Protein Alignment Pi3K92E and Smg1

DIOPT Version :9

• Sequence 1: NP_001262770.1
• Gene: Pi3K92E / 42446
• FlyBaseID: FBgn0015279
• Length: 1088
• Species: Drosophila melanogaster
• Sequence 2: NP_001026984.1
• Gene: Smg1 / 233789
• MGIID: 1919742
• Length: 3658
• Species: Mus musculus
• Alignment Length: 1084
• Identity: 190/1084 - (17%)
• Similarity: 345/1084 - (31%)
• Gaps: 369/1084 - (34%)

  Fly   159 GSPEIDDFRLYMTQTCDNIELERS-------AYTWQQ------------RLLYEHPLRLANSTKM 204
            |.|:....:||...:....|:.:|       ||.|.:            |||......:.|  .:
Mouse  1593 GEPDFILGQLYHLSSVQAPEVAKSWAALASWAYRWGRKVVDNASQGEGVRLLPREKSEVQN--LL 1655

  Fly   205 PELIRERHPTRTFLIV---------VKNENDQSTFTLSVNEQDTPF----------------SLT 244
            |:.|.|....|.:.|:         :::|:.....|.|.:.:|...                .|.
Mouse  1656 PDTITEEEKERIYGILGQAVCRPAGIQDEDITLQITESEDNEDDDMVDVIWRQLISSCPWLSELD 1720

  Fly   245 ESTLQKMNRSQMKMNDR--------TSDY--ILKVSGRDEYLLGDYPLIQFLYIQEMLSDSAVPN 299
            |:..:.:.:...|:.||        .|.|  .||::.....|..|.|.:...:..|..:|..
Mouse  1721 ENATEGVIKVWRKVVDRIFSLYKLSCSAYFTFLKLNAGQVLLDEDDPRLHLSHRAEQSTDDV--- 1782

  Fly   300 VVLQSVYRLESYINHHNEQAMVTKRPLPKKRTVHLHKSISSLWDMGNYFQLTL-HSISNVNFDKT 363
            :|:.::..|...:.|..|.....:..|....|......|..|:...|:.::.: .||.|:   ..
Mouse  1783 IVMATLRLLRLLVKHAGELRQYLEHGLETTPTAPWRGIIPQLFSRLNHPEVYVRQSICNL---LC 1844

  Fly   364 RALKVGVHVCLYHGDKKLCAQRSTDSPNGN-----FDTFLFNDLVMDFDIQMRNLPRMTRLCIVI 423
            |..:...|:.||.......:..|....:||     ..|.|.|       ||...|        ::
Mouse  1845 RVAQDSPHLILYPAIVGTISLSSESQASGNKYSSAIPTLLGN-------IQGEEL--------LV 1894

  Fly   424 FEVTKMSRSKKSSNNKDIALKDVPYNKNPLAWVNTTIFDHKDILRTGRHTLYTWTYADDIQSVEV 488
            .|....|......:|||          .|.:.:|
Mouse  1895 SECEGGSPPASQDSNKD----------EPKSGLN------------------------------- 1918

  Fly   489 FHPLGTIEPNPRKEECALVDLTFLSSGTGTVRYPSEEVVLQYAADREQVNRLQRQLAGPEKPIKE 553
                   |.....::|....:..|||...|       :||       ||..|          :.|
Mouse  1919 -------EDQAMMQDCYSKIVDKLSSANPT-------MVL-------QVQML----------VAE 1952

  Fly   554 LKELMANYTGLDKIYEMVDQDRNAIWERRNDILRELPEELSILLHCVYWKERDDVADMWY-LLKQ 617
            |:.:                  ..:|:                             ::|. :|.|
Mouse  1953 LRRV------------------TVLWD-----------------------------ELWLGVLLQ 1970

  Fly   618 WPLISIERSLELLDYAYPDPAVRRFAIRCLHFLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLE 682
            ..:..:.|..:|.|      .|:|  ::..:.|:.|:.:..:.:     ||.:.::.  :||.||
Mouse  1971 QHMYVLRRIQQLED------EVKR--VQNNNTLRKEEKIAIMRE-----KHTALMKP--IVFALE 2020

  Fly   683 RALRNQRIGHYFFWHLRSEMQTPS-------MQTRFGLLLEVYLKGCKHHVAPLRKQLHVLEKLK 740
                          |:||....|:       .|..:|..::                 :.|||||
Mouse  2021 --------------HVRSITAAPAETPHEKWFQDNYGDAID-----------------NALEKLK 2054

  Fly   741 QGSLIAKKGSK----EKVKTMLQDFLRDQRNSAVFQNIQ--NP-----LNPSFRCSGVTPDR--- 791
            ..|..||.||.    :::...||.  |.|:.::....:.  :|     .|......|....|
Mouse  2055 TPSNPAKPGSSWIPFKEIMLSLQQ--RAQKRASYILRLDEISPWLAAMTNTEIALPGEVSARDTV 2117

  Fly   792 --------CKVMDSKMRPLWVVFENADVNASDVHIIFKNGDDLRQDMLTLQMLRVMDQLW----K 844
                    ..::.:|.:|..::|..:|  ......:||..:||..|...:|.|.:::.::    :
Mouse  2118 TIHSVGGTITILPTKTKPKKLLFLGSD--GKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINR 2180

  Fly   845 RDGMDFRMNIYNCISMEKSLGMIEVV-----------RHAETIANIQKEKGMFSATSP------- 891
            ::...|....|:...:....|:|:.|           |..:..|.:|.:|...|..:|
Mouse  2181 QETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAALQAQKAQDSYQTPQNPSIVP 2245

  Fly   892 -------FKKGSLL------------SW-----------LKEHNKP-------------ADKLNK 913
                   .|.|..|            .|           |.|...|             .|:..:
Mouse  2246 RPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTPDEWWR 2310

  Fly   914 AINEFTLSCAGYCVATYVLGVADRHSDNIMV-KRNGQLFHIDFGHILGHFKEKLGVR-RERVPFV 976
            ....:..|.|...:..|::|:.|||.||::: ...|::.|||:...   |::...:| .|:|||.
Mouse  2311 VTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVC---FEKGKSLRVPEKVPFR 2372

  Fly   977 LTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPELSSEKDLDY 1041
            :|.:....:  |....|..    |:..||:...::|:....:|:|....:...|.:.::..:..:
Mouse  2373 MTQNIETAL--GVTGVEGV----FRLSCEQVLHIMRRGRETLLTLLEAFVYDPLVDWTAGGEAGF 2431

  Fly  1042 L--------RETLVLDYTEEKAREHFRAKFSEALANSWKTSLNW 1077
            .        ::........|..||..|:.||..:|   :..:||
Mouse  2432 AGAVYGGGGQQAESKQSKREMEREITRSLFSSRVA---EIKVNW 2472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322
		PI3K_rbd	200..307	CDD:197540	25/141 (18%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	30/183 (16%)
		PI3Ka_I	552..723	CDD:238444	25/178 (14%)
		PI3Kc_I	727..1084	CDD:270709	86/448 (19%)
Smg1	NP_001026984.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..99
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..142
		SMG1	629..1240	CDD:292413
		HEAT	1815..1850		7/37 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1896..1917		6/30 (20%)
		PIKKc_SMG1	2119..2424	CDD:270714	59/315 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3565..3588
		FATC	3628..3657	CDD:280430

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900