DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrrk and LRRK2

DIOPT Version :9

Sequence 1:NP_001262772.1 Gene:Lrrk / 42447 FlyBaseID:FBgn0038816 Length:2513 Species:Drosophila melanogaster
Sequence 2:NP_940980.4 Gene:LRRK2 / 120892 HGNCID:18618 Length:2527 Species:Homo sapiens


Alignment Length:2691 Identity:586/2691 - (21%)
Similarity:959/2691 - (35%) Gaps:926/2691 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    87 HKNVAIDFPQFNAREEVRQIKHGELRTAVISGDERTV--RVLLAALGTERQII------------ 137
            |:.|.:.....::.:||.|.....|.|.:    |:.|  |.:|.:.|....::            
Human   398 HREVMLSMLMHSSSKEVFQASANALSTLL----EQNVNFRKILLSKGIHLNVLELMQKHIHSPEV 458

  Fly   138 -------VNMAPSGANTLL---------FLACQSGYESITQRLLDA----------GADGRSHAV 176
                   :|....|:||.|         .|.....:|:.....|:|          |....|...
Human   459 AESGCKMLNHLFEGSNTSLDIMAAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESRED 523

  Fly   177 TKY-----------------SPLYAAVHS--GHLGIARLMLD------HFPELIQQPTVERWLPL 216
            |::                 ..:.||::.  |:.||.:..|.      |||:.::..::|     
Human   524 TEFHHKLNMVKKQCFKNDIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFPDALEMLSLE----- 583

  Fly   217 HAACINGHIKLLELLISYSYPDYLYQTYRDEEGQWEWRLPFDANAHDVTGQTSLYIASILGNKQL 281
              ..::..:..|::     |||       |:|.|.   |......:.:|.:........|..|.|
Human   584 --GAMDSVLHTLQM-----YPD-------DQEIQC---LGLSLIGYLITKKNVFIGTGHLLAKIL 631

  Fly   282 VGVLLKWQLHCRRTLGDSASSVSTPITPTRKRISFGIQAIMSKLHISGE---------------S 331
            |..|.:::         ..:.:.|.          |.|.|::.|.:|..               .
Human   632 VSSLYRFK---------DVAEIQTK----------GFQTILAILKLSASFSKLLVHHSFDLVIFH 677

  Fly   332 EGPDDLASQESTECQRCPINVNLLCGAARETALLAAVRGGHLD---------VVQSLLQHGANPN 387
            :...::..|:..:.      :||.|....:.|:...::...|:         :|:.||..||   
Human   678 QMSSNIMEQKDQQF------LNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVECLLLLGA--- 733

  Fly   388 IVAKPVEDHNDPKCCEEIYGLSNVPIAEAC-KQRSLAMLDLLLKHGARD-DNGTAIGMAITCGDE 450
                   |.|..|....:       |.:.| |:.|..:::|||..|:|: |...|:.::|..||.
Human   734 -------DANQAKEGSSL-------ICQVCEKESSPKLVELLLNSGSREQDVRKALTISIGKGDS 784

  Fly   451 AILSRLLAR--------------------------RVHPDSDYKINK------------------ 471
            .|:|.||.|                          .:.||....:.|                  
Human   785 QIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVIRYQMK 849

  Fly   472 ----KGLPTPVEVN------------VFLPSTSNISYSAMFPNNPTIIDWHSMGSSVQLSVVRVP 520
                :|..:..:.|            .|:|.:|..|..|...      |..|.||.....|.:..
Human   850 SAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSD------DLDSEGSEGSFLVKKKS 908

  Fly   521 WMVS-------GVL------------------------------------LLNPKLQSHPRLNE- 541
            ..:|       .||                                    |.:.|||||.|.:: 
Human   909 NSISVGEFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLRSSKLQSHMRHSDS 973

  Fly   542 VALTA-----ITRIDFSHNVLTSI---PQEL---FHLVSLRYLNVAQNKITDLPAPIGQTYGCPV 595
            ::..|     ||.:|.|.|.|..|   .|:.   .||..|..|.:.||.:|..|..:.:|  ...
Human   974 ISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQLCET--LKS 1036

  Fly   596 LDELFLQDNQLTTLPAAIFHLPALSILDVSNNKL-QQLPFD-LWRAPKLRELNVAFNLLRDLPVP 658
            |..|.|..|:.|:.|:.:..:..::.||||.|.: ..:..| ..:.|.|::.|:::|.|      
Human  1037 LTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQL------ 1095

  Fly   659 PMQTSSSLLSLDKLNLQSFEEPPSNKPRNVTQQRLTHRNLWSATLDITDNDMKWQHEQDLGDG-K 722
                                   |..|.|:|                   |:..:.||.:.:| |
Human  1096 -----------------------SFVPENLT-------------------DVVEKLEQLILEGNK 1118

  Fly   723 TAGVGS----SQLSSLNIANNLFTSIP----AALPCLAVNLTRLNMSYNSLRSMGHVTSYPATLK 779
            .:|:.|    .:|..||::.|..:|:.    .|.|.:.....|:|.    |.:|..:   |.::.
Human  1119 ISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNF----LAAMPFL---PPSMT 1176

  Fly   780 QLDLSHNEISCWPSLPRITESDPHLLCYSCVQLPEGRDDDYKTASSKGSSSSATSFRASVLKSVC 844
            .|.||.|:.||.|.              :.:.||..|..|..:...:.....|            
Human  1177 ILKLSQNKFSCIPE--------------AILNLPHLRSLDMSSNDIQYLPGPA------------ 1215

  Fly   845 RHRRHLRLEALRTLILADNLLTRIQLSTDDATTLFNESEDADWSVVGVNRSKVIFPNLSMLDMTN 909
                |.:...||.|:.:.|.:                      |::.::....::..:..|.:::
Human  1216 ----HWKSLNLRELLFSHNQI----------------------SILDLSEKAYLWSRVEKLHLSH 1254

  Fly   910 NCLKEIPASLHELSSLSVLNISGNVNITELPPHLGLLSRLWNLNTRGCLLQEPLRSMIES--KKH 972
            |.|||||..:..|.:|:.|::|.|:.:...|..:|.||::|:|         ||..:..:  .||
Human  1255 NKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDL---------PLDELHLNFDFKH 1310

  Fly   973 ---KTMDIVGYLKSIYEDAQPYARMKLMVVGVAGIGKSTLLDLLRQGAGSGSSSSSHRSRASENH 1034
               |..||:.:|:...:.|.||.|||||:||..|.||:|||..|.:...|.....|         
Human  1311 IGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQS--------- 1366

  Fly  1035 WAKRMGHARSTSRSHRHSSASSANISTVGVDIGTW---ICEKRKRAPGSHGPVVFRTWDFGGQKE 1096
                                     :|||:|:..|   |.:||||      .:|...|||.|::|
Human  1367 -------------------------ATVGIDVKDWPIQIRDKRKR------DLVLNVWDFAGREE 1400

  Fly  1097 YYATHQYFLSKRSLYLVLWRISDGHKGLAELLQWLGNIQARAPNSPVIIVGTHFDAVGESISPQK 1161
            :|:||.:|:::|:|||.::.:|.|...:..:..||.||:|||.:||||:||||.|...|.   |:
Human  1401 FYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEK---QR 1462

  Fly  1162 AEQLQQLIRE-----KFIAIPDAEKIGLPRVIDSIEISCRTLHNIHLLANIIYDTAMQLRSPGSK 1221
            ...:.::.:|     .|.||.|...:......|::....:|:.|..|...|             :
Human  1463 KACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNFKI-------------R 1514

