Protein Alignment Pi3K92E and Pik3cb

DIOPT Version :10

• Sequence 1: NP_650902.1
• Gene: Pi3K92E / 42446
• FlyBaseID: FBgn0015279
• Length: 1088
• Species: Drosophila melanogaster
• Sequence 2: NP_083370.2
• Gene: Pik3cb / 74769
• MGIID: 1922019
• Length: 1064
• Species: Mus musculus
• Alignment Length: 1085
• Identity: 411/1085 - (37%)
• Similarity: 629/1085 - (57%)
• Gaps: 51/1085 - (4%)

  Fly    27 PPCMRFSVNLWKNEML----NWVDLICLLPNGFLLELRVNPANTIQVIKVEMVNQAKQMPLGYVI 87
            ||.|..::::|..:..    ..:.:..|||.|..::|.|....||..||..:..|....|:..::
Mouse     2 PPAMADNLDIWAVDSQIASDGAISVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNYPMFNLL 66

  Fly    88 KEACEYQVYGIS-TFNIEPYTDETKRLSEVQPYFGILSLGERTDTTSFSSDYELTKMVNGMIGTT 151
            .:...|....:: |...|...|||:||.:|:|:..:|.|    .|.|.....:|...:..:||..
Mouse    67 MDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKL----VTRSCDPAEKLDSKIGVLIGKG 127

  Fly   152 FDHNRTHGSPEIDDFRLYMTQTCDNIELERSAYTWQQRLLYEHPLRLANSTKMPELIRERHPTRT 216
            .........||:::||..|.:..:.........:|...|.:.:|..  :...:.|.:.::.....
Mouse   128 LHEFDALKDPEVNEFRRKMRKFSEAKIQSLVGLSWIDWLKHTYPPE--HEPSVLENLEDKLYGGK 190

  Fly   217 FLIVVKNENDQSTFTLSVNEQDTPFSLTESTLQKMNRSQMKMNDRT-SDYILKVSGRDEYLLGDY 280
            .::.|..||.|..|:..|:....|..:.|..:||....:.|.::.: .||:|:||||.||:.||:
Mouse   191 LVVAVHFENSQDVFSFQVSPNLNPIKINELAIQKRLTIRGKEDEASPCDYVLQVSGRVEYVFGDH 255

  Fly   281 PLIQFLYIQEMLSDSAVPNVVL-----------QSVYRLESYINHHNEQAMVTKRPLPKKRTVHL 334
            |||||.||:..:.:..:|:.:|           |.:..:|:.||.::....:   |||.|:|
Mouse   256 PLIQFQYIRNCVMNRTLPHFILVECCKIKKMYEQEMIAIEAAINRNSSNLPL---PLPPKKT--- 314

  Fly   335 HKSISSLWDMGNYFQLTLHSISNVNFDKTRALKVGVHVCLYHGDKKLCAQRSTDSPNGNFDTFLF 399
             :.||.:||..|.||:||...:.:|.::|  :||.|...|:||.:.||....:...:|..| .::
Mouse   315 -RVISHIWDNNNPFQITLVKGNKLNTEET--VKVHVRAGLFHGTELLCKTVVSSEISGKND-HIW 375

  Fly   400 NDLVMDFDIQMRNLPRMTRLCIVIFEVTKMSRSKKSSN----NKDIALKDVPYNKNPLAWVNTTI 460
            |: .::|||.:.:||||.|||..::.|....::|||:.    :|...::.......|:|||||.:
Mouse   376 NE-QLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMV 439

  Fly   461 FDHKDILRTGRHTLYTW-TYADDIQSVEVFHPLGTIEPNPRKEECALVDLTFLSSGTGTVRYPSE 524
            ||.|..||:|...|::| ::.|:::  |:.:|:||::.||..|....:.:||..:......||..
Mouse   440 FDFKGQLRSGDVILHSWSSFPDELE--EMLNPMGTVQTNPYAENATALHITFPENKKQPCYYPPF 502

