DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K92E and zgc:158659

DIOPT Version :9

Sequence 1:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	XP_005170630.1	Gene:	zgc:158659 / 791141	ZFINID:	ZDB-GENE-070112-492	Length:	1070	Species:	Danio rerio

Alignment Length:	1082	Identity:	371/1082 - (34%)
Similarity:	587/1082 - (54%)	Gaps:	94/1082 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 CLLPNGFLLELRVNPANTIQVIKVEMVNQAKQMPLGYVIKEACEYQVYGIS-TFNIEPYTDETKR 112
            |.||||.|:.|.......:..||.::.::|::.||.::::|...|...|:: ....|.:.|||:|
Zfish    24 CCLPNGILVSLECLREAPLTSIKQQLFSEARKYPLYHLLQEESCYIFVGVTQEAEREEFYDETRR 88

  Fly   113 LSEVQPYFGILS----LGERTDTTSFSSDYELTKMVNGMIGTTFDHNRTHGSPEIDDFRLYMTQT 173
            |.:::.:..||.    ||.|.:..       |.:.:...||...........||:.|||..:...
Zfish    89 LCDLRLFHPILKVIEPLGNREEKI-------LNREIGFAIGMPICEFELVKDPEVQDFRRNILSV 146

  Fly   174 CDNIELERSAYTWQQRLLYEHPLRLANSTKMPELIRER----HPTRTFLIVVKNENDQSTFTLSV 234
            |.....||.......:.||.:|..:.:|..:|:.|..:    ....|..::|...|.:..:||.:
Zfish   147 CREAVEEREGGGAHTQALYVYPPNVESSPDLPQHIYSKLDKGRLIVTIWVIVSPSNSKQKYTLKI 211

  Fly   235 NEQDTPFSLTESTLQKMNRS------QMKM--NDRTSDYILKVSGRDEYLLGDYPLIQFLYIQEM 291
            .....|..|....::|..||      |:::  .:....|||||.|.|||.|..|||.|:.||:..
Zfish   212 AHDSLPEQLIAEAIRKKTRSMHLSAQQLRLCVQEYQGQYILKVCGCDEYFLEKYPLSQYKYIRSC 276

  Fly   292 LSDSAVPNVVLQSVYRLESYINHHNEQAMVTKRPLPKKRTVHLHK--------SISSLWDMGNYF 348
            ::...:|:::|.|...|.|.:......|     |...:||.....        |..|||....:.
Zfish   277 ITLCRLPHLMLVSKDSLYSQLPSSGFMA-----PSYSRRTPQPSPCPGGGDPGSPRSLWAFNTHL 336

  Fly   349 QLTLHSISNVNFDKTRALKVGVHVCLYHGDKKLCAQRSTD---SPNGNFDTFLFNDLVMDFDIQM 410
            ::.|...:.||.:.....|:.|...:|||.:.||...:|.   ..|..::.:|      .:||.:
Zfish   337 RVRLLCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWL------SYDIYL 395

  Fly   411 RNLPRMTRLCIVIFEVTKMSRSKKSSNNKDIALKDVPYNKNPLAWVNTTIFDHKDILRTGRHTLY 475
            .::||..|||:.|..|    :.:|.:..:..          ||||.|..:||:||.|.:|:..|.
Zfish   396 TDVPRSARLCLSICSV----KGRKGAKEEHC----------PLAWGNINLFDYKDTLVSGKVALG 446

  Fly   476 TWTYADDIQSVEVFHPLGTIEPNPRKE-ECALVDLTFLSSGTGTVRYPSEEVVLQYA---ADRE- 535
            .|.....::  ::.:|:|....||.|| .|..::..:.:.   ||.:|.|:.:.::|   ..||
Zfish   447 LWPVPHGLE--DLLNPIGVSGSNPNKETPCVELEFPWFNQ---TVVFPDEQQIEEHANWSISREL 506

  Fly   536 -------QVNRLQRQLAGPEKPIKELKELMANYTGLDKIYEMVDQDRNAIWERRNDILRELPEEL 593
                   ..:||....:..:...::|:.|.:.    |.:||:.:|:::.:|..|:..: .:||.|
Zfish   507 GYSYCLGLSSRLACDSSISQADAEQLRTLCSR----DPLYELSEQEKDFLWRHRHYCV-NIPESL 566

