DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K92E and MEC1

DIOPT Version :9

Sequence 1:NP_001262770.1 Gene:Pi3K92E / 42446 FlyBaseID:FBgn0015279 Length:1088 Species:Drosophila melanogaster
Sequence 2:NP_009694.3 Gene:MEC1 / 852433 SGDID:S000000340 Length:2368 Species:Saccharomyces cerevisiae


Alignment Length:1327 Identity:251/1327 - (18%)
Similarity:457/1327 - (34%) Gaps:458/1327 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 NTIQVIKV--------------EMVNQAKQMPLGYVIKEACEYQVYGISTFNIEPYTDETKRLSE 115
            :::|.||.              :..|.:||:.:..||:|:.:|  .|:|:        |:..::.
Yeast  1148 DSVQTIKFLIWVINDILVPAFWQSENPSKQLFVALVIQESLKY--CGLSS--------ESWDMNH 1202

  Fly   116 VQPYFGILSLGERTDTTSFSSDYELTKMVNGMIGTTFDHNRTHGSPEIDDFRLYMTQTCDNIELE 180
            .:.|.....|.|:.::.|.::.|.|..                        .||:.|        
Yeast  1203 KELYPNEAKLWEKFNSVSKTTIYPLLS------------------------SLYLAQ-------- 1235

  Fly   181 RSAYTWQQRLLYEHPLRLANSTK----------MPELIR----ERHPTRTFLIVVKNENDQ-STF 230
                :|::.:..::|   :|:.|          ..:|::    |.||...|..:::.::.. |.|
Yeast  1236 ----SWKEYVPLKYP---SNNFKEGYKIWVKRFTLDLLKTGTTENHPLHVFSSLIREDDGSLSNF 1293

  Fly   231 TL---SVN-----EQDTPF------------SLTESTLQKMNRSQMKMNDRTSDYILKVSGRDEY 275
            .|   |::     |:.||:            |:....|:.||..|:.......:.|.:|.   ||
Yeast  1294 LLPYISLDIIIKAEKGTPYADILNGIIIEFDSIFTCNLEGMNNLQVDSLRMCYESIFRVF---EY 1355

  Fly   276 -------LLGDYPLIQFLYIQEMLSDSAVPNVVLQSVYRLESYINHHNEQAMVTKRPLPKKRTVH 333
                   ...:|..:...:|   :.|:...|::|    |::.::.       .|...|..:|::.
Yeast  1356 CKKWATEFKQNYSKLHGTFI---IKDTKTTNMLL----RIDEFLR-------TTPSDLLAQRSLE 1406

  Fly   334 LHKSISSLWDMGNYFQLTLHSISNVNFDKTRALKVGVHVCLYH--GDKKLCAQRSTDSPNGNFDT 396
            ......|...:...::...|. .|.|....:.|::     .|.  ||        .||.:|...|
Yeast  1407 TDSFERSALYLEQCYRQNPHD-KNQNGQLLKNLQI-----TYEEIGD--------IDSLDGVLRT 1457

  Fly   397 FLFNDLVMDF-DIQMRNLPRMTRLCIVIF--------EVTKM--------------SRSKKSSNN 438
            |...:||... ::|.....::.:.|..:.        ..|:|              |.|...|::
Yeast  1458 FATGNLVSKIEELQYSENWKLAQDCFNVLGKFSDDPKTTTRMLKSMYDHQLYSQIISNSSFHSSD 1522

  Fly   439 KDIALK------------------DVPYNKNPLAWVN-----TTIFDHKDILRTG-RHTLYTWTY 479
            ..|:|.                  :|...||   ||.     ..|.|.:.:|:.. ...|...:.
Yeast  1523 GKISLSPDVKEWYSIGLEAANLEGNVQTLKN---WVEQIESLRNIDDREVLLQYNIAKALIAISN 1584

  Fly   480 ADDIQSVEVFHP----LGTIEPNPRKEEC------------ALVDLTFLSSGTGTVRYPSEEVVL 528
            .|.:::.:..|.    :||......||..            :|.||:||||......|.|...:|
Yeast  1585 EDPLRTQKYIHNSFRLIGTNFITSSKETTLLKKQNLLMKLHSLYDLSFLSSAKDKFEYKSNTTIL 1649

  Fly   529 QYAADR------------------EQVNRLQRQLAGPEKPIKELKELMANYTGLD---------- 565
            .|..:|                  :|:...::..|...|....|.:|..|...||          
Yeast  1650 DYRMERIGADFVPNHYILSMRKSFDQLKMNEQADADLGKTFFTLAQLARNNARLDIASESLMHCL 1714

