DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pi3K92E and TRRAP

DIOPT Version :9

Sequence 1:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_001362453.1	Gene:	TRRAP / 8295	HGNCID:	12347	Length:	3873	Species:	Homo sapiens

Alignment Length:	742	Identity:	136/742 - (18%)
Similarity:	239/742 - (32%)	Gaps:	277/742 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 NLW-KNEM-LNWVDLICLL---PN--------------GFLLELRVNPANTIQVIKVEMVNQAKQ 80
            ::| |:|: |.|.|.:.:.   ||              .|||.:..:||         :::..|.
Human  2144 DMWPKSELKLQWFDKLLMTVEQPNQVNYGNICTGLEVLSFLLTVLQSPA---------ILSSFKP 2199

  Fly    81 MPLGYVIKEACEYQVYGISTFNIEPYTDETKRLSEVQPYFGILSLGERTDTTSFSSDYELTKMVN 145
            :..|......|.      :|..:........||..:.|        ....|:|.:|.||..:.:.
Human  2200 LQRGIAACMTCG------NTKVLRAVHSLLSRLMSIFP--------TEPSTSSVASKYEELECLY 2250

  Fly   146 GMIG-------TTFDHNRTHGSP-EIDDFRLYMTQTCDN----IELERSAYTWQ-QRLLYEH--P 195
            ..:|       |.:: ..|:.:| ::....:.:...|.|    |:...|.:... |:::.||  |
Human  2251 AAVGKVIYEGLTNYE-KATNANPSQLFGTLMILKSACSNNPSYIDRLISVFMRSLQKMVREHLNP 2314

  Fly   196 LRLANSTKMP-----------ELIRERHPTRTFLIVVKNE---NDQSTFTLSVNEQDTPFSLTES 246
            ...:.||:..           ||::.|      |.|:..|   |.......|:.|:.....:..:
Human  2315 QAASGSTEATSGTSELVMLSLELVKTR------LAVMSMEMRKNFIQAILTSLIEKSPDAKILRA 2373

  Fly   247 TLQKM-----NRSQMKMND------------RTSDYILKVSGRDEYLLGDY-PLIQFLYIQEMLS 293
            .::.:     |.|.|..|.            :...||.|....|..|...: .|:.::|..|.||
Human  2374 VVKIVEEWVKNNSPMAANQTPTLREKSILLVKMMTYIEKRFPEDLELNAQFLDLVNYVYRDETLS 2438

  Fly   294 DSAVPNVVLQSVYRLE-SYINHHNEQAMVTKRPLPK-----------KRTVH---LHKSISSLWD 343
            .|       :...:|| ::::     .:...:||.:           ||.|:   |:.:.|..|:
Human  2439 GS-------ELTAKLEPAFLS-----GLRCAQPLIRAKFFEVFDNSMKRRVYERLLYVTCSQNWE 2491

  Fly   344 -MGNYFQLTLHSISNVNFDKTRALKVGVHVCLYHGDKKLCAQRSTDSPNGNFDTFLFNDLVMDFD 407
             |||:|.:            .:.:::.:.||          ::||  |.|.             .
Human  2492 AMGNHFWI------------KQCIELLLAVC----------EKST--PIGT-------------S 2519

  Fly   408 IQMRNLPRMTRLC-----------IVIFEVTKMSRSKKSSNNK------DIALKDVPYNKNPLAW 455
            .|...||.:|.:.           .::..|.:..|.:::|.:|      ||.|........|
Human  2520 CQGAMLPSITNVINLADSHDRAAFAMVTHVKQEPRERENSESKEEDVEIDIELAPGDQTSTP--- 2581

  Fly   456 VNTTIFDHKDI-----LRTGRHTLY-----------------------------TWTYADDIQSV 486
             .|.....|||     :.|.||..:                             ||        |
Human  2582 -KTKELSEKDIGNQLHMLTNRHDKFLDTLREVKTGALLSAFVQLCHISTTLAEKTW--------V 2637

  Fly   487 EVFHPLGTIEPNPRKEECALVDLTFLSSGTGTVR---------------------YPSEEVVLQY 530
            ::|..|..|..:.::...|.....||.||:..|:                     .|....||:|
Human  2638 QLFPRLWKILSDRQQHALAGEISPFLCSGSHQVQRDCQPSALNCFVEAMSQCVPPIPIRPCVLKY 2702

  Fly   531 AADREQV----------NRLQRQLAGPEKPIKELKELMANYTGLDKIYEMVDQDRNAIWERRNDI 585
            ......:          ...::.|:...|| |:..|          .||     :.:|...:.:|
Human  2703 LGKTHNLWFRSTLMLEHQAFEKGLSLQIKP-KQTTE----------FYE-----QESITPPQQEI 2751

  Fly   586 LRELPEELSILLHCVYWKERDDVADMW 612
            |..|.|..|:|      :|.|..|.:|
Human  2752 LDSLAELYSLL------QEEDMWAGLW 2772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322	11/75 (15%)
		PI3K_rbd	200..307	CDD:197540	26/138 (19%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	42/229 (18%)
		PI3Ka_I	552..723	CDD:238444	15/61 (25%)
		PI3Kc_I	727..1084	CDD:270709
TRRAP	NP_001362453.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	491..541
		Interaction with TP53. /evidence=ECO:0000269\|PubMed:12138177	2017..2395		52/280 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2030..2051
		Bipartite nuclear localization signal. /evidence=ECO:0000255	2054..2069
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2550..2585		8/38 (21%)
		TEL1	<2552..3873	CDD:227365	48/255 (19%)
		FAT	2868..3200	CDD:367004
		PIKK_TRRAP	3510..3797	CDD:270707
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900