  Fly   594 SILLHCVYWKERDDVADMWYLLKQWPLISIERSLELLDYAYPDPAVRRFAIRCL-HFLKDEDLLL 657
            ..||..|.|..||:|:.::.|||.|||:..|.||||||..:|||.||.||:||| ..|.|:.|..
Zfish   567 PKLLLSVKWNSRDEVSQIYCLLKDWPLMQPESSLELLDCNFPDPMVREFALRCLIQGLTDDKLSQ 631

  Fly   658 YLLQLVQAIKHESYLESDLVVFLLERALRNQRIGHYFFWHLRSEMQTPSMQTRFGLLLEVYLKGC 722
            |||||||.:|:|.||::.|..||:::||.||||||:|||||:|||...::..|||||||.:.:.|
Zfish   632 YLLQLVQVLKYEMYLDNPLARFLIKKALTNQRIGHFFFWHLKSEMHNKTVSRRFGLLLEAFCRAC 696

  Fly   723 KHHVAPLRKQLHVLEKLKQGSLIAKKGSKEKVKTMLQDFLRDQRN----SAVFQNIQNPLNPSFR 783
            ..::..|.:|:..::||...:...|:..|::.:.....||.:..:    ....|...:||||..:
Zfish   697 GMYLKHLNRQVEAMDKLVNLTDTLKQEKKDETQKTQMKFLVEHMSRPDYMEALQGFVSPLNPVHQ 761

  Fly   784 CSGVTPDRCKVMDSKMRPLWVVFENADVNA----SDVHIIFKNGDDLRQDMLTLQMLRVMDQLWK 844
            ...:..:.|::|.|..||||:.:||.|:.:    ::..|||||||||||||||||::::|:.:|:
Zfish   762 LGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFTNNEIIFKNGDDLRQDMLTLQIIKIMENIWQ 826

  Fly   845 RDGMDFRMNIYNCISMEKSLGMIEVVRHAETIANIQKEKGMFSATSPFKKGSLLSWLKEHNKPAD 909
            ..|:|.||..|.|:|:...:|:||||:::.||..||.:.|:..|.. |...:|..|:::.|| .:
Zfish   827 NQGLDLRMLPYGCLSIGDCVGLIEVVKNSHTIMQIQCKGGLKGALQ-FNSNTLHHWIRDRNK-GE 889

  Fly   910 KLNKAINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVP 974
            ..::||:.||.|||||||||::||:.|||:.|||||.|||||||||||.|.|.|:|.|.:|||||
Zfish   890 AYDRAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKENGQLFHIDFGHFLDHKKKKFGYKRERVP 954

  Fly   975 FVLTHDFVYVINKGFND-RESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPELSSEKD 1038
            ||||.||:.||:||..: .::|||..|||:|.:|:|.:|:|..|.::|||:::..|:|||.|..|
Zfish   955 FVLTQDFLIVISKGVQECTKTKEFERFQEMCYKAYLAIRQHASLFINLFSLLLGCGMPELQSFDD 1019

  Fly  1039 LDYLRETLVLDYTEEKAREHFRAKFSEALANSWKTSLNWASH 1080
            :.|||:||.|:.::::|.|:|..:.::|....|.|.::|..|
Zfish  1020 IAYLRKTLALEKSQQEALEYFTKQMNDAHHGGWTTKMDWIFH 1061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322	21/80 (26%)
		PI3K_rbd	200..307	CDD:197540	33/118 (28%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	46/181 (25%)
		PI3Ka_I	552..723	CDD:238444	81/171 (47%)
		PI3Kc_I	727..1084	CDD:270709	154/363 (42%)
zgc:158659	XP_005170630.1	PI3K_p85B	32..107	CDD:280372	18/74 (24%)
		PI3K_rbd	173..292	CDD:279173	33/118 (28%)
		C2_PI3K_class_I_alpha	327..486	CDD:176043	46/183 (25%)
		PI3Ka_I	528..697	CDD:238444	81/173 (47%)
		PKc_like	696..1065	CDD:304357	155/368 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579750
Domainoid	1	1.000	170	1.000	Domainoid score	I3727
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	1	1.000	-	-		FOG0001201
OrthoInspector	1	1.000	-	-		otm25525
orthoMCL	1	0.900	-	-		OOG6_100986
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5021
SonicParanoid	1	1.000	-	-		X531
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.680