Protein Alignment Pi3K92E and pik3cd

DIOPT Version :10

• Sequence 1: NP_650902.1
• Gene: Pi3K92E / 42446
• FlyBaseID: FBgn0015279
• Length: 1088
• Species: Drosophila melanogaster
• Sequence 2: NP_957493.1
• Gene: pik3cd / 394174
• ZFINID: ZDB-GENE-040426-1128
• Length: 1039
• Species: Danio rerio
• Alignment Length: 1099
• Identity: 428/1099 - (38%)
• Similarity: 630/1099 - (57%)
• Gaps: 99/1099 - (9%)

  Fly    27 PPCMRFSVNLWKNEMLNWVDLICLLPNGFLLELRVNPANTIQVIKVEMVNQAKQMPLGYVIKEAC 91
            ||.:.....:|:.|....|::..|||.|..|...|..::||..||..:...||..||...:.:..
Zfish     2 PPGVYGMQEVWEMEGRQHVNIEFLLPTGIYLNFTVACSDTISTIKKMLWKNAKNEPLFSALSDPD 66

  Fly    92 EYQVYGIS-TFNIEPYTDETKRLSEVQPYFGILSL----GERTDTTSFSSDYELTKMVNGMIGT- 150
            .|....|: |...|...||.:||.:|:|:..||.|    |:|.:..       :|..:|.:||.
Zfish    67 AYVFTCINMTAEREELEDEQRRLCDVRPFLPILRLVAREGDRVEKL-------ITTQINQLIGKG 124

  Fly   151 --TFDHNRTHGSPEIDDFRLYMTQTCDNIELERSAYTWQQRLLYEHPLRLANSTKMPELIRERHP 213
              .||..:.|   |:::||..|...|:.....|....|.:.:.|..|..|...:.:.:..:.|..
Zfish   125 HHEFDSQKNH---ELNEFRTKMRAFCEEHAYLRQTLPWDKWMEYNFPCDLEPCSSVTQSGKSRSI 186

  Fly   214 TRTFLIVVKNENDQSTFTLSVNEQDTPFSLTESTLQKMN---RSQMKMNDRTSDYILKVSGRDEY 275
            .:.| :.||.|..:.||.|..:.||.|..|..:.|:|.:   ||..:  ::..||.|:|:.|.|:
Zfish   187 KKIF-VNVKFEGSEETFVLQQDPQDLPVVLKRNALRKKSTVFRSVKQ--EKPEDYSLQVNERWEF 248

  Fly   276 LLGDYPLIQFLYIQEMLSDSAVPNVVLQSVYRLESYINHHNEQAMVTKR-----------PLPKK 329
            :.|.|||.||.||...|.....|::   ::....|.:.:..||:.::.:           |||.|
Zfish   249 IYGKYPLCQFKYIFTCLHGGLTPHL---TMVHYSSIVKYQEEQSGLSNQVSRSRAQSKPPPLPLK 310

  Fly   330 RTVHLHKSISSLWDMGNYFQLTLHSISNVNFDKTRALKVGVHVCLYHGDKKLCAQRSTDSPNGNF 394
            |     ::..|||.:...|.:.|...|.||.|:  .:|:.|...|:||.:.||...:::..:..|
Zfish   311 R-----QNTCSLWSIQEPFYIYLLQGSRVNADE--GMKLVVQAGLFHGSELLCKVVTSNEVSVCF 368

  Fly   395 DTFLFNDLVMDFDIQMRNLPRMTRLCIVIF---EVTKMSRSKKSSNNKDIALKDVPYNKNPLAWV 456
            |......||  |||.:.:||||:|||..::   |.||...:||.:...|.          |||||
Zfish   369 DPVWDQKLV--FDINVSDLPRMSRLCFALYGVIEKTKKRPTKKKNKRADC----------PLAWV 421

  Fly   457 NTTIFDHKDILRTGRHTLYTWTYADDIQSVEVFHPLGTIEPNPRKEECALVDLTFLSSGTG-TVR 520
            ||.:||:||.|:||..:|.||....|.:. ::.:|:||:|.||.           :.|..| .:|
Zfish   422 NTMVFDYKDQLKTGEFSLSTWPSVPDDKG-DLLNPMGTVEKNPN-----------IDSTAGLLIR 474

