DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K92E and pik3c2a

DIOPT Version :9

Sequence 1:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	XP_005159362.2	Gene:	pik3c2a / 571356	ZFINID:	ZDB-GENE-030328-39	Length:	1691	Species:	Danio rerio

Alignment Length:	1263	Identity:	327/1263 - (25%)
Similarity:	527/1263 - (41%)	Gaps:	308/1263 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ETPPEEAEPPCMRFSVNLWKNEMLNWVDLICLLPNGFLLELRVNPANTIQVIKVEMV-------- 75
            |..|:.:|||      |:.:.|   |:||              :|.|..:.::||..
Zfish   246 EPLPQPSEPP------NISRFE---WLDL--------------DPLNKRKEVEVEETPAVSSCPF 287

  Fly    76 ----NQAKQMPLGYVIKEACEYQVYGISTFNIEPYTDETKRLSEVQP----YFGILSLGERTDTT 132
                .:||. |...|:::..|      :..|..|..:|  :....||    ....::..:....:
Zfish   288 IEESGKAKD-PWDAVLQDEHE------TVDNGSPKAEE--KCKATQPRRASTGAAVTKSQSLSIS 343

  Fly   133 SFSSDYELTKMVNGMIGTTFDHNRTHGSPEIDDFRLYMTQTCDNIELERSAYTWQQRLLYEHPLR 197
            |.|::....|.||.  |:|...::.....|.:...|.:...|::|...||.:....  |..:|
Zfish   344 SNSTNQSTGKQVNK--GSTNVLSKYSALQEKEAQNLEVVAFCEDISKLRSKFPHDD--LSTNP-- 402

  Fly   198 LANSTKMPELIRERHP------TRTFLIVVKNENDQSTFTLSVNEQDTPFSLTESTLQKM----- 251
               ...:..:|.:|..      :....|.:.:.....|||..|.   :|..|.  .:|.:
Zfish   403 ---GYVLSPVITQRDAGGDNGGSVKVSIEISDSQQPVTFTCDVT---SPVDLL--IMQALCWVHD 459

  Fly   252 NRSQMKMNDRTSDYILKVSGRDEYLLGDYPL-----------------IQFLYIQEMLSDSA--- 296
            :.:|:.:|    .|:|||.|::|.|...:.|                 :|.|::..|..|.|
Zfish   460 DLNQVDIN----SYVLKVCGQEEVLQNKHSLGSHEYVQNCRKWESEIKLQLLFLSTMRRDLARTA 520

  Fly   297 ---------------VPNVVLQSVYR--LESYI------------NHHN---------------- 316
                           |.....::|.|  |..|:            |.:|
Zfish   521 EDDISPIDLEKYLGLVERPFKEAVTREGLAEYLEGFHKQVNLCLQNENNQYKTVDNVVQSVKNLC 585

  Fly   317 ------EQAMVTKRPLPKKRTVHL------------------------------HKSISSLWD-- 343
                  |...:|......||:|:|                              .:|::.|.|
Zfish   586 CALDEVETPAITDAVKRLKRSVNLPRTRSPEHYAELQAGATSSGGSANGYSSPVEESLAVLTDAV 650

  Fly   344 -----------------------------------MGNYFQLTLHSISNV------NFDKTRALK 367
                                               ...:.|.||.::..:      :|:|...:
Zfish   651 YELAKLYLQSFCPISPGFMIEEHKEDERDSKEASGTTEHLQFTLFAVHGIPATWVSSFEKYYLM- 714

  Fly   368 VGVHVCLYHGDKKLCAQRSTDSPN-GNFDTFLFN---DLVMDFDIQMRNLPRMTRLCIVIFEVTK 428
                ..|.|.::.|.  :...|.. |.:.:|.::   |.:::|.|.:..||....|.:.::.|..
Zfish   715 ----CALTHNNRNLF--KPVQSKKVGTYKSFFYHIKWDELINFPISVSLLPLEAMLSLSLYGVLS 773

  Fly   429 MSRSKKSSNNKDIALKDVPYNKNP--LAWVNTTIFDHKDILRTGRHTLYTWTYADDIQSVEVFHP 491
            .:.:....:||.        .|.|  |..|:..:||.:.:|..|...|..||      |.:...|
Zfish   774 QNANNSPDSNKQ--------RKGPELLGKVSMPLFDFRRVLSRGSKLLSLWT------SPQALQP 824

  Fly   492 LGTIEPNPRKEECALVDLTFLSSGTGTVRYPSEEVVLQY-----AADREQVNRLQRQLAGPEK-- 549
                                  ...|..|.|:|:::||.     |.|...|...:.....|:.
Zfish   825 ----------------------GAAGKGRNPTEKIILQVDFPSPAVDVLYVGPQENGCPNPQSLD 867

