Protein Alignment Pi3K92E and Pik3c2b

DIOPT Version :10

• Sequence 1: NP_650902.1
• Gene: Pi3K92E / 42446
• FlyBaseID: FBgn0015279
• Length: 1088
• Species: Drosophila melanogaster
• Sequence 2: NP_001092746.2
• Gene: Pik3c2b / 240752
• MGIID: 2685045
• Length: 1632
• Species: Mus musculus
• Alignment Length: 1093
• Identity: 322/1093 - (29%)
• Similarity: 508/1093 - (46%)
• Gaps: 179/1093 - (16%)

  Fly    97 GISTFNIEPYTDETKRLSEVQPYFGILSLGERTDTTSFSSDYELTKMVNGMIGTTFDHNRTHGSP 161
            |...|.:....||     ||..:..:|.:   ..|.|...||.||    |.:.:|...:..|...
Mouse   321 GHELFEVSEERDE-----EVAAFCHMLDI---LRTGSDIQDYSLT----GCVWSTVTPSPEHLGD 373

  Fly   162 EIDDFRLYMTQTCDNIELERSAYTW----------QQRLLYEH-PLR-------LANSTKMPELI 208
            |::   |.:|..||::. |...:|.          .|.|.|.| .||       :.....:.|.:
Mouse   374 EVN---LKVTVLCDSLR-EPLTFTCNCSSTVDLLIHQTLCYTHDELREVDVGDFVLKPCGLEEFL 434

  Fly   209 RERHP---------TRTF-----LIVVKNENDQSTFTLSVNEQDTPFSLT-------ESTLQKMN 252
            :.:|.         .|.|     |.:::.:..:|....:||:..:|.:|.       ....|.::
Mouse   435 QNKHALGSHEYIQYCRKFDISIRLQLMEQKAIRSDLARTVNDDQSPSTLNYLIHLQERPVKQTIS 499

  Fly   253 RSQMKMNDRTSDYILKVSGRDEYLL--GDYPLIQFLYIQEMLSDSAVPNVVLQ-SVYRLESYINH 314
            |..:.:...|  |..:|   |.:||  ||:||.....:|   |..|:.|.:.. ....:.|.:|.
Mouse   500 RQALSLLFDT--YHNEV---DAFLLADGDFPLKADRVVQ---SVKAICNALAAVETPEITSALNQ 556

  Fly   315 -----HNEQAMVTKRP----LPKKRTVHLHKSISSLWDMGNYFQLTL-------------HSI-- 355
                 ...|..:.|.|    :.:.|...:....:::.|:...:..|.             |.:
Mouse   557 LPPCPSRMQPKIQKDPSVLSVRENREKVVEALTAAILDLVELYCSTFNADFQTAVPGSRKHDLVQ 621

  Fly   356 SNVNFDKTRALKV-GVH----------------VCLYHGDKKLCAQRSTDSPNGNFDTFLFNDLV 403
            ...:|....|..| |.|                ..|.||.|:||:...|  ...:|..:||:.::
Mouse   622 EACHFPGALAFTVYGTHRIPIIWATSYEDFYLSCSLSHGGKELCSPLQT--RRAHFSKYLFHLII 684

  Fly   404 MD----FDIQMRNLPRMTRLCIVIFEVTKMSRSKKSSNNKDIALKDVPYNKNPLAWVNTTIFDHK 464
            .|    |.:|:..|||.|.||..::.:........|..||.   |.||   ..|.||.|.:|:.:
Mouse   685 WDQQICFPVQVNRLPRETLLCATLYALPVPPPGGSSEANKQ---KRVP---EALGWVTTPLFNFR 743

  Fly   465 DILRTGRHTLYTWTYADDIQSVEVFHPLGTIEPNPRKEECALVDLTFLSSGTGTVRY---PSEEV 526
            .:|..||..|..|....:.....      ...||..:.:..::.:.|.||.. .:::   |.::.
Mouse   744 QVLTCGRKLLGLWPATQENSGAR------WSAPNFHQPDSVILQIDFPSSAF-DIKFTSPPGDKF 801

  Fly   527 VLQYAADREQVNRLQRQLAGPEKPIKELKELMANYTGLDKIYEMVDQDRNAIWERRNDILRELPE 591
                 :.|.:...|:      |:..::||::    |..:.:|.:.|.|:..:||:|.....|:..
Mouse   802 -----SPRYEFGSLR------EEDQRKLKDI----TQKESLYWLTDADKKQLWEKRYYCHTEVSS 851

