DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K92E and Mtor

DIOPT Version :9

Sequence 1:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_064393.2	Gene:	Mtor / 56717	MGIID:	1928394	Length:	2549	Species:	Mus musculus

Alignment Length:	767	Identity:	161/767 - (20%)
Similarity:	259/767 - (33%)	Gaps:	267/767 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   322 TKRPLPKKRTVHLHKSISSLWDM----GNYFQLTLHSISNVNFDKTRALKV--------GVHVCL 374
            |..||.||.|..|.|:: .|:.:    |.:..::|...:|:. |..|.|.:        .|:..|
Mouse  1861 TPSPLQKKVTEDLSKTL-LLYTVPAVQGFFRSISLSRGNNLQ-DTLRVLTLWFDYGHWPDVNEAL 1923

  Fly   375 YHGDKKLCAQRSTDSPNGNFDTFLFNDLVMDFDIQMRNLPRMTRLCIVIFEVTKMSRSKKSSNNK 439
            ..|.|.:           ..||:|            :.:|::
Mouse  1924 VEGVKAI-----------QIDTWL------------QVIPQL----------------------- 1942

  Fly   440 DIALKDVPYNKNPLAWVNTTIFDHKDILRTGR--HTLYTWTYADDIQSVEVFHPLGTIEPNPRKE 502
             ||..|.|   .||               .||  |.|.|        .:..:||...|.|
Mouse  1943 -IARIDTP---RPL---------------VGRLIHQLLT--------DIGRYHPQALIYP----- 1975

  Fly   503 ECALVDLTFLSSGTGTVRYPSEEVVLQYAADREQVNRLQRQLAGPEKPIKELKELMANYTGLDKI 567
                  ||..|..|.|.|:.:...:|:...  |..|.|.:|..
Mouse  1976 ------LTVASKSTTTARHNAANKILKNMC--EHSNTLVQQAM---------------------- 2010

  Fly   568 YEMVDQD--RNAI-WERRNDILRELPEELSILLHCVYWKERDDVADMWYLLKQWPL-ISIERSLE 628
              ||.::  |.|| |   :::..|..||.|.|    |:.|| :|..|:.:|:  || ..:||..:
Mouse  2011 --MVSEELIRVAILW---HEMWHEGLEEASRL----YFGER-NVKGMFEVLE--PLHAMMERGPQ 2063

  Fly   629 LLDYAYPDPAVRRFAIR----CLHFLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLERALRNQR 689
            .|.....:.|..|..:.    |..::|..:    :..|.||        .||
Mouse  2064 TLKETSFNQAYGRDLMEAQEWCRKYMKSGN----VKDLTQA--------WDL------------- 2103

  Fly   690 IGHYFFWHLRSEMQTPSMQTRFGLLLEVYLKGCKHHVAPLRKQLHVLEKLKQGSLIAKKGSKEKV 754
               |:....|...|.|.:.:     ||:      .:|:|.......||....|:
Mouse  2104 ---YYHVFRRISKQLPQLTS-----LEL------QYVSPKLLMCRDLELAVPGT----------- 2143

  Fly   755 KTMLQDFLRDQRNSAVFQNIQNPLNPSFRCSGVTPDRCKVMDSKMRPLWVVFENADVNASDVHII 819
                                .:|..|..|...:.|. .:|:.||.||..:....:  |..:...:
Mouse  2144 --------------------YDPNQPIIRIQSIAPS-LQVITSKQRPRKLTLMGS--NGHEFVFL 2185

  Fly   820 FKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNI----YNCISMEKSLGMIEVVRHAET----- 875
            .|..:|||||...:|:..:::.|...|....|.|:    |..|.:..:.|:|..|.|.:|
Mouse  2186 LKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALI 2250

  Fly   876 ---------IANIQKEKGMFSATSPFKKGSLLSWLK--EH---NKPADKLNKAI----------- 915
                     :.||: .:.|......:...:|:..::  ||   |...|.|.|.:
Mouse  2251 RDYREKKKILLNIE-HRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWF 2314

  Fly   916 ---NEFTLSCAGYCVATYVLGVADRHSDNIMVKR-NGQLFHIDFGHI--LGHFKEKLGVRRERVP 974
               ..:|.|.|...:..|:||:.|||..|:|:.| :|::.|||||..  :...:||.   .|::|
Mouse  2315 DRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKF---PEKIP 2376

  Fly   975 FVLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMI 1026
            |.||......:.....|...:..||      ....|||:|...::::....:
Mouse  2377 FRLTRMLTNAMEVTGLDGNYRTTCH------TVMEVLREHKDSVMAVLEAFV 2422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322
		PI3K_rbd	200..307	CDD:197540
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	33/191 (17%)
		PI3Ka_I	552..723	CDD:238444	37/178 (21%)
		PI3Kc_I	727..1084	CDD:270709	74/340 (22%)
Mtor	NP_064393.2	Interaction with NBN. /evidence=ECO:0000250	1..651
		TEL1	363..2549	CDD:227365	161/767 (21%)
		HEAT 16	637..683
		HEAT repeat	655..681	CDD:293787
		HEAT 17	686..724
		HEAT repeat	691..721	CDD:293787
		HEAT 18	727..766
		HEAT repeat	729..759	CDD:293787
		HEAT 19	769..811
		HEAT repeat	772..805	CDD:293787
		HEAT 20	814..853
		HEAT repeat	817..847	CDD:293787
		DUF3385	854..1024	CDD:288698
		HEAT 21	857..893
		HEAT 22	894..942
		HEAT 23	943..988
		HEAT repeat	955..981	CDD:293787
		HEAT 24	989..1027
		HEAT repeat	993..1021	CDD:293787
		HEAT 25	1029..1068
		HEAT repeat	1033..1062	CDD:293787
		HEAT 26	1069..1105
		HEAT repeat	1073..1099	CDD:293787
		HEAT 27	1106..1144
		HEAT repeat	1111..1142	CDD:293787
		HEAT 28	1145..1188
		HEAT repeat	1154..1180	CDD:293787
		HEAT 29	1189..1225
		HEAT 30	1226..1273
		HEAT 31	1274..1311
		HEAT 32	1312..1345
		TPR 1	1346..1382
		TPR 2	1383..1408
		TPR 3	1409..1442
		TPR 4	1443..1473
		TPR 5	1474..1507
		TPR 6	1508..1541
		TPR 7	1542..1574
		TPR 8	1575..1614
		TPR 9	1615..1649
		TPR 10	1650..1693
		TPR 11	1694..1731
		TPR 12	1732..1786
		TPR 13	1787..1846
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1825..1867		3/5 (60%)
		TPR 14	1898..1930		8/32 (25%)
		TPR 15	1931..1970		16/100 (16%)
		TPR 16	1971..2005		11/46 (24%)
		Sufficient for interaction with the FKBP1A/rapamycin complex	2012..2144		41/211 (19%)
		Rapamycin_bind	2015..2112	CDD:285924	31/134 (23%)
		PIKKc_TOR	2153..2431	CDD:270713	67/283 (24%)
		Interaction with MLST8. /evidence=ECO:0000250	2258..2296		7/38 (18%)
		FATC	2518..2549	CDD:280430
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900