DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K92E and SMG1

DIOPT Version :9

Sequence 1:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	XP_005255239.1	Gene:	SMG1 / 23049	HGNCID:	30045	Length:	3689	Species:	Homo sapiens

Alignment Length:	1208	Identity:	216/1208 - (17%)
Similarity:	380/1208 - (31%)	Gaps:	428/1208 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 ANTIQVIKVEMVNQAKQMPLGYVIKEACEYQVYGISTFNIEPYTDETKRLSEVQPYFGILSLGER 128
            |..||....|:..|.||     |.:...:....|:||            ||:     .||:|.|.
Human  1529 AKWIQAEWKEISGQLKQ-----VYRAQHQQNFTGLST------------LSK-----NILTLIEL 1571

  Fly   129 TDTTSFSSDY---ELTKMVNGMIGTTFDHNRTHGSPEIDDFRLYMTQTCDNIELERS-------A 183
            ....:...:|   |....|:  ||.        |.|:....:||...:....|:.:|       |
Human  1572 PSVNTMEEEYPRIESESTVH--IGV--------GEPDFILGQLYHLSSVQAPEVAKSWAALASWA 1626

  Fly   184 YTWQQ------------RLLYEHPLRLANSTKMPELIRERHPTRTFLIV---------VKNENDQ 227
            |.|.:            |||......:.|  .:|:.|.|....|.:.|:         :::|:
Human  1627 YRWGRKVVDNASQGEGVRLLPREKSEVQN--LLPDTITEEEKERIYGILGQAVCRPAGIQDED-- 1687

  Fly   228 STFTLSV-----NEQD-------------TPF--SLTESTLQKMNRSQMKMNDRT-SDYILKVSG 271
              .||.:     ||:|             .|:  .|.||..:.:.:...|:.||. |.|.|..|.
Human  1688 --ITLQITESEDNEEDDMVDVIWRQLISSCPWLSELDESATEGVIKVWRKVVDRIFSLYKLSCSA 1750

  Fly   272 RDEYL---LGDYPLIQ---FLYIQEMLSDSAVPNVVLQSVYRLESYINHHNEQAMVTKRPLPKKR 330
            ...:|   .|..||.:   .|::...:..|....:|:.::..|...:.|..|.....:..|....
Human  1751 YFTFLKLNAGQIPLDEDDPRLHLSHRVEQSTDDMIVMATLRLLRLLVKHAGELRQYLEHGLETTP 1815

  Fly   331 TVHLHKSISSLWDMGNYFQLTL-HSISNVNFDKTRALKVGVHVCLYHGDKKLCAQRSTDSPNGN- 393
            |......|..|:...|:.::.: .||.|:   ..|..:...|:.||.......:..|....:||
Human  1816 TAPWRGIIPQLFSRLNHPEVYVRQSICNL---LCRVAQDSPHLILYPAIVGTISLSSESQASGNK 1877

  Fly   394 ----FDTFLFNDLVMDFDIQMRNLPRMTRLCIVIFEVTKMSRSKKSSNNKDIALKDVPYNKNPLA 454
                ..|.|.|       ||...|        ::.|....|......:|||          .|.:
Human  1878 FSTAIPTLLGN-------IQGEEL--------LVSECEGGSPPASQDSNKD----------EPKS 1917

  Fly   455 WVNTTIFDHKDILRTGRHTLYTWTYADDIQSVEVFHPLGTIEPNPRKEECALVDLTFLSSGTGTV 519
            .:|                                      |.....::|....:..|||...|
Human  1918 GLN--------------------------------------EDQAMMQDCYSKIVDKLSSANPT- 1943

  Fly   520 RYPSEEVVLQYAADREQVNRLQRQLAGPEKPIKELKELMANYTGLDKIYEMVDQDRNAIWERRND 584
                  :||       ||..|          :.||:.:                  ..:|:
Human  1944 ------MVL-------QVQML----------VAELRRV------------------TVLWD---- 1963

