DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K92E and prkdc

DIOPT Version :9

Sequence 1:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	XP_009301676.1	Gene:	prkdc / 562283	ZFINID:	ZDB-GENE-030131-9008	Length:	4119	Species:	Danio rerio

Alignment Length:	1312	Identity:	243/1312 - (18%)
Similarity:	431/1312 - (32%)	Gaps:	485/1312 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 QMPLGYVIKEACEYQVYGISTFNIEPYTDETKRLSEVQP------YFGIL--SLGERTDTTSFSS 136
            |.|:|.::.|  |..::|... :.||.....:...|:.|      :...|  |||
Zfish  2894 QQPMGILLLE--ESLLHGAGA-SEEPPLKRARGKRELPPDTERWIHLAKLYRSLG---------- 2945

  Fly   137 DYELTK-MVNGMIGT---TFD----------------HNRTHGSPEIDDFRLYMTQT-------- 173
            ||::.: :.:|.|||   ||.                :|......:.||....:|:.
Zfish  2946 DYDVVRGIFSGKIGTKSITFTALQAEAKSDYAEAVKLYNEALNKEDWDDGEPTITEKDFWEIAAL 3010

  Fly   174 --------------CDNIELERSAYTWQQRLLYEHPLRLANSTKMPELIRERHPTRTFLIVVKNE 224
                          |..:.::.|:           |:||           :|..|.||.:
Zfish  3011 EAYNHLTEWKSLEYCATVNIDDSS-----------PIRL-----------DRMWTETFYV----- 3048

  Fly   225 NDQSTFTLSVNEQDTPFSLTESTLQKMNRS---QMKMNDRTSDYILKVSG---RDEYLLGDYPLI 283
                                |:.||.|.||   |::|.:...|.:..|..   .:|:.:    ::
Zfish  3049 --------------------ETYLQYMMRSMLKQLQMGETNQDLLSFVDAAMKTEEHKI----IM 3089

  Fly   284 QFLYIQEMLSDSAVPNVVLQSVY-RLESYINHHNE---QAMVTKRPLPKKRTVHLHKSISSLWDM 344
            :..|.||:   |.:  .:||..| |.:.|.|:..:   |...:..||..:..:.:.:|:.:|.::
Zfish  3090 ETHYSQEL---SLL--YILQEDYDRAKYYANNCMQVFMQNYSSIDPLLNRSRLTVLQSVQALTEI 3149

  Fly   345 GNYFQLTLHSISNVNFDKTRALKVGVHVCLYH-GDKKLCAQRSTDSPNGNFDTFLFNDLVMDFDI 408
            .::.......:| ||     :||..:.....| .|.||      |..|      :::|::
Zfish  3150 QDFLNYITGDVS-VN-----SLKFMIRRWTSHYPDAKL------DPMN------VWDDII----- 3191

  Fly   409 QMRNLPRMTRLCIVIFEVTKMSRS-----------------------KKSSNNKDIALKDVPYNK 450
                    |..|..:.::.|..:|                       |....|..:.:.|..:.:
Zfish  3192 --------TSRCFFLDKILKRLKSTPENSMEVDGADQGSGEELGVLVKTCKFNMKLQMADSAWKQ 3248

  Fly   451 N--PLA--------------------WVNT-TIFDHKDILRTGRHTLYTWTYADDIQSVEVFHPL 492
            |  |:|                    ||:: :.|.||.|.|.|.        ::.|.::....||
Zfish  3249 NNFPVASKLLKELHRHAKIDDARLLRWVHSFSRFTHKRIARLGP--------SEKINALLKTVPL 3305

  Fly   493 GTIEPNPRKEEC----------ALVDLTF-LSSGTGTVRYP------SEEVV-----LQYAADRE 535
              ::...|:.|.          .|:..|: |.:|... |.|      .||.|     |..|:...
Zfish  3306 --LKDAERQSEALSARMLRDQRILLGTTYDLMAGAAD-RSPFALETLGEEKVQKILQLSQASSIA 3367

  Fly   536 Q-VNRLQRQL----------AGPEKP-----------IKELKELMANYTGLDKIYEMVDQDRNAI 578
            | |..||.|.          |..|:.           |.|....|||:  .|:.....:|...||
Zfish  3368 QVVEGLQIQALELLRSAACKAEEEEQSFSQQHVNTHGIVEAYMTMANF--CDRRLRESEQKEEAI 3430

  Fly   579 WERRNDILRELPEE-LSILLHC--------------------VYWKERDD--------------- 607
            ..:    |:.|||. :.::|..                    ||..|..|
Zfish  3431 SSK----LQSLPEHVVKMMLKALKLSSEEARLKFPRLLQLVEVYPAETLDLMVREVVSVPCWLLI 3491