  Fly  1222 EPMLL-QKIPASYIALEDIVNVIACNLRAAGRDPVLDGEQYKRLVTE-QMRLHNYKSFRDAAELQ 1284
            :.::: |.||..|:.||.|  :::.........||:|.::..:||.| |::|       |..||.
Human  1515 DQLVVGQLIPDCYVELEKI--ILSERKNVPIEFPVIDRKRLLQLVRENQLQL-------DENELP 1570

  Fly  1285 QATTWCHENGVLLHYDDATLR--DYYFLDPQWLCDMLAHVVTVR-EINPFAPTGVMKLDDLQMLF 1346
            .|..:.:|:|||||:.|..|:  |.||::|:|||.::|.::||: |..|..|.|::...|::...
Human  1571 HAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPKHPKGIISRRDVEKFL 1635

  Fly  1347 RSVQVQGNGNRSYIVSLLNKFEVALTWDSRTLLIPSLLPSQEAATPNSGSTVKLSQRSRGRSLGC 1411
            ...:.......|....||.||::||......||:||.|....       ..::|           
Human  1636 SKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHR-------PVIEL----------- 1682

  Fly  1412 SVSQEVNLNNLIYEQRSAPSSSSSSASVSQGLRRILLMTYFPSGFWSRLITRILADEQIIEAIRG 1476
                              |...:|...:     |:..|.|||.|||||||.|:|....       
Human  1683 ------------------PHCENSEIII-----RLYEMPYFPMGFWSRLINRLLEISP------- 1717

  Fly  1477 VYMASQDYADFDLRTSLEQDTQWNLWQTGLALYYGPILIFKIWEVPFQKTERTQPFRTDGNRFKL 1541
             ||.|      ....:|..:..:  |:.|:.|.:.|                             
Human  1718 -YMLS------GRERALRPNRMY--WRQGIYLNWSP----------------------------- 1744

  Fly  1542 KQDGIWSDVNLSSSSILEVYFPLYEVNISQEVDDNERQLLAEIR-PHMSQVAKLLALTVDHIDLL 1605
                             |.|     ..:..||.||..:...:|. |...:...||...|||||.|
Human  1745 -----------------EAY-----CLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSL 1787

  Fly  1606 LEDWYPSLGTRFVHTSEGRFLITRLVLCPRCLWKLQLQQNNEPSDREVPPVGCNRPSRSSRRGAG 1670
            :|:|:|.| .......||..|:.:        |.                               
Human  1788 MEEWFPGL-LEIDICGEGETLLKK--------WA------------------------------- 1812

  Fly  1671 AYFLHGVGDPGEDGALNVFSAYLNATARRERRSEDSLGAGSDADSGVGPDSAGSSRNTSVDGHPG 1735
               |:...| ||:              .::...:|.:....:.|..|.||               
Human  1813 ---LYSFND-GEE--------------HQKILLDDLMKKAEEGDLLVNPD--------------- 1844

  Fly  1736 YHLPDNSNVCYAWMIEECILSVYNQSKISCPVHLEQSMAQLAPDVIFADIPDKHTIPSECI---- 1796
                                    |.:::.|:      :|:|||:|.||:|....:.::.:    
Human  1845 ------------------------QPRLTIPI------SQIAPDLILADLPRNIMLNNDELEFEQ 1879

  Fly  1797 IKGSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQ 1861
            ....|||.|:||.|::|      |...:.||:|:..        |.::|...             
Human  1880 APEFLLGDGSFGSVYRA------AYEGEEVAVKIFN--------KHTSLRLL------------- 1917

  Fly  1862 HSCKAYCTARQELAVLLTLKHPNIVPLVGICIKPLALVLELAPLGGLDALLRHYRRSGAHMGPHT 1926
                     ||||.||..|.||:::.|:...|:|..||:|||..|.||.||:..:.|......| 
Human  1918 ---------RQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQH- 1972

