DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K92E and PIK3CG

DIOPT Version :9

Sequence 1:NP_001262770.1 Gene:Pi3K92E / 42446 FlyBaseID:FBgn0015279 Length:1088 Species:Drosophila melanogaster
Sequence 2:NP_001269355.1 Gene:PIK3CG / 5294 HGNCID:8978 Length:1102 Species:Homo sapiens


Alignment Length:1061 Identity:336/1061 - (31%)
Similarity:533/1061 - (50%) Gaps:155/1061 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    92 EYQVYGISTFNIEPYTDETKRLSEVQPYFGILSLGERTDTTSFSSDYELTKMVNGMIG-TTFDHN 155
            :|||  :.|.:...|...|.|    .|  |.:.|.:|...:..|..::  :.:..:|| ...|.:
Human   112 KYQV--VQTLDCLRYWKATHR----SP--GQIHLVQRHPPSEESQAFQ--RQLTALIGYDVTDVS 166

  Fly   156 RTHGSPEIDDFRLYMTQTCDNIELERSAYTWQQ---------RLLYEHPLRLANSTKMPELIRER 211
            ..|.               |.:|..|......:         :|...||  ...|..:||.:.::
Human   167 NVHD---------------DELEFTRRGLVTPRMAEVASRDPKLYAMHP--WVTSKPLPEYLWKK 214

  Fly   212 HPTRTFLIVVKNENDQSTFTLSVNEQDTPFSLTESTLQKMNRSQMKM----NDRTSDYILKVSGR 272
            .......||:  ....::.|:.|:..|||.::.:|...||.:.:..|    :....|::|:|.||
Human   215 IANNCIFIVI--HRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGR 277

  Fly   273 DEYLLGDYPLIQFLYIQEMLSDSAVPNVVLQS-------VYRLESY--------INHHNEQAMVT 322
            ||||:|:.|:..|.:::..|.:....:|||.:       ..|.|.:        :..::||.   
Human   278 DEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQL--- 339

  Fly   323 KRPLPKKRTVH--LHKSI--SSLWDMGNYFQLTLHSISNVNFDKTRALKVGVHVCLYHGDKKLCA 383
                    |:|  .|:|:  .||||....|::.:..|......:...|.|.|...:.||.:.||.
Human   340 --------TIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQ 396

  Fly   384 QRSTDSPNGNFDTFLFNDLVMDFDIQMRNLPRMTRLCIVIF------EVTKMSRSKKSSNNK-DI 441
            :|::..|   |...:..::.::|.|::::||:...|.:.|:      ..:|.|....||.:| .:
Human   397 RRTSPKP---FTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKV 458

  Fly   442 ALKDVPYNKNPLAWVNTTIFDHKDILRTGRHTLYTWTY-----------ADDIQSVEVFHPLGTI 495
            .|         |.:||..:.||:.:||.|.:.|:.|..           ||.:.|.         
Human   459 QL---------LYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSA--------- 505

  Fly   496 EPNPRKEECALVDLTFLSSGTGTVRYPSEEVVLQYAADR---EQVNRLQRQLAGPEKPIKELKEL 557
             .||.||....:.: .|.:....:..|..:.......||   |..|:|:          |:|:.:
Human   506 -TNPDKENSMSISI-LLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLR----------KQLEAI 558

  Fly   558 MANYTGLDKIYEMVDQDRNAIWERRNDILRELPEELSILLHCVYWKERDDVADMWYLLKQ---W- 618
            :|.    |.:..:..:|:..:|..|.:.|:. |:....|...|.|.:::.||..:.||.:   | 
Human   559 IAT----DPLNPLTAEDKELLWHFRYESLKH-PKAYPKLFSSVKWGQQEIVAKTYQLLARREVWD 618

  Fly   619 -PLISIERSLELLDYAYPDPAVRRFAIRCLHFLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLE 682
             ..:.:..:::|||..:.|..||..|::.|..|:|:|:|.||||||||:|.|.|.:|.|..|||:
Human   619 QSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLK 683

  Fly   683 RALRNQRIGHYFFWHLRSEM-QTPSMQTRFGLLLEVYLKGCKHHVAPLR---KQLHVLEKLKQGS 743
            |.|||:||||:.||.||||: |:...|.||.::||.||:||  ..|.|.   :|:.|:|.|::.:
Human   684 RGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGC--GTAMLHDFTQQVQVIEMLQKVT 746

  Fly   744 LIAKKGSKEK------VKTMLQDFLRDQRNSAVFQNIQNPLNPSFRCSGVTPDRCKVMDSKMRPL 802
            |..|..|.||      |.:.|:..|.:.:||.:.::.:.|.:|..:...:..::||||.||.:||
Human   747 LDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPL 811

  Fly   803 WVVFENADVNA---SDVHIIFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCISMEKSL 864
            |:.|:.||..|   ..:.||||:|||||||||.||:||:|:.:|:.:.:|..:..|.|||....:
Human   812 WLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKI 876

  Fly   865 GMIEVVRHAETIANIQKEKGMFSATSPFKKGSLLSWLKEHNKPADKLNKAINEFTLSCAGYCVAT 929
            ||||:|:.|.|||.||  :.....|..||...|..||||.:...:|...|:..|..|||||||||
Human   877 GMIEIVKDATTIAKIQ--QSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVAT 939

  Fly   930 YVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPFVLTHDFVYVINKGFNDRES 994
            :|||:.|||:||||:...|.|||||||||||::|..||:.:||||||||.||::|:... ..:.|
Human   940 FVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTS-GKKTS 1003

  Fly   995 KEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPELSSEKDLDYLRETLVLDYTEEKAREHF 1059
            ..|..||::|.:|:|.||.|..|::.|||||:.||:|:|:|::|::|:|:.|.:...||.|:::|
Human  1004 PHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYF 1068

  Fly  1060 RAKFSEALANSWKTSLNWASH 1080
            ..:........|....||..|
Human  1069 LDQIEVCRDKGWTVQFNWFLH 1089

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K92ENP_001262770.1 PI3K_p85B 56..132 CDD:295322 11/39 (28%)
PI3K_rbd 200..307 CDD:197540 30/117 (26%)
C2_PI3K_class_I_beta_delta 339..517 CDD:176075 46/195 (24%)
PI3Ka_I 552..723 CDD:238444 68/176 (39%)
PI3Kc_I 727..1084 CDD:270709 155/366 (42%)
PIK3CGNP_001269355.1 PI3K_rbd 203..312 CDD:197540 30/110 (27%)
C2_PI3K_class_I_gamma 350..527 CDD:176044 46/199 (23%)
PI3Ka_I 549..725 CDD:238444 71/192 (37%)
PI3Kc_IB_gamma 729..1095 CDD:270627 154/364 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146177
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D204282at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100986
Panther 1 1.100 - - O PTHR10048
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X531
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.750

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