Protein Alignment Pi3K92E and pik3cg

DIOPT Version :9

• Sequence 1: NP_001262770.1
• Gene: Pi3K92E / 42446
• FlyBaseID: FBgn0015279
• Length: 1088
• Species: Drosophila melanogaster
• Sequence 2: XP_021330656.1
• Gene: pik3cg / 406598
• ZFINID: ZDB-GENE-040426-2532
• Length: 1113
• Species: Danio rerio
• Alignment Length: 1107
• Identity: 349/1107 - (31%)
• Similarity: 562/1107 - (50%)
• Gaps: 163/1107 - (14%)

  Fly    57 LELRVNPANTIQVIKVEMVNQA-----------KQMPLGYVI----KEACEYQVYG----ISTFN 102
            |:|.|....|::.:||::.::|           |..| .|.|    |:...|::|.    ..|.:
Zfish    73 LQLDVTGNWTVEQVKVQLWHRAVTSKLCPEFYQKYSP-DYCILLYQKKGNWYEIYDKQQVFQTLD 136

  Fly   103 IEPYTDETKRLSEVQPYFGILSLGERTDTTSFSSDYELTKMVNGMIG-TTFDHNRTHGSPEIDDF 166
            ...|....::  :|    |.:.|..|......|..|:  :.:|.:|| ...|.:..|     ||
Zfish   137 CIRYWKALRK--DV----GKIHLVVRQQPAEDSLQYQ--RFLNHLIGYDVTDVSNVH-----DD- 187

  Fly   167 RLYMTQTCDNIELERSAYTWQQRLLYEHPLRLAN-------------STKMPELIRERHPTRTFL 218
                       |||   :| :::||....:.|::             :|.|||.:..:......|
Zfish   188 -----------ELE---FT-RRKLLTPRKIELSDRDPNLYSMDPWMTTTPMPEYLLSKISNNHIL 237

  Fly   219 IVVKNENDQSTFTLSVNEQDTPFSLTESTLQKM--NRSQMKMND--RTSDYILKVSGRDEYLLGD 279
            :|:..|....|..:|::  |||..:.:|...|:  .|:.:.:::  ..||::|:|.||:|||.|:
Zfish   238 MVIHKETTSQTIKVSID--DTPVQVLQSFFAKITNKRALLGISEDVSESDFVLRVCGREEYLYGN 300

  Fly   280 YPLIQFLYIQEMLSDSAVPNVVL-------QSVYRLESY--------INHHNEQAMVTKRPLPKK 329
            ..:..|.:|::.|.:....::||       |.|.:.|.:        :...:||..:|::...|.
Zfish   301 NAIKDFHWIRQCLKNGEEIHLVLEHPPNPEQDVVQKEDWSQVDDCTGVAGTHEQLTITEKDHEKV 365

  Fly   330 RTVHLHKSISSLWDMGNYFQLTLHSISNVNFDKTRALKVGVHVCLYHGDKKLCAQRSTDSPNGNF 394
            .|:       ||||....|::.:..|......:...|.|.|...::||.:.|..:|::..|   |
Zfish   366 FTI-------SLWDCNRKFRVKILGIDIPVLPRNSELIVFVEASIFHGQQLLAQERTSSKP---F 420

  Fly   395 DTFLFNDLVMDFDIQMRNLPRMTRLCIVIFEVTKMSRSKKSSNNKDIALKDVPYNKNPLA-WVNT 458
            ...:..:..::|:|::::||:..||.:.:......:::.|.:..|         ||:.|. :||.
Zfish   421 TEEVIWNTWLEFNIKIKDLPKGARLSLQVSCGKAQTQTSKETECK---------NKSRLLYYVNL 476

  Fly   459 TIFDHKDILRTGRHTLYTWTY---ADDIQSVEVFHPLGTIEPNPRKEECALVDLTFLSSGTGTVR 520
            .:.||:.:||.|...|:.|..   ::|..||..  ...|...||.|.....|.:..     ....
Zfish   477 LLVDHRSLLRQGEFILHMWKMPEKSEDNSSVNA--DKLTSATNPDKNNSMAVAILL-----DKYC 534

  Fly   521 YPSEEVVLQYAADREQV--NRLQRQLAGPEKPIKELKELMANYTGLDKIYEMVDQDRNAIWERRN 583
            ||   |.|..:.|...:  .|.||::  |....|:.::::|.    |.::.:..:|:..:|..|.
Zfish   535 YP---VALPKSKDSPDIEGERGQREM--PNHLRKQFEQIIAT----DPLHPLTSEDKELLWHFRQ 590