  Fly   550 PI-----KELKELMANYT--GLDKIYEMVDQDRNAIWERRNDILRELPEEL-SILLHCVYWKERD 606
            |:     .|:::|.|..:  ||.:      .||..:|::|. ..||....| .||.....| :..
Zfish   868 PLDQDDRSEIEKLCARASTFGLSR------ADRQLLWDQRY-YCREYEYSLPKILASAPSW-DWG 924

  Fly   607 DVADMWYLLKQWPLISIERSLELLDYAYPDPAVRRFAIRCLHFLKDEDLLLYLLQLVQAIKHESY 671
            .:.::..||..||.:|...:||||:..:.|..||:.|:..:....|::|..||.|||||:|.|.:
Zfish   925 SMGEIHALLHHWPALSPVSALELLESKFADTEVRKVAVSWIQSSSDDELADYLPQLVQAVKFECH 989

  Fly   672 LESDLVVFLLERALRNQRIGHYFFWHLRSEMQTPSMQTRFGLLLEVYLKGCKHHV-APLRKQLHV 735
            |::.||.|||.|||.|..|.||.:|.||..:|.|:...|:..:|.|.|..|...: |.|.||..:
Zfish   990 LKNALVKFLLSRALGNVNIAHYLYWLLRDAVQDPAFGQRYERILCVLLCLCGTGLRAELEKQTRL 1054

  Fly   736 LEKLKQGSLIAK--KGSKEKVKTMLQDFLRDQRNSAVFQ--NIQNPLNPSFRCSGVTPDRCKVMD 796
            ::.|  |:|..|  :.|....:.:|.:.|  :|..:.||  :.:.|::||.....:....|...:
Zfish  1055 VQLL--GALAEKVRQASSSTRQVVLLEGL--ERVQSFFQKNSCRLPISPSLVAKELNIKVCSFFN 1115

  Fly   797 SKMRPLWVVFENADVNASDVHIIFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCISME 861
            |...||.:...|||....:::::||.|:|||||||.|||:|:||::|.::|:|.|:..:.|||..
Zfish  1116 SNAVPLKIALVNADPLGDEINVMFKVGEDLRQDMLALQMIRIMDRIWLQEGLDLRIVNFKCISTG 1180

  Fly   862 KSLGMIEVVRHAETIANIQKEKGMFSATSPFKKGSLLSWLKEHNKPADKLNKAINEFTLSCAGYC 926
            |..||:|:|..:||:..||.|.|:   |..||...|..||:::|...|:..||...|..:|||.|
Zfish  1181 KDKGMVELVPSSETLRKIQVEYGV---TGSFKDKPLAEWLRKYNPAEDEYEKASENFIYTCAGCC 1242

  Fly   927 VATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPFVLTHDFVYVINKGFND 991
            ||||:||:.|||:||||::..|.:||||||..|||.:.....:|:|.|||||.|..||||.|  :
Zfish  1243 VATYILGICDRHNDNIMLRSTGHMFHIDFGKFLGHAQMIGSFKRDRAPFVLTSDMAYVINGG--E 1305

  Fly   992 RESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPELSSEKDLDYLRETLVLDYTEEKAR 1056
            |.:..|..|.:||.:|:.::|||..|.|:|.|:|..:|||||:..:||.|:.:.|....|:.:|.
Zfish  1306 RPTSRFQLFVDLCSQAYNLIRKHSNLFLNLLSLMTQSGLPELTGVQDLKYVYDALQPQTTDAEAT 1370

  Fly  1057 EHFRAKFSEALANSWKTSLNWASHNFSK 1084
            ..| .:..|:...|..|..|:..||.::
Zfish  1371 IFF-TRLIESSLGSVATKFNFFIHNLAQ 1397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322	14/91 (15%)
		PI3K_rbd	200..307	CDD:197540	27/152 (18%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	35/226 (15%)
		PI3Ka_I	552..723	CDD:238444	61/173 (35%)
		PI3Kc_I	727..1084	CDD:270709	141/360 (39%)
pik3c2a	XP_005159362.2	Amelogenin	<137..207	CDD:330537
		PI3K_rbd	420..507	CDD:307097	19/95 (20%)
		C2A_PI3K_class_II	681..852	CDD:175979	41/213 (19%)
		PI3Ka	872..1038	CDD:320871	60/173 (35%)
		PKc_like	1045..1397	CDD:328722	141/361 (39%)
		PX_PI3K_C2_alpha	1428..1536	CDD:132822
		C2B_PI3K_class_II	1565..1686	CDD:176027
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579749
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750