DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K92E and si:rp71-17i16.5

DIOPT Version :9

Sequence 1:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	XP_021329311.1	Gene:	si:rp71-17i16.5 / 564261	ZFINID:	ZDB-GENE-090312-117	Length:	1069	Species:	Danio rerio

Alignment Length:	1057	Identity:	332/1057 - (31%)
Similarity:	501/1057 - (47%)	Gaps:	229/1057 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 DDFRLYMT------QTCDNIE-------LERSAYTWQQRLLYEHPLR--------LANSTKMPEL 207
            |||::..|      |..|.::       .::||.  ::|:.::|.|.        .:|:.::.||
Zfish    96 DDFQVLQTLDAPWFQGTDGLQTVFVTVLAQKSAS--EERVYFQHVLNELIGYDLDSSNANRLGEL 158

  Fly   208 IRER---------------------HPTRTFLIVVKNENDQSTF---TLSV-------------N 235
            ...|                     .|..|.:::   .|||..:   ||||             :
Zfish   159 AYTRRKFATPRTQELKKRDLIAYATEPWTTSIVL---PNDQQGYFQRTLSVTLYYNGSNLSIKAD 220

  Fly   236 EQDTPFSLTESTLQKMNRSQMKMNDRTSDYILKVSGRDEYLLGDYPLIQFLYIQEMLSD------ 294
            ....|..:.:...:.:.:..:.:...|||::|||.||:|:|.||:.|..:|:::..|.:
Zfish   221 LTQKPSDILKIFWESLPKGSLPIESWTSDHVLKVCGREEFLSGDFQLSNYLWVRHCLKNSLELHL 285

  Fly   295 -----SAVPNVVLQSVY-----RLESYINHHNEQAMVTKRPLPKKRTVHLHKSISSLWDMGNYFQ 349
                 |::|:..:.:.|     .|....:.|.|..:       ||:.|. ...:.||||....|:
Zfish   286 SVVAISSLPDDTVSTEYWPLVDSLTGLSSSHEELCL-------KKKEVE-DIVLISLWDCERKFR 342

  Fly   350 LTLHSISNVNFD------KTRALKVGVHVCLYHGDKKLCAQRSTDSPNGNFDTFLFNDLVMDFDI 408
            :.|     :.||      |..:| |.|...:.:|.|.:.:..||  |....|..|:|.. ::|||
Zfish   343 VKL-----LGFDIPDLPSKVPSL-VYVEATIIYGKKTISSICST--PKEFTDEVLWNTW-LEFDI 398

  Fly   409 QMRNLPRMTRLCIVIFEVTKMSRSKKSSNNKDIALKDVP-YNKNPLA---WVNTTIFDHKDILRT 469
            .:|::|:..:|.:.| ..|:.::..|||::|      || ::|..|.   :||..:.||:.:|..
Zfish   399 LIRDIPQGAKLGLTI-NATEAAKETKSSSSK------VPDHHKGKLQVLYFVNLQLIDHRSLLSQ 456

  Fly   470 GRHTLYTW----------TY-ADDIQSV---EVFHPLG-----------TIEPNPRKEECALVDL 509
            |.|||..|          || ||.:.:.   :|.:.:.           .:.||.|...|
Zfish   457 GPHTLNMWPFPEWDEEAVTYEADKLSTATNPDVANSMAITFMLDRYSFPVVLPNGRSSSC----- 516

  Fly   510 TFLSSGTGTVRYPSEEVVLQYAADREQVNRLQRQLAGP------------EKPIKELKELMANYT 562
                |||..|   ||...|..|.        :.:|:.|            .:.:|:.||...:|
Zfish   517 ----SGTSPV---SESSSLDLAG--------ESRLSAPFSEASSTATLTRMRNLKKFKEESVHY- 565

  Fly   563 GLDKIYEMVDQDRNAIWERRNDILRELPEELSILLHCVYWKERDDVADMWYLLKQWPLISIER-- 625
                                   :..||:    .|..|.|.....|.::.:||..|....||.
Zfish   566 -----------------------VSNLPQ----FLRTVNWMLPTVVQEVHWLLSHWGPEDIELFV 603

