DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K92E and PIK3C2G

DIOPT Version :9

Sequence 1:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	XP_016874959.1	Gene:	PIK3C2G / 5288	HGNCID:	8973	Length:	1492	Species:	Homo sapiens

Alignment Length:	1064	Identity:	286/1064 - (26%)
Similarity:	473/1064 - (44%)	Gaps:	190/1064 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 ACEYQVYGISTFNIEPYTDETKRLSEVQPYFGILSLGERTDTTSF-SSDYELTKMVNGMIGTTFD 153
            |..||::..:.|||..:.|.:.:.....|....|......:...| ::|..|.|          |
Human   277 AFPYQLFSKTKFNIHIFIDNSTQPLHFMPCANYLVKDLIAEILHFCTNDQLLPK----------D 331

  Fly   154 HNRTHGSPEIDDFRLYMTQTCDNIELERSAYTWQQRLLYEH-----PLRLANSTKMPELIRERHP 213
            |               :...|.:.|..::.:......:::.     .|.|..|.:.|..:..:|
Human   332 H---------------ILSVCGSEEFLQNDHCLGSHKMFQKDKSVIQLHLQKSREAPGKLSRKH- 380

  Fly   214 TRTFLIVVKNENDQSTFTLSVNEQDTPFSLTE-STLQKMNRSQMKMNDRTSDYILKVSGRDEYLL 277
                      |.|.|.|.|:        .|.| ..:.|::|..:....|..|:.||      |||
Human   381 ----------EEDHSQFYLN--------QLLEFMHIWKVSRQCLLTLIRKYDFHLK------YLL 421

  Fly   278 ----GDYPLIQ----------------------------------FLYIQEMLSDSAVPNVVLQ- 303
                ..|.:|:                                  |....|..:...:..|..:
Human   422 KTQENVYNIIEEVKKICSVLGCVETKQITDAVNELSLILQRKGENFYQSSETSAKGLIEKVTTEL 486

  Fly   304 --SVYRLESYINHHNEQAMVTKRPLPKKR-TVHLHKSISSLWDMGNYFQLTLHSISNVNFDKTRA 365
              |:|:|   ||.:........:|:...| |.:|:..:.|      :...|:::..|:......:
Human   487 STSIYQL---INVYCNSFYADFQPVNVPRCTSYLNPGLPS------HLSFTVYAAHNIPETWVHS 542

  Fly   366 LKVGVHVC-LYHGDKKLCAQRS-TDSPNGNFDTFLFN-DLVMDFDIQMRNLPRMTRLCIVIFEVT 427
            .|.....| |.:..||||..|: .:.|:.....||.| :..::|.:::::|||.:.|.:.:|.:.
Human   543 YKAFSFTCWLTYAGKKLCQVRNYRNIPDKKLFFFLVNWNETINFPLEIKSLPRESMLTVKLFGIA 607

  Fly   428 KMSRSKKSSNNKDIALKDVPYNKNPLAWVNTTIF-DHKDILRTGRHTLYTWTYADDIQS---VEV 488
            ..:.                 |.|.|||....:| ..|.||.:   .|::.|    :||   ||:
Human   608 CATN-----------------NANLLAWTCLPLFPKEKSILGS---MLFSMT----LQSEPPVEM 648

  Fly   489 FHP--LGTIEPNPRKEECALVDLTFLSSGTGTVRYPSEEVVLQYAADREQVNRLQRQLAGPEKPI 551
            ..|  ....:|:|     ..:.:.|.::|...::..|||            ||     :..|:|:
Human   649 ITPGVWDVSQPSP-----VTLQIDFPATGWEYMKPDSEE------------NR-----SNLEEPL 691

  Fly   552 KELKELMANYTGLDKIYEMVDQDRNAIWERR---NDILRELPEELSILLHCVYWKERDDVADMWY 613
            ||..:.:|..:.......:.::.:..:|..|   |:....||   .:|.....|.|| .|::|..
Human   692 KECIKHIARLSQKQTPLLLSEEKKRYLWFYRFYCNNENCSLP---LVLGSAPGWDER-TVSEMHT 752

  Fly   614 LLKQWPLISIERSLELLDYAYPDPAVRRFAIRCLHFLKDEDLLLYLLQLVQAIKHESYLESDLVV 678
            :|::|.......:|.||..::||..:|:.|::.|..|.:::||.||.|||||:|.|..|||.||.
Human   753 ILRRWTFSQPLEALGLLTSSFPDQEIRKVAVQQLDNLLNDELLEYLPQLVQAVKFEWNLESPLVQ 817

  Fly   679 FLLERALRNQRIGHYFFWHLRSEMQTPSMQTRFGLLLEVYL----KGCKHHVAPLRKQLHVL--- 736
            .||.|:|::.::.|..:|.|::.......::.:..||....    |......:..:|.:.:|
Human   818 LLLHRSLQSIQVAHRLYWLLKNAENEAYFKSWYQKLLAALQFCAGKALNDEFSKEQKLIKILGDI 882

  Fly   737 -EKLKQGSLIAKKGSKEKVKTMLQDFLRDQRNSAVFQNIQNPLNPSFRCSGVTPDRCKVMDSKMR 800
             |::|..|...::...:|....|::|.:|.....:      ||||:....|:..|.|....|...
Human   883 GERVKSASDHQRQEVLKKEIGRLEEFFQDVNTCHL------PLNPALCIKGIDHDACSYFTSNAL 941

  Fly   801 PLWVVFENADVNASDVHIIFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCISMEKSLG 865
            ||.:.|.||:....::.||||.|||||||||.||:::|||.:|.::|:|.:|.||.|:|..|..|
Human   942 PLKITFINANPMGKNISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQG 1006

  Fly   866 MIEVVRHAETIANIQKEKGMFSATSPFKKGSLLSWLKEHNKPADKLNKAINEFTLSCAGYCVATY 930
            ::::|..|.|:|.|.:..|:.   .|.|:.::..|..:||.......||:..|..||||:||.|:
Human  1007 LVQMVPDAVTLAKIHRHSGLI---GPLKENTIKKWFSQHNHLKADYEKALRNFFYSCAGWCVVTF 1068

  Fly   931 VLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPFVLTHDFVYVINKGFNDRESK 995
            :|||.|||:||||:.::|.:||||||..|||.:...|::|:|.||:.|.:..|.|.:|  .:..:
Human  1069 ILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEG--GKNPQ 1131

  Fly   996 EFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPELSSEKDLDYLRETLVLDYTEEKAREHFR 1060
            .|..|.|||.||:.::|||..|:|:|..||:..||||||..:||.|:...|....|:.:|..||.
Human  1132 HFQDFVELCCRAYNIIRKHSQLLLNLLEMMLYAGLPELSGIQDLKYVYNNLRPQDTDLEATSHFT 1196

  Fly  1061 AKFSEALANSWKTSLNWASHNFSK 1084
            .|..|:| ..:...||...|..::
Human  1197 KKIKESL-ECFPVKLNNLIHTLAQ 1219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322	9/41 (22%)
		PI3K_rbd	200..307	CDD:197540	25/148 (17%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	41/186 (22%)
		PI3Ka_I	552..723	CDD:238444	51/177 (29%)
		PI3Kc_I	727..1084	CDD:270709	135/360 (38%)
PIK3C2G	XP_016874959.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146179
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750