DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K92E and Pik3c2g

DIOPT Version :9

Sequence 1:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_997566.2	Gene:	Pik3c2g / 18705	MGIID:	1203730	Length:	1506	Species:	Mus musculus

Alignment Length:	1135	Identity:	300/1135 - (26%)
Similarity:	491/1135 - (43%)	Gaps:	236/1135 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 EMVNQAKQMPLGYVIKEACEYQVYGI---STFNIEPYTDETKRLSEVQPYFGILSLGERTDTTSF 134
            |.|:.....|:|      |..::..:   |..|:..:.::.|::.|                :..
Mouse   218 ENVSVESTEPIG------CPIEIVEVPQGSNKNLASFCNKVKKIRE----------------SYH 260

  Fly   135 SSDYELTKMVNGMIGTTFDHNRTHGSPEIDD--FRLYMTQTCDNIELERSAYTWQQRLLYEHP-- 195
            :||      :|...|..:.....:.|....|  ||:       .|.::.||   |..||..|.
Mouse   261 ASD------INSNSGKIWAITTAYPSRLFADTKFRV-------KISIDNSA---QLLLLMPHANY 309

  Fly   196 ----------LRLANSTKMP-----------ELIRERHPTRTFLIVVKN---------ENDQSTF 230
                      |..||....|           |.::..|......|..||         :|..:..
Mouse   310 LVKDLIAEILLLCANEPLSPKEYLLSVCGSEEFLQMDHSLGGHKIFQKNKSVIQLHLQKNRDTPG 374

  Fly   231 TLSVNEQD--TPFSLTE----STLQKMNRSQMKMNDRTSDYILKVSGRDEYLLGDYPLIQFLYIQ 289
            .||...:|  :||.|.:    :.:.|::|..:      |..:.|.:...|:||.....::..::.
Mouse   375 KLSRKSEDDHSPFHLNQLLEFTHIWKISRQCL------STVMKKYNLHVEHLLKPQKDMEEKHLS 433

  Fly   290 EMLS---DSAVPNV--VLQSVYRLESYIN-------------------------HHNEQAMVTKR 324
            .|:|   .::.|:|  ||:.|..:.|.:.                         |.|.:  .:|:
Mouse   434 SMVSGNQHTSQPHVNNVLEEVKNICSVLGCIETKQVSDAVKELNLILQRPSQNFHQNSE--TSKK 496

  Fly   325 PLPKKRTVHLHKSISSLWD-------------------------MGNYFQLTLHSISNVNFDKTR 364
            ...::.|..|.:||..|.|                         :.::...|:.|:.||......
Mouse   497 GFIERVTAELSRSIYQLIDVYCSTFCTDFQPVHTPGGVSRVHAGLQSHLSFTVCSLHNVPETWAH 561

  Fly   365 ALKVGVHVC-LYHGDKKLCAQRS------TDSPNGNFDTFLFNDLVMDFDIQMRNLPRMTRLCIV 422
            :.|.....| |.:..||||..:|      |.|    |...:..:.:::|.:::::|||.:.|.|.
Mouse   562 SYKAFSFSCWLTYAGKKLCQVKSCRPLPVTKS----FSLLVNWNEIINFPLEIKSLPRESMLIIK 622

  Fly   423 IFEVTKMSRSKKSSNNKDIALKDVPYNKNPLAWVNTTIFDHKDILRTGRHTLYTWTYADDIQS-- 485
            :|.:...:.|                 .|.|||....:|..::.:...|  |::.|    :||
Mouse   623 LFGIDSATHS-----------------TNLLAWTCLPLFPRQESVLGSR--LFSVT----LQSEP 664

  Fly   486 -VEVFHPLGT---IEPNPRKEECALVDLTFLSSGTGTVRYPSEEVVLQYAADREQVNRLQRQLAG 546
             :|:..| |.   .:|:|     ..:.:.|..:|...::..|||            ||...
Mouse   665 PIEMIAP-GVWDGSQPSP-----LTLQIDFPDAGWEYLKPESEE------------NRTDH---- 707

