Protein Alignment Pi3K92E and TOR2

DIOPT Version :9

• Sequence 1: NP_001262770.1
• Gene: Pi3K92E / 42446
• FlyBaseID: FBgn0015279
• Length: 1088
• Species: Drosophila melanogaster
• Sequence 2: NP_012719.2
• Gene: TOR2 / 853632
• SGDID: S000001686
• Length: 2474
• Species: Saccharomyces cerevisiae
• Alignment Length: 1127
• Identity: 226/1127 - (20%)
• Similarity: 380/1127 - (33%)
• Gaps: 347/1127 - (30%)

  Fly    96 YGISTFN-IEPYTDETKRLS-EVQPYFGILSLG----ERTDTTSFSSD----YELTKMVNGMIGT 150
            :|:..:: |..||...|..| :.:.|..||.|.    ::.:...|::.    .||:.:||.
Yeast  1476 WGLEQWDEIAQYTSVMKSQSPDKEFYDAILCLHRNNFKKAEVHIFNARDLLVTELSALVNE---- 1536

  Fly   151 TFDHNRTHG-------------------SPEIDDFRLYMTQTCDNIELERSAYTWQQRLL----- 191
              .:||.:.                   .|:..|.||.|.:            ||..|||
Yeast  1537 --SYNRAYNVVVRAQIIAELEEIIKYKKLPQNSDKRLTMRE------------TWNTRLLGCQKN 1587

  Fly   192 ---YEHPLRLANSTKMPELIRERHPTRTFLIVVKNEND--------------------QSTFTLS 233
               ::..||:.:                  :|:|.:.|                    :......
Yeast  1588 IDVWQRILRVRS------------------LVIKPKEDAQVRIKFANLCRKSGRMALAKKVLNTL 1634

  Fly   234 VNEQDTP-FSLTESTLQKMNRSQMKMNDRTSDYILKVSGRDEYLLGDYPLIQFLYIQEMLSDSAV 297
            :.|.|.| ...|......:..:|:|       |:.....:||.|   ..||.|  ...|..|..:
Yeast  1635 LEETDDPDHPNTAKASPPVVYAQLK-------YLWATGLQDEAL---KQLINF--TSRMAHDLGL 1687

  Fly   298 P--NVVLQSVYRLESYINHHNEQAMVTKRPLPKKRTVHLHKSISSLWDMGNYFQLTLHSISNVNF 360
            .  |::.|||.:....:..|.|
Yeast  1688 DPNNMIAQSVPQQSKRVPRHVE------------------------------------------- 1709

  Fly   361 DKTRALKVGVHVCLYHGDKKLCAQRS--TDSPNGNFDTFLFNDLVMDFDIQMRNLPRMTRLCIVI 423
            |.|:.|   ....|..|:.::|.|..  ..:|:....::|   |...||...  ........:..
Yeast  1710 DYTKLL---ARCFLKQGEWRVCLQPKWRLSNPDSILGSYL---LATHFDNTW--YKAWHNWALAN 1766

  Fly   424 FEVTKM--SRSKKSSNNKDI-ALKDVPYNKNPLAWVNTTIFDHKDILRTGRHTLYTWTYADDIQS 485
            |||..|  |.|||.....|. ::.|:....|.:..|||  ||.|::     |......:...|.:
Yeast  1767 FEVISMLTSVSKKKQEGSDASSVTDINEFDNGMIGVNT--FDAKEV-----HYSSNLIHRHVIPA 1824

  Fly   486 VE-VFHPLGTIEPNPRKEECALVDLTFLSSGTGTVRYPSEE--VVLQYAADREQVNRLQRQLAGP 547
            :: .||.:...|.:..::...|:.|.|...|.........|  .::|.....|.:.:|..::..|
Yeast  1825 IKGFFHSISLSESSSLQDALRLLTLWFTFGGIPEATQAMHEGFNLIQIGTWLEVLPQLISRIHQP 1889

  Fly   548 EKPIKELKELMANYTGLDK------IYEMVDQDRNAIWERRNDILR----------ELPEELSIL 596
            .:.:.  :.|::..:.|.|      :|.::...::....|:...|.          .|.::..::
Yeast  1890 NQIVS--RSLLSLLSDLGKAHPQALVYPLMVAIKSESLSRQKAALSIIEKMRIHSPVLVDQAELV 1952

