DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K92E and pik3cb

DIOPT Version :9

Sequence 1:NP_001262770.1 Gene:Pi3K92E / 42446 FlyBaseID:FBgn0015279 Length:1088 Species:Drosophila melanogaster
Sequence 2:NP_001072928.1 Gene:pik3cb / 780390 XenbaseID:XB-GENE-482674 Length:1065 Species:Xenopus tropicalis


Alignment Length:1092 Identity:402/1092 - (36%)
Similarity:615/1092 - (56%) Gaps:60/1092 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 PPCMRFSVNLWKNEMLNWVDLIC---LLPNGFLLELRVNPANTIQVIKVEMVNQAKQMPLGYVIK 88
            ||.|. .:::|..:.....| ||   |||.|..:::.|....:|..||..:...|:..||.:::.
 Frog     2 PPIMD-HMDIWTADTPLPPD-ICVDVLLPTGIYVQMDVPRDASISHIKQLLWKHAQSYPLFHLLL 64

  Fly    89 EACEYQVYGISTFNI-EPYTDETKRLSEVQPYFGILSLGERTDTTSFSSDYELTKMVNGMIGTTF 152
            |...|....::...: |...|||:||.:|:|:..:|.|..|    |.:...:|...:..:||...
 Frog    65 EIDSYMFQCVNHNAVHEELEDETQRLCDVRPFLPVLKLVSR----SCNPAEKLDSKIGVLIGKGL 125

  Fly   153 DHNRTHGSPEIDDFRLYMTQTCDNIELERSAYTWQQRLLYEHPLRLANSTKMPELIRERHPTRTF 217
            .........|:.:||..|....:.........||.:.|....|..|..|  :.:.|:.:......
 Frog   126 QEFDALKDNEVMEFRSKMRSISEAKIQSLLGLTWVEWLKRTFPPELEPS--IQDNIQGKLYGGNI 188

  Fly   218 LIVVKNENDQSTFTLSVNEQDTPFSLTESTLQKMNRSQMKMNDRTS------DYILKVSGRDEYL 276
            ::.:..||.|..|:..|:....|..:.|..::|    ::.::.|.:      |::|:|:||.|::
 Frog   189 VVAIHFENCQDVFSFQVSPNMVPVKVNELAIRK----RLTIHGREAEEVDPEDFVLQVNGRLEFV 249

  Fly   277 LGDYPLIQFLYIQEMLSDSAVPNVVL-----------QSVYRLESYINHHNEQAMVTKRPLPKKR 330
            .||:|||||.||:..:.:.|:|::.|           |.:..:|..:...:........|||.|:
 Frog   250 FGDHPLIQFQYIRNCVMNKALPHLTLVECCNIKKLFDQEMSEIEHAVRRKSSMHPALPMPLPPKK 314

  Fly   331 TVHLHKSISS---LWDMGNYFQLTLHSISNVNFDKTRALKVGVHVCLYHGDKKLCAQRSTDSPNG 392
            .....|:::.   :|::...:::.|...|.:|.:.:..::.|    |:||.:.||....|....|
 Frog   315 RGASMKTLNMRDIVWNIVQPYKIILSKGSRLNTEDSVLVRAG----LFHGTELLCKPTMTPEVQG 375

  Fly   393 NFDTFLFNDLVMDFDIQMRNLPRMTRLCIVIFEVTKMSRSKKSSNNKDIALKDVPYNKNPLAWVN 457
            ..| .::|: .::|:|.:.:||||.|||..|:.|....|:|..:..:.|  |.......|:||||
 Frog   376 KND-HVWNE-TLEFEINVCDLPRMARLCFAIYAVLDKPRNKNKTKYQTI--KKSGKMHFPVAWVN 436

  Fly   458 TTIFDHKDILRTGRHTLYTW-TYADDIQSVEVFHPLGTIEPNPRKEECALVDLTFLSSGTGTVRY 521
            |.:||:|..||:|.|.|:.| ::.|:::  |:.:|:||:..||..|....:.:.|.......:.|
 Frog   437 TMVFDYKGQLRSGDHVLHCWSSFPDELE--EMLNPMGTVRTNPYTENTTTLHIKFHDYSKEPISY 499

  Fly   522 PSEEVVLQYAAD-REQVNRLQRQLAGPEKPIKELKELMANYTGLDKIYEMVDQDRNAIWERRNDI 585
            |..:.:|:.||: ....:.|.....|.:|...||||:|..    |.:.::.:.:::.||..|.|.
 Frog   500 PPFDKILEKAAEIARNSDSLSTSGRGGKKLNIELKEIMER----DPLCQLSENEKDLIWTLRYDC 560

