DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K92E and Prkdc

DIOPT Version :9

Sequence 1:NP_001262770.1 Gene:Pi3K92E / 42446 FlyBaseID:FBgn0015279 Length:1088 Species:Drosophila melanogaster
Sequence 2:NP_035289.2 Gene:Prkdc / 19090 MGIID:104779 Length:4128 Species:Mus musculus


Alignment Length:1239 Identity:247/1239 - (19%)
Similarity:417/1239 - (33%) Gaps:389/1239 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   111 KRLSEVQPYFGILS--LGERTDT-----TSFSSDY-ELTKMVNGMIGTT--FDHNRTHGSPEIDD 165
            :.:.|.....||.|  ||...||     ....||| :..|:.:..:...  .|...|....|.  
Mouse  2932 RSIGEYDVLRGIFSSELGTTQDTQNALLAEARSDYCQAAKLYDEALNKLEWVDGEPTEAEKEF-- 2994

  Fly   166 FRLYMTQTCDNI----ELERSAYTWQQRLLYEHPLRLA--------NSTKMPELIRERHPTRTFL 218
            :.|......:|:    |||   |.....::.|:.|.|:        ..|.:|.:||.:     ..
Mouse  2995 WELASLDCYNNLSKWKELE---YCSTVNIVSENSLDLSKMWSEPFYQETYLPYVIRSK-----LK 3051

  Fly   219 IVVKNENDQSTFTL---SVNE--QDTPFSLTES----------------TLQKMNRSQMKMNDRT 262
            ::::.|.:||..|.   ::|:  |.|...|..|                |....|..|:.|.:.:
Mouse  3052 LLLQGEGNQSLLTFVDEAMNKELQKTVLELQYSQELSLLYILQDDIDRATYYIKNGIQIFMQNYS 3116

  Fly   263 SDYILKVSGRDEYLLGDYPLIQFL-YIQEMLS---------------------DSAVPNVVLQSV 305
            |..:|....|    |.....:|.| .|:|.||                     .|..|:||...:
Mouse  3117 SIDVLLYRSR----LAKLQSVQTLAEIEEFLSFICKHGDLSSLGPLRRLLKTWTSRYPDVVTDPM 3177

  Fly   306 Y------------------RLESYINHH------NEQAMVTKRPLPKK---------RTVHLHKS 337
            :                  ||.:....|      :|:::..:...||:         |.....|.
Mouse  3178 HIWDDIITNRCFFLSKIEERLTAPSGDHSMSVDEDEESIDREVYEPKEDVRCMLQSCRFTMKMKM 3242

  Fly   338 ISSLWDMGNYFQLTLHSISNVNFD-KTRALKVGVHVCLYHGDKKLCAQRS-TDSPNGNFDTFLFN 400
            |.|.|...| |.|::..:..::.: |||.:   ..|...|...:|...|| |.||.......|..
Mouse  3243 IESAWKQSN-FSLSMKLLKEMHKESKTREI---WRVQWLHSYSQLNHCRSHTQSPREQVLNMLKT 3303

  Fly   401 DLVMD-FDIQ---MRNLPRMTRLCIVIFEVTKMSRSKKSSNNKDIALKDVPYNK-NPLAWVNTTI 460
            ..::| .||.   .:|:.......|::....::.....|  .:...|.|:..|| |.:..::.:.
Mouse  3304 ITLLDESDISNYLNKNIQASCDQSILLGTTCRIMADALS--REPACLSDLEENKVNSILTLSGSN 3366

  Fly   461 FDHKDILRTGRHTLYTWTYADDIQSVEVFHPLGTIEPNPRKE------------ECALVDLTFLS 513
            .::.:.:.||   ||.          ..||.|.....:..:|            |.|...:|.:.
Mouse  3367 AENTETVITG---LYQ----------RAFHHLSKAVQSAEEETQLSCWGHEAAAERAHAYMTLVG 3418

  Fly   514 SGTGTVRYPSEEVVLQYAADREQVNRLQRQLAGPEKPIKELK----ELMANYTGLDKIYEMVDQD 574
            .....:|...|....:.:|:.|....|.     .||.::.||    |....:..|.:|.|...: 
Mouse  3419 FCDQQLRKVEESASQKTSAEMEAYPALV-----VEKMLRALKLNSSEARLKFPRLLQIIEQYSE- 3477

  Fly   575 RNAIWERRNDILRELPEELSILLHCVYWKERDDVADMWYLLKQWPLISIERSLELLDYAYPDPAV 639
                     :.|..:.:|:| .:.|  |:....::.|..||.:...|:::.::|.:...||...:
Mouse  3478 ---------ETLNIMTKEIS-SIPC--WQFIGWISHMMALLDKEEAIAVQHTVEEIADNYPQAII 3530

