DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K92E and Atr

DIOPT Version :9

Sequence 1:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_063917.1	Gene:	Atr / 245000	MGIID:	108028	Length:	2641	Species:	Mus musculus

Alignment Length:	1152	Identity:	218/1152 - (18%)
Similarity:	371/1152 - (32%)	Gaps:	384/1152 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 GFLLELRVNPANTIQVIKVEMVNQAKQMPLGYVIKE-ACEYQVYGI---------STFNIEPYTD 108
            |||.:|.........|..|..:.:|:..     :|| ..|::..|:         ....:||
Mouse  1674 GFLQKLYAAMHEPDGVAGVSAIRKAEPS-----LKEQILEHESIGLLRDATACYDRAIQLEP--- 1730

  Fly   109 ETKRLSEVQPYFGI----LSLGERTDTTSFSSDYELTKMVNGMIGTTFDH-NRTHGSPEIDDFRL 168
                 .::..|.|:    |.||:.:...:         .|||:      | ||:..:.|::.:|:
Mouse  1731 -----DQIIHYHGVVKSMLGLGQLSTVIT---------QVNGV------HANRSEWTDELNTYRV 1775

  Fly   169 ---YMTQTCDNIE----LERSAYTWQQRLLYEHPLRLANSTKMPELIRERHPTRTFLIVVKNEND 226
               :.....|.:|    .:..:.||..||     .:|..|.|       :..|.||
Mouse  1776 EAAWKLSQWDLVENYLAADGKSTTWSVRL-----GQLLLSAK-------KRDTTTF--------- 1819

  Fly   227 QSTFTLSVNEQDTPFSLTESTLQKMNRSQMKMNDRTSDYILKVSGRDEYLLGDYPLIQFLYIQEM 291
            ..|..|...||..|.|.....                        |..|..| |..|..|::...
Mouse  1820 YDTLKLVRAEQIVPLSAASFE------------------------RGSYQRG-YEFIVRLHMLCE 1859

  Fly   292 LSDSAVPNVVLQSVYRL-------ESYINHHNEQAMVTKRPLPKKRTVHLHKSISSLWDMGNYFQ 349
            |..|      |:.::|.       |..:|......|.......|:..:.|.:::.||....:|.:
Mouse  1860 LEHS------LKPLFRKSPGDSCNEDSLNWGARLEMTQNSYRAKEPILALRRALLSLNKRPDYNE 1918

  Fly   350 LTLHSISNVNFDKTR-ALKVGVHVCLYHGDKKLCAQRSTDSPNGNFDTFLFNDLVMDFDIQMRNL 413
            :    :........| |.|.|.|...|:.                    |.|
Mouse  1919 M----VGECWLQSARVARKAGHHQTAYNA--------------------LLN------------- 1946

  Fly   414 PRMTRLCIVIFEVTKMSRSKKSSNNKDIALKD-----VPYNKNPLAWVNTTIFDHKDILRTGRHT 473
            ...:||..:..|..|...||...:...|.|:.     .|.||:|        .:.|.:|..||.|
Mouse  1947 AGESRLAELYVERAKWLWSKGDVHQALIVLQKGVELCFPENKSP--------SESKHMLIHGRAT 2003

  Fly   474 LYTWTYADDIQSVEVFHPLGTIEPNPRKEECALVDLTFLSSGTGTVRYPSEEVVLQYAADREQVN 538
            |....:.::                                   |..:.|..|:.:|    :.|.
Mouse  2004 LLVGRFMEE-----------------------------------TANFESNAVMKKY----KDVT 2029

  Fly   539 RLQRQLAGPEKPIKELKELMANYTGLDKIYEMVDQDRNAIWERRNDILR---------------- 587
                 |..||  .::....:|.|  .||:..||..::   .|::.|::|
Mouse  2030 -----LFLPE--WEDGHFYLAKY--YDKLMPMVTDNK---MEKQGDLIRYIVLHFGRSLQYGNQF 2082

