| Sequence 1: | NP_001262770.1 | Gene: | Pi3K92E / 42446 | FlyBaseID: | FBgn0015279 | Length: | 1088 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001373429.1 | Gene: | MTOR / 2475 | HGNCID: | 3942 | Length: | 2549 | Species: | Homo sapiens |
| Alignment Length: | 772 | Identity: | 163/772 - (21%) |
|---|---|---|---|
| Similarity: | 255/772 - (33%) | Gaps: | 277/772 - (35%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 322 TKRPLPKKRTVHLHKSI-------------SSLWDMGNYFQLTLHSISNVNFDKTRALKVG---- 369
Fly 370 VHVCLYHGDKKLCAQRSTDSPNGNFDTFLFNDLVMDFDIQMRNLPRMTRLCIVIFEVTKMSRSKK 434
Fly 435 SSNNKDIALKDVPYNKNPLAWVNTTIFDHKDILRTGR--HTLYTWTYADDIQSVEVFHPLGTIEP 497
Fly 498 NPRKEECALVDLTFLSSGTGTVRYPSEEVVLQYAADREQVNRLQRQLAGPEKPIKELKELMANYT 562
Fly 563 GLDKIYEMVDQD--RNAI-WERRNDILRELPEELSILLHCVYWKERDDVADMWYLLKQWPL-ISI 623
Fly 624 ERSLELLDYAYPDPAVRRFAIR----CLHFLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLERA 684
Fly 685 LRNQRIGHYFFWHLRSEMQTPSMQTRFGLLLEVYLKGCKHHVAPLRKQLHVLEKLKQGSLIAKKG 749
Fly 750 SKEKVKTMLQDFLRDQRNSAVFQNIQNPLNPSFRCSGVTPDRCKVMDSKMRPLWVVFENADVNAS 814
Fly 815 DVHIIFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNI----YNCISMEKSLGMIEVVRHAET 875
Fly 876 --------------IANIQKEKGMFSATSPFKKGSLLSWLK--EH---NKPADKLNKAI------ 915
Fly 916 --------NEFTLSCAGYCVATYVLGVADRHSDNIMVKR-NGQLFHIDFGHI--LGHFKEKLGVR 969
Fly 970 RERVPFVLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMI 1026 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Pi3K92E | NP_001262770.1 | PI3K_p85B | 56..132 | CDD:295322 | |
| PI3K_rbd | 200..307 | CDD:197540 | |||
| C2_PI3K_class_I_beta_delta | 339..517 | CDD:176075 | 35/183 (19%) | ||
| PI3Ka_I | 552..723 | CDD:238444 | 37/178 (21%) | ||
| PI3Kc_I | 727..1084 | CDD:270709 | 74/340 (22%) | ||
| MTOR | NP_001373429.1 | Interaction with NBN. /evidence=ECO:0000269|PubMed:23762398 | 1..651 | ||
| TEL1 | 363..2549 | CDD:227365 | 163/772 (21%) | ||
| HEAT 16 | 637..683 | ||||
| HEAT repeat | 655..681 | CDD:293787 | |||
| HEAT 17 | 686..724 | ||||
| HEAT repeat | 691..721 | CDD:293787 | |||
| HEAT 18 | 727..766 | ||||
| HEAT repeat | 729..759 | CDD:293787 | |||
| HEAT 19 | 769..811 | ||||
| HEAT repeat | 772..805 | CDD:293787 | |||
| HEAT 20 | 814..853 | ||||
| HEAT repeat | 817..847 | CDD:293787 | |||
| HEAT 21 | 857..893 | ||||
| HEAT 22 | 894..942 | ||||
| HEAT 23 | 943..988 | ||||
| HEAT repeat | 955..981 | CDD:293787 | |||
| HEAT 24 | 989..1027 | ||||
| HEAT repeat | 993..1021 | CDD:293787 | |||
| HEAT 25 | 1029..1068 | ||||
| HEAT repeat | 1033..1062 | CDD:293787 | |||
| HEAT 26 | 1069..1105 | ||||
| HEAT repeat | 1073..1099 | CDD:293787 | |||
| HEAT 27 | 1106..1144 | ||||
| HEAT repeat | 1111..1142 | CDD:293787 | |||
| HEAT 28 | 1145..1188 | ||||
| HEAT repeat | 1154..1180 | CDD:293787 | |||
| HEAT 29 | 1189..1225 | ||||
| HEAT 30 | 1226..1273 | ||||
| HEAT 31 | 1274..1311 | ||||
| HEAT 32 | 1312..1345 | ||||
| TPR 1 | 1346..1382 | ||||
| TPR 2 | 1383..1408 | ||||
| TPR 3 | 1409..1442 | ||||
| TPR 4 | 1443..1473 | ||||
| TPR 5 | 1474..1507 | ||||
| TPR 6 | 1508..1541 | ||||
| TPR 7 | 1542..1574 | ||||
| TPR 8 | 1575..1614 | ||||
| TPR 9 | 1615..1649 | ||||
| TPR 10 | 1650..1693 | ||||
| TPR 11 | 1694..1731 | ||||
| TPR 12 | 1732..1786 | ||||
| TPR 13 | 1787..1846 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1812..1867 | 3/5 (60%) | |||
| TPR 14 | 1898..1930 | 11/38 (29%) | |||
| TPR 15 | 1931..1970 | 16/100 (16%) | |||
| TPR 16 | 1971..2005 | 11/46 (24%) | |||
| Sufficient for interaction with the FKBP1A/rapamycin complex. /evidence=ECO:0000250 | 2012..2144 | 41/211 (19%) | |||
| Interaction with MLST8 | 2258..2296 | 7/38 (18%) | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_COG5032 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 0 | 0.000 | Not matched by this tool. | |||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.900 | |||||