  Fly   626 SLELLDYAYPDPAVRRFAIRCLHFLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLERALRNQRI 690
            :||||...:.|..|||.|::.|..|.::::|.|||||||.:|.|.|.:|.|..|||:||||::||
Zfish   604 ALELLSVDFADLKVRRLAVQRLEILSNDEVLKYLLQLVQTLKVEPYHDSFLARFLLKRALRSKRI 668

  Fly   691 GHYFFWHLRSEMQ-TPSMQTRFGLLLEVYLKGC-KHHVAPLRKQLHVLEKLKQGSLIAK------ 747
            ||:|||:||||:. .|..:.|..::||.||.|| :..:|..:.|:.|:..|...:|..|
Zfish   669 GHFFFWYLRSEVAGCPFFRQRMAVILEAYLLGCGEAMLAEFQSQVQVVSYLHDVALAVKLLYPDR 733

  Fly   748 ----KGSKEKVKTMLQ--DFLRDQRNSAVFQNIQNPLNPSFRCSGVTPDRCKVMDSKMRPLWVVF 806
                ..:.:|::.:|:  |...|         .|.|.:|..|...:....||:|.||.:|||:.|
Zfish   734 TDLPSTAPQKLQELLEKCDLPSD---------FQVPFDPRVRAGSIILKDCKIMASKKKPLWLEF 789

  Fly   807 ENADVNA---SDVHIIFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCISMEKSLGMIE 868
            ......|   ..|.||||:|||||||||.:|.|.|||.:|:..|:|..:..|.|||...::||||
Zfish   790 SCIQSEAPPSPPVGIIFKHGDDLRQDMLIIQTLVVMDSIWQEKGLDLNLVPYGCISTGFNIGMIE 854

  Fly   869 VVRHAETIANIQKEKGMFSATSPFKKGSLLSWLKEHNKPADKLNKAINEFTLSCAGYCVATYVLG 933
            :||:|.|||::|:.:|  .....||..:|..||:......:|..:|..:|..|||||||||||||
Zfish   855 IVRNAITIASVQRSQG--GVAGAFKNNALYDWLQTKCPFQEKHFQATEKFVNSCAGYCVATYVLG 917

  Fly   934 VADRHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPFVLTHDFVYVINKGFNDRESKEFC 998
            :.|||:||||:...|.|||||||||||:.|...||.|||||||||.||:||:.: ...|.|..|.
Zfish   918 IGDRHNDNIMITDQGNLFHIDFGHILGNTKSFWGVNRERVPFVLTPDFLYVMGR-VKGRPSLYFQ 981

  Fly   999 HFQELCERAFLVLRKHGCLILSLFSMMISTGLPELSSEKDLDYLRETLVLDYTEEKAREHFRAKF 1063
            .|::.|..|:|.||....|:::|||:|:.||:||||..:|:.|||..|..|.:||:||.|...:.
Zfish   982 RFRDTCINAYLSLRAQSRLLVTLFSLMLLTGIPELSMSQDMLYLRTALQQDQSEEEARNHLLQQI 1046

  Fly  1064 SEALANSWKTSLNWASH 1080
            :......|....||..|
Zfish  1047 ALCEHKGWTVQANWWFH 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322
		PI3K_rbd	200..307	CDD:197540	32/159 (20%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	57/212 (27%)
		PI3Ka_I	552..723	CDD:238444	65/174 (37%)
		PI3Kc_I	727..1084	CDD:270709	153/369 (41%)
si:rp71-17i16.5	XP_021329311.1	PI3K_rbd	189..292	CDD:321949	23/105 (22%)
		C2	332..506	CDD:326325	51/189 (27%)
		PI3Ka	557..702	CDD:320871	63/172 (37%)
		PI3Kc_IB_gamma	706..1069	CDD:270627	153/370 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579753
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	1	1.000	-	-		FOG0001201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100986
Panther	1	1.100	-	-	O	PTHR10048
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.750