  Fly   588 ---ELPEELSILL----HCVYWKE--RDDVADMWYLLKQWPLISIERSLELLDYAYPDPAVRRFA 643
               .:|..||:.|    ....|::  |.|...|...|.:...:..|.:..|..|.:
Mouse  2083 IYQSMPRMLSLWLDFGAKAYEWEKGGRSDRLQMRNDLAKINSVLTEHTNRLAPYQF--------- 2138

  Fly   644 IRCLHFLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLERALRNQRIGHYFFWHLRSEMQTPSMQ 708
                        |....||:..|.|.   ..::.|.|:|      .|...|..:.:..|...:..
Mouse  2139 ------------LTAFSQLISRICHS---HDEVFVVLME------IIAKVFLAYPQQAMWMMTAV 2182

  Fly   709 TRFGLLLEVYLKGCKHHVAPLRKQLHVLEKLKQ----GSLIAKK----------GSKEKVK---- 755
            ::....:.|  ..||.   .|.|.:|:.:.|::    .:.:..|          ||...:.
Mouse  2183 SKSSYPMRV--NRCKE---ILTKAIHMKKSLEKFVGDATRLTDKLLELCNKSVDGSNSTLSMSTH 2242

  Fly   756 -TMLQDFLRDQRNSAV---FQNIQNPLNPSFRCSGVT--------------PDRCKVMDSKMRPL 802
             .||:..:.|...|.:   .|::..|..||...:...              .|..:::.|..:|.
Mouse  2243 FKMLKRLVEDPTFSEILIPLQSVMIPTLPSVLGAHANHDPFPGHWAYLAGFDDVVEILSSLQKPK 2307

  Fly   803 WVVFENADVNASDVHIIF-KNGDDLRQDMLTLQMLRVMDQLWKRDG----MDFRMNIYNCISMEK 862
            .:..:.:|   ...:|:. |..||||:|...::...::::..::|.    .:..:..|..|.:..
Mouse  2308 KISLKGSD---GKFYIMMCKPKDDLRKDCRLMEFNSLINKSLRKDAESRRRELHIRTYAVIPLND 2369

  Fly   863 SLGMIEVVRHA----ETIANIQKEKGMFSATSPFK-----KGSLLSWLKEHNKPADKLNKAINEF 918
            ..|:||.|.:.    ..:..|.||||::......:     |.:.||         :|| |...|.
Mouse  2370 ECGIIEWVNNTAGLRPILTKIYKEKGVYMTGKELRQCMLPKSAALS---------EKL-KVFQEL 2424

  Fly   919 TL-----------------------SCAGYCVAT-------YVLGVADRHSDNIMVKR-NGQLFH 952
            .|                       |.:.||.:|       |:||:.|||.:||:... .|:..|
Mouse  2425 LLPRHPPVFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSFTGECVH 2489

  Fly   953 IDFGHILGHFKEKLGVRRERVPFVLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCL 1017
            :||..:..  |.:.....|.|||.|||:.|    .|.....::..  |:..||....::|.....
Mouse  2490 VDFNCLFN--KGETFEVPEIVPFRLTHNMV----NGMGPMGTEGL--FRRACEVTLRLMRDQREP 2546

  Fly  1018 ILSLFSMMISTGLPELS------SEKDLDYLRETLVLDYTEEKAREH 1058
            ::|:....:...|.|.|      |:..|:...|.:     .|||:.|
Mouse  2547 LMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVV-----NEKAKTH 2588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322	16/89 (18%)
		PI3K_rbd	200..307	CDD:197540	20/106 (19%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	29/183 (16%)
		PI3Ka_I	552..723	CDD:238444	33/195 (17%)
		PI3Kc_I	727..1084	CDD:270709	87/419 (21%)
Atr	NP_063917.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	423..447
		HEAT repeat	690..720	CDD:293787
		HEAT repeat	729..788	CDD:293787
		HEAT 1	799..835
		HEAT repeat	802..837	CDD:293787
		UME	1119..1225	CDD:214825
		HEAT 2	1329..1365
		NR_LBD	1529..>1607	CDD:299703
		FAT	1771..2092	CDD:280429	81/468 (17%)
		TEL1	<2123..2641	CDD:227365	104/527 (20%)
		PIKKc_ATR	2290..2564	CDD:270625	64/294 (22%)
		FATC	2610..2641	CDD:280430
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900