 -------DANQAKEGSSL-------ICQVCEKESSPKLVELLLNSGSREQDVRKALTISIGKGDS 784

  Fly   451 AILSRLLAR--------------------------RVHPDSDYKINK------------------ 471
            .|:|.||.|                          .:.||....:.|                  
Human   785 QIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVIRYQMK 849

  Fly   472 ----KGLPTPVEVN------------VFLPSTSNISYSAMFPNNPTIIDWHSMGSSVQLSVVRVP 520
                :|..:..:.|            .|:|.:|..|..|...      |..|.||.....|.:..
Human   850 SAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSD------DLDSEGSEGSFLVKKKS 908

  Fly   521 WMVS-------GVL------------------------------------LLNPKLQSHPRLNE- 541
            ..:|       .||                                    |.:.|||||.|.:: 
Human   909 NSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLRSSKLQSHMRHSDS 973

  Fly   542 VALTA-----ITRIDFSHNVLTSI---PQEL---FHLVSLRYLNVAQNKITDLPAPIGQTYGCPV 595
            ::..|     ||.:|.|.|.|..|   .|:.   .||..|..|.:.||.:|..|..:.:|  ...
Human   974 ISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQLCET--LKS 1036

  Fly   596 LDELFLQDNQLTTLPAAIFHLPALSILDVSNNKL-QQLPFD-LWRAPKLRELNVAFNLLRDLPVP 658
            |..|.|..|:.|:.|:.:..:..::.||||.|.: ..:..| ..:.|.|::.|:::|.|      
Human  1037 LTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQL------ 1095

  Fly   659 PMQTSSSLLSLDKLNLQSFEEPPSNKPRNVTQQRLTHRNLWSATLDITDNDMKWQHEQDLGDG-K 722
                                   |..|.|:|                   |:..:.||.:.:| |
Human  1096 -----------------------SFVPENLT-------------------DVVEKLEQLILEGNK 1118

  Fly   723 TAGVGS----SQLSSLNIANNLFTSIP----AALPCLAVNLTRLNMSYNSLRSMGHVTSYPATLK 779
            .:|:.|    .:|..||::.|..:|:.    .|.|.:.....|:|.    |.:|..:   |.::.
Human  1119 ISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNF----LAAMPFL---PPSMT 1176

  Fly   780 QLDLSHNEISCWPSLPRITESDPHLLCYSCVQLPEGRDDDYKTASSKGSSSSATSFRASVLKSVC 844
            .|.||.|:.||.|.              :.:.||..|..|..:...:.....|            
Human  1177 ILKLSQNKFSCIPE--------------AILNLPHLRSLDMSSNDIQYLPGPA------------ 1215

  Fly   845 RHRRHLRLEALRTLILADNLLTRIQLSTDDATTLFNESEDADWSVVGVNRSKVIFPNLSMLDMTN 909
                |.:...||.|:.:.|.:                      |::.::....::..:..|.:::
Human  1216 ----HWKSLNLRELLFSHNQI----------------------SILDLSEKAYLWSRVEKLHLSH 1254

  Fly   910 NCLKEIPASLHELSSLSVLNISGNVNITELPPHLGLLSRLWNLNTRGCLLQEPLRSMIES--KKH 972
            |.|||||..:..|.:|:.|::|.|:.:...|..:|.||::|:|         ||..:..:  .||
Human  1255 NKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDL---------PLDELHLNFDFKH 1310

  Fly   973 ---KTMDIVGYLKSIYEDAQPYARMKLMVVGVAGIGKSTLLDLLRQGAGSGSSSSSHRSRASENH 1034
               |..||:.:|:...:.|.||.|||||:||..|.||:|||..|.:...|.....|         
Human  1311 IGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQS--------- 1366

  Fly  1035 WAKRMGHARSTSRSHRHSSASSANISTVGVDIGTW---ICEKRKRAPGSHGPVVFRTWDFGGQKE 1096
                                     :|||:|:..|   |.:||||      .:|...|||.|::|
Human  1367 -------------------------ATVGIDVKDWPIQIRDKRKR------DLVLNVWDFAGREE 1400