  Fly   640 RRFAIRCLHFLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLERALRNQRIGH---YFFWHLRSE 701
            ..|                      .|..|||            :.:|...||   .|...::|:
Mouse  3531 YPF----------------------IISSESY------------SFKNTSSGHNNKAFVERIKSK 3561

  Fly   702 MQTPSMQTRF----------GLLLEVYLKGCKHHVA--PLRKQLHVLEKLKQ------GSLIA-- 746
            :....:...|          .||.:.::...|..:.  |:.|:  .:|||.:      |.|.|  
Mouse  3562 LDHGEVIHSFINALDQLSNPDLLFKDWVSDTKDELGKNPVNKK--NIEKLYERMYAALGDLRAPG 3624

  Fly   747 ---------KKGSKEKVKTM-----------LQDF--------LRDQRNSAVFQNIQ-------- 775
                     :...||.||:.           :.||        :|.:::|.:..|::        
Mouse  3625 LGPFRRRFIQAFGKEFVKSFGNGGSKLLTMKVDDFCKITGSLLVRMKKDSKLPGNLKEYSPWMSE 3689

  Fly   776 --------------------NPLNPSF--RCSGVTPDRCKVMDSKMRPLWVVFENADVNASDVHI 818
                                .|| |.:  |.||. .:|.|||.|..:|..:|....|  ..:...
Mouse  3690 FKAQFLKNELEIPGQYDGKSKPL-PEYHVRISGF-DERVKVMLSLRKPKRIVIRGHD--EKEYPF 3750

  Fly   819 IFKNGDDLRQDMLTLQMLRVMDQLWKRDG----MDFRMNIYNCISMEKSLGMIEVVRHAET---- 875
            :.|.|:|||||....|:..||:.:..:|.    .:.::..|..:.|...||:||.:.:..|    
Mouse  3751 LVKGGEDLRQDQRIEQIFEVMNAILSQDAACSQRNMQLRTYRVVPMTSRLGLIEWIENTMTLKDL 3815

  Fly   876 -IANIQKEKGMFSATSP------FKKGSLLSWL------------------------------KE 903
             ::|:.:|:.:.:.:.|      :|     .||                              :|
Mouse  3816 LLSNMSQEEKVANNSDPKAPIRDYK-----DWLMKVSGKSDAGAYVLMYSRANRTETVVAFRRRE 3875

  Fly   904 HNKPADKLNKAI--------------NEFTLSCAGYCVATYVLGVADRHSDNIMV-KRNGQLFHI 953
            ...|.|.|.:|.              :.|..|.|..|::.::||:.|||.:|.|| ...|.:..|
Mouse  3876 SQVPPDLLKRAFVKMSTSPEAFLALRSHFASSHALLCISHWLLGIGDRHLNNFMVAMETGSVIGI 3940

  Fly   954 DFGHILGHFKEKLGVRRERVPFVLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLI 1018
            ||||..|...:.|.| .|.:||.||..||.::   ...:|:...|.......|||     ..|..
Mouse  3941 DFGHAFGSATQFLPV-PELMPFRLTRQFVSLM---LPMKETGLMCTVMVHALRAF-----RSCAG 3996

  Fly  1019 LSLFSMMISTGLPELSSEKDLDYLRETLVLDYTEEKAREHFRAKFSEALANSWKTSLNWASHNFS 1083
            |...:|.|....|..    |.....:|::                  ....||...:|....|:.
Mouse  3997 LLTDTMEIFVKEPSF----DWKSFEQTML------------------RKGGSWIQEINVTEKNWY 4039

  Fly  1084 KNNK 1087
            ..:|
Mouse  4040 PQHK 4043

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K92ENP_001262770.1 PI3K_p85B 56..132 CDD:295322 8/27 (30%)
PI3K_rbd 200..307 CDD:197540 31/167 (19%)
C2_PI3K_class_I_beta_delta 339..517 CDD:176075 39/196 (20%)
PI3Ka_I 552..723 CDD:238444 31/187 (17%)
PI3Kc_I 727..1084 CDD:270709 104/484 (21%)
PrkdcNP_035289.2 HEAT 1 288..323
HEAT 2 1001..1037
HEAT 3 1050..1086
Interaction with C1D. /evidence=ECO:0000250 1501..1536
Leucine-zipper 1501..1536
TPR 1 1720..1753
ArAE_1_C <1766..1822 CDD:288564
NUC194 1812..2198 CDD:285387
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2049..2071
KIP-binding. /evidence=ECO:0000250 2432..3213 58/294 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2614..2635
FAT 3024..3470 CDD:280429 92/478 (19%)
PIKKc_DNA-PK 3719..4014 CDD:270716 78/315 (25%)
FATC 4097..4128 CDD:280430
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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