DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K92E and VPS34

DIOPT Version :9

Sequence 1:NP_001262770.1 Gene:Pi3K92E / 42446 FlyBaseID:FBgn0015279 Length:1088 Species:Drosophila melanogaster
Sequence 2:NP_013341.1 Gene:VPS34 / 850941 SGDID:S000004230 Length:875 Species:Saccharomyces cerevisiae


Alignment Length:986 Identity:226/986 - (22%)
Similarity:407/986 - (41%) Gaps:279/986 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   256 MKMNDRT------SDYILKVSGRDEYLLGDYPLIQFLYIQEMLSDSAVPNVVL--QSVYRLESYI 312
            |.:|:.|      .|..|||  :.:.|.|..||::  ..|::|:    |.::|  .:|:      
Yeast     1 MSLNNITFCVSQDLDVPLKV--KIKSLEGHKPLLK--PSQKILN----PELMLIGSNVF------ 51

  Fly   313 NHHNEQAMVTKRPLPKKRTVHLHKSI---------SSLWDMGNYFQLTLHSISNVNFDKTRALKV 368
              .:...:|:.:...|:|..:|...|         |..||    :.|||..       :.:.|..
Yeast    52 --PSSDLIVSLQVFDKERNRNLTLPIYTPYIPFRNSRTWD----YWLTLPI-------RIKQLTF 103

  Fly   369 GVHVCL----YHGDKKLCAQRSTDSPNGNFDTFLFN-----------------------DLVMD- 405
            ..|:.:    |:|.|::        |..|.:|.:||                       ::|.| 
Yeast   104 SSHLRIILWEYNGSKQI--------PFFNLETSIFNLKDCTLKRGFESLKFRYDVIDHCEVVTDN 160

  Fly   406 ---------FDIQMRNLPRMTRLCIVIFEVTKMSRSKKSSN--------NKDIALKDVPYNKNPL 453
                     |..:...||.:..:.|     :|:.:.:::..        |.:..:.::|      
Yeast   161 KDQENLNKYFQGEFTRLPWLDEITI-----SKLRKQRENRTWPQGTFVLNLEFPMLELP------ 214

  Fly   454 AWVNTTIFDHKDILRTGRHTLYTWTYADDIQSVEVFHPLGT--IEPNPRKEECALVDLTFLSSGT 516
                 .:|..::|:.|..          :|.:::....|.|  .|||....:   :.::......
Yeast   215 -----VVFIEREIMNTQM----------NIPTLKNNPGLSTDLREPNRNDPQ---IKISLGDKYH 261

  Fly   517 GTVRY-----PSEEVVLQYAADREQVNRLQR--QLAGPEKPIK-ELKELMANYTGLDKIY----- 568
            .|:::     |:.:.:      .|:..||:|  :.|..:|.:| ::|:  .:|  |:||.     
Yeast   262 STLKFYDPDQPNNDPI------EEKYRRLERASKNANLDKQVKPDIKK--RDY--LNKIINYPPG 316

  Fly   569 -EMVDQDRNAIWERRNDILRELPEELSILLHCVYWKERDDVADMWYLLKQWPLISIERSLELLDY 632
             ::...::.:||:.|..::.. .:.|:.||.....:|..:..::..|:..|..|.|:.:||||..
Yeast   317 TKLTAHEKGSIWKYRYYLMNN-KKALTKLLQSTNLREESERVEVLELMDSWAEIDIDDALELLGS 380

  Fly   633 AYPDPAVRRFAIRCLHFLKDEDLLLYLLQLVQAIKHES--------------------------- 670
            .:.:.:||.:|:..|....|::|.|||||||:|:..|:                           
Yeast   381 TFKNLSVRSYAVNRLKKASDKELELYLLQLVEAVCFENLSTFSDKSNSEFTIVDAVSSQKLSGDS 445

  Fly   671 -----------------------------YLESDLVVFLLERALRNQRIGHYFFWHLRSEMQ--- 703
                                         .:.|.|..||:.|||.|.|:|.:|:|:|:||.:   
Yeast   446 MLLSTSHANQKLLKSISSESETSGTESLPIVISPLAEFLIRRALVNPRLGSFFYWYLKSESEDKP 510

  Fly   704 -----TPSMQTRFGLLLEVYLKGCKHHVAPLRKQLHVLEKLKQGSLIAKKGS------KEKVKTM 757
                 ..|..:|........|......:..||:....:::||..:  |||..      :.||:.:
Yeast   511 YLDQILSSFWSRLDKKSRNILNDQVRLINVLRECCETIKRLKDTT--AKKMELLVHLLETKVRPL 573

  Fly   758 LQDFLRDQRNSAVFQNIQNPLNPSFRCSGVTPDRCKVMDSKMRPLWVVFENADVNASDVHIIFKN 822
            ::           .:.|..||:|......|.|:..||..|.:.||.:.|:.. :| ...|::||.
Yeast   574 VK-----------VRPIALPLDPDVLICDVCPETSKVFKSSLSPLKITFKTT-LN-QPYHLMFKV 625

  Fly   823 GDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCISMEKSLGMIEVVRHAETIANIQKEKGMFS 887
            |||||||.|.:|::.:|::|.|.:.:|.::..|..::.....|.||.:.: :|:|:|..      
Yeast   626 GDDLRQDQLVVQIISLMNELLKNENVDLKLTPYKILATGPQEGAIEFIPN-DTLASILS------ 683

  Fly   888 ATSPFKKGSLLSWLKEH----NKPADKLNKAINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNG 948
                 |...:|.:||.|    |.........::.|..|||||||.||:|||.|||.||::|..:|
Yeast   684 -----KYHGILGYLKLHYPDENATLGVQGWVLDNFVKSCAGYCVITYILGVGDRHLDNLLVTPDG 743

  Fly   949 QLFHIDFGHILGHFKEKLGVRRERVPFVLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRK 1013
            ..||.|||:|||         ::..||.........|.:.|...||..:..|:..|..|:.:||:
Yeast   744 HFFHADFGYILG---------QDPKPFPPLMKLPPQIIEAFGGAESSNYDKFRSYCFVAYSILRR 799

  Fly  1014 HGCLILSLFSMMISTGLPELSSEKD--LDYLRETLVLDYTEEKAREHFRAKFSEA---------- 1066
            :..|||:||.:|.::.:|::..:.:  :..:||...|:.:||.|..||:...:::          
Yeast   800 NAGLILNLFELMKTSNIPDIRIDPNGAILRVRERFNLNMSEEDATVHFQNLINDSVNALLPIVID 864

  Fly  1067 ----LANSWKT 1073
                ||..|:|
Yeast   865 HLHNLAQYWRT 875

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K92ENP_001262770.1 PI3K_p85B 56..132 CDD:295322
PI3K_rbd 200..307 CDD:197540 16/58 (28%)
C2_PI3K_class_I_beta_delta 339..517 CDD:176075 34/224 (15%)
PI3Ka_I 552..723 CDD:238444 54/241 (22%)
PI3Kc_I 727..1084 CDD:270709 109/373 (29%)
VPS34NP_013341.1 TEL1 <1..872 CDD:227365 224/981 (23%)
PI3Kc_III 528..871 CDD:270628 107/378 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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