DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K92E and Pik3c2a

DIOPT Version :9

Sequence 1:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_001101970.1	Gene:	Pik3c2a / 361632	RGDID:	1310389	Length:	1687	Species:	Rattus norvegicus

Alignment Length:	1225	Identity:	332/1225 - (27%)
Similarity:	529/1225 - (43%)	Gaps:	273/1225 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 HQPKYETPPEEAEPPCMRFSVNLWKNEMLNWVDLICL---LPNGFLLELRVNP------------ 63
            |:.:.:.|...||.|               | |.:.|   .|....||.:||.
  Rat   291 HEEEKKNPVLLAEDP---------------W-DAVLLEERSPTSRHLERKVNGKSLSGATVTRSQ 339

  Fly    64 ---ANTIQVIKVE-MVNQAKQMPLGYVIKEACEYQVYGISTFNIEPYTDETKRLSEVQPYFGILS 124
               ..|.||.|.: .|:|........:...:...|.:.:....:..:.....:|....||
  Rat   340 SLIVRTTQVTKAQSQVSQKDPNGTSSLATGSSLLQEFEVQNEEVAAFCQSIMKLKTKFPY----- 399

  Fly   125 LGERTDTTSFSSDYELTKMV--NGMIGTTFDHNRTHGSPEIDDFRLYMTQTCD---NIE-LERSA 183
                ||..: :..|.|:.:.  ..|.|   ::.....|.||:.|:..:|.|||   .:: :...|
  Rat   400 ----TDHCT-NPGYLLSPVTVQRNMCG---ENASVKVSIEIEGFQQPVTFTCDVSSTVDIIIMQA 456

  Fly   184 YTW-------------------QQRLL--------YEHPLRLANSTKMPELIRERHPTRTFLIVV 221
            ..|                   |:.:|        :||   :.|..|....|:.:  ..||..:.
  Rat   457 LCWVHDDLNQVDVGSYILKVCGQEEVLQNNHCLGSHEH---IQNCRKWDTEIKLQ--LLTFSAMC 516

  Fly   222 KN-----ENDQSTFTLS--VNEQDTPFS--LTESTLQKMNRS---------QMKMNDRTSDYILK 268
            :|     |:|::...|:  :.:.:.|:.  :|...::::..|         |.:...|..|.::|
  Rat   517 QNLARTAEDDEAPVDLNKYLYQIEKPYKEVMTRHPVEELLDSYHYQVELALQTENQHRAIDQVIK 581

  Fly   269 VSGRDEYLLGDYPLIQFLYIQEMLS--DSAVPNVVLQSVYRLESYIN-HHNEQAMVT-------- 322
            .                  ::::.|  |......|.::|.:|:..:| ..|:.|.||
  Rat   582 A------------------VRKICSALDGVETPAVTEAVKKLKRAVNLPRNKSADVTSLSGGDTS 628

  Fly   323 ----------KRPLPKKR---------TVHLH--------------KSISSLWDMGNYFQLTL-- 352
                      :.|:....         .:.||              ::|...|......|.|:
  Rat   629 KNSTRGSLNLENPVQVSMDHLTAAIYDLLRLHTNSCKSSTVCPQGSRNIKEAWTATEQLQFTVYA 693

  Fly   353 -HSISN---VNFDKTRALKVGVHVC-LYHGDKKLCAQRSTDSPNGNFDTFLF----NDLVMDFDI 408
             |.||:   .|::|...      :| |.|..|.|.....:... |.:..|.:    ::|:: |.|
  Rat   694 AHGISSNWVSNYEKYYL------ICSLSHNGKDLFKPIQSKKV-GTYKNFFYLIKWDELII-FPI 750

  Fly   409 QMRNLPRMTRLCIVIFEVTKMSRSKKSSNNKDIALKDVPYNKNP--LAWVNTTIFDHKDILRTGR 471
            |:..||..:.|.:.:|.|...|......:||.        .|.|  |..|:.|:||.|..|..|.
  Rat   751 QISQLPLESVLHLTLFGVLNQSSGSSPDSNKQ--------RKGPEALGKVSLTLFDFKRFLTCGT 807

  Fly   472 HTLYTWTYADDIQSVEVFHPLGTIEPNPRKEECALVDLTFLSSGTGTVRYPSEEVVLQ------- 529
            ..||.|| :....|:.     |.|   |:|.                  |..|.:|||
  Rat   808 KLLYLWT-SSHTNSIP-----GAI---PQKS------------------YVMERIVLQVDFPSPA 845