  Fly  1097 YYATHQYFLSKRSLYLVLWRISDGHKGLAELLQWLGNIQARAPNSPVIIVGTHFDAVGESISPQK 1161
            :|:||.:|:::|:|||.::.:|.|...:..:..||.||:|||.:||||:||||.|...|.   |:
Human  1401 FYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEK---QR 1462

  Fly  1162 AEQLQQLIRE-----KFIAIPDAEKIGLPRVIDSIEISCRTLHNIHLLANIIYDTAMQLRSPGSK 1221
            ...:.::.:|     .|.||.|...:......|::....:|:.|..|...|             :
Human  1463 KACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNFKI-------------R 1514

  Fly  1222 EPMLL-QKIPASYIALEDIVNVIACNLRAAGRDPVLDGEQYKRLVTE-QMRLHNYKSFRDAAELQ 1284
            :.::: |.||..|:.||.|  :::.........||:|.::..:||.| |::|       |..||.
Human  1515 DQLVVGQLIPDCYVELEKI--ILSERKNVPIEFPVIDRKRLLQLVRENQLQL-------DENELP 1570

  Fly  1285 QATTWCHENGVLLHYDDATLR--DYYFLDPQWLCDMLAHVVTVR-EINPFAPTGVMKLDDLQMLF 1346
            .|..:.:|:|||||:.|..|:  |.||::|:|||.::|.::||: |..|..|.|::...|::...
Human  1571 HAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPKHPKGIISRRDVEKFL 1635

  Fly  1347 RSVQVQGNGNRSYIVSLLNKFEVALTWDSRTLLIPSLLPSQEAATPNSGSTVKLSQRSRGRSLGC 1411
            ...:.......|....||.||::||......||:||.|....       ..::|           
Human  1636 SKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHR-------PVIEL----------- 1682

  Fly  1412 SVSQEVNLNNLIYEQRSAPSSSSSSASVSQGLRRILLMTYFPSGFWSRLITRILADEQIIEAIRG 1476
                              |...:|...:     |:..|.|||.|||||||.|:|....       
Human  1683 ------------------PHCENSEIII-----RLYEMPYFPMGFWSRLINRLLEISP------- 1717

  Fly  1477 VYMASQDYADFDLRTSLEQDTQWNLWQTGLALYYGPILIFKIWEVPFQKTERTQPFRTDGNRFKL 1541
             ||.|      ....:|..:..:  |:.|:.|.:.|                             
Human  1718 -YMLS------GRERALRPNRMY--WRQGIYLNWSP----------------------------- 1744

  Fly  1542 KQDGIWSDVNLSSSSILEVYFPLYEVNISQEVDDNERQLLAEIR-PHMSQVAKLLALTVDHIDLL 1605
                             |.|     ..:..||.||..:...:|. |...:...||...|||||.|
Human  1745 -----------------EAY-----CLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSL 1787

  Fly  1606 LEDWYPSLGTRFVHTSEGRFLITRLVLCPRCLWKLQLQQNNEPSDREVPPVGCNRPSRSSRRGAG 1670
            :|:|:|.| .......||..|:.:        |.                               
Human  1788 MEEWFPGL-LEIDICGEGETLLKK--------WA------------------------------- 1812

  Fly  1671 AYFLHGVGDPGEDGALNVFSAYLNATARRERRSEDSLGAGSDADSGVGPDSAGSSRNTSVDGHPG 1735
               |:...| ||:              .::...:|.:....:.|..|.||               
Human  1813 ---LYSFND-GEE--------------HQKILLDDLMKKAEEGDLLVNPD--------------- 1844

  Fly  1736 YHLPDNSNVCYAWMIEECILSVYNQSKISCPVHLEQSMAQLAPDVIFADIPDKHTIPSECI---- 1796
                                    |.:::.|:      :|:|||:|.||:|....:.::.:    
Human  1845 ------------------------QPRLTIPI------SQIAPDLILADLPRNIMLNNDELEFEQ 1879

