DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi3K92E and Y75B8A.24

DIOPT Version :9

Sequence 1:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_499596.2	Gene:	Y75B8A.24 / 176653	WormBaseID:	WBGene00013557	Length:	2106	Species:	Caenorhabditis elegans

Alignment Length:	1254	Identity:	265/1254 - (21%)
Similarity:	455/1254 - (36%)	Gaps:	342/1254 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 FSVNLWKNEMLNWV-------------DLICLLP-------NGFLLELRVNPANTIQVIKVEMVN 76
            |...||..::|..:             |..|..|       .|:.::|:.:......|:| :...
Worm   961 FPYLLWNTKVLTTILRLLQELEDNLQKDPTCREPQFTIEGFGGWTIQLQDSIEGRRSVVK-DFSM 1024

  Fly    77 QAKQMPLGYVIKEACEYQVYGISTFNIEPYTDE--TKRLSEVQPYFGILSLGERTDTTSFSSDYE 139
            :.||     ::|||..:......: |:..|..:  ::|.:.:|......|.|.....:..:|.|:
Worm  1025 RVKQ-----ILKEALRWAPASTHS-NLLEYVSKFGSERDAAMQLAIDATSEGSGKSGSYLTSLYK 1083

  Fly   140 LTK---MVNGMIGTTFDHNRTHGSPE---IDDFRLYMTQTC---DNIELER-----SAYTWQQRL 190
            .:.   .|.||:.||...:....:.|   ||.......:.|   .::|:|:     :|.....|.
Worm  1084 RSNYLGQVKGMLATTLSGDIDQVTAENQLIDRLEKDFQRACKSGKDMEMEQAVLLLTALFVSLRS 1148

  Fly   191 LYEHPLRLANSTKM----------------------PE----LIRERHPTRTFLIVVKNENDQST 229
            |.|..|.|...|.:                      ||    .:.|:  .|.|.       |.|.
Worm  1149 LNERILSLLVRTPLLNFTESTVSLCTMAWNWLLSARPEAHSLFLHEQ--ARAFA-------DSSR 1204

  Fly   230 FTLSVNEQD----TPFSLTESTLQKMNRSQMKMNDRT-SDYILKVSGRDEYLLGDYPLIQFLYIQ 289
            |.|.:.|::    :|.      .||:.|.....|.|. .::|..:..|.:  :..|...:.|.:.
Worm  1205 FGLGLFEKEVVGGSPL------CQKLERPPPSANFRPHREWIEFIGERCD--VASYSSREQLDVL 1261

  Fly   290 EMLSDSAVPNVVLQSVYRLESYINHHNEQAMVTKRPLPKKRTVHLHKSISSLWDMGNYFQLTLHS 354
            ||:....           |.::|.                 |.|||.|.:    ..|...|...|
Worm  1262 EMMFSQT-----------LSAHIG-----------------TGHLHGSTA----CSNPASLAGPS 1294

  Fly   355 ISNVNFDKTRALK-VGVH--------------VCLYHGDKKLCAQR--------STDSPNG---- 392
            ........||.:: |||.              .||......|..||        .|.:|.|
Worm  1295 RKETINQVTRGIEAVGVRFRLLSCVLGMVQQDACLLRPTNVLIRQRVYSCAFHYFTIAPQGPTQP 1359

  Fly   393 ------------NFDTFLFNDLVMDFDIQMRNLPRMTRLCIVIFEVTKMSRSKKSSNNKDIALKD 445
                        .|...|.||   ...:|...|.:..:..::...:::|    :::..|.:.:..
Worm  1360 EERLREDIRLLTRFFEHLKND---KHYMQKEALAKTDKNLVMSSTMSQM----QTNFEKSLLISG 1417

  Fly   446 VPYNKNPLAWVNT--------------TIFDHKDI------LRTGR-----------HTLYTW-- 477
            .|.........||              |:...|.:      :|:|:           ..:.||
Worm  1418 TPVTATAAGTPNTSLMLPPSTNYANTLTLSSQKSMAATSASIRSGKSIETKLSIEEDRRIKTWMK 1482

  Fly   478 -------TYADDIQSVEVF-HPLGTIEPNPRKEECALVDLTFLSSGTGTVRYPSEEVVLQYAADR 534
                   ..|::|:.:..: |||...:     |:|||....||.......:....|
Worm  1483 QRNMLMLLVANEIERLSAWLHPLALAQ-----EDCALDSEEFLRGAFTQAKATGGE--------- 1533

