DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K92E and Pik3c2b

DIOPT Version :9

Sequence 1:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	XP_006249816.1	Gene:	Pik3c2b / 289021	RGDID:	1306541	Length:	1633	Species:	Rattus norvegicus

Alignment Length:	1088	Identity:	326/1088 - (29%)
Similarity:	513/1088 - (47%)	Gaps:	169/1088 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 GISTFNIEPYTDETKRLSEVQPYFGILSLGERTDTTSFSSDYELTKMVNGMIGTTFDHNRTHGSP 161
            |...|.:....||     ||..:..:|.:   ..|.|.:.||.||    |.:.:|...:..|...
  Rat   321 GHELFEVSEERDE-----EVAAFCHMLDI---LRTGSDTQDYSLT----GCVWSTVTPSPEHLGD 373

  Fly   162 EIDDFRLYMTQTCDNIELERSAYTWQ----------QRLLYEH-PLR-------LANSTKMPELI 208
            |::   |.:|..||::. |...:|..          |.|.|.| .||       :.....:.|.:
  Rat   374 EVN---LKVTVLCDSLR-EPLTFTCNCSSTVDLLIYQTLCYTHDELREVDVGDFVLKPCGLEEFL 434

  Fly   209 RERHP---------TRTF-----LIVVKNENDQSTFTLSVNEQDTPFSLT-------ESTLQKMN 252
            :.:|.         .|.|     |.:::.:..:|....:||:..:|.:|.       ....|.::
  Rat   435 QNKHALGSHEYIQHCRKFDINIRLQLMEQKAIRSDLARTVNDDQSPSTLNYLIHLQERPVKQTIS 499

  Fly   253 RSQMKMNDRTSDYILKVSGRDEYLL--GDYPLIQFLYIQEMLSDSAVPNVVLQ-SVYRLESYINH 314
            |..:.:...|  |..:|   |.:||  ||:||.....:|   |..|:.|.:.. ....:.|.:|.
  Rat   500 RQALSLLFDT--YHNEV---DAFLLAEGDFPLKADRVVQ---SVKAICNALAAVETPEITSALNQ 556

  Fly   315 ------------HNEQAMVTKRPLPKKRTVHLHKSISSLWDMGNY-------FQLTL-----HSI 355
                        ..:.:::|.|...:|....|..:|..|.::  |       ||..:     |.:
  Rat   557 LPPCPSRMQPKIQKDPSVLTVRENREKVVEALTAAILDLVEL--YCSTFNADFQTAVPGSRKHDL 619

  Fly   356 --SNVNFDKTRALKV-GVH----------------VCLYHGDKKLCAQRSTDSPNGNFDTFLFND 401
              ...:|....|..| |.|                ..|.||.|:||:...|  ...:|..:||:.
  Rat   620 VQEACHFSGALAFTVYGTHRIPIIWATSYEEFYLSCSLSHGGKELCSPLQT--RRAHFSKYLFHL 682

  Fly   402 LVMD----FDIQMRNLPRMTRLCIVIFEVTKMSRSKKSSNNKDIALKDVPYNKNPLAWVNTTIFD 462
            ::.|    |.:|:..|||.|.||..::.:........|..||.   |.||   ..|.||.|.:|:
  Rat   683 IIWDQQICFPVQVNRLPRETLLCATLYALPIPPPGSSSEANKQ---KRVP---EALGWVTTPLFN 741

  Fly   463 HKDILRTGRHTLYTWTYADDIQSVEVFHPLGTIEPNPRKEECALVDLTFLSSGTGTVRY---PSE 524
            .:.:|..||..|..|....:..|..      ...||..:.:..::.:.|.:|.. .:::   |.:
  Rat   742 FRQVLTCGRKLLGLWPATQENSSAR------WSAPNFHQPDSVILQIDFPTSAF-DIKFTSPPGD 799

  Fly   525 EVVLQYAADREQVNRLQRQLAGPEKPIKELKELMANYTGLDKIYEMVDQDRNAIWERRNDILREL 589
            :.     :.|.:...|:      |:..::||::    |..:.:|.:.|.|:..:||:|.....|:
  Rat   800 KF-----SPRYEFGSLR------EEDQRKLKDI----TQKESLYWLSDADKKQLWEKRYYCHTEV 849