  Fly  1797 IKGSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQ 1861
            ....|||.|:||.|::|      |...:.||:|:..        |.::|...             
Human  1880 APEFLLGDGSFGSVYRA------AYEGEEVAVKIFN--------KHTSLRLL------------- 1917

  Fly  1862 HSCKAYCTARQELAVLLTLKHPNIVPLVGICIKPLALVLELAPLGGLDALLRHYRRSGAHMGPHT 1926
                     ||||.||..|.||:::.|:...|:|..||:|||..|.||.||:..:.|......| 
Human  1918 ---------RQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQH- 1972

  Fly  1927 FQTLVLQAARAIEYLHRRRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYGISRQTAPSG 1991
              .:.|..|..:.|||...|||||||..|||::.|       .|...:..|||||||::.....|
Human  1973 --RIALHVADGLRYLHSAMIIYRDLKPHNVLLFTL-------YPNAAIIAKIADYGIAQYCCRMG 2028

  Fly  1992 AKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENIS--------LRQPFEGHESIKECI 2048
            .|...||.||.|||:.|  |...|.::.|.:|||:.:|:.::        |:.|.|    ..|..
Human  2029 IKTSEGTPGFRAPEVAR--GNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNE----FDELE 2087

  Fly  2049 LEGSRPALTQRETQFPTCCLD-LMVLCWHEQPRRRPTASQIVSILSAPECIHLLDVVAMPHSEKI 2112
            ::|..|...:.....|...:: |:..|..|.|:.|||::|:..||::.|.:.|...:.:|.:..:
Human  2088 IQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIV 2152

  Fly  2113 VCGVFQSLVGMGDDERCGLELWL---PSFGSRIDILDCSPSGSLLQCNSISCSPQPQVAPPKTPE 2174
            .|     :|....:.| ...:||   .:...::..||.:..|                   .|.|
Human  2153 EC-----MVATHHNSR-NASIWLGCGHTDRGQLSFLDLNTEG-------------------YTSE 2192

  Fly  2175 NGANSRARSAQRLPKMNMLCCCLVGEAI----WM--GDVSGNLHAYST--STYAHLFSYMLDPNI 2231
            ..|:||           :||..||...:    |:  |..||.|...:|  ....|....|.|.  
Human  2193 EVADSR-----------ILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTDS-- 2244

  Fly  2232 KSAVISLVYMEKIAR-------VAVGTHNGRVFLVDATQMPSNCAFAEGSFVLTEICSGFVLHAA 2289
                ::.:|....::       :.|||.:|::                                 
Human  2245 ----VTCLYCNSFSKQSKQKNFLLVGTADGKL--------------------------------- 2272

  Fly  2290 CSVVVDGIYELWCGEIAGKINVFPLNENGVSGHQALCHSEEPNLIE-----------------DV 2337
                  .|:|....::.|...:..||...|| ...:|.||..|..|                 |.
Human  2273 ------AIFEDKTVKLKGAAPLKILNIGNVS-TPLMCLSESTNSTERNVMWGGCGTKIFSFSNDF 2330

  Fly  2338 KVARMC-SNESHVFS----------------CLY------PGCMVYQWDVISKRIENKLDCSKLL 2379
            .:.::. :..|.:||                .||      |  :|..||..::::...:||...|
Human  2331 TIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYIAKQNSP--VVEVWDKKTEKLCGLIDCVHFL 2393

  Fly  2380 ------PCSESLQSIAIDEHVNLIKCQISALAAHNSELYIGTTWGCLIVAELHTLRPISVFRPYE 2438
                  ...||...::....|..:..|      .|:.|:|||..|.:::.:|.|.|.|.|...:.
Human  2394 REVMVKENKESKHKMSYSGRVKTLCLQ------KNTALWIGTGGGHILLLDLSTRRLIRVIYNFC 2452

  Fly  2439 NEIKSIITL---SKDNVPLIATIGRR 2461
            |.::.::|.   |..||.|:....|:
Human  2453 NSVRVMMTAQLGSLKNVMLVLGYNRK 2478

