Protein Alignment Pi3K92E and Atr

DIOPT Version :9

• Sequence 1: NP_001262770.1
• Gene: Pi3K92E / 42446
• FlyBaseID: FBgn0015279
• Length: 1088
• Species: Drosophila melanogaster
• Sequence 2: XP_003750609.1
• Gene: Atr / 685055
• RGDID: 1305796
• Length: 2636
• Species: Rattus norvegicus
• Alignment Length: 1155
• Identity: 213/1155 - (18%)
• Similarity: 368/1155 - (31%)
• Gaps: 390/1155 - (33%)

  Fly    54 GFLLELRVNPANTIQVIKVEMVNQAKQMPLGYVIKE-ACEYQVYGI---------STFNIEPYTD 108
            |||.:|.........|..|..:.:|:..     :|| ..|::..|:         ....:||
  Rat  1669 GFLQKLYAAMHEPDGVAGVSAIRKAEPS-----LKEQILEHESIGLLRDATACYDRAIQLEP--- 1725

  Fly   109 ETKRLSEVQPYFGI----LSLGERTDTTSFSSDYELTKMVNGMIGTTFDH-NRTHGSPEIDDFRL 168
                 .::..|.|:    |.||:.:...:         .|||:      | ||:..:.|::.:|:
  Rat  1726 -----DQIIHYHGVVKSMLGLGQLSTVIT---------QVNGV------HANRSEWTDELNTYRV 1770

  Fly   169 ---YMTQTCDNIE----LERSAYTWQQRLLYEHPLRLANSTKMPELIRERHPTRTFLIVVKNEND 226
               :.....|.:|    .:..:.||..||
  Rat  1771 EAAWKLSQWDLVENYLAADGKSTTWSVRL------------------------------------ 1799

  Fly   227 QSTFTLSVNEQDTPFSLTESTLQKMNRSQMKMNDRTSDYILKVSG----RDEYLLGDYPLIQFLY 287
             ....||..::||  :....||:.:...|          |:.:|.    |..|..| |..|..|:
  Rat  1800 -GQLLLSAKKRDT--TAFYDTLKLVRAEQ----------IVPLSAASFERGSYQRG-YEFIVRLH 1850

  Fly   288 IQEMLSDSAVP-----------NVVLQSVYRLESYINHHNEQAMVTKRPLPKKRTVHLHKSISSL 341
            :...|..|..|           ...|....|||...|.:.     .|.|:     :.|.:::.||
  Rat  1851 MLCELEHSLKPLFHKFPGDSCNEDSLNWAARLEMTQNSYR-----AKEPI-----LALRRALLSL 1905

  Fly   342 WDMGNYFQLTLHSISNVNFDKTR-ALKVGVHVCLYHGDKKLCAQRSTDSPNGNFDTFLFNDLVMD 405
            ....:|.::    :........| |.|.|.|...|:.                    |.|
  Rat  1906 NKRPDYNEM----VGECWLQSARVARKAGHHQTAYNA--------------------LLN----- 1941

  Fly   406 FDIQMRNLPRMTRLCIVIFEVTKMSRSKKSSNNKDIALKD-----VPYNKNPLAWVNTTIFDHKD 465
                    ...:||..:..|..|...||...:...|.|:.     .|.||:|.        :.|.
  Rat  1942 --------AGESRLAELYVERAKWLWSKGDVHQALIVLQKGVELCFPENKSPT--------ESKH 1990

  Fly   466 ILRTGRHTLYTWTYADDIQSVEVFHPLGTIEPNPRKEECALVDLTFLSSGTGTVRYPSEEVVLQY 530
            :|..||.||....:.::                                   |..:.|..::.:|
  Rat  1991 MLIHGRATLLVGRFMEE-----------------------------------TANFESNAIMKKY 2020

  Fly   531 AADREQVNRLQRQLAGPEKPIKELKELMANYTGLDKIYEMVDQDRNAIWERRNDILR-------- 587
                :.|.     |..||  .::....:|.|  .||:..||..::   .|::.|::|
  Rat  2021 ----KDVT-----LFLPE--WEDGHFYLAKY--YDKLMPMVTDNK---MEKQGDLIRYIVLHFGR 2069