  Fly   566 --KIYEMVDQDRNAIWER-RND----ILRELPEE------------LSILLHCVYWKERDDVADM 611
              ::.:...:....:|:: .||    |::|:.|:            .::||....|.:..:.:..
Yeast  1715 ERRLPQAELEFAEILWKQGENDRALKIVQEIHEKYQENSSVNARDRAAVLLKFTEWLDLSNNSAS 1779

  Fly   612 WYLLKQW------------PLISI----ERSLE---------------------LLDYAYPDPAV 639
            ..::||:            |..||    .|.||                     ||.:......|
Yeast  1780 EQIIKQYQDIFQIDSKWDKPYYSIGLYYSRLLERKKAEGYITNGRFEYRAISYFLLAFEKNTAKV 1844

  Fly   640 RRFAIRCLHFLKD---------------------EDLLLYLLQLVQAIKH-ESYLESDLVVFLLE 682
            |....:.:.|..|                     ||:..:   :.:|::| .:|:...::..||.
Yeast  1845 RENLPKVITFWLDIAAASISEAPGNRKEMLSKATEDICSH---VEEALQHCPTYIWYFVLTQLLS 1906

  Fly   683 RALRN-----QRIGH-----------YFFWHLRSEMQTPSMQTRFGLLLEVYLKGCKHHVAPLRK 731
            |.|.:     |.|.|           :..|::.:.:.:.|.:.        .|:|          
Yeast  1907 RLLHSHQSSAQIIMHILLSLAVEYPSHILWYITALVNSNSSKR--------VLRG---------- 1953

  Fly   732 QLHVLEKLKQGS-----LIA-----------------KKGSKEKVKTMLQDFLRDQRNSA----- 769
             .|:|||.:|.|     |::                 |..:....|::.:||..|. |.|     
Yeast  1954 -KHILEKYRQHSQNPHDLVSSALDLTKALTRVCLQDVKSITSRSGKSLEKDFKFDM-NVAPSAMV 2016

  Fly   770 --VFQNIQ--NPLNPSFRCSGVTPDR-----------CKVMDSKMRPLWVVFENADVNASDVHII 819
              |.:|:.  :||. |....|..|.|           .||..|..:|..:....:|.|   ::.|
Yeast  2017 VPVRKNLDIISPLE-SNSMRGYQPFRPVVSIIRFGSSYKVFSSLKKPKQLNIIGSDGN---IYGI 2077

  Fly   820 FKNGDDLRQDMLTLQMLRVMDQLWKRD----GMDFRMNIYNCISMEKSLGMIEVVRHAETIANI- 879
            ....:|:|||...:|....||.|..:|    .....:|||:.:|:.:..|::|:|.:..|:.:| 
Yeast  2078 MCKKEDVRQDNQYMQFATTMDFLLSKDIASRKRSLGINIYSVLSLREDCGILEMVPNVVTLRSIL 2142

  Fly   880 ----QKEKGMFSATSPFKKGS---------------------LLSWLKEHNKPADKLN--KAINE 917
                :..|..:|..|...:..                     |..|..| |.| |.:|  .|.|.
Yeast  2143 STKYESLKIKYSLKSLHDRWQHTAVDGKLEFYMEQVDKFPPILYQWFLE-NFP-DPINWFNARNT 2205

  Fly   918 FTLSCAGYCVATYVLGVADRHSDNIMVK-RNGQLFHIDFGHILGHFKEKLGVRRERVPFVLTHDF 981
            :..|.|...:..::||:.|||.:||::. :.|::.|:||..:....| :|.| .|.|||.||.:.
Yeast  2206 YARSYAVMAMVGHILGLGDRHCENILLDIQTGKVLHVDFDCLFEKGK-RLPV-PEIVPFRLTPNL 2268

  Fly   982 VYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPELSSEKDLDYLR--- 1043
            :..:  |....|..    |::..|....::||:...::::...::.....:.|.:|.|..||   
Yeast  2269 LDAL--GIIGTEGT----FKKSSEVTLALMRKNEVALMNVIETIMYDRNMDHSIQKALKVLRNKI 2327

  Fly  1044 -----------------ETLVLDYTEE 1053
                             |||:.:.|.|
Yeast  2328 RGIDPQDGLVLSVAGQTETLIQEATSE 2354

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K92ENP_001262770.1 PI3K_p85B 56..132 CDD:295322 16/80 (20%)
PI3K_rbd 200..307 CDD:197540 28/148 (19%)
C2_PI3K_class_I_beta_delta 339..517 CDD:176075 46/242 (19%)
PI3Ka_I 552..723 CDD:238444 44/274 (16%)
PI3Kc_I 727..1084 CDD:270709 97/422 (23%)
MEC1NP_009694.3 TEL1 194..2368 CDD:227365 251/1327 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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