  Fly   586 LRELPEELSILLHCVYWKERDDVADMWYLLKQWPLISIERSLELLDYAYPDPAVRRFAIRCLHFL 650
            ....|..|..||..|.|.:.:|||.:..||:.|..:....:|||||:.|||..||.:|:.||..:
 Frog   561 RENFPGSLPKLLLSVKWNKLEDVAQLQALLQIWSKLPPRDALELLDFNYPDQYVREYAVNCLKPM 625

  Fly   651 KDEDLLLYLLQLVQAIKHESYLESDLVVFLLERALRNQRIGHYFFWHLRSEMQTPSMQTRFGLLL 715
            .||:|..|||||||.:|:|.:|:..|..|||:|||.|:|||.:.|||||||:..|::..:|||||
 Frog   626 SDEELSQYLLQLVQVLKYEPFLDCALSRFLLQRALDNRRIGQFLFWHLRSEVHNPAVSVQFGLLL 690

  Fly   716 EVYLKGCKHHVAPLRKQLHVLEKLK--QG--SLIAKKGSKEKVKTMLQDFLRDQRNSAVFQNIQN 776
            |.|.:|...|:..|.:|:..|.||:  .|  .|.|.|.||.|.|..:...||:........:||:
 Frog   691 EAYCRGSVAHMKVLSRQVEALNKLRTLNGLIKLNAVKLSKVKNKDNMHTCLRENAYKEALMHIQS 755

  Fly   777 PLNPSFRCSGVTPDRCKVMDSKMRPLWVVFENADVNASDVHIIFKNGDDLRQDMLTLQMLRVMDQ 841
            |||||...|.:..::||.|||||:|||:|:.|....:..:.||||||||||||||.||:||:||.
 Frog   756 PLNPSITLSELVVEKCKYMDSKMKPLWIVYNNRGFGSDSLGIIFKNGDDLRQDMLALQLLRLMDM 820

  Fly   842 LWKRDGMDFRMNIYNCISMEKSLGMIEVVRHAETIANIQKEKGMFSATSPFKKGSLLSWLKE-HN 905
            |||..|:|.|:..|.|::.....|.||||..|||||:||.:....:|.:.|.|.:||:|:|| |:
 Frog   821 LWKEAGLDLRIVPYGCLATGDRCGFIEVVSAAETIADIQLDSSNLAAAAAFNKDALLNWIKECHS 885

  Fly   906 KPADKLNKAINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRR 970
              .|.|.:||.|||||||||||||||||:.|||:|||||::.|||||||||||||:||.|..::|
 Frog   886 --GDDLERAIEEFTLSCAGYCVATYVLGIGDRHNDNIMVRKTGQLFHIDFGHILGNFKSKFKIKR 948

  Fly   971 ERVPFVLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPELSS 1035
            ||.||:||:||::||.:| ....:::|..|::.||.|:|:||::|.||::||::|::.|||||||
 Frog   949 ERGPFILTYDFIHVIQQG-KPGNTEKFGRFRQCCEDAYLILRRNGNLIITLFALMLTAGLPELSS 1012

  Fly  1036 EKDLDYLRETLVLDYTEEKAREHFRAKFSEALANSWKTSLNWASHNFSKNNK 1087
            .||:.|::::|.|...||.|.:.||.||.|||..||.|.:||.:|...|:.|
 Frog  1013 VKDIQYVKDSLALGKKEEDALKQFRQKFDEALKESWTTKVNWMAHTMRKDYK 1064

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K92ENP_001262770.1 PI3K_p85B 56..132 CDD:295322 20/76 (26%)
PI3K_rbd 200..307 CDD:197540 30/123 (24%)
C2_PI3K_class_I_beta_delta 339..517 CDD:176075 53/181 (29%)
PI3Ka_I 552..723 CDD:238444 75/170 (44%)
PI3Kc_I 727..1084 CDD:270709 183/361 (51%)
pik3cbNP_001072928.1 PI3K_p85B 33..108 CDD:308030 21/78 (27%)
PI3K_rbd 171..279 CDD:307097 30/113 (27%)
C2_PI3K_class_I_beta_delta 328..495 CDD:176075 53/176 (30%)
PI3Ka_I 533..697 CDD:238444 73/167 (44%)
PI3Kc_IA_beta 701..1062 CDD:270717 183/363 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 260 1.000 Domainoid score I1942
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 667 1.000 Inparanoid score I750
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D204282at2759
OrthoFinder 1 1.000 - - FOG0001201
OrthoInspector 1 1.000 - - otm49374
Panther 1 1.100 - - O PTHR10048
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X531
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
88.160

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