Protein Alignment Pi3K92E and Pi3K68D

DIOPT Version :10

• Sequence 1: NP_650902.1
• Gene: Pi3K92E / 42446
• FlyBaseID: FBgn0015279
• Length: 1088
• Species: Drosophila melanogaster
• Sequence 2: XP_061511792.1
• Gene: Pi3K68D / 4577553
• VectorBaseID: AGAMI1_000983
• Length: 2016
• Species: Anopheles gambiae
• Alignment Length: 1140
• Identity: 301/1140 - (26%)
• Similarity: 466/1140 - (40%)
• Gaps: 279/1140 - (24%)

  Fly   105 PYT-DETKRLSEV--QPYFGILSLGERTDTTSFSSDYELTKMVNGMIGTTFDHNRTHGSPEIDDF 166
            |:| |.|..:..|  |.|..:  .|:..:|.   |||.|               :..|..||...
Mosquito   679 PFTCDITTTVEHVIAQVYCAL--EGQIRNTV---SDYAL---------------KAIGIQEILCV 723

  Fly   167 RLYMTQ-TC--DNIELERSAYTWQQRLLYEHPLRLANSTKMPELIRERHPTRTFLIVVKNENDQS 228
            |..:.| .|  |:|:|             ||.::|....|         ..||..::.:...|..
Mosquito   724 RSRLNQLQCVHDSIKL-------------EHDVQLGFVAK---------TARTMRVIARTAQDDG 766

  Fly   229 ------------TFTLSVNEQDTPFSLTESTLQKMNRSQMKMNDRTSD-YILKVSGRDE------ 274
                        ..|......|....|.|:...::::.|...:|..|. .||..||..:
Mosquito   767 RDADMRLEHLLPKETSHAIGYDDLMILLETLEAEIDKLQSSADDGPSGRTILTCSGVIQAVKAIC 831

  Fly   275 YLLGDYPLIQ------------------FLYIQEMLSDSAVPNVVLQSVYRLESYINHHNEQAMV 321
            .|||....::                  :.|...:.||.|..|..|       :.::...:.|.|
Mosquito   832 NLLGPLDTLEIAKSIEDLRACCDQGQTVYSYRDSVASDEAYSNGSL-------AIVSESGDYAEV 889

  Fly   322 TKRPLPKKRTV---------HLHKSISSLWDM-GNYFQLTLH-----------SISNVNFDKTRA 365
            ..||    |||         .:..:|.||.:: ...|::...           ||.|:    ::|
Mosquito   890 KLRP----RTVAEQIRYRCNEVRHAIQSLLEIYAQAFRVNFSVNVPEYNANPISICNI----SQA 946

  Fly   366 LKVGVH-----------------VCLYHGDKKLC---AQRSTDSPNGNFDTFLFNDLVMDFDIQM 410
            :.|.|.                 |.:|||.:.:.   ..:.::..:|.:....||..:| |...:
Mosquito   947 VMVNVSCLHRPPLHWRHDEYNLGVQIYHGARYISEPYVVQCSNELSGIYPRLTFNSWIM-FRNPV 1010

  Fly   411 RNLPRMTRLCIVIFEVTKM---------------SRSKKSSNNKDIALKDVP------YNKNPLA 454
            ..|||..||.:|::...:.               ..|..:|......:.| |      ..|..|.
Mosquito  1011 CTLPREARLVVVLYGCVREPVDGGGTSDGGGASGGASGGASGGAAPGVND-PGGSEGRMTKVELG 1074

  Fly   455 WVNTTIFDHKDILRTGRHTLYTWTYADDIQSVEVFHPLGTIEPNPRKEECALVDLTFLSSGTGTV 519
            |.:...||.:..:..|.:.|..|....|    :.|.|..:....|......::.:...|.| |.|
Mosquito  1075 WSSLQFFDFERKMVQGSYLLPMWPPTTD----KFFGPAPSKGTYPIGGSFPILSIEIPSYG-GAV 1134