  Fly   597 LHCVYWKERDDVADMWYLLKQWPLISIERSLELLDYAYPDPAVRRFAIRCLH-----FLKDEDLL 656
            .|     |...:|.:|:  :||             |...|.|.|:|...  |     |...|.|.
Yeast  1953 SH-----ELIRMAVLWH--EQW-------------YEGLDDASRQFFGE--HNTEKMFAALEPLY 1995

  Fly   657 LYLLQLVQAIKHESYLES------DLVVFLL------ERALRNQRIGHYFFWHLRSEMQTPSMQT 709
            ..|.:..:.::..|:..|      |...:|:      :.:..||....|:....:...|.|.:||
Yeast  1996 EMLKRGPETLREISFQNSFGRDLNDAYEWLMNYKKSKDVSNLNQAWDIYYNVFRKIGKQLPQLQT 2060

  Fly   710 RFGLLLEVYLKGCKHHVAPLRKQLHVLEKLKQGSLIAKKGSKEKVKTMLQDFLRDQRNSAVFQNI 774
                 ||:      .||:|.....|.||....|:  ...|.|..||.
Yeast  2061 -----LEL------QHVSPKLLSAHDLELAVPGT--RASGGKPIVKI------------------ 2094

  Fly   775 QNPLNPSFRCSGVTPDRCKVMDSKMRPLWVVFENADVNASDVHIIFKNGDDLRQDMLTLQMLRVM 839
             :...|.|          .|:.||.||.....:.:|  ..|...:.|..:|:|||.|.:|:..::
Yeast  2095 -SKFEPVF----------SVISSKQRPRKFCIKGSD--GKDYKYVLKGHEDIRQDSLVMQLFGLV 2146

  Fly   840 DQLWKRDGMDFRMNI----YNCISMEKSLGMIEVVRHAETIANIQKEKG-------------MFS 887
            :.|.:.|...||.::    |..|.:....|::..|.:::|...:.:|..             |..
Yeast  2147 NTLLQNDAECFRRHLDIQQYPAIPLSPKSGLLGWVPNSDTFHVLIREHREAKKIPLNIEHWVMLQ 2211

  Fly   888 ATSPFKKGSLLS---------------------WLKEHNKPADKLNKAINEFTLSCAGYCVATYV 931
            ....:...:||.                     |||  ::.::...:....:|.|.|...:..|:
Yeast  2212 MAPDYDNLTLLQKVEVFTYALNNTEGQDLYKVLWLK--SRSSETWLERRTTYTRSLAVMSMTGYI 2274

  Fly   932 LGVADRHSDNIMVKR-NGQLFHIDFGHIL--GHFKEKLGVRRERVPFVLTHDFVYVIN-KGFNDR 992
            ||:.|||..|:|:.| .|::.|||||...  ...:||.   .|:|||.||....|.:. .|...
Yeast  2275 LGLGDRHPSNLMLDRITGKVIHIDFGDCFEAAILREKF---PEKVPFRLTRMLTYAMEVSGIEG- 2335

  Fly   993 ESKEFCHFQELCERAFLVLRKH-GCLILSL----FSMMISTG--LPELSSEKD----LDYLRETL 1046
                  .|:..||....|||.: |.|:..|    |..:|:.|  ||....|::    |..:....
Yeast  2336 ------SFRITCENVMKVLRDNKGSLMAILEAFAFDPLINWGFDLPTKKIEEETGIQLPVMNANE 2394

  Fly  1047 VLD---YTEEKAR----EHFRA 1061
            :|.   .|||:.:    ||..|
Yeast  2395 LLSNGAITEEEVQRVENEHKNA 2416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322	10/41 (24%)
		PI3K_rbd	200..307	CDD:197540	22/129 (17%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	38/183 (21%)
		PI3Ka_I	552..723	CDD:238444	36/203 (18%)
		PI3Kc_I	727..1084	CDD:270709	92/395 (23%)
TOR2	NP_012719.2	TEL1	290..2474	CDD:227365	226/1127 (20%)
		HEAT repeat	599..620	CDD:293787
		HEAT repeat	642..667	CDD:293787
		HEAT repeat	677..707	CDD:293787
		HEAT repeat	715..748	CDD:293787
		HEAT repeat	758..787	CDD:293787
		HEAT repeat	801..828	CDD:293787
		HEAT repeat	843..873	CDD:293787

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900