DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pi3K92E and Pik3cd

DIOPT Version :9

Sequence 1:NP_001262770.1 Gene:Pi3K92E / 42446 FlyBaseID:FBgn0015279 Length:1088 Species:Drosophila melanogaster
Sequence 2:XP_006538704.1 Gene:Pik3cd / 18707 MGIID:1098211 Length:1074 Species:Mus musculus


Alignment Length:1121 Identity:423/1121 - (37%)
Similarity:624/1121 - (55%) Gaps:107/1121 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 PPCMRFSVNLWKNEMLNWVDLICLLPNGFLLELRVNPANTIQVIKVEMVNQAKQMPLGYVIKEAC 91
            ||.:...:..|..|....|.:..|||.|..|...|:....:..||..:.::|:..||.:::.:..
Mouse     2 PPGVDCPMEFWTKEESQSVVVDFLLPTGVYLNFPVSRNANLSTIKQVLWHRAQYEPLFHMLSDPE 66

  Fly    92 EYQVYGIS-TFNIEPYTDETKRLSEVQPYFGILSL----GERTDTTSFSSDYELTKMVNGMIGT- 150
            .|....:: |...:...||.:||.::||:..:|.|    |:|           :.|::|..|.. 
Mouse    67 AYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLVAREGDR-----------VKKLINSQISLL 120

  Fly   151 ------TFDHNRTHGSPEIDDFRLYMTQTCDNIELERSAYTWQQRLLYEHPLRLANSTKMPELIR 209
                  .||..|   .||::|||..|.|.|:.....|....|.:.|.|..||:|..|.:......
Mouse   121 IGKGLHEFDSLR---DPEVNDFRTKMRQFCEEAAAHRQQLGWVEWLQYSFPLQLEPSARGWRAGL 182

  Fly   210 ERHPTRTFLIVVKNENDQSTFTLSVNEQDTPFSLTESTL-QKMNRSQMKMNDRTSDYILKVSGRD 273
            .|...|..|:.||.|..:.:||..|:.:|.|.:|....| :|....:..:.::..:|.|:|:||.
Mouse   183 LRVSNRALLVNVKFEGSEESFTFQVSTKDMPLALMACALRKKATVFRQPLVEQPEEYALQVNGRH 247

  Fly   274 EYLLGDYPLIQFLYIQEMLSDSAVPNVVLQSVYRLESYINHHNEQAMVTKRPLPKKRTVHLHKSI 338
            |||.|:|||..|.||...|.....|::.:.....:.:..:..:..|...::|..|...:...|..
Mouse   248 EYLYGNYPLCHFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPS 312

  Fly   339 S-SLWDMGNYFQLTLHSISNVNFDKTRALKVGVHVCLYHGDKKLCAQRSTDSPNGNFDTFLFNDL 402
            | |||.:...|.:.|.....||.|:  .:|:.|...|:||::.||...|:...|      :.::.
Mouse   313 SVSLWSLEQPFSIELIEGRKVNADE--RMKLVVQAGLFHGNEMLCKTVSSSEVN------VCSEP 369

  Fly   403 V----MDFDIQMRNLPRMTRLCIVIF---EVTKMSRS-KKSSNNKDIALKDVPYNKNPLAWVNTT 459
            |    ::|||.:.:||||.|||..::   |..|.:|| ||.|...|.          |:||.|..
Mouse   370 VWKQRLEFDISVCDLPRMARLCFALYAVVEKAKKARSTKKKSKKADC----------PIAWANLM 424

  Fly   460 IFDHKDILRTGRHTLYTWTYADDIQSVEVFHPLGTIEPNPRKEECALVDLTFLSSGTGTVRYPSE 524
            :||:||.|:||...||.|....| :..|:.:|.||:..||..|..|.:.:.........|.:|:.
Mouse   425 LFDYKDQLKTGERCLYMWPSVPD-EKGELLNPAGTVRGNPNTESAAALVIYLPEVAPHPVYFPAL 488

  Fly   525 EVVLQYA--ADREQVNRLQRQLAGPEKPIKELKELMANYTGLDKIYEMVDQDRNAIWERRNDILR 587
            |.:|:..  .:|.::.. :.||        :|:|::.. .|..::||   .:::.:|:.|:::..
Mouse   489 EKILELGRHGERGRITE-EEQL--------QLREILER-RGSGELYE---HEKDLVWKMRHEVQE 540

