Protein Alignment Pi3K92E and SH3PXD2A

DIOPT Version :9

• Sequence 1: NP_001262770.1
• Gene: Pi3K92E / 42446
• FlyBaseID: FBgn0015279
• Length: 1088
• Species: Drosophila melanogaster
• Sequence 2: NP_001380944.1
• Gene: SH3PXD2A / 9644
• HGNCID: 23664
• Length: 1133
• Species: Homo sapiens
• Alignment Length: 491
• Identity: 81/491 - (16%)
• Similarity: 167/491 - (34%)
• Gaps: 163/491 - (33%)

  Fly   498 NPRKEECALVDLTFLSSGTGTV----------------RYPSE----------------EVVLQY 530
            ||.|....::::|:..|.:.|:                ::|.|                :::.:.
Human    19 NPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPIEGGQKDPKQRIIPFLPGKILFRR 83

  Fly   531 AADRE-QVNRLQRQLAGPEKPIKE----LKELMANYTGLDKIYEMVDQDRNAIWERRNDILRELP 590
            :..|: .|.||        |||.|    |..|..:.:..|:::.        .:|.|       |
Human    84 SHIRDVAVKRL--------KPIDEYCRALVRLPPHISQCDEVFR--------FFEAR-------P 125

  Fly   591 EELSILLHCVYWKERDDVA-----DMWYLLKQWPLISIERSLELLDYAYPDPAVRRFAIRCLHFL 650
            |:::        ..::|..     .:|  |..| ..|.::.:...| |..:|.:....:...::.
Human   126 EDVN--------PPKEDYGSSKRKSVW--LSSW-AESPKKDVTGAD-ATAEPMILEQYVVVSNYK 178

  Fly   651 KDEDLLLYLLQLVQAIKHESYLESDLVVFLLERALRNQRIGHYFFWHLRSEMQTPS--MQTRFGL 713
            |.|:             .|..|::..||.::|:    ...|.:|......:...|:  ::.:.|.
Human   179 KQEN-------------SELSLQAGEVVDVIEK----NESGWWFVSTSEEQGWVPATYLEAQNGT 226

  Fly   714 LLEVYLKGCKHHVAPLRKQLHVLEKLKQ----GSLIAKKGSKEKVKTMLQDFLRDQRNSAVFQNI 774
            ..:..:...|......|::.| |.:|.:    |.::.::.|:|:....:|.:....::...|:
Human   227 RDDSDINTSKTGEVSKRRKAH-LRRLDRRWTLGGMVNRQHSREEKYVTVQPYTSQSKDEIGFE-- 288

  Fly   775 QNPLNPSFRCSGVTPDRCKVMDSKMRPLWVVFENADVNASDVHIIFKNGDDLRQDMLTLQMLRVM 839
                      .|||   .:|:...:...|.:........:....:.|..|||.
Human   289 ----------KGVT---VEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLP------------ 328

  Fly   840 DQLWKRDGMDFRMNIYNCISMEKSL-GMIEVVRHAETIANIQKEKGMFSATSPFKKGSLLSWLKE 903
                               :.:|:| |.:|::.:...|:|:..:|......:|..:|      :.
Human   329 -------------------TRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEG------EG 368

  Fly   904 HNKPADKLNKAINEFTLSCAGYCVAT--YVLGVADR 937
            |..|..|     .|.:|..  .|.|:  ..:||.||
Human   369 HEAPIAK-----KEISLPI--LCNASNGSAVGVPDR 397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322
		PI3K_rbd	200..307	CDD:197540
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	5/18 (28%)
		PI3Ka_I	552..723	CDD:238444	27/181 (15%)
		PI3Kc_I	727..1084	CDD:270709	38/218 (17%)
SH3PXD2A	NP_001380944.1	PX_FISH	6..124	CDD:132798	20/120 (17%)
		SH3_Tks5_1	170..222	CDD:213007	10/68 (15%)
		SH3_Tks5_2	269..322	CDD:213010	7/67 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	415..446
		SH3_Tks5_3	451..504	CDD:213012
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	505..840
		SH3_Tks5_4	844..896	CDD:212952
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	899..924
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	941..964
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1029..1059
		SH3_Tks5_5	1076..1132	CDD:212953

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900