DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pi3K92E and pik3c3

DIOPT Version :9

Sequence 1:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	XP_021333200.1	Gene:	pik3c3 / 548346	ZFINID:	ZDB-GENE-050410-13	Length:	887	Species:	Danio rerio

Alignment Length:	922	Identity:	237/922 - (25%)
Similarity:	400/922 - (43%)	Gaps:	221/922 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 LLGDYPLIQF--LYIQEMLSDSAVPNVV----------LQSVYRLESYINHHNE-QAMVTKRP-L 326
            ||.| |:::|  || ||..||..|...|          :::.|:..|...:.|| ..:..|.| |
Zfish    37 LLED-PMLRFSGLY-QESCSDLYVTCQVFAEGKPLALPVRTSYKAFSTRWNWNEWLRLPVKYPDL 99

  Fly   327 PKKRTVHLHKSISSLWDMGNYFQLTLHSISNVN-FDKTRALKVGVHVCLYHGDKKLC------AQ 384
            |:...|.|     ::||:....:.|....:.|. |.|....:.|:|      |.|:.      ..
Zfish   100 PQSAQVTL-----TVWDVYGPGRATPVGGTTVTLFGKYGMFRQGMH------DLKVWPGVEGDGT 153

  Fly   385 RSTDSPNGNFDTFLFND----LVMDFDIQMRN----------------LPRMTRLCIVIFEVTKM 429
            ..|.:| |...:.|..|    |....|:::.:                |.|:|     ..|:..:
Zfish   154 EPTSTP-GRTSSSLAEDQMGRLAKGPDLEILSDLTKAHRQGHMVKVDWLDRLT-----FREIEMI 212

  Fly   430 SRSKKSSNNKDIALKDVPYNKNPLAWVNTTIFDHKDILRTGRHTLYTWTYADDIQSVEVFHPLGT 494
            :.|:|.|:|....:.:.|.                  :::|... |:..|.:  :..:...||.|
Zfish   213 NESEKRSSNFMYLMVEFPR------------------VKSGERE-YSIVYYE--KDADESSPLPT 256

  Fly   495 IE-----PNPRKEECALVD------LTFLSSGTGTVRYPSEEVVLQYAADREQVNRLQRQLAGPE 548
            ..     |:|:.....||:      ...|.||      ||:..:...||.|:|:|.:   ::.|
Zfish   257 SSDIVKVPDPQMCMENLVESKHHKLARSLRSG------PSDHDLKPNAATRDQLNII---VSYP- 311

  Fly   549 KPIKELKELMANYTGLDKIYEMVDQDRNAIWERRNDILRELPEELSILLHCVYWKERDDVADMWY 613
             |.|:|.                .::::.:|:.|. .|....:.|:..|.||.|....:......
Zfish   312 -PTKQLS----------------SEEQDLVWKFRY-YLTTQEKALTKFLKCVNWDLPQEAKQALE 358

  Fly   614 LLKQWPLISIERSLELLDYAYPDPAVRRFAIRCLHFLKDEDLLLYLLQLVQAIKHESY------- 671
            ||.:|..:.:|.|||||...:.:|.|||:|:..|....|||||:||||||||:|:|::
Zfish   359 LLGKWRPMDVEDSLELLSSQFTNPTVRRYAVARLQQADDEDLLMYLLQLVQALKYENFNDIQGGL 423

  Fly   672 -----------------------------------------------LESDLVVFLLERALRNQR 689
                                                           ||.||..||:.||.:|..
Zfish   424 EPANKRDNQGGLTESSTTGDLDSSQLASAIAVMPSSQKGKEGTDGENLEQDLCTFLISRACKNST 488

  Fly   690 IGHYFFWHLRSEMQTPSMQTRFGLLLEVY-----------LKGCKHHVAPLR----KQLHVLEKL 739
            :.:|.:|::..|.:....|.|.....::|           |||.| .|..:|    .|...:::|
Zfish   489 LANYLYWYVIVECEDQDTQQRDPKTHDMYLNVMRRFSQALLKGDK-SVRVMRSLLASQQTFVDRL 552

  Fly   740 KQ--GSLIAKKGSKEKVKTMLQDFLRDQR--NSAVFQNIQNPLNPSFRCSGVTPDRCKVMDSKMR 800
            .|  .::..:.|:::|....||..|.|..  |.:..:.|..||.|..|..|:.|:...:..|.:.
Zfish   553 VQLMKAVQRESGNRKKKTERLQSLLADNEKVNLSEIEPIPLPLEPQIRIKGIIPETATLFKSALM 617

  Fly   801 PLWVVFENADVNASDVHIIFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCISMEKSLG 865
            |..::|:..|  .....:|||:|||||||.|.||::.:||:|.:::.:|.::..|..::.....|
Zfish   618 PAKLIFKTED--GEQYPVIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHG 680

  Fly   866 MIEVVRH---AETIANIQKEKGMFSATSPFKKGSLLSWLKEHNKPADKLNKAINEFTLSCAGYCV 927
            .::.|:.   ||.:|.....:..|...:|..||           |....::.::.:..|||||||
Zfish   681 FMQFVQSVPVAEVLATEGNIQSFFRKYAPNDKG-----------PYGISSEVMDTYVKSCAGYCV 734

  Fly   928 ATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPFVLTHDFVYVINKGFNDR 992
            .||:|||.|||.||:::.:.|:|||||||:|||...:.|     ..|..|:.:.|    :|....
Zfish   735 ITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPL-----PPPMKLSKEMV----EGMGGM 790

  Fly   993 ESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPELSSEKD--LDYLRETLVLDYTEEKA 1055
            :|:::..|::.|..|||.||::..|||:|||:|:...:|:::.|.|  :..:::...||.::|:|
Zfish   791 QSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEA 855

  Fly  1056 REHFRAKFSEAL 1067
            ..:.::...|::
Zfish   856 VHYMQSLIDESV 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322
		PI3K_rbd	200..307	CDD:197540	13/42 (31%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	39/215 (18%)
		PI3Ka_I	552..723	CDD:238444	58/235 (25%)
		PI3Kc_I	727..1084	CDD:270709	106/354 (30%)
pik3c3	XP_021333200.1	C2_PI3K_class_III	25..194	CDD:176042	40/170 (24%)
		PI3Ka_III	291..503	CDD:238442	59/233 (25%)
		PI3Kc_III	539..883	CDD:270628	106/351 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820