Protein Alignment Pi3K92E and pik3ca

DIOPT Version :9

• Sequence 1: NP_001262770.1
• Gene: Pi3K92E / 42446
• FlyBaseID: FBgn0015279
• Length: 1088
• Species: Drosophila melanogaster
• Sequence 2: XP_009304451.1
• Gene: pik3ca / 561737
• ZFINID: ZDB-GENE-130409-1
• Length: 1069
• Species: Danio rerio
• Alignment Length: 1119
• Identity: 396/1119 - (35%)
• Similarity: 614/1119 - (54%)
• Gaps: 118/1119 - (10%)

  Fly    21 PPEEAEPPCMRFSVNLWKNEMLNWVDLI-CLLPNGFLLELRVNPANTIQVIKVEMVNQAKQMPLG 84
            ||..:       |..||...::....|: ||||||.:|.|......|:..||.|:..:|::.||.
Zfish     2 PPRPS-------SGELWGIHLMPPRILVDCLLPNGMILTLECLREATLITIKHELFKEARKYPLH 59

  Fly    85 YVIKEACEYQVYGIS-TFNIEPYTDETKRLSEV---QPYFGILS-LGERTDTTSFSSDYELTKMV 144
            ::::|...|....:: ....|.:.|||:||.::   ||:..::. :|.|.:           |::
Zfish    60 HLLQEETSYIFVSVTQEAEREEFYDETRRLCDLRLFQPFLKVIEPVGNREE-----------KIL 113

  Fly   145 NGMIG-------TTFDHNRTHGSPEIDDFRLYMTQTC-DNIELERSAYTWQQRLLYEHPLRLANS 201
            |..||       ..||..:   .||:.|||..:...| |::|| |.|.....|.||.:|..:.:|
Zfish   114 NREIGFAIGMPVCEFDLVK---DPEVQDFRRNILNVCKDSVEL-RDASGAHSRALYVYPPNVESS 174

  Fly   202 TKMPELIRERHPTRTFLIV----VKNENDQSTFTLSVNEQDTPFSLTESTLQKMNRS------QM 256
            .::|:.|..:......::|    |...||:..:||.:|....|..:....::|..||      |:
Zfish   175 PELPKHIYGKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSAEQL 239

  Fly   257 KM--NDRTSDYILKVSGRDEYLLGDYPLIQFLYIQEMLSDSAVPNVVLQSVYRLESYINHHN--- 316
            ||  .:....|||||.|.|||||..||:.|:.|::..:....:||::|.|...|.|.:...|
Zfish   240 KMCVQEYQGKYILKVCGCDEYLLEKYPISQYKYVRSCIMLGRLPNLMLMSKDSLYSQLPMDNFTM 304

  Fly   317 ---EQAMVTKRPLPKKRTVHLHKSISSLWDMGNYFQLTLHSISNVNFDKTRALKVGVHVCLYHGD 378
               .:.:.|..|.     ::...|..|||.:.:..::.:...:.||.:.....|:.|...:|||.
Zfish   305 PSYSRRISTATPY-----MNGEASTKSLWTINSTLRIRVLCATYVNVNIRDIDKIYVRTGIYHGG 364

  Fly   379 KKLCAQRSTD---SPNGNFDTFLFNDLVMDFDIQMRNLPRMTRLCIVIFEVTKMSRSKKSSNNKD 440
            ::||...:|.   ..|..::.:|      .:|:.:.::||..|||:.|..|    :.:|.:..:.
Zfish   365 EQLCDNVNTQRVPCSNPRWNEWL------TYDMYIPDIPRAARLCLSICSV----KGRKGAKEEH 419

  Fly   441 IALKDVPYNKNPLAWVNTTIFDHKDILRTGRHTLYTWTYADDIQSVEVFHPLGTIEPNPRKE-EC 504
            .          ||||.|..:||:...|.:|:..|..|.....::  ::.:|:|....||.|| .|
Zfish   420 C----------PLAWGNVNLFDYTHTLVSGKMALNLWPVPHGLE--DLLNPIGVTGSNPNKETPC 472

  Fly   505 ALVDLTFLSSGTGTVRYPSEEVVLQYA---ADRE---------QVNRLQRQLAGPEKPIKELKEL 557
            ..::..:.||   .|::|....:..:|   ..||         |.:|:.|..|..|..|::|::|
Zfish   473 LELEFDYFSS---PVKFPDMATIEDHANWIISREMGYNYCQSGQSSRVARDHAMTEADIEQLRQL 534

