DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pi3K92E and PIK1

DIOPT Version :9

Sequence 1:NP_001262770.1 Gene:Pi3K92E / 42446 FlyBaseID:FBgn0015279 Length:1088 Species:Drosophila melanogaster
Sequence 2:NP_014132.1 Gene:PIK1 / 855454 SGDID:S000005211 Length:1066 Species:Saccharomyces cerevisiae


Alignment Length:1181 Identity:230/1181 - (19%)
Similarity:413/1181 - (34%) Gaps:321/1181 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 SVNLWKNEML------------NWVDLICLLPNGFLL------ELRVNPANTI-----QVIKVEM 74
            ::.|.|||.|            |.|:|:|.......:      :|...|.:.:     |:::|.:
Yeast    14 TIELKKNEQLLKLINSSEFTLHNCVELLCKHSENIGIHYYLCQKLATFPHSELQFYIPQLVQVLV 78

  Fly    75 VNQAKQMPLGYVIKEACEYQVYGISTFNIEPYTDETKRLSEVQPYFGILSLGE--------RTDT 131
            ..:.:.|.|                       .|...||....|:|.:|:..:        .||.
Yeast    79 TMETESMAL-----------------------EDLLLRLRAENPHFALLTFWQLQALLTDLSTDP 120

  Fly   132 TSFSSDYELTKMVNGMIGTTFDHNRTHGSPEIDDFRLYMTQTCDNIELER-------------SA 183
            .|:.  :::.:.|...:.|.. .|.:.||.:             |:::..             ||
Yeast   121 ASYG--FQVARRVLNNLQTNL-FNTSSGSDK-------------NVKIHENVAPALVLSSMIMSA 169

  Fly   184 YTWQQRLLYEHPL-------------RLANSTKMPELIRERHPTRTFLIVVKNENDQSTFTLSVN 235
            ..:.|......||             :||.|. |.:..:......|.|    |:....:..:|.|
Yeast   170 IAFPQLSEVTKPLVESQGRRQKAFVFKLARSA-MKDFTKNMTLKNTLL----NKKTSRSKRVSSN 229

  Fly   236 EQDTPFS----------LTESTLQKMNRSQMKMN-------------DRTSDYILKVSGRDEYLL 277
            ...||.|          ..:::.:|...|::|::             :|.|..|.....:.:||.
Yeast   230 RSSTPTSPIDLIDPIKTKEDASFRKSRHSEVKLDFDIVDDIGNQVFEERISSSIKLPKRKPKYLD 294

  Fly   278 GDYPLIQFLYIQEMLS-DSAVPNVVLQSVYRLESYI-------------NHHNEQAMVTKRPLPK 328
            ..|  :...|..:.:: |.::.|...........||             |:.:|....|:.....
Yeast   295 NSY--VHRTYDGKNINRDGSISNTAKALDGNKGDYISPKGRNDENNEIGNNEDETGGETEEDADA 357

  Fly   329 KRTVHLHKSISSLWDMGNYFQLTLHSISNVNFDKTRALKVGVHVCLYHGDKKLCAQRSTDSPNGN 393
            ..:.|.   .||:.|:.| .|....|.|:.:.:.|..|.       ....:.|..|...:|...|
Yeast   358 LNSDHF---TSSMPDLHN-IQPRTSSASSASLEGTPKLN-------RTNSQPLSRQAFKNSKKAN 411

  Fly   394 FDTFLFNDLVMDFDI-QMRNLPRMTRL------CIVIFEVTKMSRSKKSSNNKDIALKDVPYNKN 451
                  :.|..:.|: |:....::..|      |...|.:...:.|::        |..||....
Yeast   412 ------SSLSQEIDLSQLSTTSKIKMLKANYFRCETQFAIALETISQR--------LARVPTEAR 462

  Fly   452 PLAWVNTTIFDHKDILRTGRHTLYTWTYADDIQSVEVFHPLGTIEPNPRKEECALVDLTFLSSGT 516
            ..|........::|:                  ..||..|. .:.||.:.:...||.:|   :..
Yeast   463 LSALRAELFLLNRDL------------------PAEVDIPT-LLPPNKKGKLHKLVTIT---ANE 505

