DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K92E and PRKDC

DIOPT Version :9

Sequence 1:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_008835.5	Gene:	PRKDC / 5591	HGNCID:	9413	Length:	4128	Species:	Homo sapiens

Alignment Length:	1289	Identity:	262/1289 - (20%)
Similarity:	461/1289 - (35%)	Gaps:	375/1289 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 CLL----PNGF-LLE---LRVNPANTIQVIKVEMVNQAKQMP--------LGYVIKEACEYQVY- 96
            ||.    |.|. |||   ||:.||.    :..:.|....::|        |..:.:...||.|.
Human  2880 CLASLQQPVGIRLLEEALLRLLPAE----LPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLR 2940

  Fly    97 GISTFNIEPYTDETKRLSEVQPYFGILSLGERTDTTSFSSDYE--LTKMVNGMIGTTFDHNRTHG 159
            ||.|..|     .||::::     ..|....|:|.:..:..|:  |.|           .:...|
Human  2941 GIFTSEI-----GTKQITQ-----SALLAEARSDYSEAAKQYDEALNK-----------QDWVDG 2984

  Fly   160 SP-EID-DFRLYMTQTCDN--IELERSAYTWQQRLLYEHPLRL--------ANSTKMPELIRERH 212
            .| |.: ||....:..|.|  .|.:...|.....:..|:|..|        ...|.:|.:||.:
Human  2985 EPTEAEKDFWELASLDCYNHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSK- 3048

  Fly   213 PTRTFLIVVKNENDQSTFTLSVNEQDTPFSLTESTLQKMNRSQMKM-------NDRTSDYILKVS 270
                ..::::.|.|||..|..  ::.....|.::.|:.....::.:       .||...||  .:
Human  3049 ----LKLLLQGEADQSLLTFI--DKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYI--QN 3105

  Fly   271 GRDEYLLGDYPLIQFLYIQEMLSDSAVPNVVLQSVYRL---ESYINHHNEQAMVTKRPLPKKRTV 332
            |...: :.:|..|..|..|..|:.       ||||..|   :.:|:..::|..::.: :|.||.:
Human  3106 GIQSF-MQNYSSIDVLLHQSRLTK-------LQSVQALTEIQEFISFISKQGNLSSQ-VPLKRLL 3161

  Fly   333 H--------LHKSISSLWDMGNYFQLTLHSISNVNFDKTRALKVGVHVCLYHGDKKLCAQRSTDS 389
            :        ......::||         ..|:|..|..::.            ::||......:|
Human  3162 NTWTNRYPDAKMDPMNIWD---------DIITNRCFFLSKI------------EEKLTPLPEDNS 3205

  Fly   390 PNGNFDTFLFNDLV--MDFDIQMRNLPRMTRLCIVIFEVTKMSRSKKSSNNKDIA---LKDVPYN 449
            .|.:.|    .|..  |:...|..::..:.|.|....:: ||..|.:..||..:|   ||::...
Human  3206 MNVDQD----GDPSDRMEVQEQEEDISSLIRSCKFSMKM-KMIDSARKQNNFSLAMKLLKELHKE 3265

  Fly   450 KNP-----LAWV---------------------------------NTTIFDHKDILR-TGRHTLY 475
            ...     ::||                                 |.:.:..|:||. ..::.|.
Human  3266 SKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTVLKTVSLLDENNVSSYLSKNILAFRDQNILL 3330

  Fly   476 TWTY---ADDIQSVEVFHP--LGTIEPNPRKEECALVDLTFLSSGTGTVRYPSEEVV-------L 528
            ..||   |:.:.|    .|  |..||.:..:.   :::|      :|:....||:|:       .
Human  3331 GTTYRIIANALSS----EPACLAEIEEDKARR---ILEL------SGSSSEDSEKVIAGLYQRAF 3382

  Fly   529 QYAADREQVNRLQRQ----LAGPEKPI------------KELKELMANYTGLD------------ 565
            |:.::..|....:.|    ..||...:            ::|::...|.:.:|
Human  3383 QHLSEAVQAAEEEAQPPSWSCGPAAGVIDAYMTLADFCDQQLRKEEENASVIDSAELQAYPALVV 3447

