DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K92E and Pik3cb

DIOPT Version :9

Sequence 1:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_445933.1	Gene:	Pik3cb / 85243	RGDID:	620917	Length:	1070	Species:	Rattus norvegicus

Alignment Length:	1085	Identity:	407/1085 - (37%)
Similarity:	626/1085 - (57%)	Gaps:	51/1085 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 PPCMRFSVNLWKNEML----NWVDLICLLPNGFLLELRVNPANTIQVIKVEMVNQAKQMPLGYVI 87
            ||.|..::::|..:..    ..:.:..|||.|..::|.|....||..||..:..|....|:..::
  Rat     8 PPAMADTLDIWAVDSQIASDGSISVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNYPMFNLL 72

  Fly    88 KEACEYQVYGIS-TFNIEPYTDETKRLSEVQPYFGILSLGERTDTTSFSSDYELTKMVNGMIGTT 151
            .:...|....:: |...|...|||:||.:|:|:..:|.|    .|.|.....:|...:..:||..
  Rat    73 MDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKL----VTRSCDPAEKLDSKIGVLIGKG 133

  Fly   152 FDHNRTHGSPEIDDFRLYMTQTCDNIELERSAYTWQQRLLYEHPLRLANSTKMPELIRERHPTRT 216
            .........||:::||..|.:..::........:|...|.:.:|..  :...:.|.:.::.....
  Rat   134 LHEFDALKDPEVNEFRRKMRKFSEDKIQSLVGLSWIDWLKHTYPPE--HEPSVLENLEDKLYGGK 196

  Fly   217 FLIVVKNENDQSTFTLSVNEQDTPFSLTESTLQKMNRSQMKMNDRT-SDYILKVSGRDEYLLGDY 280
            .::.|..||.|..|:..|:....|..:.|..:||....:.|..:.: .||:|:||||.||:.||:
  Rat   197 LVVAVHFENSQDVFSFQVSPNLNPIKINELAIQKRLTIRGKEEEASPCDYVLQVSGRVEYVFGDH 261

  Fly   281 PLIQFLYIQEMLSDSAVPNVVL-----------QSVYRLESYINHHNEQAMVTKRPLPKKRTVHL 334
            |||||.||:..:.:..:|:.:|           |.:..:|:.||.::....:   |||.|:|
  Rat   262 PLIQFQYIRNCVMNRTLPHFILVECCKIKKMYEQEMIAIEAAINRNSSSLPL---PLPPKKT--- 320

  Fly   335 HKSISSLWDMGNYFQLTLHSISNVNFDKTRALKVGVHVCLYHGDKKLCAQRSTDSPNGNFDTFLF 399
             :.||.:|...|.||:.|...:.:|.::|  :||.|...|:||.:.||....:...:|..| .::
  Rat   321 -RVISHVWGNNNPFQIVLVKGNKLNTEET--VKVHVRAGLFHGTELLCKTVVSSEISGKND-HIW 381

  Fly   400 NDLVMDFDIQMRNLPRMTRLCIVIFEVTKMSRSKKSSN----NKDIALKDVPYNKNPLAWVNTTI 460
            |: .::|||.:.:||||.|||..::.|....::|||:.    :|...::.......|:|||||.:
  Rat   382 NE-QLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMV 445

  Fly   461 FDHKDILRTGRHTLYTW-TYADDIQSVEVFHPLGTIEPNPRKEECALVDLTFLSSGTGTVRYPSE 524
            ||.|..||:|...|::| ::.|:::  |:.:|:||::.||..|....:.:.|..:......||..
  Rat   446 FDFKGQLRSGDVILHSWSSFPDELE--EMLNPMGTVQTNPYAENATALHIKFPENKKQPYYYPPF 508

  Fly   525 EVVLQYAADREQVNRLQRQLAGPEKPIKELKELMANYTGLDKIYEMVDQDRNAIWERRNDILREL 589
            :.:::.||:....:.......|.:|.:..|||::..    |.:.::.:.:.:.||..|.|.....
  Rat   509 DKIIEKAAEIASGDSANVSSRGGKKFLAVLKEILDR----DPLSQLCENEMDLIWTLRQDCRENF 569

