DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K92E and Pi4ka

DIOPT Version :9

Sequence 1:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_001360884.1	Gene:	Pi4ka / 224020	MGIID:	2448506	Length:	2105	Species:	Mus musculus

Alignment Length:	1054	Identity:	203/1054 - (19%)
Similarity:	382/1054 - (36%)	Gaps:	288/1054 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 ELTKMVNGMIGTTFDHNR-THGSPEIDDFR----LYMTQTCDNIELERSAYTW-QQRLLYEHPLR 197
            :|.||:...:.|..||:. .|.:..:  |:    |..::.||...|..  ..| ..|:..||.:.
Mouse  1171 DLNKMMVQDLITALDHSHPQHYTQAM--FKLTAMLISSKDCDPQLLHH--LCWGPLRMFNEHGME 1231

  Fly   198 LA-----------NSTKMP---ELIRERHPTRTFLIVVKNENDQSTFTLSVNEQDTPFSLTEST- 247
            .|           |..::|   |:....|.|        .|.....|::...|.| |.:.:|::
Mouse  1232 TALACWEWLLAGKNGVEVPFMREMAGAWHMT--------VEQKFGLFSVETKEAD-PLAASEASQ 1287

  Fly   248 ------------------LQKMNRSQMKMNDRTSDY--------ILKVSG----RDEYLLGDYPL 282
                              :|:...::...:|:...:        .|.:.|    .:.::....|.
Mouse  1288 PRPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIFSSLLQRSMSLNIGGARGSMNRHVAAIGPR 1352

  Fly   283 IQFLYI-QEMLSDSAVPNVVLQSVYRLESYINHHNEQAMVTKRPLPKKRTVHLHKSISSLWDMGN 346
            .:.|.: ..:|....|||..:::|.|.:.|....:..:...|.|...::  .|.:.||
Mouse  1353 FKLLTLGLSLLHADVVPNATIRNVLREKIYSTAFDYFSCPPKFPTQGEK--RLREDIS------- 1408

  Fly   347 YFQLTLHSISNVNFDKTRALKVGVHVCLYHGDKKLCAQRSTDSPNGNFDTFLFNDLVMDFDIQMR 411
                               :.:.....::...|.|.|.:..  |..|.||      ..:.||.:.
Mouse  1409 -------------------IMIKFWTAMFSDKKYLTASQLV--PPDNQDT------RSNLDITVG 1446

  Fly   412 NLPRMTRLCIVIFEVT--------KMSRSKKSSNNKDIALKDVPYNKNPLAWVNTTIFDHKDILR 468
            :..:.|:..|..:.::        |...|||::....:                     ||..::
Mouse  1447 SRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQL---------------------HKYYMK 1490

  Fly   469 TGRHTLYTWTYADDIQS-VEVFHPLGTIEPNPRKEECALVDLTFLSSGTGTV-RYPSEEVVLQYA 531
              |.||.....|.:|:. :..::||...|            |....:|..:| .:.|:.:.|...
Mouse  1491 --RRTLLLSLLATEIERLITWYNPLSAPE------------LELDQAGENSVANWRSKYISLSEK 1541

  Fly   532 ADREQVNRLQRQLAGPEKPIKELKELMANYTGLD----KIYEMVDQDRNAIWERRNDILRELPEE 592
            ..::.||     ||....|...: :|.|.:...:    ::..:|..|..|:        .::||.
Mouse  1542 QWKDNVN-----LAWSISPYLAV-QLPARFKNTEAIGNEVTRLVRLDPGAV--------SDVPEA 1592

  Fly   593 LSILL-------------HCVYWKERDDVADMWYLLKQWPLISIERSLELLDYAYPDPAVRRFAI 644
            :..|:             |.:.|...|....:.|....:|               |.|...::.:
Mouse  1593 IKFLVTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYP---------------PHPLTAQYGV 1642

  Fly   645 RCLHFLKDEDLLLYLLQLVQAIKHE--SYLESDLVVFLLERALRNQRIGHYFFWHLRSEM----- 702
            :.|.....:.:|.|:.|:|||::::  .|:..    ::|..|.::|.:.|.|.|::::.:
Mouse  1643 KVLRSFPPDAILFYIPQIVQALRYDKMGYVRE----YILWAAAKSQLLAHQFIWNMKTNIYLDEE 1703

  Fly   703 ---QTPSMQTRFGLLLEVYLKGCKHHVAPLRKQLHVLE-----KLKQGSLIAK---KGSKEK--- 753
               :.|.:    |.|||..::.....::...|..:..|     |:...|.|.|   ||.:.|
Mouse  1704 GHQKDPDI----GDLLEQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKAC 1764

  Fly   754 ------VKTMLQDFLR----------DQRNSAVFQN-IQNPLNPSFR---------------CSG 786
                  ||.....:|.          |.::....|: .:.|....|:               |..
Mouse  1765 LSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLQCRS 1829

  Fly   787 VTPDRCKVMDSKMRPL-WVVFENADVNASDVHIIFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDF 850
            ...|.|...::..:.: |..            .|||.|||.|||||.||::.:...:::..|:|.
Mouse  1830 DAEDECFSQEADGKKICWQA------------AIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDL 1882

  Fly   851 RMNIYNCISMEKSLGMIEVVRHAETIANI--QKEKGMFS-ATSPFKKGSLLSWLKEHNKPADKLN 912
            .:..|..::.....|:||.:....:...:  |.:.||:. .|..:...|.|::           .
Mouse  1883 FVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAF-----------Q 1936

  Fly   913 KAINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPFV- 976
            :|...|..|.|.|.:..::|.:.|||:.|||:.:.|.:.|||||.:   |:...|......|.:
Mouse  1937 QARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFM---FESSPGGNLGWEPDIK 1998

  Fly   977 LTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPELSSEKDLDY 1041
            ||.:.|.::.   ...|:..|..|.|:|.|.:|.:|.:...::||.::|:.||||....: .:..
Mouse  1999 LTDEMVMIMG---GKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQ-TIKL 2059

  Fly  1042 LRETLVLDYTEEKA 1055
            |:.....:.||.:|
Mouse  2060 LKHRFSPNMTEREA 2073

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322
		PI3K_rbd	200..307	CDD:197540	22/141 (16%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	28/186 (15%)
		PI3Ka_I	552..723	CDD:238444	34/197 (17%)
		PI3Kc_I	727..1084	CDD:270709	88/377 (23%)
Pi4ka	NP_001360884.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		PI4Ka	1550..1725	CDD:238443	36/206 (17%)
		PI4Kc_III_alpha	1786..2104	CDD:270711	76/318 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810