DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lrrk and lrrk2

DIOPT Version :9

Sequence 1:NP_001262772.1 Gene:Lrrk / 42447 FlyBaseID:FBgn0038816 Length:2513 Species:Drosophila melanogaster
Sequence 2:XP_002932250.3 Gene:lrrk2 / 100145062 XenbaseID:XB-GENE-5768572 Length:2514 Species:Xenopus tropicalis


Alignment Length:2725 Identity:587/2725 - (21%)
Similarity:937/2725 - (34%) Gaps:1003/2725 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    87 HKNVAIDFPQFNAREEVRQIKHGELRTAVISGDERTVRVLLAALGTERQIIVNMAPSGANTLLFL 151
            ||.|.:.....::.::|.|.....|  |.:|.....:|.||...|....:|..|..       .|
 Frog   388 HKEVMLSMLMHSSSKDVFQASTAAL--ATLSEHNVNIRKLLLEKGVHINVIEIMKK-------HL 443

  Fly   152 ACQSGYES---ITQRLLDAGADGRSHAVTKYSPLYAAVHSGHLGIARLMLDHFPELIQQ------ 207
            .|....||   :.|.|.:..:......|..::.:.:|... |..|..:.|:....|:|.      
 Frog   444 CCPEAAESACRVLQHLFNGSSFNLDIMVGAFTVVLSAAKK-HKNIPSVQLEALRVLLQMVYEDEE 507

  Fly   208 -------PTVERWLPL-----------------------------HAA----------CINGHIK 226
                   |..|..|.|                             |.|          |::....
 Frog   508 LNLQNSTPISEETLFLNLPQKVIKNQCLLEGTHNLVLQAMNKFIGHRAIQECGLKVLRCLSECSG 572

  Fly   227 LLELLISYSYPDYLYQTYRDEEGQWEWRLPFDANAHDVTGQTSLYIASILGNKQLVGVLLKWQLH 291
            .||:|......|.:..|.:...|..|                          .|.||:.|...|.
 Frog   573 ALEILSQQGALDTILHTLQMYPGDSE--------------------------IQYVGLFLLANLV 611

  Fly   292 CRRTLGDSASS-VSTPITPTRKRISFGIQ----------AIMSKLHISGESEGPDD--------- 336
            .|:.|..:... :||.:..|.:|....::          .:|...|...:....::         
 Frog   612 TRKNLCIATMHLLSTHLVSTLQRYKDDVRIQEEGFLTALTLMKLSHSFAKLLDLEEFEKVLFYQI 676

  Fly   337 ---LASQESTECQRCPINVNLLCGAARE---------TALLAAVRGGHLDVVQSLLQHGANPN-- 387
               ||::.|.:.|:      |.||...|         |.|:.|....::.:.:.||..||:.|  
 Frog   677 SMCLANKRSMKFQK------LCCGCFAEMTSKDELKNTLLVKACADNYIVIAECLLLLGADVNTK 735

  Fly   388 -----IVAKPVEDHNDPKCCEEIYGLSNVPIAEACKQRSLAMLDLLLKHGARD-DNGTAIGMAIT 446
                 ::.:..|..|:||                       |::|||.:|.|: |...|:.::|.
 Frog   736 TKHTTLIIQVCEKGNNPK-----------------------MVELLLNNGVREQDARKALNVSIK 777

  Fly   447 CGDEAILSRLLAR------------------RVHP-------------------DSDYK------ 468
            ..|..|:|.||.:                  |..|                   |.:.|      
 Frog   778 KCDNEIISLLLKKLGLDAANNSICLGGFHIGRTEPSWLIPLFTEKQPLLKQPSVDQEGKKGSILA 842

  Fly   469 ---------------------------INKKGLPTPVEVNVFLPSTSNISYS------------- 493
                                       |::|...:...::||  ..:.||||             
 Frog   843 RMVLRYHRKNSEIERCRSSGDLSFTEEIHEKSEDSLPHLDVF--EEAGISYSDVDSEGSGGSLRI 905