  Fly  1927 FQTLVLQAARAIEYLHRRRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYGISRQTAPSG 1991
              .:.|..|..:.|||...|||||||..|||::.|       .|...:..|||||||::.....|
Human  1973 --RIALHVADGLRYLHSAMIIYRDLKPHNVLLFTL-------YPNAAIIAKIADYGIAQYCCRMG 2028

  Fly  1992 AKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENIS--------LRQPFEGHESIKECI 2048
            .|...||.||.|||:.|  |...|.::.|.:|||:.:|:.::        |:.|.|    ..|..
Human  2029 IKTSEGTPGFRAPEVAR--GNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNE----FDELE 2087

  Fly  2049 LEGSRPALTQRETQFPTCCLD-LMVLCWHEQPRRRPTASQIVSILSAPECIHLLDVVAMPHSEKI 2112
            ::|..|...:.....|...:: |:..|..|.|:.|||::|:..||::.|.:.|...:.:|.:..:
Human  2088 IQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIV 2152

  Fly  2113 VCGVFQSLVGMGDDERCGLELWL---PSFGSRIDILDCSPSGSLLQCNSISCSPQPQVAPPKTPE 2174
            .|     :|....:.| ...:||   .:...::..||.:..|                   .|.|
Human  2153 EC-----MVATHHNSR-NASIWLGCGHTDRGQLSFLDLNTEG-------------------YTSE 2192

  Fly  2175 NGANSRARSAQRLPKMNMLCCCLVGEAI----WM--GDVSGNLHAYST--STYAHLFSYMLDPNI 2231
            ..|:||           :||..||...:    |:  |..||.|...:|  ....|....|.|.  
Human  2193 EVADSR-----------ILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTDS-- 2244

  Fly  2232 KSAVISLVYMEKIAR-------VAVGTHNGRVFLVDATQMPSNCAFAEGSFVLTEICSGFVLHAA 2289
                ::.:|....::       :.|||.:|::                                 
Human  2245 ----VTCLYCNSFSKQSKQKNFLLVGTADGKL--------------------------------- 2272

  Fly  2290 CSVVVDGIYELWCGEIAGKINVFPLNENGVSGHQALCHSEEPNLIE-----------------DV 2337
                  .|:|....::.|...:..||...|| ...:|.||..|..|                 |.
Human  2273 ------AIFEDKTVKLKGAAPLKILNIGNVS-TPLMCLSESTNSTERNVMWGGCGTKIFSFSNDF 2330

  Fly  2338 KVARMC-SNESHVFS----------------CLY------PGCMVYQWDVISKRIENKLDCSKLL 2379
            .:.::. :..|.:||                .||      |  :|..||..::::...:||...|
Human  2331 TIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYIAKQNSP--VVEVWDKKTEKLCGLIDCVHFL 2393

  Fly  2380 ------PCSESLQSIAIDEHVNLIKCQISALAAHNSELYIGTTWGCLIVAELHTLRPISVFRPYE 2438
                  ...||...::....|..:..|      .|:.|:|||..|.:::.:|.|.|.|.|...:.
Human  2394 REVMVKENKESKHKMSYSGRVKTLCLQ------KNTALWIGTGGGHILLLDLSTRRLIRVIYNFC 2452

  Fly  2439 NEIKSIITL---SKDNVPLIATIGRR 2461
            |.::.::|.   |..||.|:....|:
Human  2453 NSVRVMMTAQLGSLKNVMLVLGYNRK 2478

