DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K92E and pik3c2b

DIOPT Version :9

Sequence 1:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	XP_003199535.1	Gene:	pik3c2b / 567938	ZFINID:	ZDB-GENE-050309-145	Length:	1587	Species:	Danio rerio

Alignment Length:	1152	Identity:	316/1152 - (27%)
Similarity:	491/1152 - (42%)	Gaps:	269/1152 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 TFNIEPYTDETKRLSEVQPYFGILSLGERTDTTSFSSDYELTKMVNGMIGTTFDHNRTHGSPEID 164
            |:...|.:..::|...|.|    :|||.|.:    ...|||.::                |.|.|
Zfish   238 TYLPTPKSTRSQRRVSVDP----VSLGSRPN----GFGYELFQV----------------SEERD 278

  Fly   165 DFRLYMTQTCDNIELERSAY-----------TWQQRLLYEHPLR-LANSTKMPELIRERHPTRTF 217
            :   .:...|..::|.||||           .|...:..:...: |..|.|
Zfish   279 E---EVAAFCHVLDLLRSAYPCNDYSKNSGFVWSPCVAQDELQQGLGVSIK-------------- 326

  Fly   218 LIVVKNENDQSTFTLSVNEQDTPFSLTESTLQKMNRSQMKMNDRTSDYILKVSGRDEYLLGDYPL 282
             :.|.:::.:...|.|.:...|...|...||...: ..:.|.| ..||:||:..:.|:|.....|
Zfish   327 -VTVYSDHFREPLTFSCDGSSTIDLLIYQTLCYAH-DDLDMID-VDDYLLKICSQAEFLKNTQTL 388

  Fly   283 IQFLYIQEML------------------------SDSAVPNVVLQSVYRLESYINH--------- 314
            ..|.|||:.|                        .|...|:.:..|:...|..|..
Zfish   389 ASFEYIQQCLKFDWDIRLILTKRSSVNMELARTTEDDDTPSTMNHSILLQERPIKQTVTKEALTL 453

  Fly   315 -----HNE----------------------QAMVTK---------------------RPLPK--- 328
                 |||                      :|:.|.                     |..||
Zfish   454 LLDTFHNEAESFLLSEVELPLHVERLVQSVKALCTSLAAVETPDITAALNQLPACPCRLQPKVQK 518

  Fly   329 ---------KRTVHLHKSISSLWDMGNYFQLTLHSISNVNFDK-----------------TRALK 367
                     .|...:.|..:::.|:...:..|.    |.||..                 |..|.
Zfish   519 DVSVLAKKENRVAIVEKLTAAILDLVELYCSTF----NANFHTMPHSSRSTAPIQEAGMVTNVLS 579

  Fly   368 VGVHVC-------------------LYHGDKKLCAQRSTDSPNGNFDTFLFNDLVMD----FDIQ 409
            ..|:..                   |.||..:|||.:.|...  :...:||:.:|.|    |.:|
Zfish   580 FSVYAAHRVPITWAASYENFFLSCSLTHGGVELCAPQHTSKQ--SVSKYLFHLVVWDQRVCFPVQ 642

  Fly   410 MRNLPRMTRLCIVIF-----------EVTKMSRSKKSSNNKDIALKDVPYNKNPLAWVNTTIFDH 463
            :..|||.::|.:.::           |.:|..||.:|                 |.||...:|:.
Zfish   643 INQLPRESQLTVTLYATPLPPPGGAEEKSKQKRSIES-----------------LGWVTMPLFNF 690

  Fly   464 KDILRTGRHTLYTWTYADDIQSVEVFHPLGTIEPNPRKEECALVDLTFLSSGTGTVRYPS---EE 525
            :.:|..||..|..|.......:..      :..||..:.:..::.:.|.:| :..||:.:   .|
Zfish   691 RHVLTCGRKLLGLWPSTPGSGNAR------SSTPNFSQPDSVILQVDFPTS-SFEVRFSTPAPAE 748

  Fly   526 VVLQYA-ADREQVNRLQRQLAGPEKPIKELKELMANYTGLDK--IYEMVDQDRNAIWERRNDILR 587
            ...||. :..:||:  ||||                :..|.|  ::.:..:||..:||:|.....
Zfish   749 FSPQYEFSHLDQVS--QRQL----------------HDVLHKKSLFWLSPEDRRLLWEKRYFCHV 795