  Fly   521 YPSEEVVLQYAADREQVNRLQRQLAGP--EKPI------KELKELMANYTGLDKIYEMVDQDRNA 577
            :|:......|....|::|.|     ||  ||.|      ::|||::.|....    |..:.::..
Zfish   475 FPNIRPHPLYYPPIEKLNEL-----GPNGEKVIATKEEHQKLKEIVDNKNST----EFFEDEKEP 530

  Fly   578 IWERRNDILRELPEELSILLHCVYWKERDDVADMWYLLKQWPLISIERSLELLDYAYPDPAVRRF 642
            :|:.|.::..:.||.|..||....|.:.:|||.|..||::||.:....:||||||::|||.||.|
Zfish   531 LWKLREELRLKYPESLPKLLLITKWNKHEDVAQMVGLLQKWPELPALHALELLDYSFPDPHVRFF 595

  Fly   643 AIRCLHFLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLERALRNQRIGHYFFWHLRSEMQTPSM 707
            .||||..|.|:.|..|||||||.:|:||||:.||..|||||||.|::|||:.||||||||..||:
Zfish   596 TIRCLRKLPDDKLFQYLLQLVQVLKYESYLDCDLTSFLLERALANKKIGHFLFWHLRSEMHVPSV 660

  Fly   708 QTRFGLLLEVYLKGCKHHVAPLRKQLHVLEKLKQGSLIAKKGSKE--KVKTM--LQDFLRDQRNS 768
            ..||||:||.|.:|...|:..|.||...|.|:|..:...|..|::  :::|.  ::..::.:...
Zfish   661 SLRFGLILEAYCRGSIFHIKSLMKQNEALNKMKALNDFVKSASQKATRIQTTEDMKVCIKQETYM 725

  Fly   769 AVFQNIQNPLNPSFRCSGVTPDRCKVMDSKMRPLWVVFENADVNASDVHIIFKNGDDLRQDMLTL 833
            ....::.:||:||.....:..|:||.|||||:|||:::::   ....|.||||||||||||||||
Zfish   726 EALSDVVSPLSPSIILCELCADKCKFMDSKMKPLWLMYKS---KYDSVGIIFKNGDDLRQDMLTL 787

  Fly   834 QMLRVMDQLWKRDGMDFRMNIYNCISMEKSLGMIEVVRHAETIANIQKEKGMFSATSPFKKGSLL 898
            ||:::||.|||.:|:|.||..|.|:|.....|:||||::::||||||:.....:||:.|.|.:||
Zfish   788 QMIQIMDILWKTEGLDLRMQPYGCLSTGNKTGLIEVVKNSDTIANIQRNNSNSAATAAFNKDALL 852

  Fly   899 SWLKEHNKPADKLNKAINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFK 963
            :|||..| |.|||::||.|||||||||||||||||:.||||||||::.:||||||||||.||:||
Zfish   853 NWLKSKN-PGDKLDQAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFK 916

  Fly   964 EKLGVRRERVPFVLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMIST 1028
            .|.|:.||||||:||:|||:||.:| ....|::|..|:..||:|:.:|.::|.|.::||::|.:.
Zfish   917 SKFGINRERVPFILTYDFVHVIQEG-RTNNSEKFERFRVCCEQAYKILCRNGTLFVNLFALMKAA 980

  Fly  1029 GLPELSSEKDLDYLRETLVLDYTEEKAREHFRAKFSEALANSWKTSLNWASHNFSKNNK 1087
            |||||:|.||:.||:::|.|..:||:|.::|:.||:|||..||||.:||..|.|:|:|:
Zfish   981 GLPELNSSKDIQYLKDSLALGKSEEEALKNFKVKFNEALRESWKTKVNWMMHTFAKDNR 1039

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_650902.1	PI3K_p85B	56..132	CDD:470589	25/80 (31%)
		PI3K_rbd	200..307	CDD:197540	32/109 (29%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	61/180 (34%)
		PI3Ka_I	552..723	CDD:238444	83/170 (49%)
		PI3Kc_I	727..1084	CDD:270709	178/360 (49%)
pik3cd	NP_957493.1	PI3K_p85B	34..107	CDD:460483	22/72 (31%)
		PI3K_rbd	188..280	CDD:413336	31/97 (32%)
		C2_PI3K_class_I_beta_delta	315..481	CDD:176075	64/191 (34%)
		PI3Ka_I	505..676	CDD:238444	83/174 (48%)
		PI3Kc_IA_delta	676..1038	CDD:270718	180/366 (49%)