  Fly   585 ILRELPEELSILLHCVYWKERDDVADMWY-LLKQWPLISIERSLELLDYAYPDPAVRRFAIRCLH 648
                                     ::|. :|.|..:..:.|..:|.|      .|:|  ::..:
Human  1964 -------------------------ELWLGVLLQQHMYVLRRIQQLED------EVKR--VQNNN 1995

  Fly   649 FLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLERALRNQRIGHYFFWHLRSEMQTPS------- 706
            .|:.|:.:..:.:     ||.:.::.  :||.||              |:||....|:
Human  1996 TLRKEEKIAIMRE-----KHTALMKP--IVFALE--------------HVRSITAAPAETPHEKW 2039

  Fly   707 MQTRFGLLLEVYLKGCKHHVAPLRKQLHVLEKLKQGSLIAKKGSK----EKVKTMLQDFLRDQRN 767
            .|..:|..:|                 :.|||||.....||.||.    :::...||.  |.|:.
Human  2040 FQDNYGDAIE-----------------NALEKLKTPLNPAKPGSSWIPFKEIMLSLQQ--RAQKR 2085

  Fly   768 SAVFQNIQ--NP-----LNPSFRCSGVTPDR-----------CKVMDSKMRPLWVVFENADVNAS 814
            ::....::  :|     .|......|....|           ..::.:|.:|..::|..:|  ..
Human  2086 ASYILRLEEISPWLAAMTNTEIALPGEVSARDTVTIHSVGGTITILPTKTKPKKLLFLGSD--GK 2148

  Fly   815 DVHIIFKNGDDLRQDMLTLQMLRVMDQLW----KRDGMDFRMNIYNCISMEKSLGMIEVV----- 870
            ....:||..:||..|...:|.|.:::.::    :::...|....|:...:....|:|:.|
Human  2149 SYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATP 2213

  Fly   871 ------RHAETIANIQKEKGMFSATSPFKKG---------------------------------- 895
                  |..:..|.:|.:|...|..:|...|
Human  2214 LFGLYKRWQQREAALQAQKAQDSYQTPQNPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLH 2278

  Fly   896 ---SLLSWLKEHNKP-------------ADKLNKAINEFTLSCAGYCVATYVLGVADRHSDNIMV 944
               ::|..|.|...|             .|:..:....:..|.|...:..|::|:.|||.||:::
Human  2279 VMKAVLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLI 2343

  Fly   945 -KRNGQLFHIDFGHIL--GHFKEKLGVRR------------------------ERVPFVLTHDFV 982
             ...|::.|||:....  |:.|......|                        |:|||.:|.:..
Human  2344 DMTTGEVVHIDYNVCFEKGNIKVDFTFMRAKCFLVKGQKYNDLSFQGKSLRVPEKVPFRMTQNIE 2408

  Fly   983 YVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPELSSEKDLDYL----- 1042
            ..:  |....|..    |:..||:...::|:....:|:|....:...|.:.::..:..:.
Human  2409 TAL--GVTGVEGV----FRLSCEQVLHIMRRGRETLLTLLEAFVYDPLVDWTAGGEAGFAGAVYG 2467

  Fly  1043 ---RETLVLDYTEEKAREHFRAKFSEALANSWKTSLNW 1077
               ::........|..||..|:.||..:|   :..:||
Human  2468 GGGQQAESKQSKREMEREITRSLFSSRVA---EIKVNW 2502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322	17/67 (25%)
		PI3K_rbd	200..307	CDD:197540	30/142 (21%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	30/183 (16%)
		PI3Ka_I	552..723	CDD:238444	26/178 (15%)
		PI3Kc_I	727..1084	CDD:270709	84/473 (18%)
SMG1	XP_005255239.1	SMG1	631..1242	CDD:292413
		PIKKc_SMG1	2121..2454	CDD:270714	58/340 (17%)
		FATC	3659..3688	CDD:280430
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900