  Fly   520 RYPSEEVVLQYAADREQVNRLQRQLAGPEKPIKELKELM-ANYTGLDK--IYEMVD--------- 572
            .:|                          :||:.|..:: .::..||:  ..|::|
Mosquito  1135 VFP--------------------------EPIRNLPPVVQLDFASLDRNLQQELIDTAEQGYSPD 1173

  Fly   573 --QDRNAIWERRNDILRELPEELSILLHCVYWKERDDVADMWYLLKQWPLISIERSLELLDYAYP 635
              :.|..:||:|: .|...|..|..:||..:..:...::|:..|:|.|..:|..::||||...||
Mosquito  1174 KLEKREVLWEKRH-YLHRFPHALPKILHAAHSWDYACLSDLHALIKSWTALSPVQALELLLPRYP 1237

  Fly   636 DPAVRRFAIRCLHFLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLERALRNQRIGHYFFWHLRS 700
            |..|||.|:..:..:.:::.:.||.||:||:||::|..|.|.:.||.::|.:.||.|:.:|.|..
Mosquito  1238 DLEVRRQAVEWIAAMPNDEFVDYLPQLLQALKHDTYEGSPLAMLLLRKSLESPRIAHHLYWLLLH 1302

  Fly   701 EMQTPSMQT---------------------RFGLLLEVYLKGCKHHV------------------ 726
            .:...:.|.                     |..|:|...|..|...:
Mosquito  1303 SLPGEAPQNMIDAQETACDAVLMNQARYHRRNQLMLRALLAICGEKLTGRFLSQNMMCKRLGEVA 1367

  Fly   727 --APLRKQLHVLEKLKQGSLIAKKGSKEKVKTMLQDFLRDQRNSAVFQNIQNPLNPSFRCSGVTP 789
              ..|.|..|.|:.||||        .|.|..:|.|      ...|.     ||.|....:||..
Mosquito  1368 QSVKLAKDSHRLQVLKQG--------LESVNQLLID------GPTVL-----PLEPGAEVTGVIV 1413

  Fly   790 DRCKVMDSKMRPLWVVFENADVNASDVHIIFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNI 854
            ..|...:|...||.:.|...|  ...|..|||.||||:||.||:||:|:||::|.|:|:|.:|..
Mosquito  1414 RSCNYFNSNTLPLKINFAGPD--RVVVPAIFKAGDDLQQDALTIQMVRIMDKMWLREGLDLKMVT 1476

  Fly   855 YNCISMEKSLGMIEVVRHAETIANIQKEKGMFSATSPFKKGSLLSWLKEHNKPADKLNKAINEFT 919
            :||:......||||:|..:||:..||.|.|:   |..||..|:..||.:.|....:..:|:..||
Mosquito  1477 FNCVPTAYKKGMIELVSESETLRKIQVEWGV---TGSFKDKSIAEWLAKQNPSQLEYQRAVENFT 1538

  Fly   920 LSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPFVLTHDFVYV 984
            .|||||.||||:||:.|||:||||:|.:|.|||||||..||..:.....:|:|.|||||.|..||
Mosquito  1539 RSCAGYSVATYILGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDMAYV 1603

  Fly   985 INKGFNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPELSSEKDLDYLRETLVLD 1049
            ||.|  ||.|.:|..|.:||..||.::|:|..|:|.:|::|.::|:|.::.|. ::|:|..|:..
Mosquito  1604 INGG--DRPSAKFHQFVDLCCTAFNIVRRHSDLLLHMFALMATSGIPGVTVEA-VNYVRNALLPG 1665

  Fly  1050 YTEEKAREHFRAKFSEALANSWKTSLNWASHNFSK 1084
            .:..:|...| ||.......||.|..|:..||.::
Mosquito  1666 QSNPEAAATF-AKMIHISLKSWFTQFNFFLHNIAQ 1699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_650902.1	PI3K_p85B	56..132	CDD:470589	8/29 (28%)
		PI3K_rbd	200..307	CDD:197540	24/143 (17%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	42/230 (18%)
		PI3Ka_I	552..723	CDD:238444	54/205 (26%)
		PI3Kc_I	727..1084	CDD:270709	142/356 (40%)
Pi3K68D	XP_061511792.1	None