  Fly   592 ELSILLHCVYWKERDDVADMWYLLKQWPLISIERSLELLDYAYPDPAVRRFAIRCLHFLKDEDLL 656
            ...:|.....| |...:.|::.||:||..::.:.:|.||...:||..|||.|::.:..|.|.:||
Mouse   852 LPLVLASAPSW-EWACLPDIYALLQQWTHMNHQDALGLLHATFPDQEVRRMAVQWIGSLSDAELL 915

  Fly   657 LYLLQLVQAIKHESYLESDLVVFLLERALRNQRIGHYFFWHLRSEMQTPSMQTRFGLLLEVYL-- 719
            .||.|||||:|:|.||:|.||.|||:||:.:.|:.|||||.|:..::......|:..||...|
Mouse   916 DYLPQLVQALKYECYLDSPLVRFLLKRAISDLRVTHYFFWLLKDSLKDSQFSIRYQYLLAALLCC 980

  Fly   720 --KGCKHH-------VAPLRKQLHVLEKLKQGSLIAKKG----SKEKVKTMLQDFLRDQRNSAVF 771
              ||.:..       |..|.|   :.:::::.:..|::|    ..|:||...          |:.
Mouse   981 CGKGLREEFNRQCWLVNTLAK---LAQQVREATPSARQGILRVGLEEVKQFF----------ALN 1032

  Fly   772 QNIQNPLNPSFRCSGVTPDRCKVMDSKMRPLWVVFENADVNASDVHIIFKNGDDLRQDMLTLQML 836
            .:.:.||:||....|:.|..|...:|...||.:.|:|.|....::.:|||.|||||||||||||:
Mouse  1033 GSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLAFQNVDPLGENIRVIFKCGDDLRQDMLTLQMI 1097

  Fly   837 RVMDQLWKRDGMDFRMNIYNCISMEKSLGMIEVVRHAETIANIQKEKGMFSATSPFKKGSLLSWL 901
            |:|.::|.::|:|.||.|:.|.|..:..||:|::.:|||:..||.|.|:   |..||...|..||
Mouse  1098 RIMSKIWVQEGLDMRMVIFRCFSTGRGKGMVEMIPNAETLRKIQVEHGV---TGSFKDRPLADWL 1159

  Fly   902 KEHNKPADKLNKAINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKEKL 966
            ::||...|:..||:..|..||||.|||||:||:.|||:||||:|..|.:||||||..|||.:...
Mouse  1160 QKHNPGEDEYEKAVENFIYSCAGCCVATYILGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQMFG 1224

  Fly   967 GVRRERVPFVLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLP 1031
            .::|:|.|||.|.|..||||.|  |:.|..|..|.:||.:|:.::|||..|.|:|..:|:|.|:|
Mouse  1225 NIKRDRAPFVFTSDMAYVINGG--DKPSSRFHDFVDLCCQAYNLIRKHTHLFLNLLGLMLSCGIP 1287

  Fly  1032 ELSSEKDLDYLRETLVLDYTEEKAREHFRAKFSEALANSWKTSLNWASHNFSK 1084
            |||..:||.|:.:.|....||..|..:| .:..|:...|..|.||:..||.::
Mouse  1288 ELSDLEDLKYVYDALRPQDTEANATTYF-TRLIESSLGSVATKLNFFIHNLAQ 1339

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_650902.1	PI3K_p85B	56..132	CDD:470589	7/34 (21%)
		PI3K_rbd	200..307	CDD:197540	26/130 (20%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	48/213 (23%)
		PI3Ka_I	552..723	CDD:238444	63/174 (36%)
		PI3Kc_I	727..1084	CDD:270709	145/360 (40%)
Pik3c2b	NP_001092746.2	PI3K_rbd	363..465	CDD:395642	20/105 (19%)
		C2A_PI3K_class_II	621..793	CDD:175979	45/186 (24%)
		PI3Ka_II	812..980	CDD:238441	62/172 (36%)
		PI3Kc_C2_beta	986..1339	CDD:119421	146/371 (39%)
		PX_PI3K_C2_beta	1368..1476	CDD:132823
		C2B_PI3K_class_II	1504..1626	CDD:176027