  Fly   588 ELPEELSILLHCVYWKERDDVADMWYLLKQWPLISIERSLELLDYAYPDPAVRRFAIRCLHFLKD 652
            |......:|.....| |...:.|::.||:||..::...:|.||:..:||...||.|::.:..:.|
Zfish   796 EASRLPLVLASAPSW-EWACLPDIYALLRQWGCMNHLDALGLLNATFPDQECRRTAVQWMDSISD 859

  Fly   653 EDLLLYLLQLVQAIKHESYLESDLVVFLLERALRNQRIGHYFFWHLRSEMQTPSMQTRFGLLLEV 717
            .:||.:|.|||||:|:|.||:|.||.|||.||:.:.||.||.||.|:..:|......|:..||..
Zfish   860 PELLDFLPQLVQALKYECYLDSHLVRFLLRRAIGDVRIAHYLFWLLKDTLQDSQFSVRYQYLLAA 924

  Fly   718 YL----KGCKHHVAPLRKQLHVLEKLKQGSLIAKKGSKEKVKTMLQDFLRDQRN-SAVFQNIQNP 777
            .|    :|.:.........::||.|:.|....|...|::.:   |::.|.|.:. .::..:.:.|
Zfish   925 LLCCSGRGLREEFDRQCWLVNVLAKVAQRVREASPSSRQAI---LREGLDDVKQFFSINSSCRLP 986

  Fly   778 LNPSFRCSGVTPDRCKVMDSKMRPLWVVFENADVNASDVHIIFKNGDDLRQDMLTLQMLRVMDQL 842
            |||.....|:....|...:|...||.:.|:|.|....::::|||.||||||||||||::|:|:::
Zfish   987 LNPGLLVKGINIQSCSYFNSNAVPLKLSFQNQDHLGDNINVIFKAGDDLRQDMLTLQIIRIMNKI 1051

  Fly   843 WKRDGMDFRMNIYNCISMEKSLGMIEVVRHAETIANIQKEKGMFSATSPFKKGSLLSWLKEHNKP 907
            |.::|:|.||.|:.|.|..:..||:|::..|||:..||.|.|:   |..||...|..||::||..
Zfish  1052 WVQEGLDMRMVIFRCFSTGRGRGMVEMIPSAETLRKIQVEHGV---TGSFKDRPLADWLQKHNPT 1113

  Fly   908 ADKLNKAINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRER 972
            .::..||:..|..||||.|||||:||:.|||:||||:|.:|.:||||||..|||.:....::|:|
Zfish  1114 EEEYEKAVENFIYSCAGCCVATYILGICDRHNDNIMLKTSGHMFHIDFGKFLGHAQMFGNIKRDR 1178

  Fly   973 VPFVLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPELSSEK 1037
            .|||.|.|..||||.|  |:.|..|..|.:||..|:..:|||..|.|:|..:|:|:|:||||...
Zfish  1179 APFVFTSDMAYVINGG--DKPSSRFHDFVDLCCEAYNRIRKHAHLFLNLLGLMLSSGIPELSDVD 1241

  Fly  1038 DLDYLRETLVLDYTEEKAREHFRAKFSEALANSWKTSLNWASHNFSK 1084
            ||.|:.:.|....:|..|..|| .:..|:...|..|.||:..||.::
Zfish  1242 DLKYVYDALRPHESEADATMHF-TRLIESSLGSVATKLNFFIHNLAQ 1287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322	9/31 (29%)
		PI3K_rbd	200..307	CDD:197540	26/130 (20%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	43/228 (19%)
		PI3Ka_I	552..723	CDD:238444	58/176 (33%)
		PI3Kc_I	727..1084	CDD:270709	143/357 (40%)
pik3c2b	XP_003199535.1	PI3K_rbd	322..413	CDD:295323	23/107 (21%)
		C2A_PI3K_class_II	569..741	CDD:175979	39/197 (20%)
		PI3Ka	763..928	CDD:294194	61/181 (34%)
		PI3Kc_C2_beta	934..1287	CDD:119421	143/361 (40%)
		PX_domain	1317..1425	CDD:295365
		C2B_PI3K_class_II	1458..1579	CDD:176027
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579751
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750