  Fly   590 PEELSILLHCVYWKERDDVADMWYLLKQWPLISIERSLELLDYAYPDPAVRRFAIRCLHFLKDED 654
            .....:|.....| |...:.|::.||:||..::.:.:|.||...:||..|||.|::.:..|.|.:
  Rat   850 SSLPLVLASAPSW-EWACLPDIYALLQQWTHMNHQDALGLLHATFPDQEVRRMAVQWIGSLSDAE 913

  Fly   655 LLLYLLQLVQAIKHESYLESDLVVFLLERALRNQRIGHYFFWHLRSEMQTPSMQTRFGLLLEVYL 719
            ||.||.|||||:|:|.||:|.||.|||:||:.:.|:.|||||.|:..::......|:..||...|
  Rat   914 LLDYLPQLVQALKYECYLDSPLVRFLLKRAISDLRVTHYFFWLLKDSLKDSQFSIRYQYLLAALL 978

  Fly   720 KGCKHHVAPLRKQ-------LHVLEKLKQGSLIAKKGSKEKVKTMLQDFLRDQRN-SAVFQNIQN 776
            ..|.   ..||::       ::.|.||.|....|...:::.:   |:..|.:.|. .|:..:.:.
  Rat   979 CCCG---KGLREEFNRQCWLVNTLAKLAQQVREATPSARQGI---LRAGLEEVRQFFALNGSCRL 1037

  Fly   777 PLNPSFRCSGVTPDRCKVMDSKMRPLWVVFENADVNASDVHIIFKNGDDLRQDMLTLQMLRVMDQ 841
            ||:||....|:.|..|...:|...||.:.|:|.|....::.:|||.|||||||||||||:|:|.:
  Rat  1038 PLSPSLLVKGIVPRDCSYFNSNAVPLKLAFQNVDPLGENIRVIFKCGDDLRQDMLTLQMIRIMSK 1102

  Fly   842 LWKRDGMDFRMNIYNCISMEKSLGMIEVVRHAETIANIQKEKGMFSATSPFKKGSLLSWLKEHNK 906
            :|.::|:|.||.|:.|.|..:..||:|::.:|||:..||.|.|:   |..||...|..||::||.
  Rat  1103 IWVQEGLDMRMVIFRCFSTGRGKGMVEMIPNAETLRKIQVEHGV---TGSFKDRPLADWLQKHNP 1164

  Fly   907 PADKLNKAINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRE 971
            ..|:..||:..|..||||.|||||:||:.|||:||||:|..|.:||||||..|||.:....::|:
  Rat  1165 GEDEYEKAVENFIYSCAGCCVATYILGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQMFGNIKRD 1229

  Fly   972 RVPFVLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPELSSE 1036
            |.|||.|.|..||||.|  |:.|..|..|.:||.:|:.::|||..|.|:|..:|:|.|:||||..
  Rat  1230 RAPFVFTSDMAYVINGG--DKPSSRFHDFVDLCCQAYNLIRKHTHLFLNLLGLMLSCGIPELSDL 1292

  Fly  1037 KDLDYLRETLVLDYTEEKAREHFRAKFSEALANSWKTSLNWASHNFSK 1084
            :||.|:.:.|....||..|..:| .:..|:...|..|.||:..||.::
  Rat  1293 EDLKYVYDALRPQDTEANATTYF-TRLIESSLGSVATKLNFFIHNLAQ 1339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322	7/34 (21%)
		PI3K_rbd	200..307	CDD:197540	26/130 (20%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	50/212 (24%)
		PI3Ka_I	552..723	CDD:238444	61/170 (36%)
		PI3Kc_I	727..1084	CDD:270709	148/364 (41%)
Pik3c2b	XP_006249816.1	PI3K_rbd	363..465	CDD:395642	20/105 (19%)
		C2A_PI3K_class_II	621..793	CDD:175979	45/186 (24%)
		PI3Ka_II	812..980	CDD:238441	62/172 (36%)
		PI3Kc_C2_beta	986..1339	CDD:119421	147/361 (41%)
		PX_PI3K_C2_beta	1368..1476	CDD:132823
		C2B_PI3K_class_II	1504..1626	CDD:176027
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339943
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750