  Fly   608 --VADMWYLLKQWPLISIERSLELLDYAYPDPAVRRFAIRCLHFLKDEDLLLYLLQLVQAIKHES 670
              ::.|..||.:....:::..:|.:...||...:..:.|...::..:|.        ....::..
Zfish  3492 GWISQMMALLDKPQATAVQHVIEEIAECYPQALIYPYMISSENYTFEES--------ASGQRNRE 3548

  Fly   671 YLESDLVVFLLERA------------LRNQRIGHYFFW-HLRSEMQTPSM--------------- 707
            ::|.  :..||::.            |.|..:....:| .:::::..|::
Zfish  3549 FVEK--LESLLDKGGVIQGFVDALQQLSNPEMLFKDWWDEVKNQLDKPNLDKKKMKLQYMTELLG 3611

  Fly   708 ---QTRFGLLLEVYLKGCKHHVAPLRKQLHVLEKLKQGSLIAKKGSK-----------EKVKTML 758
               ..|||.....:::.....|          ||     |:...|||           ::|..|:
Zfish  3612 DAKSPRFGSYRRKFIQKFSKEV----------EK-----LLGAGGSKLYERRKDKDFLQQVDRMV 3661

  Fly   759 QD---FLRDQRNSAVF---------QNIQNPLN------------PSFRCSGVT--PDRCKVMDS 797
            |.   |.::..|...:         :.::|.|.            |.:... :|  .:|.|||.|
Zfish  3662 QSMRGFQKEPGNMKEYSPWLSSFKAETLKNELEVPGQYDGKSKPLPEYHAK-ITGFDERVKVMTS 3725

  Fly   798 KMRPLWVVFENADVNASDVHIIFKNGDDLRQDMLTLQMLRVMDQLWKRD----GMDFRMNIYNCI 858
            ..||..::....|  ..|...:.|.|:|||||....|:..||:.:..:|    .....:..|..|
Zfish  3726 IRRPKRIIIRGDD--ERDYPFLVKGGEDLRQDQRIEQLFGVMNMILSQDTACSQRSLALRTYQVI 3788

  Fly   859 SMEKSLGMIEVVRHAETIANI----QKEKGMFSATSP------------------------FKKG 895
            .:...:|:||.:.:..|:.:.    :.|:...:.|.|                        :||.
Zfish  3789 PITSRIGLIEWMENTCTLKDFLSSRRTEQEQKTITRPNEFYDEWISKVAGKVEGIRRYAELYKKA 3853

  Fly   896 SLLSWLK-----EHNKPADKLNKAI--------------NEFTLSCAGYCVATYVLGVADRHSDN 941
            ..:..:.     |...|.|.|.:|.              :.|:.|.|..|::.::||:.|||..|
Zfish  3854 KRVDTVNNFRRIEQMVPDDLLKRAFVRMSTTPEAFLSLRSHFSSSHAVLCISHWILGIGDRHLSN 3918

  Fly   942 IMVK-RNGQLFHIDFGHILGHFKEKLGVRRERVPFVLTHDFVYVINKGFNDRESKEFCHFQELCE 1005
            .|:. ..|.:..|||||..|...:.|.| .|.:||.||..|:.::      |...|....|.:..
Zfish  3919 FMINTETGGMIGIDFGHAFGSATQFLPV-PELMPFRLTRQFINLM------RPLAESGLIQSVMV 3976

  Fly  1006 RAFLVLRKHGCLILSLFSMMISTGLPELSSEKDLDYLRETLVLDYTEEKAREHFRAKFSEALANS 1070
            .:....|....|:|:...:.:        .|..||:               ::|..|..:. ..:
Zfish  3977 HSLRAFRAEPDLLLNTMDVFV--------KEPSLDW---------------KNFELKQLKK-GGT 4017

  Fly  1071 WKTSLNWASHNF 1082
            |..|:|....|:
Zfish  4018 WTESVNTKEINW 4029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322	14/59 (24%)
		PI3K_rbd	200..307	CDD:197540	22/113 (19%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	40/235 (17%)
		PI3Ka_I	552..723	CDD:238444	35/239 (15%)
		PI3Kc_I	727..1084	CDD:270709	92/445 (21%)
prkdc	XP_009301676.1	NUC194	1830..2211	CDD:285387
		FAT	3070..3465	CDD:280429	85/451 (19%)
		PIKKc_DNA-PK	3713..4006	CDD:270716	72/324 (22%)
		FATC	4089..4119	CDD:280430
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900