  Fly   494 ---------------------------AMFPNNPTI---IDWHSM---GSSVQLSVVRVPWMVS- 524
                                       ..:.:.||:   .|:..|   |:.:.|::.|...:.| 
 Frog   906 RKSNSIGNLEIHKLDHVKLWRRHCNSLGTWADEPTVHRKKDFPQMDYPGAKLSLNIKRADSLSSL 970

  Fly   525 -------------------GVLLLNPKLQSHPRLNEVALTAITRIDFSHNVLTSIPQELFH-LVS 569
                               .:::....|.:|       |..:.:::..||.|:|.|:.|.. |.|
 Frog   971 AEKDHIKSLDLSTNDLENINLIVKKGSLTNH-------LERLEKLELQHNSLSSFPKSLCEALRS 1028

  Fly   570 LRYLNVAQNKITDLPAPIGQTYGCPVLDELFLQDNQLTTLPAAIFHLPALSILDVSNNKLQQLPF 634
            |.||:                          |:.|...:.|..|..:.:|..||||.|::.  |.
 Frog  1029 LTYLD--------------------------LRGNSFKSFPHYILEISSLVFLDVSRNEIG--PN 1065

  Fly   635 DLWRA----PKLRELNVAFNLLRDLPVPPMQTSSSLLSLDKLNLQSFEEPPSNKPRNVTQQRLTH 695
            ..|.:    |.|::||:::|                      .|.||.|...|..:|:.:..:..
 Frog  1066 LDWNSTKMCPNLKQLNLSYN----------------------QLMSFPENIGNITQNLEELIMEG 1108

  Fly   696 RNLWSA----------TLDITDNDMKWQHEQDLGDGKTAGVGSSQLSSLNIANNLFTSIPAALPC 750
            .|:...          |:::..|.:.:.....|.|.......|:..:.|:||.||...|.|    
 Frog  1109 NNISEIHIPLCLPELHTINLNKNSIHFLATDFLKDCVKLETFSATTNLLSIAPNLPQKISA---- 1169

  Fly   751 LAVNLTRLNMSYNSLRSMGHVTSYPATLKQL------DLSHNEISC------WPSLPRITESDPH 803
                   :.:|:|.      ||:.|..:.||      |||:|:|:.      |.||         
 Frog  1170 -------VKLSHNK------VTNIPTEILQLSHLRSIDLSNNQIAHLPGPLEWTSL--------- 1212

  Fly   804 LLCYSCVQLPEGRDDDYKTASSKGSSSSATSFRASVLKSVCRHRRHLRLEALRTLILADNLLTRI 868
                                                              .||.:||..|.::.:
 Frog  1213 --------------------------------------------------NLREIILNHNHISVL 1227

  Fly   869 QLSTDDATTLFNESEDADWSVVGVNRSKVIFPNLSMLDMTNNCLKEIPASLHELSSLSVLNISGN 933
            .||.|...          ||            .|..|.::.|.:||||..:..|.:::..:||.|
 Frog  1228 NLSKDACR----------WS------------RLEKLHLSYNKIKEIPPEIGFLENITSFDISYN 1270

  Fly   934 VNITELPPHLGLLSRLWNLNTRGCLLQEPLRSMIESKKH---KTMDIVGYLKSIYEDAQPYARMK 995
            .::...|..:|.|:::|:|...|..|...|       ||   |..|::.:|:...:.|.||.|||
 Frog  1271 PDLRTFPDEMGKLTKIWDLPLDGLCLDIDL-------KHIGCKAKDLIRFLQQRLKKAVPYNRMK 1328

  Fly   996 LMVVGVAGIGKSTLLDLLRQGAGSGSSSSSHRSRASENHWAKRMGHARSTSRSHRHSSASSANIS 1060
            :::||..|.||:||:..|.:                    .:|:.|              .|..:
 Frog  1329 VLIVGNTGSGKTTLVQQLMK--------------------CRRLEH--------------GAEKA 1359

  Fly  1061 TVGVDIGTW---ICEKRKRAPGSHGPVVFRTWDFGGQKEYYATHQYFLSKRSLYLVLWRISDGHK 1122
            |||:|:..|   |..|.|:      .:....|||.||:|:|.:|.:|::.::||||::.:|.|..
 Frog  1360 TVGIDVKDWPILIRGKIKK------EITLNVWDFAGQEEFYCSHPHFMTPQALYLVVYDLSKGVS 1418