  Fly   535 EQVNRLQRQLA---GPEKPIKELKELMANYTGLDKIYEMVDQDRNAIWERRNDILRELPEELSIL 596
            :.:.|.|.|||   .||..|    :|.:.:.|..::.:.||    .:...:.:.:..:||.|.:.
Worm  1534 KNIWREQAQLAWDISPELAI----QLPSRFRGSPELVKYVD----VLVRGQPEPVAHIPEALPLF 1590

  Fly   597 L---HCVYWKERDDVADMWYLLKQWPLISIERSLELL-DYAYP-DPAVRRFAIRCLHFLKDEDLL 656
            |   ..|:     :.:||.::| .|...|...:|.|| ...|| .|...::|:|.|.....::||
Worm  1591 LGNGSTVF-----ETSDMSHVL-TWARCSPVMALSLLTPRIYPMHPISMQYAVRVLRSYSADELL 1649

  Fly   657 LYLLQLVQAIKHES--YLESDLVVFLLERALRNQRIGHYFFWHLRSEMQT-PSMQTRFGLLLEV- 717
            ||:.|:|||:::::  |: |:|:::|   |..:|.:.|...|::::.|.| ...:.:..:|.|.
Worm  1650 LYIPQIVQAVRYDTMGYI-SELIIWL---AGHSQLLSHQLIWNMQTNMFTDEESKVKDPVLFEAL 1710

  Fly   718 ---------YLKGC--KHHVAPLRKQLHVLEKLKQGSLIAKKGSKEKVKTMLQDFLRDQRNSAVF 771
                     .|:|.  :.|.|.. |..|.|..:........||...| |..|: .|.|.:...:.
Worm  1711 NDIMQKILSQLEGAARRFHEAEF-KLFHQLTAISGTIKPFPKGDARK-KACLK-ALADVKIETIT 1772

  Fly   772 QNIQNP----LNPSFRCSGVTP---------------DRCKVMDSKMRPLWVVFENADVNASDVH 817
            ....||    |:..:  |..||               .||.|.:         .|:..:.|...|
Worm  1773 YLPSNPEAVLLDLDY--SSGTPMQSAAKAPFLARFRVKRCGVRE---------LEHIGLQAQSEH 1826

  Fly   818 ------------------------IIFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCI 858
                                    .|||.|||:|||||.||::::|..:|...|:..|:..|..:
Worm  1827 GGKTTEADLEELKKVQDSRVCWQAAIFKVGDDVRQDMLALQLMQLMKNVWAGLGLPVRVFPYRVV 1891

  Fly   859 SMEKSLGMIEVVRHAETIANIQKEKGMFSATSPFKKGSLLSWLKEH--NKPADKLNKAINEFTLS 921
            :.....|:||.|.::       |.:......:.|   .|..:.|..  ::.::...:|...|..|
Worm  1892 ATSPGCGVIECVPNS-------KSRDQLGRQTDF---GLYEYFKTQYGDESSETFQEARRNFVRS 1946

  Fly   922 CAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVP-FVLTHDFVYVI 985
            .|.|.|.:::|.:.|||:.|||:..:|.:.|||||.:   |:...|......| |.|:.:.|.::
Worm  1947 MAAYSVFSFLLQIKDRHNGNIMIDLDGHIIHIDFGFM---FESSPGGNLGFEPDFKLSEEMVAIM 2008

  Fly   986 NKGFNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPELSSEKDLDYLRETLVLDY 1050
            .   ...|:..|..|..||..|:|.:|.:....:||.|:|:.|.||.... |.::.||.....:.
Worm  2009 G---GKMEAAPFRQFASLCVHAYLAVRPYHKSFVSLVSLMLDTHLPCFRG-KTINQLRARFAPEM 2069

  Fly  1051 TEEKAREHFRAKFSEALAN 1069
            .|:.|.::..:..:....|
Worm  2070 NEKDAAKYMYSVITNCFLN 2088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322	14/77 (18%)
		PI3K_rbd	200..307	CDD:197540	23/137 (17%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	44/257 (17%)
		PI3Ka_I	552..723	CDD:238444	45/190 (24%)
		PI3Kc_I	727..1084	CDD:270709	95/389 (24%)
Y75B8A.24	NP_499596.2	PI4Ka	1544..1720	CDD:238443	47/193 (24%)
Y75B8A.24	NP_499596.2	PI4Kc_III_alpha	1781..2105	CDD:270711	82/336 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810