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrrkNP_001262772.1 Ank_2 111..200 CDD:289560 25/153 (16%)
ANK 146..286 CDD:238125 33/183 (18%)
ANK repeat 146..177 CDD:293786 9/49 (18%)
Ank_4 179..232 CDD:290365 11/77 (14%)
ANK repeat 179..209 CDD:293786 9/54 (17%)
Ank_2 216..389 CDD:289560 31/196 (16%)
ANK 361..477 CDD:238125 33/174 (19%)
ANK repeat 361..390 CDD:293786 7/37 (19%)
Ank_2 364..464 CDD:289560 28/136 (21%)
ANK repeat 406..435 CDD:293786 8/29 (28%)
ANK repeat 437..464 CDD:293786 9/52 (17%)
LRR_8 <544..580 CDD:290566 15/46 (33%)
leucine-rich repeat 547..569 CDD:275380 10/27 (37%)
LRR_8 569..629 CDD:290566 18/59 (31%)
leucine-rich repeat 570..595 CDD:275380 7/24 (29%)
leucine-rich repeat 596..618 CDD:275380 6/21 (29%)
leucine-rich repeat 619..641 CDD:275380 6/23 (26%)
leucine-rich repeat 642..676 CDD:275380 4/33 (12%)
leucine-rich repeat 677..730 CDD:275380 11/57 (19%)
LRR_8 729..788 CDD:290566 16/62 (26%)
leucine-rich repeat 731..754 CDD:275380 7/26 (27%)
LRR_8 855..933 CDD:290566 16/77 (21%)
leucine-rich repeat 855..901 CDD:275380 5/45 (11%)
leucine-rich repeat 902..924 CDD:275380 8/21 (38%)
leucine-rich repeat 925..949 CDD:275380 8/23 (35%)
P-loop_NTPase 993..1211 CDD:304359 70/225 (31%)
COR 1230..1471 CDD:292713 69/244 (28%)
STYKc 1796..2092 CDD:214568 94/308 (31%)
STKc_LRRK 1801..2095 CDD:270902 96/302 (32%)
LRRK2NP_940980.4 Required for RAB29-mediated activation. /evidence=ECO:0000269|PubMed:29212815 1..969 111/644 (17%)
LRR 1 983..1004 8/20 (40%)
leucine-rich repeat 985..1012 CDD:275380 9/26 (35%)
LRR 1012..>1286 CDD:227223 77/382 (20%)
LRR 2 1012..1033 6/20 (30%)
leucine-rich repeat 1013..1036 CDD:275380 7/24 (29%)
LRR 3 1036..1057 6/20 (30%)
leucine-rich repeat 1037..1084 CDD:275380 12/46 (26%)
LRR 4 1059..1080 6/20 (30%)
LRR 5 1084..1105 8/68 (12%)
leucine-rich repeat 1085..1108 CDD:275380 9/70 (13%)
LRR 6 1108..1129 6/20 (30%)
leucine-rich repeat 1109..1130 CDD:275380 6/20 (30%)
LRR 7 1130..1150 5/19 (26%)
leucine-rich repeat 1131..1174 CDD:275380 12/49 (24%)
LRR 8 1174..1196 7/35 (20%)
leucine-rich repeat 1175..1197 CDD:275380 8/35 (23%)
LRR 9 1197..1218 4/36 (11%)
leucine-rich repeat 1198..1221 CDD:275380 4/38 (11%)
LRR 10 1221..1241 5/41 (12%)
leucine-rich repeat 1222..1246 CDD:275380 5/45 (11%)
LRR 11 1246..1267 7/20 (35%)
leucine-rich repeat 1247..1269 CDD:275380 8/21 (38%)
LRR 12 1269..1291 6/21 (29%)
RocCOR 1334..1507 CDD:206741 67/215 (31%)
COR 1527..1740 CDD:318343 74/278 (27%)
STKc_LRRK2 1884..2135 CDD:270970 96/302 (32%)
WD 1 2139..2183 7/49 (14%)
WD 2 2188..2228 15/69 (22%)
WD 3 2233..2276 9/87 (10%)
WD 4 2281..2327 10/46 (22%)
WD 5 2333..2377 7/45 (16%)
WD 6 2402..2438 10/41 (24%)
WD 7 2443..2497 10/36 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 88 1.000 Domainoid score I7954
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D10820at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm42176
orthoMCL 1 0.900 - - OOG6_105040
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
76.680

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