  Fly   517 GTVRYPSEEV----VLQYAADR-------EQVNRLQRQLAGPEKPI---------KELKE----- 556
            ..|...:|:|    :::|..|.       |...||.::::|.:..:         ||..|     
Yeast   506 AQVLNSAEKVPYLLLIEYLRDEFDFDPTSETNERLLKKISGNQGGLIFDLNYMNRKENNENRNES 570

  Fly   557 -LMANYTGLDKIYEMVDQDRNAIWERRNDILRELPEELSILLHCVYWK--ERDDVADMWYLLKQW 618
             |.:|.| ...:|:....:..|   .||:.|.......|.....|..:  :.:|:.||       
Yeast   571 TLTSNNT-RSSVYDSNSFNNGA---SRNEGLSSTSRSDSASTAHVRTEVNKEEDLGDM------- 624

  Fly   619 PLISIERSLELLDYAYPDPAVRRFAIRCLHFLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLER 683
            .::.:....:  |.||.:..|.:.|.. :..|.|:.         |....|....|:|...|:|.
Yeast   625 SMVKVRNRTD--DEAYRNALVIQSAAN-VPILPDDS---------QDRSPELNFGSNLDEVLIEN 677

  Fly   684 ALRNQRIGHYFFWHLRSEMQTPSMQTRFGLLLEVYLKGCKHHVAPLRKQL--HVLEKLKQGSLIA 746
            .:.::.|        .|:....:.|.|...::...|......::...||:  .::..:|:     
Yeast   678 GINSKNI--------HSQTDALADQMRVSAVMLAQLDKSPQQLSESTKQIRAQIISSMKE----- 729

  Fly   747 KKGSKEKVKTMLQD-----FLRDQRNSAVFQNIQNPLNPSFRCSGVTPDRCKVMDSKMRPLWVV- 805
                       :||     .|......|..:.::|.|    ...|:.       .|.:...|.. 
Yeast   730 -----------VQDKFGYHDLEALHGMAGERKLENDL----MTGGID-------TSYLGEDWATK 772

  Fly   806 ------------FENADVNASDVHIIFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCI 858
                        |||.|:    ..:|.|.||||||:....||::.|..:|.::.:|..:.....:
Yeast   773 KERIRKTSEYGHFENWDL----CSVIAKTGDDLRQEAFAYQMIQAMANIWVKEKVDVWVKRMKIL 833

  Fly   859 SMEKSLGMIEVVRHAETIANIQK--EKGMFSATSPFKKGSLLSWLKEH------NKPADKLNKAI 915
            ....:.|::|.:.:|.::.:|:|  .|.|........||.:.| |.:|      |....|..:|.
Yeast   834 ITSANTGLVETITNAMSVHSIKKALTKKMIEDAELDDKGGIAS-LNDHFLRAFGNPNGFKYRRAQ 897

  Fly   916 NEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPFVLTHD 980
            :.|..|.|.|.|..|:|.|.|||:.|||:...|.:.|||||.:|.:....:|.  |..||.||::
Yeast   898 DNFASSLAAYSVICYLLQVKDRHNGNIMIDNEGHVSHIDFGFMLSNSPGSVGF--EAAPFKLTYE 960

  Fly   981 FVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPEL--SSEKDLDYLR 1043
            ::.::    ...|.:.|..|.||.:.:|..|||:...|:|:..:|....:...  :.|:....||
Yeast   961 YIELL----GGVEGEAFKKFVELTKSSFKALRKYADQIVSMCEIMQKDNMQPCFDAGEQTSVQLR 1021

  Fly  1044 ETLVLDYTEEK 1054
            :...||.:|::
Yeast  1022 QRFQLDLSEKE 1032

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K92ENP_001262770.1 PI3K_p85B 56..132 CDD:295322 14/94 (15%)
PI3K_rbd 200..307 CDD:197540 22/130 (17%)
C2_PI3K_class_I_beta_delta 339..517 CDD:176075 33/184 (18%)
PI3Ka_I 552..723 CDD:238444 34/178 (19%)
PI3Kc_I 727..1084 CDD:270709 89/358 (25%)
PIK1NP_014132.1 TEL1 <1..1066 CDD:227365 230/1181 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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