  Fly   547 PEKPIKELKELMANYTGLDKIYEMVDQDRNAIWERR---NDILRELPEELSILLHCVYWKERDDV 608
             |:|.:|..:.:|..:.......:.::.|..:|..|   |:....||   .:|.....|.| :.|
Mouse   708 -EEPPRECLKHIAKLSQKKSPLLLSEEKRRYLWFYRLYCNNENSSLP---LVLGSAPGWDE-ETV 767

  Fly   609 ADMWYLLKQWPLISIERSLELLDYAYPDPAVRRFAIRCLHFLKDEDLLLYLLQLVQAIKHESYLE 673
            ::|..:|::|.......:|.||...:||..:|..|::.|..|..::||..|.|||||:|.|..||
Mouse   768 SEMHAILRRWTFSHPWEALGLLTSRFPDQDIREVAVQQLDTLLTDELLDCLPQLVQAVKFEWNLE 832

  Fly   674 SDLVVFLLERALRNQRIGHYFFWHLRSEMQTPSMQTRFGLLLEVYLKGC-----KHHVAPLRKQL 733
            |.||..||.|:|::.|:.|..:|.||........::.:..||.. |:.|     ...::..:|.:
Mouse   833 SPLVELLLRRSLQSIRVAHRLYWLLRDAQGEAYFKSWYQELLAA-LQFCAGEALNEELSKEQKLV 896

  Fly   734 HVL----EKLKQGSLIAKKGSKEKVKTMLQDFLRDQRNSAVFQNIQNPLNPSFRCSGVTPDRCKV 794
            .:|    ||:|..|...:|...:|....|::|.:|      .:....||||:....|:..|.|..
Mouse   897 KLLGDIGEKVKSASDPQRKDVLKKEIGSLEEFFKD------IKTCHLPLNPALCIKGIDRDACSY 955

  Fly   795 MDSKMRPLWVVFENADVNASDVHIIFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCIS 859
            ..|...||.:.|.||:....::.:|||.|||||||||.||:::|||..|.::|:|.:|..|.|:|
Mouse   956 FTSNASPLKITFINANPMGKNISVIFKAGDDLRQDMLALQIIQVMDNAWLQEGLDMQMITYGCLS 1020

  Fly   860 MEKSLGMIEVVRHAETIANIQKEKGMFSATSPFKKGSLLSWLKEHNKPADKLNKAINEFTLSCAG 924
            ..::.|.||:|..|.|:|.|....|:.   .|.|:.::..|..:||...:...||:..|..||||
Mouse  1021 TGRAQGFIEMVPDAVTLAKIHLHSGLI---GPLKENTIKKWFSQHNHLKEDYEKALRNFFYSCAG 1082

  Fly   925 YCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPFVLTHDFVYVINKGF 989
            :||.|::|||.|||:||||:.::|.:||||||..|||.:...|::|:|.||:.|.:..|.|.:|
Mouse  1083 WCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEG- 1146

  Fly   990 NDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPELSSEKDLDYLRETLVLDYTEEK 1054
             .:.::.|..|.|||.||:.::|||..|||||..||:..|||||...:||.|:...|....|:.:
Mouse  1147 -GKNTQHFQDFVELCCRAYNIVRKHSQLILSLLEMMLHAGLPELRGIEDLKYVHNNLRPQDTDLE 1210

  Fly  1055 AREHFRAKFSEALANSWKTSLNWASHNFSK 1084
            |..||..|..|:| ..:...||...|..::
Mouse  1211 ATSHFTKKIKESL-ECFPVKLNNLIHTLAQ 1239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322	9/61 (15%)
		PI3K_rbd	200..307	CDD:197540	28/137 (20%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	42/215 (20%)
		PI3Ka_I	552..723	CDD:238444	52/178 (29%)
		PI3Kc_I	727..1084	CDD:270709	137/360 (38%)
Pik3c2g	NP_997566.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		C2A_PI3K_class_II	538..698	CDD:175979	40/192 (21%)
		PI3Ka	713..880	CDD:320871	51/171 (30%)
		PI3Kc_C2_gamma	886..1239	CDD:270721	137/364 (38%)
		PX_PI3K_C2_gamma	1268..1368	CDD:132806
		C2	1390..1502	CDD:326325
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836280
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850