  Fly  1123 GLAELLQWLGNIQARAPNSPVIIVGTHFDAVGESISPQKAEQL------QQLIREKFIAIPDAEK 1181
            .:..:..||.||:|||.:||||:||||.|     :|.:|.::.      |:|..::         
 Frog  1419 EVDAIKPWLFNIKARASSSPVILVGTHLD-----VSDEKCQKACISKIKQELCNQR--------- 1469

  Fly  1182 IGLPRVIDSIEISCRTLHNIHLLANIIYDTAMQLRSPGSKE---------PMLLQKIPASYIALE 1237
             |||        |.|..|.::  |:...|...:||....:|         |:|.|.||.||:.||
 Frog  1470 -GLP--------SIREYHFVN--ASEESDLLAKLRKTIIRECLNFKIREQPVLGQLIPDSYLELE 1523

  Fly  1238 DIVNVIACNLRAAGRDPVLDGEQYKRLVTEQMRLHNYKSFRDAAELQQATTWCHENGVLLHYDDA 1302
            .  .::..........||:..|:...:| |:.:||     .|..||..|..:.:|:|||||::|.
 Frog  1524 K--KILNERKNVPLEFPVISHERMLEIV-EESQLH-----LDENELTHAVHFLNESGVLLHFEDP 1580

  Fly  1303 T--LRDYYFLDPQWLCDMLAHVVTVREIN-PFAPTGVMKLDDLQMLFRSVQVQGNGNRSYIVSLL 1364
            .  |||.||:||||||.::|.::|||... ...|.|::..:|::......:.......|....||
 Frog  1581 ALQLRDLYFVDPQWLCKIIAQILTVRADGCQKYPKGIIHCNDVERFLEKKKKFPKNYMSQYFKLL 1645

  Fly  1365 NKFEVALTWDSRTLLIPSLLPSQEAATPNSGSTVKLSQRSRGRSLGCSVSQEVNLNNLIYEQRSA 1429
            .||::||......|||||.|....       ..::|                             
 Frog  1646 EKFQIALPLGEDQLLIPSSLSDHR-------PVIEL----------------------------- 1674

  Fly  1430 PSSSSSSASVSQGLRRILLMTYFPSGFWSRLITRILADEQIIEAIRGVYMASQDYADFDLRTSLE 1494
            |...:|...:     |:..|:|||.|||||||.|:|.        ...||.|          ..|
 Frog  1675 PHCENSEVII-----RLYEMSYFPMGFWSRLINRLLE--------VSTYMLS----------GRE 1716

  Fly  1495 QDTQWN--LWQTGLALYYGPILIFKIWEVPFQKTERTQPFRTDGNRFKLKQDGIWSDVNLSSSSI 1557
            :..:.|  .|:.|:.|.:.|                                             
 Frog  1717 RAQRPNRMYWRQGIYLNWSP--------------------------------------------- 1736

  Fly  1558 LEVYFPLYEVNISQEVDDNERQLLAEIRPHMSQVAKLLALTVDHIDLLLEDWYPSLGTRFVHTSE 1622
             |.|. |.|   |.::|.|....|....|...:...||...|||||.|:|:|:|.|....: ..|
 Frog  1737 -EAYC-LVE---STKLDRNPNSFLKVTVPSCRKGCILLGQVVDHIDSLMEEWFPGLLESDI-CEE 1795

  Fly  1623 GRFLITRLVLCPRCLWKLQLQQNNEPSDREVPPVGCNRPSRSSRRGAGAYFLHGVGDPGEDGALN 1687
            |..|:.:.||                                       |..    |.|::....
 Frog  1796 GEALLKKWVL---------------------------------------YSF----DDGQEHKKI 1817

  Fly  1688 VFSAYLNATARRERRSEDSLGAGSDADSGVGPDSAGSSRNTSVDGHPGYHLPDNSNVCYAWMIEE 1752
            :.|              |......:.|..|.|:.            |...:|             
 Frog  1818 LLS--------------DLQAKAEEGDLLVNPED------------PRQTIP------------- 1843