  Fly   590 PEELSILLHCVYWKERDDVADMWYLLKQWPLISIERSLELLDYAYPDPAVRRFAIRCLHFLKDED 654
            |:.|..||..:.|.:.:|||.:..||:.||.:....:|||||:.|||..||.:|:.||..:.||:
  Rat   570 PQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEE 634

  Fly   655 LLLYLLQLVQAIKHESYLESDLVVFLLERALRNQRIGHYFFWHLRSEMQTPSMQTRFGLLLEVYL 719
            |..|||||||.:|:|.:|:..|..|||||||.|:|||.:.|||||||:.||::..:||::||.|.
  Rat   635 LSQYLLQLVQVLKYEPFLDCALSRFLLERALDNRRIGQFLFWHLRSEVHTPAVSIQFGVILEAYC 699

  Fly   720 KGCKHHVAPLRKQLHVLEKLKQ-GSLI---AKKGSKEKVKTMLQDFLRDQRNSAVFQNIQNPLNP 780
            :|...|:..|.||:..|.|||. .|||   |.|.::.|.|..:...|:.........::|:||||
  Rat   700 RGSVGHMKVLSKQVEALNKLKTLNSLIKLNAMKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNP 764

  Fly   781 SFRCSGVTPDRCKVMDSKMRPLWVVFENADVNASDVHIIFKNGDDLRQDMLTLQMLRVMDQLWKR 845
            ....|.:..::|:.|||||:|||:|:.|.......|.:|||||||||||||||||||:||.|||.
  Rat   765 CVILSELYVEKCRYMDSKMKPLWLVYSNRAFGEDAVGVIFKNGDDLRQDMLTLQMLRLMDLLWKE 829

  Fly   846 DGMDFRMNIYNCISMEKSLGMIEVVRHAETIANIQKEKGMFSATSPFKKGSLLSWLKEHNKPADK 910
            .|:|.||..|.|::.....|:||||..:||||:||......:||:.|.|.:||:||||:|. .|.
  Rat   830 AGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAATAAFNKDALLNWLKEYNS-GDD 893

  Fly   911 LNKAINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPF 975
            |::||.||||||||||||:||||:.||||||||||:.|||||||||||||:||.|.|::||||||
  Rat   894 LDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPF 958

  Fly   976 VLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPELSSEKDLD 1040
            :||:||::||.:| ....:::|..|::.||.|:|:||:||.|.::||::|::.|||||:|.||:.
  Rat   959 ILTYDFIHVIQQG-KTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQ 1022

  Fly  1041 YLRETLVLDYTEEKAREHFRAKFSEALANSWKTSLNWASHNFSKN 1085
            ||:::|.|..:||:|.:.|:.||.|||..||.|.:||.:|...|:
  Rat  1023 YLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKD 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322	20/76 (26%)
		PI3K_rbd	200..307	CDD:197540	33/118 (28%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	57/182 (31%)
		PI3Ka_I	552..723	CDD:238444	73/170 (43%)
		PI3Kc_I	727..1084	CDD:270709	186/360 (52%)
Pik3cb	NP_445933.1	PI3K_p85B	41..118	CDD:197539	22/80 (28%)
		PI3K_rbd	180..288	CDD:197540	32/107 (30%)
		C2_PI3K_class_I_beta_delta	324..501	CDD:176075	57/182 (31%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250	410..418		3/7 (43%)
		PI3Ka_I	532..702	CDD:238444	73/173 (42%)
		PI3Kc_IA_beta	706..1067	CDD:270717	186/362 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339944
Domainoid	1	1.000	279	1.000	Domainoid score	I1619
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	705	1.000	Inparanoid score	I630
OMA	1	1.010	-	-		QHG57536
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	1	1.000	-	-		FOG0001201
OrthoInspector	1	1.000	-	-		otm63531
orthoMCL	1	0.900	-	-		OOG6_100986
Panther	1	1.100	-	-	O	PTHR10048
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X531
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770