  Fly   530 ----YAADREQVNRLQR-QLAGPEKPIKELKELMANYTGLDKIYEMVDQDRNAIWERRNDILRE- 588
                |.:.:...|.:|: :|...|   .|:|..:.:....|..:.:..:|:..:||:|...|:.
  Rat   846 FDIIYTSPQIDRNIIQQYKLEALE---NEIKGKLLDIVHRDSSFGLSKEDKAFLWEKRYYCLKHP 907

  Fly   589 --LPEELSILLHCVYWKERDDVADMWYLLKQWPLISIERSLELLDYAYPDPAVRRFAIRCLHFLK 651
              ||:   ||.....||.. ::|..:.||.|||.:....:|||||..:.|..||..|:..:..:.
  Rat   908 NCLPK---ILASAPNWKWA-NLAKTYSLLHQWPPLCPLAALELLDAKFADQEVRSLAVSWIEAIS 968

  Fly   652 DEDLLLYLLQLVQAIKHESYLESDLVVFLLERALRNQRIGHYFFWHLRSEMQTPSMQTRF----G 712
            |::|...|.|.|||:|:|.||.|.||.|||.|||.|.:|.|..:|.|:..:......:|:    |
  Rat   969 DDELTDLLPQFVQALKYEIYLNSSLVRFLLSRALGNIQIAHSLYWLLKDALHDTRFGSRYEHVLG 1033

  Fly   713 LLLEVYLKGCKHHVAPLRKQLHVL----EKLKQGSLIAK----KGSKEKVKTMLQDFLRDQRNSA 769
            .||.|..||.:..::...|.:.:|    ||::|.|..|:    :.|.|:|::.   |||::
  Rat  1034 ALLSVGGKGLREELSKQMKLVQLLGGVAEKVRQASGSARQVVLQKSMERVQSF---FLRNK---- 1091

  Fly   770 VFQNIQNPLNPSFRCSGVTPDRCKVMDSKMRPLWVVFENADVNASDVHIIFKNGDDLRQDMLTLQ 834
                .:.||.||.....:....|....|...||.|...|||....:::::||.|:|||||||.||
  Rat  1092 ----CRVPLKPSLVAKELNIKSCSFFSSNAMPLKVTMVNADPLGEEINVMFKVGEDLRQDMLALQ 1152

  Fly   835 MLRVMDQLWKRDGMDFRMNIYNCISMEKSLGMIEVVRHAETIANIQKEKGMFSATSPFKKGSLLS 899
            |:::||::|.::|:|.||.|:.|:|..:..||:|:|..::|:..||.|.|:   |..||...|..
  Rat  1153 MIKIMDKIWLKEGLDLRMVIFKCLSTGRDQGMVELVPASDTLRKIQVEYGV---TGSFKDKPLAE 1214

  Fly   900 WLKEHNKPADKLNKAINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKE 964
            ||:::|...::..||...|..||||.||||||||:.|||:||||::..|.:||||||..|||.:.
  Rat  1215 WLRKYNPSEEEYEKASENFIYSCAGCCVATYVLGICDRHNDNIMLRSTGHMFHIDFGKFLGHAQM 1279

  Fly   965 KLGVRRERVPFVLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTG 1029
            ....:|:|.|||||.|..||||.|  ::.:..|..|.:||.:|:.::||...|.|:|.|:||.:|
  Rat  1280 FGSFKRDRAPFVLTSDMAYVINGG--EKPTIRFQLFVDLCCQAYNLIRKQTNLFLNLLSLMIPSG 1342

  Fly  1030 LPELSSEKDLDYLRETLVLDYTEEKAREHFRAKFSEALANSWKTSLNWASHNFSK 1084
            ||||:|.:||.|:|:.|....|:.:|...| .:..|:...|..|..|:..||.::
  Rat  1343 LPELTSIQDLKYVRDALQPQTTDAEATIFF-TRLIESSLGSIATKFNFFIHNLAQ 1396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322	16/91 (18%)
		PI3K_rbd	200..307	CDD:197540	20/126 (16%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	46/190 (24%)
		PI3Ka_I	552..723	CDD:238444	61/177 (34%)
		PI3Kc_I	727..1084	CDD:270709	142/364 (39%)
Pik3c2a	NP_001101970.1	PI3K_rbd	411..514	CDD:279173	21/110 (19%)
		C2A_PI3K_class_II	678..850	CDD:175979	51/214 (24%)
		PI3Ka_II	871..1039	CDD:238441	58/171 (34%)
		PI3Kc_C2_alpha	1044..1396	CDD:270720	142/368 (39%)
		PX_PI3K_C2_alpha	1427..1535	CDD:132822
		C2B_PI3K_class_II	1561..1682	CDD:176027
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339942
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750