  Fly  1753 CILSVYNQSKISCPVHLEQSMAQLAPDVIFADIPDKHTIPSECI----IKGSLLGRGAFGFVFKA 1813
                                ::|:|||::.||:|....:.:|.:    ....|||.|.||.|::|
 Frog  1844 --------------------VSQIAPDIVLADLPRNIMLNAEELEFDQAPEFLLGDGGFGSVYRA 1888

  Fly  1814 NCKVRGARSFKPVAMKMLQPVPPGARAKESALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLL 1878
            :.|      .:.||:|:..      :...|.|:                        ||||.||.
 Frog  1889 SYK------GEDVAVKIFN------KHTSSRLL------------------------RQELTVLS 1917

  Fly  1879 TLKHPNIVPLVGICIKPLALVLELAPLGGLDALLRHYRRSGAHMGPHTFQTLVLQAARAIEYLHR 1943
            .|.||::|.|:...:.|..||:||||.|.||.||:....|......|   .:.|..|..:.|||.
 Frog  1918 HLHHPSLVCLLAAGVHPRMLVMELAPKGSLDHLLQQDCASLTRTLQH---RIALHVADGLRYLHS 1979

  Fly  1944 RRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYGISRQTAPSGAKGFGGTEGFMAPEIIR 2008
            ..|||||||..|||::.|       .|.:.:..|||||||::.....|.|...||.||.|||:.|
 Frog  1980 AMIIYRDLKPHNVLLFTL-------YPNSAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVAR 2037

  Fly  2009 YNGEEEYTEKVDCFSFGMFIYENIS--------LRQPFEGHESIKECILEGSRPALTQRETQFPT 2065
              |...|.::.|.:|||:.:|:.::        |:.|.|    ..|..:.|..|...:.....|.
 Frog  2038 --GNVIYNQQADVYSFGLLLYDILTGGARMVEGLKFPNE----FDELAIHGRLPDPVKEYNCAPW 2096

  Fly  2066 CCLDLMV-LCWHEQPRRRPTASQIVSILSAPECIHLLDVVAMPHSEKIVCGVFQS--------LV 2121
            ..::::: .|..|.|::|||::.:..||::.|.:.|:..:.:.......|.|..|        .|
 Frog  2097 PEVEVLIKKCLKENPQQRPTSATVYEILNSAELLCLMRNIVIFSMLTAECMVAASPLVKKHAVWV 2161

  Fly  2122 GMGDDERCGLELWLPSFGSRIDILDCSPSGSLLQCNSISCSPQPQVAPPKTPENGANSRARSAQR 2186
            |.|...:           .::..:|.:..|                   :|.|:.::||      
 Frog  2162 GNGSTRK-----------GQMCCIDFNKGG-------------------QTCEDFSDSR------ 2190

  Fly  2187 LPKMNMLCCCLV---GEA---IWMGDVSG--------------NLHAYSTSTYAHLFSYMLDPNI 2231
                 :||..||   ||.   |..|..||              .||..:.|....|||.:...:.
 Frog  2191 -----ILCLTLVTLPGEKQSWILAGTQSGEIIAADSEDLKIKHTLHKLTDSVTCLLFSCIQGESP 2250

  Fly  2232 KSAVISLVYMEKIARVAVGTHNGRVFLVDATQMPSNCAFAEGSFVLT-EICSGFVLHAACSVVVD 2295
            |...|           ..||.||||.:.:.|.:  .|..|....|:. ...|..|:|...|....
 Frog  2251 KKYYI-----------LAGTANGRVAVFENTAV--KCTDAAPMKVINIGDSSTPVMHLCESTYSP 2302

  Fly  2296 GIYELWCGEIAGKINVFPLNENGVSGHQALCHSEEPNLIE--DVKVARMCS----NESHVFSCLY 2354
            ....:|                |:.|.:....|.|..:.:  |.:||.:.|    :||:: :|:.
 Frog  2303 EKKSVW----------------GICGTKIFSLSSEFTVQKTIDTRVATLYSHGSYSESNI-TCIA 2350