  Fly   588 -----------ELPEELSILL----HCVYWKE--RDDVADMWYLLKQWPLISIERSLELLDYAYP 635
                       .:|..||:.|    ....|::  |.|...|...|.:...:..|.:..|..|.:
  Rat  2070 SLQYGNQFIYQSMPRMLSLWLDFGAKAYEWEKGGRSDRLQMRNDLAKINSVLTEHTNRLAPYQF- 2133

  Fly   636 DPAVRRFAIRCLHFLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLERALRNQRIGHYFFWHLRS 700
                                |....||:..|.|.   ..::.|.|:|      .|...|..:.:.
  Rat  2134 --------------------LTAFSQLISRICHS---HDEVFVVLME------IIAKVFLAYPQQ 2169

  Fly   701 EMQTPSMQTRFGLLLEVYLKGCKHHVAPLRKQLHVLEKLKQ----GSLIAKK----------GSK 751
            .|...:..::....:.|  ..||.   .|.|.:|:.:.|::    .:.:..|          ||.
  Rat  2170 AMWMMTAVSKSSYPMRV--NRCKE---ILTKAIHMKKSLEKFVGDATRLTDKLLELCNKSVDGSN 2229

  Fly   752 EKVK-----TMLQDFLRDQRNSAV---FQNIQNPLNPSFRCSGVT--------------PDRCKV 794
            ..:.     .||:..:.|...|.:   .|::..|..||...:...              .|..::
  Rat  2230 STLSMSTHFKMLKKLVEDPTFSEILIPLQSVMIPTLPSILGAHANHDPFPGHWAYLAGFDDVVEI 2294

  Fly   795 MDSKMRPLWVVFENADVNASDVHIIF-KNGDDLRQDMLTLQMLRVMDQLWKRDG----MDFRMNI 854
            :.|..:|..:..:.:|   ...:|:. |..||||:|...::...::::..::|.    .:..:..
  Rat  2295 LSSLQKPKKISLKGSD---GKFYIMMCKPKDDLRKDCRLMEFNSLINKSLRKDAESRRRELHIRT 2356

  Fly   855 YNCISMEKSLGMIEVVRHA----ETIANIQKEKGMFSATSPFK-----KGSLLSWLKEHNKPADK 910
            |..|.:....|:||.|.:.    ..:..:.||||::......:     |.:.||         :|
  Rat  2357 YAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALS---------EK 2412

  Fly   911 LNKAINEFTL-----------------------SCAGYCVAT-------YVLGVADRHSDNIMVK 945
            | |...|..|                       |.:.||.:|       |:||:.|||.:||:..
  Rat  2413 L-KVFQEILLPRHPPVFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFD 2476

  Fly   946 R-NGQLFHIDFGHILGHFKEKLGVRRERVPFVLTHDFVYVINKGFNDRESKEFCHFQELCERAFL 1009
            . .|:..|:||..:..  |.:.....|.|||.|||:.|    .|.....::..  |:..||....
  Rat  2477 SFTGECVHVDFNCLFN--KGETFEVPEIVPFRLTHNMV----NGMGPMGTEGL--FRRACEVTLR 2533

  Fly  1010 VLRKHGCLILSLFSMMISTGLPELSSE-KDLDYLRETLVLDYTEEKAREH 1058
            ::|.....::|:....:...|.|.|.. |...........:...|||:.|
  Rat  2534 LMRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPPNETGEVVNEKAKTH 2583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322	16/89 (18%)
		PI3K_rbd	200..307	CDD:197540	19/121 (16%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	29/183 (16%)
		PI3Ka_I	552..723	CDD:238444	33/195 (17%)
		PI3Kc_I	727..1084	CDD:270709	84/414 (20%)
Atr	XP_003750609.1	UME	1120..1226	CDD:214825
		FAT	1766..2087	CDD:280429	79/476 (17%)
		TEL1	<2118..2636	CDD:227365	101/522 (19%)
		PIKKc_ATR	2285..2559	CDD:270625	63/294 (21%)
		FATC	2605..2636	CDD:280430

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900