Protein Alignment Pi3K92E and PIK3C3

DIOPT Version :10

• Sequence 1: NP_650902.1
• Gene: Pi3K92E / 42446
• FlyBaseID: FBgn0015279
• Length: 1088
• Species: Drosophila melanogaster
• Sequence 2: NP_002638.2
• Gene: PIK3C3 / 5289
• HGNCID: 8974
• Length: 887
• Species: Homo sapiens
• Alignment Length: 957
• Identity: 236/957 - (24%)
• Similarity: 409/957 - (42%)
• Gaps: 225/957 - (23%)

  Fly   232 LSVNEQDTPFSLTESTLQKMNRSQMKMNDRTSDYILKVSGRDEYLLGDYPLIQFLYIQ-EMLSDS 295
            |.:|.|....||.....||..::.::      |.:||.||..:....|      ||:. ::.::.
Human    15 LDINVQLKIGSLEGKREQKSYKAVLE------DPMLKFSGLYQETCSD------LYVTCQVFAEG 67

  Fly   296 AVPNVVLQSVYRLESYINHHNE-QAMVTKRP-LPKKRTVHLHKSISSLWDM---GNYFQLTLHSI 355
            ....:.:::.|:..|...:.|| ..:..|.| ||:...|.|     ::||:   |....:...::
Human    68 KPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVAL-----TIWDVYGPGKAVPVGGTTV 127

  Fly   356 SNVNFDKTRALKVGVHVCLYHGDKKLCAQRSTDSPNGNFDTFLFNDLVMDFDIQMRNLPRMTRL- 419
            |  .|.|....:.|:|......:.:......|.:| |...:.|..|       ||..|.::|:.
Human   128 S--LFGKYGMFRQGMHDLKVWPNVEADGSEPTKTP-GRTSSTLSED-------QMSRLAKLTKAH 182

  Fly   420 ------------CIVIFEVTKMSRSKKSSNN--------KDIALKDVPYNKNPLAWVNTTIFDHK 464
                        .:...|:..::.|:|.|:|        :.:...|..|.         .::..|
Human   183 RQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYG---------IVYYEK 238

  Fly   465 DILRTGRHTLYTWTYADDIQSVEVFHPLGTIEPNPRKEECALVD------LTFLSSGTGTVRYPS 523
            |              .|:...:.....|..: |:|:.....||:      ...|.||      ||
Human   239 D--------------GDESSPILTSFELVKV-PDPQMSMENLVESKHHKLARSLRSG------PS 282

  Fly   524 EEVVLQYAADREQVNRLQRQLAGPEKPIKELKELMANYTGLDKIYEMVDQDRNAIWERRNDILRE 588
            :..:...||.|:|:|.:   ::.|  |.|:|            .||    :::.:|:.|. .|..
Human   283 DHDLKPNAATRDQLNII---VSYP--PTKQL------------TYE----EQDLVWKFRY-YLTN 325

  Fly   589 LPEELSILLHCVYWKERDDVADMWYLLKQWPLISIERSLELLDYAYPDPAVRRFAIRCLHFLKDE 653
            ..:.|:..|.||.|....:......||.:|..:.:|.|||||...|.:|.|||:|:..|....||
Human   326 QEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDE 390

  Fly   654 DLLLYLLQLVQAIKHESY----------------------------------------------- 671
            |||:||||||||:|:|::
Human   391 DLLMYLLQLVQALKYENFDDIKNGLEPTKKDSQSSVSENVSNSGINSAEIDSSQIITSPLPSVSS 455

  Fly   672 ---------------LESDLVVFLLERALRNQRIGHYFFWHLRSEMQTPSMQTRFGLLLEVY--- 718
                           ||.||..||:.||.:|..:.:|.:|::..|.:....|.|.....|:|
Human   456 PPPASKTKEVPDGENLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNV 520

  Fly   719 --------LKGCKHHVAPLRKQL-----------HVLEKLKQGSLIAKKGSKEKVKTMLQDFLRD 764
                    |||.| .|..:|..|           |:::.:::.|     |:::|....||..|.|
Human   521 MRRFSQALLKGDK-SVRVMRSLLAAQQTFVDRLVHLMKAVQRES-----GNRKKKNERLQALLGD 579

  Fly   765 --QRNSAVFQNIQNPLNPSFRCSGVTPDRCKVMDSKMRPLWVVFENADVNASDVHIIFKNGDDLR 827
              :.|.:..:.|..||.|..:..|:.|:...:..|.:.|..:.|:..|  .....:|||:|||||
Human   580 NEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTED--GGKYPVIFKHGDDLR 642

  Fly   828 QDMLTLQMLRVMDQLWKRDGMDFRMNIYNCISMEKSLGMIEVVRHAETIANIQKEKGMFSATSPF 892
            ||.|.||::.:||:|.:::.:|.::..|..::.....|.::.:: :..:|.:...:|  |..:.|
Human   643 QDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQ-SVPVAEVLDTEG--SIQNFF 704

  Fly   893 KKGSLLSWLKEHNKPADKLNKAINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGH 957
            :|     :....|.|.....:.::.:..|||||||.||:|||.|||.||:::.:.|:|||||||:
Human   705 RK-----YAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGY 764

  Fly   958 ILGHFKEKLGVRRERVPFVLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLILSLF 1022
            |||...:.|     ..|..|..:.|    :|....:|:::..|::.|..|||.||::..|||:||
Human   765 ILGRDPKPL-----PPPMKLNKEMV----EGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLF 820

  Fly  1023 SMMISTGLPELSSEKD--LDYLRETLVLDYTEEKAREHFRAKFSEAL 1067
            |:|:...:|:::.|.|  :..:::...||.::|:|..:.::...|::
Human   821 SLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESV 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_650902.1	PI3K_p85B	56..132	CDD:470589
		PI3K_rbd	200..307	CDD:197540	15/75 (20%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	35/207 (17%)
		PI3Ka_I	552..723	CDD:238444	62/243 (26%)
		PI3Kc_I	727..1084	CDD:270709	103/356 (29%)
PIK3C3	NP_002638.2	C2_PI3K_class_III	26..186	CDD:176042	38/186 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	149..170		4/21 (19%)
		PI3Ka_III	283..503	CDD:238442	62/241 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	447..467		0/19 (0%)
		PI3Kc_III	539..883	CDD:270628	103/353 (29%)
		G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	611..617		1/5 (20%)
		Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	740..748		5/7 (71%)
		Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	759..780		10/25 (40%)