Sequence 1: | NP_001262772.1 | Gene: | Lrrk / 42447 | FlyBaseID: | FBgn0038816 | Length: | 2513 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_940980.4 | Gene: | LRRK2 / 120892 | HGNCID: | 18618 | Length: | 2527 | Species: | Homo sapiens |
Alignment Length: | 2691 | Identity: | 586/2691 - (21%) |
---|---|---|---|
Similarity: | 959/2691 - (35%) | Gaps: | 926/2691 - (34%) |
- Green bases have known domain annotations that are detailed below.
Fly 87 HKNVAIDFPQFNAREEVRQIKHGELRTAVISGDERTV--RVLLAALGTERQII------------ 137
Fly 138 -------VNMAPSGANTLL---------FLACQSGYESITQRLLDA----------GADGRSHAV 176
Fly 177 TKY-----------------SPLYAAVHS--GHLGIARLMLD------HFPELIQQPTVERWLPL 216
Fly 217 HAACINGHIKLLELLISYSYPDYLYQTYRDEEGQWEWRLPFDANAHDVTGQTSLYIASILGNKQL 281
Fly 282 VGVLLKWQLHCRRTLGDSASSVSTPITPTRKRISFGIQAIMSKLHISGE---------------S 331
Fly 332 EGPDDLASQESTECQRCPINVNLLCGAARETALLAAVRGGHLD---------VVQSLLQHGANPN 387
Fly 388 IVAKPVEDHNDPKCCEEIYGLSNVPIAEAC-KQRSLAMLDLLLKHGARD-DNGTAIGMAITCGDE 450
Fly 451 AILSRLLAR--------------------------RVHPDSDYKINK------------------ 471
Fly 472 ----KGLPTPVEVN------------VFLPSTSNISYSAMFPNNPTIIDWHSMGSSVQLSVVRVP 520
Fly 521 WMVS-------GVL------------------------------------LLNPKLQSHPRLNE- 541
Fly 542 VALTA-----ITRIDFSHNVLTSI---PQEL---FHLVSLRYLNVAQNKITDLPAPIGQTYGCPV 595
Fly 596 LDELFLQDNQLTTLPAAIFHLPALSILDVSNNKL-QQLPFD-LWRAPKLRELNVAFNLLRDLPVP 658
Fly 659 PMQTSSSLLSLDKLNLQSFEEPPSNKPRNVTQQRLTHRNLWSATLDITDNDMKWQHEQDLGDG-K 722
Fly 723 TAGVGS----SQLSSLNIANNLFTSIP----AALPCLAVNLTRLNMSYNSLRSMGHVTSYPATLK 779
Fly 780 QLDLSHNEISCWPSLPRITESDPHLLCYSCVQLPEGRDDDYKTASSKGSSSSATSFRASVLKSVC 844
Fly 845 RHRRHLRLEALRTLILADNLLTRIQLSTDDATTLFNESEDADWSVVGVNRSKVIFPNLSMLDMTN 909
Fly 910 NCLKEIPASLHELSSLSVLNISGNVNITELPPHLGLLSRLWNLNTRGCLLQEPLRSMIES--KKH 972
Fly 973 ---KTMDIVGYLKSIYEDAQPYARMKLMVVGVAGIGKSTLLDLLRQGAGSGSSSSSHRSRASENH 1034
Fly 1035 WAKRMGHARSTSRSHRHSSASSANISTVGVDIGTW---ICEKRKRAPGSHGPVVFRTWDFGGQKE 1096
Fly 1097 YYATHQYFLSKRSLYLVLWRISDGHKGLAELLQWLGNIQARAPNSPVIIVGTHFDAVGESISPQK 1161
Fly 1162 AEQLQQLIRE-----KFIAIPDAEKIGLPRVIDSIEISCRTLHNIHLLANIIYDTAMQLRSPGSK 1221
Fly 1222 EPMLL-QKIPASYIALEDIVNVIACNLRAAGRDPVLDGEQYKRLVTE-QMRLHNYKSFRDAAELQ 1284
Fly 1285 QATTWCHENGVLLHYDDATLR--DYYFLDPQWLCDMLAHVVTVR-EINPFAPTGVMKLDDLQMLF 1346
Fly 1347 RSVQVQGNGNRSYIVSLLNKFEVALTWDSRTLLIPSLLPSQEAATPNSGSTVKLSQRSRGRSLGC 1411
Fly 1412 SVSQEVNLNNLIYEQRSAPSSSSSSASVSQGLRRILLMTYFPSGFWSRLITRILADEQIIEAIRG 1476
Fly 1477 VYMASQDYADFDLRTSLEQDTQWNLWQTGLALYYGPILIFKIWEVPFQKTERTQPFRTDGNRFKL 1541
Fly 1542 KQDGIWSDVNLSSSSILEVYFPLYEVNISQEVDDNERQLLAEIR-PHMSQVAKLLALTVDHIDLL 1605
