Protein Alignment Pi3K92E and PI4KA

DIOPT Version :9

• Sequence 1: NP_001262770.1
• Gene: Pi3K92E / 42446
• FlyBaseID: FBgn0015279
• Length: 1088
• Species: Drosophila melanogaster
• Sequence 2: NP_477352.3
• Gene: PI4KA / 5297
• HGNCID: 8983
• Length: 2102
• Species: Homo sapiens
• Alignment Length: 1126
• Identity: 216/1126 - (19%)
• Similarity: 402/1126 - (35%)
• Gaps: 330/1126 - (29%)

  Fly   121 GILSLGER-----TDTTSFSSDYELTKM----VNGMI---GTTFDHNRTHGSPEIDDFRLYMTQT 173
            |...|.||     .|.::|.:...|...    |.|||   |||         .::.|....|.|.
Human  1121 GATQLSERPACVKKDYSNFMASLNLRNRYAGEVYGMIRFSGTT---------GQMSDLNKMMVQD 1176

  Fly   174 CDNIELERSAYTWQQRLLYEHPLRLANSTKM-PELIRERH----PTRTFLIVVKNENDQST---- 229
            ..: .|:||......:.:::....|.:|... |:|:  .|    |.|.|     ||:...|
Human  1177 LHS-ALDRSHPQHYTQAMFKLTAMLISSKDCDPQLL--HHLCWGPLRMF-----NEHGMETALAC 1233

  Fly   230 ---------------------------------FTLSVNEQDTPFSLTEST-------------- 247
                                             |:..:.|.| |.:.:|::
Human  1234 WEWLLAGKDGVEVPFMREMAGAWHMTVEQKFGLFSAEIKEAD-PLAASEASQPKPCPPEVTPHYI 1297

  Fly   248 -----LQKMNRSQMKMNDRTSDY--------ILKVSG----RDEYLLGDYPLIQFLYI-QEMLSD 294
                 :|:...::...:|:...:        .|.:.|    .:.::....|..:.|.: ..:|..
Human  1298 WIDFLVQRFEIAKYCSSDQVEIFSSLLQRSMSLNIGGAKGSMNRHVAAIGPRFKLLTLGLSLLHA 1362

  Fly   295 SAVPNVVLQSVYRLESYINHHNEQAMVTKRPLPKKRTVHLHKSISSLWDMGNYFQLTLHSISNVN 359
            ..|||..:::|.|.:.|....:..:...|.|...::  .|.:.||
Human  1363 DVVPNATIRNVLREKIYSTAFDYFSCPPKFPTQGEK--RLREDIS-------------------- 1405

  Fly   360 FDKTRALKVGVHVCLYHGDKKLCAQRSTDSPNGNFDTFLFNDLVMDFDIQMRNLPRMTRLCIVIF 424
                  :.:.....::...|.|.|.:..  |..|.||      ..:.||.:.:..:.|:..|..:
Human  1406 ------IMIKFWTAMFSDKKYLTASQLV--PPDNQDT------RSNLDITVGSRQQATQGWINTY 1456

  Fly   425 EVT--------KMSRSKKSSNNKDIALKDVPYNKNPLAWVNTTIFDHKDILRTGRHTLYTWTYAD 481
            .::        |...|||::....:                     ||..::  |.||.....|.
Human  1457 PLSSGMSTISKKSGMSKKTNRGSQL---------------------HKYYMK--RRTLLLSLLAT 1498

  Fly   482 DIQS-VEVFHPLGTIEPNPRKEECALVDLTFLSSGTGTV-RYPSEEVVLQYAADREQVNRLQRQL 544
            :|:. :..::||...|            |....:|..:| .:.|:.:.|.....::.||     |
Human  1499 EIERLITWYNPLSAPE------------LELDQAGENSVANWRSKYISLSEKQWKDNVN-----L 1546

  Fly   545 AGPEKPIKELKELMANYTGLD----KIYEMVDQDRNAIWERRNDILRELPEELSILL-------- 597
            |....|...: :|.|.:...:    ::..:|..|..|:        .::||.:..|:
Human  1547 AWSISPYLAV-QLPARFKNTEAIGNEVTRLVRLDPGAV--------SDVPEAIKFLVTWHTIDAD 1602

  Fly   598 -----HCVYWKERDDVADMWYLLKQWPLISIERSLELLDYAYPDPAVRRFAIRCLHFLKDEDLLL 657
                 |.:.|...|....:.|....:|               |.|...::.::.|.....:.:|.
Human  1603 APELSHVLCWAPTDPPTGLSYFSSMYP---------------PHPLTAQYGVKVLRSFPPDAILF 1652

  Fly   658 YLLQLVQAIKHE--SYLESDLVVFLLERALRNQRIGHYFFWHLRSEM--------QTPSMQTRFG 712
            |:.|:|||::::  .|:..    ::|..|.::|.:.|.|.|::::.:        :.|.:    |
Human  1653 YIPQIVQALRYDKMGYVRE----YILWAASKSQLLAHQFIWNMKTNIYLDEEGHQKDPDI----G 1709

  Fly   713 LLLEVYLKGCKHHVAPLRKQLHVLE-----KLKQGSLIAK---KGSKEK---------VKTMLQD 760
            .||:..::.....::...|..:..|     |:...|.|.|   ||.:.|         ||.....
Human  1710 DLLDQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQPGC 1774

  Fly   761 FLR----------DQRNSAVFQN-IQNPLNPSF---------------RCSGVTPDRCKVMDSKM 799
            :|.          |.::....|: .:.|....|               ||...:.|.|...::..
Human  1775 YLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADG 1839

  Fly   800 RPL-WVVFENADVNASDVHIIFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCISMEKS 863
            :.: |..            .|||.|||.|||||.||::.:...:::..|:|..:..|..::....
Human  1840 QKISWQA------------AIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPG 1892

  Fly   864 LGMIEVVRHAETIANI--QKEKGMFS-ATSPFKKGSLLSWLKEHNKPADKLNKAINEFTLSCAGY 925
            .|:||.:....:...:  |.:.||:. .|..:...|.|::           .:|...|..|.|.|
Human  1893 CGVIECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAF-----------QQARYNFIRSMAAY 1946

  Fly   926 CVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPFV-LTHDFVYVINKGF 989
            .:..::|.:.|||:.|||:.:.|.:.|||||.:   |:...|......|.: ||.:.|.::.
Human  1947 SLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFM---FESSPGGNLGWEPDIKLTDEMVMIMG--- 2005

  Fly   990 NDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPELSSEKDLDYLRETLVLDYTEEK 1054
            ...|:..|..|.|:|.|.:|.:|.:...::||.::|:.||||....: .:..|:.....:.||.:
Human  2006 GKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQ-TIKLLKHRFSPNMTERE 2069

  Fly  1055 AREHFRAKFSEA--LANSWKT 1073
            | .:|..|..::  |:|..:|
Human  2070 A-ANFIMKVIQSCFLSNRSRT 2089

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322	5/15 (33%)
		PI3K_rbd	200..307	CDD:197540	26/180 (14%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	28/186 (15%)
		PI3Ka_I	552..723	CDD:238444	33/197 (17%)
		PI3Kc_I	727..1084	CDD:270709	94/397 (24%)
PI4KA	NP_477352.3	PI4Ka	1547..1722	CDD:238443	35/206 (17%)
		PI4Kc_III_alpha	1783..2101	CDD:270711	82/338 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810