DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K92E and Pik3c3

DIOPT Version :9

Sequence 1:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_075247.1	Gene:	Pik3c3 / 65052	RGDID:	620899	Length:	887	Species:	Rattus norvegicus

Alignment Length:	960	Identity:	234/960 - (24%)
Similarity:	404/960 - (42%)	Gaps:	231/960 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 LSVNEQDTPFSLTESTLQKMNRSQMKMNDRTSDYILKVSGRDEYLLGDYPLIQFLYIQ-EMLSDS 295
            |.:|.|....||.....||..::.::      |.:||.||..:....|      ||:. ::.::.
  Rat    15 LDINVQLKIGSLEGKREQKSYKAVLE------DPMLKFSGLYQETCSD------LYVTCQVFAEG 67

  Fly   296 AVPNVVLQSVYRLESYINHHNE-QAMVTKRP-LPKKRTVHLHKSISSLWDM---GNYFQLTLHSI 355
            ....:.:::.|:..|...:.|| ..:..|.| ||:...|.|     ::||:   |....:...::
  Rat    68 KPLALPVRTSYKPFSTRWNWNEWLKLPVKYPDLPRNAQVAL-----TIWDVYGPGRAVPVGGTTV 127

  Fly   356 SNVNFDKTRALKVGVHVCLYHGDKKLCAQRSTDSPNGNFDTFLFNDLVMDFDIQMRNLPRMTRL- 419
            |  .|.|....:.|:|......:.:......|.:| |...:.|..|       ||..|.::|:.
  Rat   128 S--LFGKYGMFRQGMHDLKVWPNVEADGSEPTRTP-GRTSSTLSED-------QMSRLAKLTKAH 182

  Fly   420 ------------CIVIFEVTKMSRSKKSSNN--------KDIALKDVPYNKNPLAWVNTTIFDHK 464
                        .:...|:..::.|:|.|:|        :.:...|..|.         .::..|
  Rat   183 RQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYG---------IVYYEK 238

  Fly   465 DILRTGRHTLYTWTYADDIQSVEVFHPLGTIEPNPRKEECALVD------LTFLSSGTGTVRYPS 523
            |              .|:...:.....|..: |:|:.....||:      ...|.||      ||
  Rat   239 D--------------GDESSPILTSFELVKV-PDPQMSMENLVESKHHKLARSLRSG------PS 282

  Fly   524 EEVVLQYAADREQVNRLQRQLAGPEKPIKELKELMANYTGLDKIYEMVDQDRNAIWERRNDILRE 588
            :..:...|..|:|:|.:   ::.|  |.|:|            .||    :::.:|:.|. .|..
  Rat   283 DHDLKPNATTRDQLNII---VSYP--PTKQL------------TYE----EQDLVWKFRY-YLTN 325

  Fly   589 LPEELSILLHCVYWKERDDVADMWYLLKQWPLISIERSLELLDYAYPDPAVRRFAIRCLHFLKDE 653
            ..:.|:..|.||.|....:......||.:|..:.:|.|||||...|.:|.|||:|:..|....||
  Rat   326 QEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDE 390

  Fly   654 DLLLYLLQLVQAIKHESY----------------------------------------------- 671
            |||:||||||||:|:|::
  Rat   391 DLLMYLLQLVQALKYENFDDIKNGLEPTKKDSQASVSESLSSSGVSSADIDSSQIITNPLPPVAS 455

  Fly   672 ---------------LESDLVVFLLERALRNQRIGHYFFWHLRSEMQTPSMQTRFGLLLEVY--- 718
                           ||.||..||:.||.:|..:.:|.:|::..|.:....|.|.....|:|
  Rat   456 PPPASKSKEVSDGENLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNV 520

  Fly   719 --------LKGCKHHVAPLRKQL-----------HVLEKLKQGSLIAKKGSKEKVKTMLQDFLRD 764
                    |||.| .|..:|..|           |:::.:::.|     |:::|....||..|.|
  Rat   521 MRRFSQALLKGDK-SVRVMRSLLAAQQTFVDRLVHLMKAVQRES-----GNRKKKNERLQALLGD 579

  Fly   765 --QRNSAVFQNIQNPLNPSFRCSGVTPDRCKVMDSKMRPLWVVFENADVNASDVHIIFKNGDDLR 827
              :.|.:..:.|..||.|..:..|:.|:...:..|.:.|..:.|:..|  .....:|||:|||||
  Rat   580 NEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTED--GGKYPVIFKHGDDLR 642

  Fly   828 QDMLTLQMLRVMDQLWKRDGMDFRMNIYNCISMEKSLGMIEVVRH---AETIANIQKEKGMFSAT 889
            ||.|.||::.:||:|.:::.:|.::..|..::.....|.::.::.   ||.:......:..|...
  Rat   643 QDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKY 707

  Fly   890 SPFKKGSLLSWLKEHNKPADKLNKAINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHID 954
            :|.:.|           |.....:.::.:..|||||||.||:|||.|||.||:::.:.|:|||||
  Rat   708 APSETG-----------PNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHID 761

  Fly   955 FGHILGHFKEKLGVRRERVPFVLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLIL 1019
            ||:|||...:.|     ..|..|..:.|    :|....:|:::..|::.|..|||.||::..|||
  Rat   762 FGYILGRDPKPL-----PPPMKLNKEMV----EGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLIL 817

  Fly  1020 SLFSMMISTGLPELSSEKD--LDYLRETLVLDYTEEKAREHFRAKFSEAL 1067
            :|||:|:...:|:::.|.|  :..:::...||.::|:|..:.::...|::
  Rat   818 NLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESV 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322
		PI3K_rbd	200..307	CDD:197540	15/75 (20%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	35/207 (17%)
		PI3Ka_I	552..723	CDD:238444	62/243 (26%)
		PI3Kc_I	727..1084	CDD:270709	102/359 (28%)
Pik3c3	NP_075247.1	C2_PI3K_class_III	26..186	CDD:176042	38/186 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..170		4/21 (19%)
		PI3Ka_III	283..503	CDD:238442	61/241 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..467		0/50 (0%)
		PI3Kc_III	539..883	CDD:270628	102/356 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820