Fly 1606 LEDWYPSLGTRFVHTSEGRFLITRLVLCPRCLWKLQLQQNNEPSDREVPPVGCNRPSRSSRRGAG 1670
Fly 1671 AYFLHGVGDPGEDGALNVFSAYLNATARRERRSEDSLGAGSDADSGVGPDSAGSSRNTSVDGHPG 1735
Fly 1736 YHLPDNSNVCYAWMIEECILSVYNQSKISCPVHLEQSMAQLAPDVIFADIPDKHTIPSECI---- 1796
Fly 1797 IKGSLLGRGAFGFVFKANCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQ 1861
Fly 1862 HSCKAYCTARQELAVLLTLKHPNIVPLVGICIKPLALVLELAPLGGLDALLRHYRRSGAHMGPHT 1926
Fly 1927 FQTLVLQAARAIEYLHRRRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYGISRQTAPSG 1991
Fly 1992 AKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENIS--------LRQPFEGHESIKECI 2048
Fly 2049 LEGSRPALTQRETQFPTCCLD-LMVLCWHEQPRRRPTASQIVSILSAPECIHLLDVVAMPHSEKI 2112
Fly 2113 VCGVFQSLVGMGDDERCGLELWL---PSFGSRIDILDCSPSGSLLQCNSISCSPQPQVAPPKTPE 2174
Fly 2175 NGANSRARSAQRLPKMNMLCCCLVGEAI----WM--GDVSGNLHAYST--STYAHLFSYMLDPNI 2231
Fly 2232 KSAVISLVYMEKIAR-------VAVGTHNGRVFLVDATQMPSNCAFAEGSFVLTEICSGFVLHAA 2289
Fly 2290 CSVVVDGIYELWCGEIAGKINVFPLNENGVSGHQALCHSEEPNLIE-----------------DV 2337
Fly 2338 KVARMC-SNESHVFS----------------CLY------PGCMVYQWDVISKRIENKLDCSKLL 2379
Fly 2380 ------PCSESLQSIAIDEHVNLIKCQISALAAHNSELYIGTTWGCLIVAELHTLRPISVFRPYE 2438
Fly 2439 NEIKSIITL---SKDNVPLIATIGRR 2461 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
Lrrk | NP_001262772.1 | Ank_2 | 111..200 | CDD:289560 | 25/153 (16%) |
ANK | 146..286 | CDD:238125 | 33/183 (18%) | ||
ANK repeat | 146..177 | CDD:293786 | 9/49 (18%) | ||
Ank_4 | 179..232 | CDD:290365 | 11/77 (14%) | ||
ANK repeat | 179..209 | CDD:293786 | 9/54 (17%) | ||
Ank_2 | 216..389 | CDD:289560 | 31/196 (16%) | ||
ANK | 361..477 | CDD:238125 | 33/174 (19%) | ||
ANK repeat | 361..390 | CDD:293786 | 7/37 (19%) | ||
Ank_2 | 364..464 | CDD:289560 | 28/136 (21%) | ||
ANK repeat | 406..435 | CDD:293786 | 8/29 (28%) | ||
ANK repeat | 437..464 | CDD:293786 | 9/52 (17%) | ||
LRR_8 | <544..580 | CDD:290566 | 15/46 (33%) | ||
leucine-rich repeat | 547..569 | CDD:275380 | 10/27 (37%) | ||
LRR_8 | 569..629 | CDD:290566 | 18/59 (31%) | ||
leucine-rich repeat | 570..595 | CDD:275380 | 7/24 (29%) | ||
leucine-rich repeat | 596..618 | CDD:275380 | 6/21 (29%) | ||
leucine-rich repeat | 619..641 | CDD:275380 | 6/23 (26%) | ||
leucine-rich repeat | 642..676 | CDD:275380 | 4/33 (12%) | ||
leucine-rich repeat | 677..730 | CDD:275380 | 11/57 (19%) | ||
LRR_8 | 729..788 | CDD:290566 | 16/62 (26%) | ||
leucine-rich repeat | 731..754 | CDD:275380 | 7/26 (27%) | ||
LRR_8 | 855..933 | CDD:290566 | 16/77 (21%) | ||
leucine-rich repeat | 855..901 | CDD:275380 | 5/45 (11%) | ||