  Fly   525 EVVLQYAADREQVNRLQRQLAGPEKPIKELKELMANYTGLDKIYEMVDQDRNAIWERRNDILREL 589
            :.:::.||:....:.......|.:|.:..|||::..    |.:.::.:.:.:.||..|.|.....
Mouse   503 DKIIEKAAELASGDSANVSSRGGKKFLAVLKEILDR----DPLSQLCENEMDLIWTLRQDCRENF 563

  Fly   590 PEELSILLHCVYWKERDDVADMWYLLKQWPLISIERSLELLDYAYPDPAVRRFAIRCLHFLKDED 654
            |:.|..||..:.|.:.:|||.:..||:.||.:....:|||||:.|||..||.:|:.||..:.||:
Mouse   564 PQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEE 628

  Fly   655 LLLYLLQLVQAIKHESYLESDLVVFLLERALRNQRIGHYFFWHLRSEMQTPSMQTRFGLLLEVYL 719
            |..|||||||.:|:|.:|:..|..|||||||.|:|||.:.|||||||:.||::..:||::||.|.
Mouse   629 LSQYLLQLVQVLKYEPFLDCALSRFLLERALDNRRIGQFLFWHLRSEVHTPAVSVQFGVILEAYC 693

  Fly   720 KGCKHHVAPLRKQLHVLEKLKQ-GSLI---AKKGSKEKVKTMLQDFLRDQRNSAVFQNIQNPLNP 780
            :|...|:..|.||:..|.|||. .|||   |.|.|:.|.|..:...|:.........::|:||||
Mouse   694 RGSVGHMKVLSKQVEALNKLKTLNSLIKLNAVKLSRAKGKEAMHTCLKQSAYREALSDLQSPLNP 758

  Fly   781 SFRCSGVTPDRCKVMDSKMRPLWVVFENADVNASDVHIIFKNGDDLRQDMLTLQMLRVMDQLWKR 845
            ....|.:..::||.|||||:|||:|:.:.......|.:|||||||||||||||||||:||.|||.
Mouse   759 CVILSELYVEKCKYMDSKMKPLWLVYSSRAFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKE 823

  Fly   846 DGMDFRMNIYNCISMEKSLGMIEVVRHAETIANIQKEKGMFSATSPFKKGSLLSWLKEHNKPADK 910
            .|:|.||..|.|::.....|:||||..:||||:||......:||:.|.|.:||:||||:|. .|.
Mouse   824 AGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAATAAFNKDALLNWLKEYNS-GDD 887

  Fly   911 LNKAINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPF 975
            |::||.||||||||||||:||||:.||||||||||:.|||||||||||||:||.|.|::||||||
Mouse   888 LDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPF 952

  Fly   976 VLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPELSSEKDLD 1040
            :||:||::||.:| ....:::|..|::.||.|:|:||:||.|.::||::|::.|||||:|.||:.
Mouse   953 ILTYDFIHVIQQG-KTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQ 1016

  Fly  1041 YLRETLVLDYTEEKAREHFRAKFSEALANSWKTSLNWASHNFSKN 1085
            ||:::|.|..:||:|.:.|:.||.|||..||.|.:||.:|...|:
Mouse  1017 YLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKD 1061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_650902.1	PI3K_p85B	56..132	CDD:470589	20/76 (26%)
		PI3K_rbd	200..307	CDD:197540	33/118 (28%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	60/182 (33%)
		PI3Ka_I	552..723	CDD:238444	73/170 (43%)
		PI3Kc_I	727..1084	CDD:270709	187/360 (52%)
Pik3cb	NP_083370.2	PI3K_p85B	35..112	CDD:197539	22/80 (28%)
		PI3K_rbd	174..282	CDD:197540	32/107 (30%)
		C2_PI3K_class_I_beta_delta	318..495	CDD:176075	60/182 (33%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250	404..412		3/7 (43%)
		PI3Ka_I	526..696	CDD:238444	73/173 (42%)
		PI3Kc_IA_beta	700..1061	CDD:270717	187/362 (52%)
		G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	772..778		4/5 (80%)
		Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	910..918		5/7 (71%)
		Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	929..955		19/25 (76%)