  Fly   566 ----KIYEMVDQDRNAIWERRNDILRELPEE-LSIL------LHCVYWKERDDVADMWYLLKQWP 619
                |..::...:....:.|...|:...||| ||::      :.|  |:....::.|..||.:..
Human  3448 EKMLKALKLNSNEARLKFPRLLQIIERYPEETLSLMTKEISSVPC--WQFISWISHMVALLDKDQ 3510

  Fly   620 LISIERSLELLDYAYPDPAVRRFAIRCLHF-LKDEDLLLYLLQLVQAIKHESYLESDLVVFLLER 683
            .::::.|:|.:...||...|..|.|....: .||........:.|..||  |.|:...|:.....
Human  3511 AVAVQHSVEEITDNYPQAIVYPFIISSESYSFKDTSTGHKNKEFVARIK--SKLDQGGVIQDFIN 3573

  Fly   684 ALRNQRIGHYFF--W--HLRSEM-QTP-------SMQTRF----------GL------LLEVYLK 720
            ||.........|  |  .:|:|: :||       .|..|.          ||      .::.:.|
Human  3574 ALDQLSNPELLFKDWSNDVRAELAKTPVNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGK 3638

  Fly   721 GCKHHVAP-----LRKQLH--------VLEKLKQGSLIAKKGSKEKVKTMLQD----FLRDQRN- 767
            ....|...     ||.:|.        :|.|:.:.|  ...|:.::....:.|    |||::..
Human  3639 EFDKHFGKGGSKLLRMKLSDFNDITNMLLLKMNKDS--KPPGNLKECSPWMSDFKVEFLRNELEI 3701

  Fly   768 SAVFQNIQNPLNPSF--RCSGVTPDRCKVMDSKMRPLWVVFENADVNASDVHIIFKNGDDLRQDM 830
            ...:.....|| |.:  |.:|. .:|..||.|..||..::....|  ..:...:.|.|:|||||.
Human  3702 PGQYDGRGKPL-PEYHVRIAGF-DERVTVMASLRRPKRIIIRGHD--EREHPFLVKGGEDLRQDQ 3762

  Fly   831 LTLQMLRVMDQLWKRDG----MDFRMNIYNCISMEKSLGMIEVVRHAETIANI------QKEKGM 885
            ...|:.:||:.:..:|.    ...::..|:.:.|...||:||.:.:..|:.::      |:||..
Human  3763 RVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAA 3827

  Fly   886 FSATSPFKKGSLLSWL------------------------------KEHNKPADKLNKAI----- 915
            :.:...........||                              :|...|||.|.:|.
Human  3828 YLSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMST 3892

  Fly   916 ---------NEFTLSCAGYCVATYVLGVADRHSDNIMV-KRNGQLFHIDFGHILGHFKEKLGVRR 970
                     :.|..|.|..|::.::||:.|||.:|.|| ...|.:..|||||..|...:.|.| .
Human  3893 SPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPV-P 3956

  Fly   971 ERVPFVLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPELSS 1035
            |.:||.||..|:.::                       |.:::.|.    ::|:|:. .|....|
Human  3957 ELMPFRLTRQFINLM-----------------------LPMKETGL----MYSIMVH-ALRAFRS 3993

  Fly  1036 EKDLDYLRETLVLDYTEEKARE--HFRAKFSEALANSWKTSLNWASHNFSKNNK 1087
            :..|  |..|:.: :.:|.:.:  :|..|..:. ..||...:|.|..|:....|
Human  3994 DPGL--LTNTMDV-FVKEPSFDWKNFEQKMLKK-GGSWIQEINVAEKNWYPRQK 4043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322	22/87 (25%)
		PI3K_rbd	200..307	CDD:197540	25/113 (22%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	39/226 (17%)
		PI3Ka_I	552..723	CDD:238444	44/222 (20%)
		PI3Kc_I	727..1084	CDD:270709	96/433 (22%)
PRKDC	NP_008835.5	HEAT 1	288..323
		HEAT 2	1004..1040
		Interaction with C1D. /evidence=ECO:0000269\|PubMed:9679063	1503..1538
		Leucine-zipper	1503..1538
		TPR 1	1723..1756
		NUC194	1816..2202	CDD:400469
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2050..2073
		KIP-binding	2436..3212		82/399 (21%)
		FAT	3023..3470	CDD:396714	86/503 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3200..3222		5/25 (20%)
		PIKKc_DNA-PK	3719..4015	CDD:270716	74/330 (22%)
		FATC	4097..4128	CDD:396715
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900