Protein Alignment Pi3K92E and SH3PXD2B

DIOPT Version :9

• Sequence 1: NP_001262770.1
• Gene: Pi3K92E / 42446
• FlyBaseID: FBgn0015279
• Length: 1088
• Species: Drosophila melanogaster
• Sequence 2: XP_016864840.1
• Gene: SH3PXD2B / 285590
• HGNCID: 29242
• Length: 939
• Species: Homo sapiens
• Alignment Length: 456
• Identity: 77/456 - (16%)
• Similarity: 134/456 - (29%)
• Gaps: 206/456 - (45%)

  Fly   321 VTKRPLPKKRTVHLHKSISSLWDMGNYFQLTLHSISNVNFDKTRALKVGVHVCLYHGDKKLCAQR 385
            |.||.:|.|..|::   |...|..|
Human    15 VQKRRVPNKHYVYI---IRVTWSSG---------------------------------------- 36

  Fly   386 STDSPNGNFDTFLFNDLVMDFDIQMRNLPRMTRLCIVIFEVTKMSRSKKSSNNKDIALKDVPYNK 450
            ||::....:..|        ||:||:.|.:.                ......||...:.:|:..
Human    37 STEAIYRRYSKF--------FDLQMQMLDKF----------------PMEGGQKDPKQRIIPFLP 77

  Fly   451 NPLAWVNTTIFDHKDILRTGRHTLYTWTYADDIQSVEVFHPLGTIEPNPRKEEC-ALVDLTFLSS 514
            ..:                    |:..::..|:....:.         |..|.| ||:.|.
Human    78 GKI--------------------LFRRSHIRDVAVKRLI---------PIDEYCKALIQLP---- 109

  Fly   515 GTGTVRYPSE-EVVLQYAADR-EQVNRLQRQLAGPEKP----------IKELKELMANY------ 561
                 .|.|: :.|||:...| |.:|..:.:..|.:|.          :.|...::|||
Human   110 -----PYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESS 169

  Fly   562 ---TGLDKIYEMVDQDRNAIW----------------ERRNDILREL---PEELSILLHCVYWK- 603
               ..:.::.::::::.:..|                |.::.:..|.   |||:|    ..||.
Human   170 EISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEVS----WRYWSL 230

  Fly   604 -----ERDDVADMWYLLKQWPLISIERSLELLDYAYPDPAVRRFAIRCLHFLKDEDLLLYLLQLV 663
                 .|..:.|::.:  .|      |..|.....||..|            :|:|
Human   231 PRPVGRRRTLGDLYAI--SW------RQEEKYTVIYPYTA------------RDQD--------- 266

  Fly   664 QAIKHESYLESDLVVFLLERALRNQRIGHYFFWHLRSEMQTPSMQTRFGLLLEVYLKGCKHHVAP 728
                 |..||...||.::::.|..       :|.:|       .|.:.|.....|||  |:...|
Human   267 -----EMNLERGAVVEVIQKNLEG-------WWKIR-------YQGKEGWAPASYLK--KNSGEP 310

  Fly   729 L 729
            |
Human   311 L 311

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322
		PI3K_rbd	200..307	CDD:197540
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	21/178 (12%)
		PI3Ka_I	552..723	CDD:238444	36/204 (18%)
		PI3Kc_I	727..1084	CDD:270709	2/3 (67%)
SH3PXD2B	XP_016864840.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900