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrrkNP_001262772.1 ANKYR 78..>287 CDD:440430 48/264 (18%)
ANK repeat 146..177 CDD:293786 9/49 (18%)
ANK repeat 179..209 CDD:293786 9/54 (17%)
ANK repeat 361..390 CDD:293786 7/37 (19%)
Ank_2 364..465 CDD:463710 29/137 (21%)
ANK repeat 406..435 CDD:293786 8/29 (28%)
ANK repeat 437..464 CDD:293786 9/52 (17%)
LRR <544..>768 CDD:443914 56/245 (23%)
leucine-rich repeat 547..569 CDD:275380 10/27 (37%)
leucine-rich repeat 570..595 CDD:275380 7/24 (29%)
leucine-rich repeat 596..618 CDD:275380 6/21 (29%)
leucine-rich repeat 619..641 CDD:275380 6/23 (26%)
leucine-rich repeat 642..676 CDD:275380 4/33 (12%)
leucine-rich repeat 677..730 CDD:275380 11/57 (19%)
leucine-rich repeat 731..754 CDD:275380 7/26 (27%)
LRR_8 855..933 CDD:404697 16/77 (21%)
leucine-rich repeat 855..901 CDD:275380 5/45 (11%)
LRR_4 900..941 CDD:463713 12/40 (30%)
leucine-rich repeat 902..924 CDD:275380 8/21 (38%)
leucine-rich repeat 925..949 CDD:275380 8/23 (35%)
P-loop containing Nucleoside Triphosphate Hydrolases 993..1211 CDD:476819 70/225 (31%)
COR 1230..>1393 CDD:406489 52/166 (31%)
STKc_LRRK 1801..2095 CDD:270902 96/302 (32%)
LRRK2NP_940980.4 Required for RAB29-mediated activation. /evidence=ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:38127736 1..969 111/644 (17%)
LRR 1. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 983..1004 8/20 (40%)
leucine-rich repeat 985..1012 CDD:275380 9/26 (35%)
LRR <1009..1279 CDD:443914 78/378 (21%)
LRR 2. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1012..1033 6/20 (30%)
leucine-rich repeat 1013..1036 CDD:275380 7/24 (29%)
LRR 3. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1036..1057 6/20 (30%)
leucine-rich repeat 1037..1084 CDD:275380 12/46 (26%)
LRR 4. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1059..1080 6/20 (30%)
LRR 5. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1084..1105 8/68 (12%)
leucine-rich repeat 1085..1108 CDD:275380 9/70 (13%)
LRR 6. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1108..1129 6/20 (30%)
leucine-rich repeat 1109..1130 CDD:275380 6/20 (30%)
LRR 7. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1130..1150 5/19 (26%)
leucine-rich repeat 1131..1174 CDD:275380 12/49 (24%)
LRR 8. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1156..1171 4/18 (22%)
LRR 9. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1174..1196 7/35 (20%)
leucine-rich repeat 1175..1197 CDD:275380 8/35 (23%)
LRR 10. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1197..1218 4/36 (11%)
leucine-rich repeat 1198..1221 CDD:275380 4/38 (11%)
LRR 11. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1221..1245 5/45 (11%)
leucine-rich repeat 1222..1246 CDD:275380 5/45 (11%)
LRR 12. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1246..1267 7/20 (35%)
leucine-rich repeat 1247..1269 CDD:275380 8/21 (38%)
LRR 13. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1269..1291 6/21 (29%)
RocCOR 1334..1507 CDD:206741 67/215 (31%)
COR 1527..1740 CDD:406489 74/278 (27%)
STKc_LRRK2 1884..2135 CDD:270970 96/302 (32%)
WD 1. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 2139..2183 7/49 (14%)
WD 2. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 2188..2228 15/69 (22%)
WD 3. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 2233..2276 9/87 (10%)
WD 4. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 2281..2327 10/46 (22%)
WD 5. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 2333..2377 7/45 (16%)
WD 6. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 2402..2438 10/41 (24%)
WD 7. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 2443..2497 10/36 (28%)

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