DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K92E and Pi4KIIIalpha

DIOPT Version :9

Sequence 1:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_001259191.1	Gene:	Pi4KIIIalpha / 31247	FlyBaseID:	FBgn0267350	Length:	2154	Species:	Drosophila melanogaster

Alignment Length:	1019	Identity:	212/1019 - (20%)
Similarity:	377/1019 - (36%)	Gaps:	292/1019 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 ELERSAYTWQQRLLYEHPLRLANSTKM---PELIRERHPTRTFLIVVKNENDQSTFTLSVNEQDT 239
            |.....:.|:..:  .|||......|:   |.||.   |...:|.::....|
  Fly  1285 EKRMGLFAWETEV--THPLAAYEGCKLVSKPILIA---PHLIWLQLLSEMVD------------- 1331

  Fly   240 PFSLTESTLQKMNRSQMKM-------------NDRTSDYILKVSGRDEYLLGDYPLIQFLYIQEM 291
                   |.:..||.:::|             :.:.:..:..|..|.:.|.....|:|...|.:.
  Fly  1332 -------TAKYCNRDKVEMFCLLLHRCLPVLKSSKQNRQVSTVGCRFKLLQCGLSLLQGNTIPKS 1389

  Fly   292 LSDSAVPNVVLQSVY--RLESYI------NHHNEQ----AMVTKRPLPKKRTVHLHKSISSLWDM 344
            ||    .|::.:.:|  .|:.:.      |...||    .|:..:.....|:...|...|.:.|
  Fly  1390 LS----RNILRERIYSNALDYFCGPPTCPNQSREQLLEDIMILLKFWQTMRSEKKHLVTSEVGD- 1449

  Fly   345 GNYFQLTLHSISNVNF--------------------DKTRALK-----VGVHVCLYHGDKKLCAQ 384
               :.||..|:|:...                    |.||::.     ||:.:.:..|
  Fly  1450 ---YDLTNASVSSTQMLAVRNNPETASLISGGGLVNDYTRSMSASGNAVGMGMGVAGG------- 1504

  Fly   385 RSTDSPNGNFDTFLFNDLVMDFDIQMRNLPRMTRLCIVIFEVTKMSRSKKSSNNKDIALKDVPYN 449
               .|.:|.::|                :|..|           .:.||:|:.:|.:..:...|:
  Fly  1505 ---GSSSGWYNT----------------IPHST-----------STLSKRSNRSKRLQYQKDSYD 1539

  Fly   450 KNPLAWVNTTIFDHKDILRTGRHTLYTWTYADDIQSVEVFHPLGTIEPNPRKEECALVDLTFLSS 514
            |:.:...|..:    ::|......|.||                 ..||      :|.||.
  Fly  1540 KDYMKKRNLIL----ELLAVELEFLITW-----------------YNPN------SLPDLI---- 1573

  Fly   515 GTGTVRYPSEEVVLQY--AADREQVNRLQRQLAGPEKPIKE--LKELMANYTGLD-KIYEMVDQD 574
                  .|.||.:.::  ...:..|.|...:||....|...  |.:.:.|...:| ::..:|..|
  Fly  1574 ------VPGEEQITEWRNRPYKSTVWRDYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRLVCSD 1632

  Fly   575 RNAIWERRNDILRELPEELSILLHCVYWKERDDVADMWYLLKQWPLISIERSLELLDYAYPD-PA 638
            ..|:.        .:||.|..|  |.......:..|:.|:|...|:..|: :|......||. |.
  Fly  1633 PIAVC--------HIPEALKYL--CTTKNLLQESPDLVYILSWSPVTPIQ-ALAYFSRQYPSHPL 1686

  Fly   639 VRRFAIRCLHFLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLERALRNQRIGHYFFWHLRSEMQ 703
            ..::|::.|.....|.:|.|:.|||||::|::.  ..:|.|:...:.|:|.:.|...|::::.|
  Fly  1687 TAQYAVKTLSSYPAESVLPYIPQLVQALRHDTM--GYVVEFIKNISRRSQIVAHQLIWNMQTNM- 1748

  Fly   704 TPSMQTRFGLLLEVYLKGCKHHVAPLRKQLHVLEKLKQGSLIAKKGSKEK--------------V 754
                          |:...:.|..|  .....|::|.|..:.:..|:.::              |
  Fly  1749 --------------YMDEDQQHKDP--NLYEALDQLSQSIIASFSGAAKRFYEREFDFFGKITAV 1797

  Fly   755 KTMLQDFLRD-QRNSAVFQNIQN---------PLNPS---------------------------- 781
            ...::.|.:. :|.:|....:..         |.||.
  Fly  1798 SGEIRSFAKGIERKNACLAALSRIKVQGGCYLPSNPEAMVLDIDYSSGTPMQSAAKAPYLARFRV 1862

  Fly   782 FRCSGVTPDRCKVMDSKMRPLWVVFENADVNA-------SDVHIIFKNGDDLRQDMLTLQMLRVM 839
            :|| |:|....:.|:....|      |:..:|       |....|||.|||:|||||.||::.:.
  Fly  1863 YRC-GITELETRAMEVSNNP------NSQEDAKMTLGVESWQAAIFKVGDDVRQDMLALQVITIF 1920

  Fly   840 DQLWKRDGMDFRMNIYNCISMEKSLGMIEVVRHAETIANI--QKEKGMFSATSPFKKGSLLSWLK 902
            ..::::.|:|..:..|..::.....|:||.|.:|::...:  |.:.|             ||...
  Fly  1921 KNIFQQVGLDLFLFPYRVVATAPGCGVIECVPNAKSRDQLGRQTDSG-------------LSEYF 1972

  Fly   903 EH---NKPADKLNKAINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKE 964
            :|   ::.:.:...|...|..|.|.|.:..|:|.:.|||:.|||:.::|.:.|||||.:   |:.
  Fly  1973 QHQYGDESSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNGNIMIDKDGHIIHIDFGFM---FES 2034

  Fly   965 KLGVRRERVP-FVLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMIST 1028
            ..|......| ..||.:.|.::....:....|.||   |||.:|||.:|.:...|:||.|:|:.|
  Fly  2035 SPGGNIGFEPDMKLTDEMVMIMGGKMDSPAFKWFC---ELCVQAFLAVRPYQDAIVSLVSLMLDT 2096

  Fly  1029 GLPELSSEKDLDYLRETLVLDYTEEKAREHFRAKFSEALANSWK 1072
            |||....: .::.|::..|.....::|..|..|    .:.||::
  Fly  2097 GLPCFRGQ-TINLLKQRFVATKNNKEAAAHMLA----VIRNSYQ 2135

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322
		PI3K_rbd	200..307	CDD:197540	21/124 (17%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	33/202 (16%)
		PI3Ka_I	552..723	CDD:238444	39/174 (22%)
		PI3Kc_I	727..1084	CDD:270709	98/411 (24%)
Pi4KIIIalpha	NP_001259191.1	PI4Ka	1600..1775	CDD:238443	46/204 (23%)
Pi4KIIIalpha	NP_001259191.1	PI4Kc_III_alpha	1836..2153	CDD:270711	86/331 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447456
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10048
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840