leucine-rich repeat | 902..924 | CDD:275380 | 8/21 (38%) | ||
leucine-rich repeat | 925..949 | CDD:275380 | 8/23 (35%) | ||
P-loop_NTPase | 993..1211 | CDD:304359 | 70/225 (31%) | ||
COR | 1230..1471 | CDD:292713 | 69/244 (28%) | ||
STYKc | 1796..2092 | CDD:214568 | 94/308 (31%) | ||
STKc_LRRK | 1801..2095 | CDD:270902 | 96/302 (32%) | ||
LRRK2 | NP_940980.4 | Required for RAB29-mediated activation. /evidence=ECO:0000269|PubMed:29212815 | 1..969 | 111/644 (17%) | |
LRR 1 | 983..1004 | 8/20 (40%) | |||
leucine-rich repeat | 985..1012 | CDD:275380 | 9/26 (35%) | ||
LRR | 1012..>1286 | CDD:227223 | 77/382 (20%) | ||
LRR 2 | 1012..1033 | 6/20 (30%) | |||
leucine-rich repeat | 1013..1036 | CDD:275380 | 7/24 (29%) | ||
LRR 3 | 1036..1057 | 6/20 (30%) | |||
leucine-rich repeat | 1037..1084 | CDD:275380 | 12/46 (26%) | ||
LRR 4 | 1059..1080 | 6/20 (30%) | |||
LRR 5 | 1084..1105 | 8/68 (12%) | |||
leucine-rich repeat | 1085..1108 | CDD:275380 | 9/70 (13%) | ||
LRR 6 | 1108..1129 | 6/20 (30%) | |||
leucine-rich repeat | 1109..1130 | CDD:275380 | 6/20 (30%) | ||
LRR 7 | 1130..1150 | 5/19 (26%) | |||
leucine-rich repeat | 1131..1174 | CDD:275380 | 12/49 (24%) | ||
LRR 8 | 1174..1196 | 7/35 (20%) | |||
leucine-rich repeat | 1175..1197 | CDD:275380 | 8/35 (23%) | ||
LRR 9 | 1197..1218 | 4/36 (11%) | |||
leucine-rich repeat | 1198..1221 | CDD:275380 | 4/38 (11%) | ||
LRR 10 | 1221..1241 | 5/41 (12%) | |||
leucine-rich repeat | 1222..1246 | CDD:275380 | 5/45 (11%) | ||
LRR 11 | 1246..1267 | 7/20 (35%) | |||
leucine-rich repeat | 1247..1269 | CDD:275380 | 8/21 (38%) | ||
LRR 12 | 1269..1291 | 6/21 (29%) | |||
RocCOR | 1334..1507 | CDD:206741 | 67/215 (31%) | ||
COR | 1527..1740 | CDD:318343 | 74/278 (27%) | ||
STKc_LRRK2 | 1884..2135 | CDD:270970 | 96/302 (32%) | ||
WD 1 | 2139..2183 | 7/49 (14%) | |||
WD 2 | 2188..2228 | 15/69 (22%) | |||
WD 3 | 2233..2276 | 9/87 (10%) | |||
WD 4 | 2281..2327 | 10/46 (22%) | |||
WD 5 | 2333..2377 | 7/45 (16%) | |||
WD 6 | 2402..2438 | 10/41 (24%) | |||
WD 7 | 2443..2497 | 10/36 (28%) |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 1 | 1.000 | 88 | 1.000 | Domainoid score | I7954 |
eggNOG | 1 | 0.900 | - | - | E2759_KOG0192 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 1 | 1.010 | - | - | D10820at33208 | |
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 1 | 1.000 | - | - | otm42176 | |
orthoMCL | 1 | 0.900 | - | - | OOG6_105040 | |
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 1 | 0.960 | - | - | ||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
7 | 6.680 |