  Fly   584 DILRELPEELSILLHCVYWKERDDVADMWYLLKQ---W--PLISIERSLELLDYAYPDPAVRRFA 643
            :.:|: |:.....|..|.|.:::.||...|||::   |  .::.:...|:|||..:.|..||..|
Zfish   591 ECMRD-PKAYPKFLSSVKWGKQEAVAITHYLLERSTIWDRSVLDVGLVLQLLDCHFSDENVRTIA 654

  Fly   644 IRCLHFLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLERALRNQRIGHYFFWHLRSEM-QTPSM 707
            :|.|..|.|:|:|.||||||||:|.|.|.:|.|..|||:||||::||||:.||.||||: |:...
Zfish   655 VRKLETLGDDDVLRYLLQLVQAVKFEPYHDSALARFLLKRALRSKRIGHFLFWFLRSEIAQSMHY 719

  Fly   708 QTRFGLLLEVYLKGC-KHHVAPLRKQLHVLEKLKQGSLIAKKGSKEKVKTMLQDFLRDQRNSAVF 771
            |.|:.::||.||:|| :..:...|||:.:.|.|::.:...|:.|.||.....|         .||
Zfish   720 QQRYAVILEAYLRGCGEEMLQDFRKQVEITEALQKVAREIKQISAEKYDISAQ---------VVF 775

  Fly   772 Q---------------NIQNPLNPSFRCSGVTPDRCKVMDSKMRPLWVVFENAD---VNASDVHI 818
            |               :.:.|.:|..|...:..::||||.||.:|||:.|:.||   :::..:.|
Zfish   776 QLRQKLEGLQVLGLPDSFKVPYDPGLRAGALVIEQCKVMASKKKPLWLQFKRADPTTLSSDTIGI 840

  Fly   819 IFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCISMEKSLGMIEVVRHAETIANIQKEK 883
            |||:|||||||||.||:|.:|:.:|:.:.:|..:..|.|||....:||||:|:.|.||||||  :
Zfish   841 IFKDGDDLRQDMLILQILLIMESIWELESLDLSLLPYGCISTGNKIGMIEIVKDATTIANIQ--Q 903

  Fly   884 GMFSATSPFKKGSLLSWLKEHNKPADKLNKAINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNG 948
            .....|..||...|..||:|.....||..:|::.|..||.||||||||||:.|||:||||:...|
Zfish   904 STVGNTGAFKDEILSQWLREKCVNEDKHQQAVDRFVFSCGGYCVATYVLGIGDRHNDNIMITETG 968

  Fly   949 QLFHIDFGHILGHFKEKLGVRRERVPFVLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRK 1013
            .|||||||||||::|..||:.:||||||||.||:|::.. ...:.|..|..||.:|.:|:|.||.
Zfish   969 NLFHIDFGHILGNYKSFLGISKERVPFVLTPDFLYLMGT-TGKKSSPNFLQFQNVCLKAYLALRH 1032

  Fly  1014 HGCLILSLFSMMISTGLPELSSEKDLDYLRETLVLDYTEEKAREHFRAKFSEALANSWKTSLNWA 1078
            |..|::.|||||:.||:|:|:|::|::|:||.|.:..:|::|::||..:........|....||.
Zfish  1033 HTNLLIILFSMMLMTGMPQLTSKEDIEYIREALTVGRSEDEAKQHFLDQIEICRDKGWTVQFNWF 1097

  Fly  1079 SH 1080
            .|
Zfish  1098 LH 1099

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322	20/93 (22%)
		PI3K_rbd	200..307	CDD:197540	32/130 (25%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	43/181 (24%)
		PI3Ka_I	552..723	CDD:238444	70/177 (40%)
		PI3Kc_I	727..1084	CDD:270709	153/372 (41%)
pik3cg	XP_021330656.1	PI3K_rbd	221..327	CDD:307097	30/107 (28%)
		C2_PI3K_class_I_gamma	366..537	CDD:176044	46/199 (23%)
		PI3Ka_I	559..735	CDD:238444	69/180 (38%)
		PI3Kc_IB_gamma	739..1105	CDD:270627	153/373 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579744
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100986
Panther	1	1.100	-	-	O	PTHR10048
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X531
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.750