DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K92E and Pi4kb

DIOPT Version :9

Sequence 1:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	XP_038959158.1	Gene:	Pi4kb / 81747	RGDID:	621214	Length:	862	Species:	Rattus norvegicus

Alignment Length:	958	Identity:	200/958 - (20%)
Similarity:	330/958 - (34%)	Gaps:	324/958 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 PLRLANSTKMPELIR--ERHPTRTFLIVVKNENDQSTFTLSVNEQDTPFSLTESTLQKMNRSQMK 257
            ||.|.|...:...||  :..||.     ::.|.|:.          .|..:  |...|..|.:.:
  Rat    99 PLELVNGDGVDNEIRCLDDPPTE-----IREEEDEM----------EPGVV--SGTAKGTRRRRQ 146

  Fly   258 MNDRTSDYILKVSGRDEYLLGDYPL-IQFLYIQEMLSDSAVPNVVLQSVYRLESYINH-----HN 316
            .|.....::|::.   |..|.|..: |.:||      :|..|.|        ::||.:     .|
  Rat   147 NNSAKQSWLLRLF---ESKLFDISMAISYLY------NSKEPGV--------QAYIGNRLFCFRN 194

  Fly   317 EQAMVTKRPLPKKRTVHLHKSISSLWDMGNYFQ-LTLHSI-SNVNFDKTRALKVGVHVCLYHGDK 379
            |.....   ||:...:::|..    .|:|:..: ..:|.. .::||....||.:|.    |..|.
  Rat   195 EDVDFY---LPQLLNMYIHMD----EDVGDAIKPYIVHRCRQSINFSLQCALLLGA----YSSDM 248

  Fly   380 KLCAQRSTDSPNGNFDTFLFNDLVMDFDI----QMRNLPRMTRLCIVIFEVTKMSRSKKSSNNKD 440
            .:..||.:....       ...|::..::    :.|.||.::..     ..|.:|.||::...
  Rat   249 HISTQRHSRGTK-------LRKLILSDELKPAHRKRELPTLSPA-----PDTGLSPSKRTHQR-- 299

  Fly   441 IALKDVPYNKNPLAWVNTTIFDHKDILRTGRHTLYTWTYADDIQSVEVFHPLGTIEPNPRKEECA 505
                                                 :.:|...|:.:...|.....||:.|.
  Rat   300 -------------------------------------SKSDATASISLSSNLKRTASNPKVEN-- 325

  Fly   506 LVDLTFLSSGTGTVRYPSEEVVLQYAADREQVNRLQ---RQLAGPEKPIKELKELMANYTGLDKI 567
              :...|||.|.::.......| :.|.:||.:..|.   ::||  ..|.||.|
  Rat   326 --EDEELSSSTESIDNSFSSPV-RLAPEREFIKSLMAIGKRLA--TLPTKEQK------------ 373

  Fly   568 YEMVDQDRNAIWERRNDILRELPEELSILLHCVYWKERDDVADMWYLLKQWPLISIERSLELLDY 632
                              .:.|..|||:|.|.:       .|.:|
  Rat   374 ------------------TQRLISELSLLNHKL-------PARVW-------------------- 393

  Fly   633 AYPDPAVRRFAIRCLH----FLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLERALRN------ 687
             .|........:|..|    .|..:|...||: .|:.::.|::..:::...:.|..:|:
  Rat   394 -LPTAGFDHHVVRVPHTQAVVLNSKDKAPYLI-YVEVLECENFDTTNVPARIPENRIRSTRSVEN 456

  Fly   688 ---------QRIGHYF----------FWHLR--SEMQTPSMQTRFGLLLEVYLKGCKHHVAPLRK 731
                     ||.|.:.          .|.:.  .|:|..        |.||:...|
  Rat   457 LPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVE--------LPEVHTNSC--------- 504

  Fly   732 QLHVLEKLKQGSL--IAKKGSKEKVKTMLQD---------------FLRDQRN-SAVFQNIQNPL 778
                 :.:.|.|:  |..:.|||.|.....|               |.||..: |||  .::.|.
  Rat   505 -----DNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAV--ALKEPW 562

  Fly   779 NPSFRCSGVTPDRCKVMDSKMR--------PLWVVFENADVNASDVHIIFKNGDDLRQDMLTLQM 835
            ....|              ::|        |.|.:          :.:|.|.||||||::|..|:
  Rat   563 QEKVR--------------RIREGSPYGHLPNWRL----------LSVIVKCGDDLRQELLAFQV 603

  Fly   836 LRVMDQLWKRDGMDFRMNIYNCISMEKSLGMIEVVRHAETIANIQKEKGMFSATSPFKKGSLLSW 900
            |:.:..:|:::.:...:..|..:.:....||||.|.:|.:|..::|:..:          |||.:
  Rat   604 LKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQL----------SLLDY 658

  Fly   901 -LKEHNK-PADKLNKAINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFK 963
             |:||.. ..:....|...|..||||||:..|:|.|.|||:.||::...|.:.|||||.||....
  Rat   659 FLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSP 723

  Fly   964 EKLGVRRERVPFVLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKH-------------G 1015
            ..||.  |...|.||.:||.|:. |.|   ...|.:::.|..:..:..|||             |
  Rat   724 RNLGF--ETSAFKLTTEFVDVMG-GLN---GDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQG 782

  Fly  1016 CLILSLFSM---------MISTGLPELSSEKDLDYLRETLVLDYTEEK 1054
            |...|..|:         :|.:.||.......:..|:|...:..|||:
  Rat   783 CRRCSGASLSGPVVTVAQVICSQLPCFHGSSTIRNLKERFHMSMTEEQ 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322
		PI3K_rbd	200..307	CDD:197540	22/109 (20%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	29/183 (16%)
		PI3Ka_I	552..723	CDD:238444	31/201 (15%)
		PI3Kc_I	727..1084	CDD:270709	98/378 (26%)
Pi4kb	XP_038959158.1	PI4KB_NTD	27..91	CDD:412074
Pi4kb	XP_038959158.1	PI4Kc_III_beta	554..862	CDD:270712	87/319 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810