  Fly   588 ELPEELSILLHCVYWKERDDVA-----------------------------DMWYLLKQWPLISI 623
            ..||.|:.||....|.:.:|||                             .|.|||..||.:.:
Mouse   541 HFPEALARLLLVTKWNKHEDVAQVSREGGSGRQPRGRWTVPAHPYLTTKLSQMLYLLCSWPELPV 605

  Fly   624 ERSLELLDYAYPDPAVRRFAIRCLHFLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLERALRNQ 688
            ..:|||||:::||..|..|||:.|..|.|::|..|||||||.:|:||||:.:|..|||.|||.|:
Mouse   606 LSALELLDFSFPDCYVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLGRALANR 670

  Fly   689 RIGHYFFWHLRSEMQTPSMQTRFGLLLEVYLKGCKHHVAPLRKQLHVLEKLKQ----GSLIAKKG 749
            :|||:.||||||||..||:..||||::|.|.:|..||:..|.||...|.|||.    ..:.::|.
Mouse   671 KIGHFLFWHLRSEMHVPSVALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKVSSQKT 735

  Fly   750 SKEKVKTMLQDFLRDQRNSAVFQNIQNPLNPSFRCSGV-TPDRCKVMDSKMRPLWVVFENADV-N 812
            :|.:.|.|:...:|.:.......::|:||:||.....| :.::|..|||||:|||:::.:.:. :
Mouse   736 TKPQTKEMMHMCMRQETYMEALSHLQSPLDPSTLLEEVCSVEQCTFMDSKMKPLWIMYSSEEAGS 800

  Fly   813 ASDVHIIFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCISMEKSLGMIEVVRHAETIA 877
            |.:|.||||||||||||||||||:::||.|||::|:|.||..|.|:......|:||||.|::|||
Mouse   801 AGNVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIA 865

  Fly   878 NIQKEKGMFSATSPFKKGSLLSWLKEHNKPADKLNKAINEFTLSCAGYCVATYVLGVADRHSDNI 942
            |||..|...:||:.|.|.:||:|||..| |.:.|::||.|||||||||||||||||:.|||||||
Mouse   866 NIQLNKSNMAATAAFNKDALLNWLKSKN-PGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNI 929

  Fly   943 MVKRNGQLFHIDFGHILGHFKEKLGVRRERVPFVLTHDFVYVINKGFNDRESKEFCHFQELCERA 1007
            |::.:||||||||||.||:||.|.|:.||||||:||:|||:||.:| ....|::|..|:..||||
Mouse   930 MIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQG-KTNNSEKFERFRGYCERA 993

  Fly  1008 FLVLRKHGCLILSLFSMMISTGLPELSSEKDLDYLRETLVLDYTEEKAREHFRAKFSEALANSWK 1072
            :.:||:||.|.|.||::|.:.||||||..||:.||:::|.|..|||:|.:|||.||:|||..|||
Mouse   994 YTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWK 1058

  Fly  1073 TSLNWASHNFSKNNKQ 1088
            |.:||.:||.||:|:|
Mouse  1059 TKVNWLAHNVSKDNRQ 1074

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K92ENP_001262770.1 PI3K_p85B 56..132 CDD:295322 19/80 (24%)
PI3K_rbd 200..307 CDD:197540 32/107 (30%)
C2_PI3K_class_I_beta_delta 339..517 CDD:176075 60/186 (32%)
PI3Ka_I 552..723 CDD:238444 77/199 (39%)
PI3Kc_I 727..1084 CDD:270709 188/362 (52%)
Pik3cdXP_006538704.1 PI3K_p85B 32..107 CDD:396665 17/74 (23%)
PI3K_rbd 182..281 CDD:395642 31/98 (32%)
C2_PI3K_class_I_beta_delta 314..481 CDD:176075 59/185 (32%)
PI3Ka 504..713 CDD:214537 82/221 (37%)
PI3Kc_IA_delta 705..1072 CDD:270718 192/368 (52%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167836286
Domainoid 1 1.000 279 1.000 Domainoid score I1681
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H3686
Inparanoid 1 1.050 732 1.000 Inparanoid score I609
Isobase 1 0.950 - 0 Normalized mean entropy S3198
OMA 1 1.010 - - QHG57536
OrthoDB 1 1.010 - - D204282at2759
OrthoFinder 1 1.000 - - FOG0001201
OrthoInspector 1 1.000 - - otm44201
orthoMCL 1 0.900 - - OOG6_100986
Panther 1 1.100 - - LDO PTHR10048
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5021
SonicParanoid 1 1.000 - - X531
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1716.750

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