Protein Alignment Pi3K92E and pifk-1

DIOPT Version :9

• Sequence 1: NP_001262770.1
• Gene: Pi3K92E / 42446
• FlyBaseID: FBgn0015279
• Length: 1088
• Species: Drosophila melanogaster
• Sequence 2: NP_508177.2
• Gene: pifk-1 / 180443
• WormBaseID: WBGene00018076
• Length: 666
• Species: Caenorhabditis elegans
• Alignment Length: 706
• Identity: 152/706 - (21%)
• Similarity: 250/706 - (35%)
• Gaps: 215/706 - (30%)

  Fly   472 HTLYTWTYADDIQSVEVFHP------LGTIEPNPRKEECALVDLTFLSSGTGTVRYPSEEVVLQY 530
            |...:||..  :.|.|.|:.      |.:|:..|        .||||.
 Worm    56 HDRQSWTMR--LISSESFNAPMAVEYLNSIQDKP--------SLTFLG----------------- 93

  Fly   531 AADREQVNRLQRQLAGPEKPIK-ELKELMANY-TGLD--KIYEMVDQDRN---------AIWERR 582
                      :|....|||.:. .|.:||..| |.:|  .:.....::||         .|| ..
 Worm    94 ----------KRLFDLPEKDLDFYLPQLMYLYVTKVDAASVSHAYIEERNKKDAQFTVLCIW-LL 147

  Fly   583 NDILRELP---EELSILLHCVYWKERDDVADMWYLLKQWPLISIERSLEL-----LDYAYPDPAV 639
            |...:.:|   |..:::|..:.  .|.:|............:|::|..|.     ..|.....|:
 Worm   148 NCFTKNVPNKYENHALMLKSLL--SRSNVPGTSQSADNMITLSLDRLEETNWTVGSSYGKSAGAL 210

  Fly   640 RRFAIRCLHFLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLERALRNQRIGHYFFWHLRSEMQT 704
            .|.||:     |:..|         ..:|:||.:|              |.|     .:.:::.|
 Worm   211 ARAAIQ-----KESTL---------TAEHDSYEKS--------------RCG-----PISTKLLT 242

  Fly   705 PSMQTRFGLLLEVYLKGCKHHV--------APLRKQLHVLEKLKQGSL----------------- 744
             :.|...|.|:.:.:|..:||:        ..|:.:|.:|..:...|:
 Worm   243 -NQQNFIGRLVYIGVKLTEHHLLSSKQEKTIALQSELSMLNSMLPNSVWIPFDFENTMFNICVNE 306

  Fly   745 IAKKGSKEKVK-TMLQDFLRDQRN--------SAVFQNIQNPLNPSFRCSGVTPDRCKVMDSKMR 800
            .|...||:||. ....:.:|...|        |:|...|:...:.|.....      |.......
 Worm   307 SAVLNSKDKVPYVFFAEVIRSSPNYNSNIKTLSSVEPRIKKSQSESVLLKN------KSYHDSTD 365

  Fly   801 PLWVVF------ENADVNASD----------VHIIFKNGDDLRQDMLTLQMLRVMDQLWKRDGMD 849
            |...||      :.|.:..|.          :.:|.|.||||.|:....|:|.....||..:|:.
 Worm   366 PSIAVFAESWAEKKARIRGSSRYENHQKWDLIPVIVKTGDDLSQEAFAQQLLFTFKDLWHEEGVP 430

  Fly   850 FRMNIYNCISMEKSLGMIEVV----------RHAETIANIQKEKGMFSATSPFKKGSLLSWLKEH 904
            ..:..|..:.:....|:||.|          ||   :.|:.:..|  :.|:|.        ||.|
 Worm   431 LYLRPYKIVCIGSDAGLIEPVLDTLSLHQIKRH---LTNVFRMNG--NVTTPS--------LKHH 482

  Fly   905 NK------PADKLNKAINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFK 963
            .:      .::....|...|..|.|.|.:.:|.|.:.|||:.||::..:|.|.|||:|.:|....
 Worm   483 FENVFGPVNSETYVNAQKNFIQSTAAYSLVSYYLQLKDRHNGNILLDMDGHLIHIDYGFLLSSSP 547

  Fly   964 EKLGVRRERVPFVLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMM--- 1025
            ..||.  |..||.||.:.:.|:. |.   :|..|.:|:.|..|..:..|||...|:||..:|
 Worm   548 RNLGF--ETAPFKLTTEIIDVMG-GI---DSDMFLYFKSLLLRGLMAARKHHRRIVSLAEIMSAG 606

  Fly  1026 ---------------ISTGLPELSSEKDLDYLRETLVLDYTEEKAREHFRAKFSEA 1066
                           :.......|:::.|..|.:|||     |.:|:.:..:|.::
 Worm   607 SKMQCFRAGAETVRALEARFHVSSTDEQLQQLVDTLV-----EGSRDSYTTRFYDS 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322
		PI3K_rbd	200..307	CDD:197540
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	13/50 (26%)
		PI3Ka_I	552..723	CDD:238444	37/191 (19%)
		PI3Kc_I	727..1084	CDD:270709	96/416 (23%)
pifk-1	NP_508177.2	PI4Kc_III_beta	367..666	CDD:270712	79/315 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810