DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K92E and pi4kaa

DIOPT Version :9

Sequence 1:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	XP_009303356.1	Gene:	pi4kaa / 556956	ZFINID:	ZDB-GENE-100204-2	Length:	2128	Species:	Danio rerio

Alignment Length:	1055	Identity:	209/1055 - (19%)
Similarity:	383/1055 - (36%)	Gaps:	260/1055 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 GILSLGERTDTTSFSSDYELTKMVNGMIGTTFDHNRTHGSPEIDDFRLYMTQTCDNIELERSAYT 185
            |::...|.|.:||     :|.|::...:....|    .|.||.....|:....     |..|:..
Zfish  1135 GMIHFSEATRSTS-----DLNKLMIRQMNEALD----GGQPEAFTEALFKMAA-----LLISSRE 1185

  Fly   186 WQQRLLYE---HPLRLANSTKMPELI------------------RERHPTRTFLIVVK----NEN 225
            |...||:.   .||::.....|...|                  ||........:.:|    ::.
Zfish  1186 WDPLLLHHLCWSPLKMFTENGMETAIACWEWLLAGRTGVEVPFMREMAGAWQMTVDLKMGLFSDA 1250

  Fly   226 DQSTFTLSVNEQDTP----------FSLTESTLQKMNRSQMKMNDRTSDY--------ILKV--- 269
            ......|:.:|:..|          :...|..:|:...::....|:...:        .|.|
Zfish  1251 QLEADPLAASEESQPIPCPPDVTPHYIWIEFLVQRFEIAKYSSADQVEIFGSLLQRSLSLNVGSP 1315

  Fly   270 -SGRDEYLLGDYPLIQFLYI-QEMLSDSAVPNVVLQSVYRLESYINHHNEQAMVTKRPLPKKRTV 332
             |..:.::....|..:.|.: ..:|....|.|..:::|.|.:.|....:..::.:|  .|.:...
Zfish  1316 KSSLNRHVAAIGPRFRLLTLGLSLLHSDVVTNATIRNVLREKIYSTAFDYFSVASK--FPTQGDK 1378

  Fly   333 HLHKSISSLWDMGNYFQLTLHSISNVNFDKTRALKVGVHVCLYHGDKKLC--AQRSTDSPNGNFD 395
            .|.:.||          :.:...:::..||.           |.|...|.  .:...:.|..:..
Zfish  1379 RLREDIS----------IMIRFYASILSDKK-----------YLGASLLVPPGELGANPPQSSLS 1422

  Fly   396 TFLFNDLVMD----FDIQMRNLPRMTRLCIVIFEVTKMSRSKKSSNNKDIALKDVPYNKNPLAWV 456
            ..:|..|::.    ..|.....|.:..|.::        .:....||.|:.:..  ..::...|:
Zfish  1423 AGIFGSLIVSSTSPISILNNQDPSLNSLSVM--------NATDPRNNMDMTVGS--RQQSAQGWI 1477

  Fly   457 NTTIFD----------------------HKDILRTGRHTLYTWTYADDIQSVEV-FHPLGTIEPN 498
            ||....                      ||..::  |.||.....|.:|:.:.. ::||.|
Zfish  1478 NTYPLSSGMSTTSKKSGMSKKSNRGTQLHKYYMK--RRTLLLALLASEIERLSTWYNPLST---- 1536

  Fly   499 PRKEECALVDLTFLSSGTGTVRYPSEEVVLQYAADREQVNRLQRQLAGPEKPIKELKELMANYTG 563
               :|.|:.  |..|..|....:.|:.:.|.....::.||     ||....|...| :|.|.:..
Zfish  1537 ---QELAIP--TEQSVETSISNWRSKYINLTEKQWKDNVN-----LAWSIAPYLAL-QLPARFKN 1590

  Fly   564 LD----KIYEMVDQDRNAIWERRNDILRELPEELSILL-------------HCVYWKERDDVADM 611
            .|    ::..:|..|..|:        .::||.:..|:             |.:.|...|....:
Zfish  1591 ADAIVAEVTRLVRLDPGAV--------SDVPEAVKFLVTWHTIDADSPELSHILCWAPADPPTGL 1647

  Fly   612 WYLLKQWPLISIERSLELLDYAYPDPAVRRFAIRCLHFLKDEDLLLYLLQLVQAIKHE--SYLES 674
            .|....:|               |.|...::.::.|.....:.:|.|:.|:|||::::  .|:..
Zfish  1648 SYFSSMYP---------------PHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVRE 1697

  Fly   675 DLVVFLLERALRNQRIGHYFFWHLRSEM--------QTPSMQTRFGLLLEVYLKGCKHHVAPLRK 731
                ::|..|.::|.:.|.|.|::::.:        :.|.:    |.|||..::...|.::...|
Zfish  1698 ----YILWAAQKSQLLAHQFIWNMKTNIFLDEEGHQKDPDI----GELLEQMVEEITHSLSGPAK 1754

  Fly   732 QLHVLE-----KLKQGSLIAK---KGSKEK---------VKTMLQDFLRDQRNSAVFQNIQNPLN 779
            ..:..|     |:...|.|.|   ||.:.|         :|.....:| .....|:..:|.....
Zfish  1755 DFYQREFDFFNKITNVSAIIKPVPKGDERKRACLKALSEIKVQPGCYL-PSNPEAIVLDIDYKSG 1818

  Fly   780 PSFRCSGVTP-------DRCKVMDSKMRPLWVVFENAD------VNASDV---HIIFKNGDDLRQ 828
            ...:.:...|       .||.|.:.:...|....::.|      :.|..|   ..|||.|||.||
Zfish  1819 TPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCPSDSQDEGDESSLTAQRVCWQAAIFKVGDDCRQ 1883

  Fly   829 DMLTLQMLRVMDQLWKRDGMDFRMNIYNCISMEKSLGMIEVVRHAETIANI--QKEKGMFSATSP 891
            |||.||::.:...:::..|:|..:..|..::.....|:||.:...::...:  |.:.||:..
Zfish  1884 DMLALQIIGLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCKSRDQLGRQTDFGMYDY--- 1945

  Fly   892 FKKGSLLSWLKEHNKPADK----LNKAINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFH 952
            |:           |:..|:    ..||...|..|.|.|.:..::|.:.|||:.|||:...|.|.|
Zfish  1946 FR-----------NQYGDESTLAFQKARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDSKGHLIH 1999

  Fly   953 IDFGHILGHFKEKLGVRRERVPFV-LTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGC 1016
            ||||.:   |:...|......|.: ||.:.|.::.   ...|:..|..|.|:|.|.:|.:|.:..
Zfish  2000 IDFGFM---FESSPGGNLGWEPDIKLTDEMVMIMG---GKMEATPFKWFMEMCVRGYLAVRPYMD 2058

  Fly  1017 LILSLFSMMISTGLP 1031
            .::||.::|:.||||
Zfish  2059 AVVSLVTLMLDTGLP 2073

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322	3/10 (30%)
		PI3K_rbd	200..307	CDD:197540	20/151 (13%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	32/206 (16%)
		PI3Ka_I	552..723	CDD:238444	36/197 (18%)
		PI3Kc_I	727..1084	CDD:270709	87/345 (25%)
pi4kaa	XP_009303356.1	PI4Ka	1573..1748	CDD:238443	38/206 (18%)
pi4kaa	XP_009303356.1	PI4Kc_III_alpha	1809..2127	CDD:270711	75/285 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810