DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K92E and PI4KB

DIOPT Version :9

Sequence 1:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	XP_011507936.1	Gene:	PI4KB / 5298	HGNCID:	8984	Length:	849	Species:	Homo sapiens

Alignment Length:	958	Identity:	195/958 - (20%)
Similarity:	327/958 - (34%)	Gaps:	324/958 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 PLRLANSTKMPELIR--ERHPTRTFLIVVKNENDQSTFTLSVNEQDTPFSLTESTLQKMNRSQMK 257
            ||.|.|...:...||  :..|.:     ::.|.|:....::            |...|..|.:.:
Human    86 PLELVNGDGVDSEIRCLDDPPAQ-----IREEEDEMGAAVA------------SGTAKGARRRRQ 133

  Fly   258 MNDRTSDYILKVSGRDEYLLGDYPL-IQFLYIQEMLSDSAVPNVVLQSVYRLESYINH-----HN 316
            .|.....::|::.   |..|.|..: |.:||      :|..|.|        ::||.:     .|
Human   134 NNSAKQSWLLRLF---ESKLFDISMAISYLY------NSKEPGV--------QAYIGNRLFCFRN 181

  Fly   317 EQAMVTKRPLPKKRTVHLHKSISSLWDMGNYFQ-LTLHSI-SNVNFDKTRALKVGVHVCLYHGDK 379
            |.....   ||:...:::|..    .|:|:..: ..:|.. .::||....||.:|.    |..|.
Human   182 EDVDFY---LPQLLNMYIHMD----EDVGDAIKPYIVHRCRQSINFSLQCALLLGA----YSSDM 235

  Fly   380 KLCAQRSTDSPNGNFDTFLFNDLVMDFDI----QMRNLPRMTRLCIVIFEVTKMSRSKKSSNNKD 440
            .:..||.:....       ...|::..::    :.|.||.::..     ..|.:|.||::...
Human   236 HISTQRHSRGTK-------LRKLILSDELKPAHRKRELPSLSPA-----PDTGLSPSKRTHQR-- 286

  Fly   441 IALKDVPYNKNPLAWVNTTIFDHKDILRTGRHTLYTWTYADDIQSVEVFHPLGTIEPNPRKEECA 505
                                                 :.:|...|:.:...|.....||:.|.
Human   287 -------------------------------------SKSDATASISLSSNLKRTASNPKVEN-- 312

  Fly   506 LVDLTFLSSGTGTVRYPSEEVVLQYAADREQVNRLQ---RQLAGPEKPIKELKELMANYTGLDKI 567
              :...|||.|.::.......| :.|.:||.:..|.   ::||  ..|.||.|
Human   313 --EDEELSSSTESIDNSFSSPV-RLAPEREFIKSLMAIGKRLA--TLPTKEQK------------ 360

  Fly   568 YEMVDQDRNAIWERRNDILRELPEELSILLHCVYWKERDDVADMWYLLKQWPLISIERSLELLDY 632
                              .:.|..|||:|.|.:       .|.:|
Human   361 ------------------TQRLISELSLLNHKL-------PARVW-------------------- 380

  Fly   633 AYPDPAVRRFAIRCLH----FLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLERALRN------ 687
             .|........:|..|    .|..:|...||: .|:.::.|::..:.:...:.|..:|:
Human   381 -LPTAGFDHHVVRVPHTQAVVLNSKDKAPYLI-YVEVLECENFDTTSVPARIPENRIRSTRSVEN 443

  Fly   688 ---------QRIGHYF----------FWHLR--SEMQTPSMQTRFGLLLEVYLKGCKHHVAPLRK 731
                     ||.|.:.          .|.:.  .|:|..        |.||:...|
Human   444 LPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVE--------LPEVHTNSC--------- 491

  Fly   732 QLHVLEKLKQGSL--IAKKGSKEKVKTMLQD---------------FLRDQRN-SAVFQNIQNPL 778
                 :.:.|.|:  |..:.|||.|.....|               |.||..: |||  .::.|.
Human   492 -----DNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAV--ALKEPW 549

  Fly   779 NPSFRCSGVTPDRCKVMDSKMR--------PLWVVFENADVNASDVHIIFKNGDDLRQDMLTLQM 835
            ....|              ::|        |.|.:          :.:|.|.||||||::|..|:
Human   550 QEKVR--------------RIREGSPYGHLPNWRL----------LSVIVKCGDDLRQELLAFQV 590

  Fly   836 LRVMDQLWKRDGMDFRMNIYNCISMEKSLGMIEVVRHAETIANIQKEKGMFSATSPFKKGSLLSW 900
            |:.:..:|:::.:...:..|..:.:....||||.|.:|.:|..::|:..:          |||.:
Human   591 LKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQL----------SLLDY 645

  Fly   901 -LKEHNK-PADKLNKAINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFK 963
             |:||.. ..:....|...|..||||||:..|:|.|.|||:.||::...|.:.|||||.||....
Human   646 FLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSP 710

  Fly   964 EKLGVRRERVPFVLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKH-------------G 1015
            ..||.  |...|.||.:||.|:    ...:...|.:::.|..:..:..|||             |
Human   711 RNLGF--ETSAFKLTTEFVDVM----GGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQG 769

  Fly  1016 CLILS---------LFSMMISTGLPELSSEKDLDYLRETLVLDYTEEK 1054
            |...|         ..:.:|.:.||.......:..|:|...:..|||:
Human   770 CRRCSGSSPSGPMMTVAQVICSQLPCFHGSSTIRNLKERFHMSMTEEQ 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322
		PI3K_rbd	200..307	CDD:197540	20/109 (18%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	29/183 (16%)
		PI3Ka_I	552..723	CDD:238444	31/201 (15%)
		PI3Kc_I	727..1084	CDD:270709	95/378 (25%)
PI4KB	XP_011507936.1	PI4Kc_III_beta	541..849	CDD:270712	84/319 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810