  Fly  2355 PGCMVYQ----------WDVISKRIENKLDCSKLLPCSESLQSIAIDEHVNLIKC--------QI 2401
            ....:|.          ||..:::|...|||.:.|.          ::.|...||        ::
 Frog  2351 IDKYIYVAKKISPYVEIWDKKAEKICEVLDCVQFLK----------EDTVKRRKCKQEEAYTARV 2405

  Fly  2402 SAL-AAHNSELYIGTTWGCLIVAELHTLRPISVFRPYENEIKSIITLSKD-----NVPLI 2455
            .|| ...|:.|::||..|.:::.:|.|.:||.:...:.:.|:|::....|     ||.|:
 Frog  2406 KALYLQKNTALWVGTGGGHILLIDLSTRQPIRIITSFCDSIRSMVPAQLDRGSIKNVVLV 2465

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LrrkNP_001262772.1 Ank_2 111..200 CDD:289560 20/91 (22%)
ANK 146..286 CDD:238125 30/194 (15%)
ANK repeat 146..177 CDD:293786 6/33 (18%)
Ank_4 179..232 CDD:290365 15/104 (14%)
ANK repeat 179..209 CDD:293786 6/42 (14%)
Ank_2 216..389 CDD:289560 40/250 (16%)
ANK 361..477 CDD:238125 33/202 (16%)
ANK repeat 361..390 CDD:293786 9/44 (20%)
Ank_2 364..464 CDD:289560 27/144 (19%)
ANK repeat 406..435 CDD:293786 5/28 (18%)
ANK repeat 437..464 CDD:293786 9/63 (14%)
LRR_8 <544..580 CDD:290566 12/36 (33%)
leucine-rich repeat 547..569 CDD:275380 7/22 (32%)
LRR_8 569..629 CDD:290566 14/59 (24%)
leucine-rich repeat 570..595 CDD:275380 3/24 (13%)
leucine-rich repeat 596..618 CDD:275380 4/21 (19%)
leucine-rich repeat 619..641 CDD:275380 8/25 (32%)
leucine-rich repeat 642..676 CDD:275380 5/33 (15%)
leucine-rich repeat 677..730 CDD:275380 10/62 (16%)
LRR_8 729..788 CDD:290566 18/64 (28%)
leucine-rich repeat 731..754 CDD:275380 7/22 (32%)
LRR_8 855..933 CDD:290566 20/77 (26%)
leucine-rich repeat 855..901 CDD:275380 10/45 (22%)
leucine-rich repeat 902..924 CDD:275380 8/21 (38%)
leucine-rich repeat 925..949 CDD:275380 6/23 (26%)
P-loop_NTPase 993..1211 CDD:304359 64/226 (28%)
COR 1230..1471 CDD:292713 71/243 (29%)
STYKc 1796..2092 CDD:214568 93/308 (30%)
STKc_LRRK 1801..2095 CDD:270902 95/302 (31%)
lrrk2XP_002932250.3 LRR 957..1273 CDD:227223 89/470 (19%)
leucine-rich repeat 977..1004 CDD:275380 3/33 (9%)
leucine-rich repeat 1005..1028 CDD:275380 7/22 (32%)
leucine-rich repeat 1029..1051 CDD:275380 7/47 (15%)
leucine-rich repeat 1052..1076 CDD:275380 8/25 (32%)
leucine-rich repeat 1077..1100 CDD:275380 9/44 (20%)
leucine-rich repeat 1101..1122 CDD:275380 1/20 (5%)
leucine-rich repeat 1123..1146 CDD:275380 4/22 (18%)
leucine-rich repeat 1147..1189 CDD:275380 15/58 (26%)
leucine-rich repeat 1190..1213 CDD:275380 8/81 (10%)
leucine-rich repeat 1214..1238 CDD:275380 10/45 (22%)
P-loop_NTPase 1326..1499 CDD:422963 67/237 (28%)
COR 1516..1732 CDD:406489 78/282 (28%)
STKc_LRRK2 1876..2127 CDD:270970 95/302 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 82 1.000 Domainoid score I8312
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D10820at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm49402
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.920

Return to query results.
Submit another query.