  Fly   558 MANYTGLDKIYEMVDQDRNAIWERRNDILRELPEELSILLHCVYWKERDDVADMWYLLKQWPLIS 622
                ...|.:.|:.:|:::.:|..|...: .:||.|..:|..|.|..||:||.|:.|||.||.|.
Zfish   535 ----GNRDPLSEITEQEKDFLWRHRQYCV-NIPEILPKILLAVKWNSRDEVAQMYCLLKDWPAIK 594

  Fly   623 IERSLELLDYAYPDPAVRRFAIRCLH-FLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLERALR 686
            .|:::||||..||||.:|.||:|||. :|.|:.|..||:||||.:|:|.||::.||.|||::||.
Zfish   595 PEQAMELLDCNYPDPMIRDFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNPLVRFLLKKALT 659

  Fly   687 NQRIGHYFFWHLRSEMQTPSMQTRFGLLLEVYLKGCKHHVAPLRKQLHVLEKLKQGSLIAKKGSK 751
            ||||||:|||||:|||...::..|||||||.|.:.|..::..|.:|:..:|||...:.|.|:..|
Zfish   660 NQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLSRQVEAMEKLINLTDILKQEKK 724

  Fly   752 EKVKTMLQDFLRDQRNSA----VFQNIQNPLNPSFRCSGVTPDRCKVMDSKMRPLWVVFENADVN 812
            ::.:.:...||.:|....    ..||..:||||:.:...:..:.|::|.|..||||:.:||.|:.
Zfish   725 DETQKVQMKFLVEQMRRPDYMDALQNFTSPLNPAHQLGNLRLEDCRIMSSAKRPLWLNWENPDIM 789

  Fly   813 A----SDVHIIFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCISMEKSLGMIEVVRHA 873
            :    .:..|||||||||||||||||::|:|:.:|:..|:|.||..|.|:|:...:|:|||||.:
Zfish   790 SELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRSS 854

  Fly   874 ETIANIQKEKGMFSATSPFKKGSLLSWLKEHNKPADKLNKAINEFTLSCAGYCVATYVLGVADRH 938
            .||..||.:.|:..|.. |...:|..|||:.|| .:..:.||:.||.|||||||||::||:.|||
Zfish   855 HTIMQIQCKGGLKGALQ-FNSTTLHQWLKDKNK-GEMYDMAIDLFTRSCAGYCVATFILGIGDRH 917

  Fly   939 SDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPFVLTHDFVYVINKGFNDR--ESKEFCHFQ 1001
            :.|||||.:||||||||||.|.|.|:|.|.:|||||||||.||:.||:||....  :::||..||
Zfish   918 NSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGGTQECTKTREFERFQ 982

  Fly  1002 ELCERAFLVLRKHGCLILSLFSMMISTGLPELSSEKDLDYLRETLVLDYTEEKAREHFRAKFSEA 1066
            |:|.:|:|.:|:|..|.::|||||:.:|:|||.|..|:.|:|:||.||.||::|.::|..:.::|
Zfish   983 EMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALDYFMKQMNDA 1047

  Fly  1067 LANSWKTSLNWASH 1080
            ....|.|.::|..|
Zfish  1048 HHGGWTTKMDWIFH 1061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322	21/80 (26%)
		PI3K_rbd	200..307	CDD:197540	36/118 (31%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	44/181 (24%)
		PI3Ka_I	552..723	CDD:238444	81/171 (47%)
		PI3Kc_I	727..1084	CDD:270709	163/364 (45%)
pik3ca	XP_009304451.1	PI3K_p85B	31..108	CDD:197539	20/76 (26%)
		PI3K_rbd	173..292	CDD:307097	36/118 (31%)
		C2_PI3K_class_I_alpha	325..484	CDD:176043	44/183 (24%)
		PI3Ka_I	529..696	CDD:238444	81/171 (47%)
		PKc_like	695..1065	CDD:328722	164/369 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	170	1.000	Domainoid score	I3727
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	1	1.000	-	-		FOG0001201
OrthoInspector	1	1.000	-	-		otm25525
orthoMCL	1	0.900	-	-		OOG6_100986
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5021
SonicParanoid	1	1.000	-	-		X531
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.750