DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pi3K92E and vps-34

DIOPT Version :9

Sequence 1:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_491741.1	Gene:	vps-34 / 172280	WormBaseID:	WBGene00006932	Length:	901	Species:	Caenorhabditis elegans

Alignment Length:	911	Identity:	226/911 - (24%)
Similarity:	387/911 - (42%)	Gaps:	227/911 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 ESYINHHNEQAMVTKRPLPKKRTVHLHKSISSLWD-------MGNYFQLTLHSISNVN-FDKTRA 365
            :..|...||...:..|.....|...||.:|   |:       ..:.|...|.:.|.:: |.|...
Worm    82 QKLIQKWNEWLTLPIRYSDLSRDAFLHITI---WEHEDDEIVNNSTFSRRLVAQSKLSMFSKRGI 143

  Fly   366 LKVGVHVCLYHGDKKLCAQRSTDSPNGNFDTFLFNDLVMDFDIQMRNLPRMTRLCIVIFEVTKMS 430
            ||.||.      |.::....:.|......:|:.::|...|            .:.::..:||:.|
Worm   144 LKSGVI------DVQMNVSTTPDPFVKQPETWKYSDAWGD------------EIDLLFKQVTRQS 190

  Fly   431 RSKKSSNNKDIALKDVPYNKNPLAWVNTTIFDHKDILRT-------GRH--------------TL 474
            |.         .::|||       |::.......:::|.       .||              |.
Worm   191 RG---------LVEDVP-------WLDPFASRRIEMIRAKYKYSSPDRHVFLVLEMAAIRLGPTF 239

  Fly   475 YTWT-YADDIQSVEVFHPLGTIEPNPRKEECALVDLTFLSSGTGTV----RY--PSEEVVLQYAA 532
            |... |.|:.:::.|                    .|.::.|.|.|    ||  ...|::|:..|
Worm   240 YKVVYYEDETKNMRV--------------------STSVNGGVGIVSACTRYCVADPELLLESLA 284

  Fly   533 D----------REQVNRLQRQLAGPEKPIKELKELMANYTGLDKIYEMVDQDRNAIWERRNDILR 587
            :          |:..:...||:    ||.|:.|:.:.....|.....:..:.|:.:|:.|: .||
Worm   285 EVKHSAMTRRIRDVEDERHRQV----KPNKQAKDRLETIVNLPSSQVLTREQRDLVWKFRH-YLR 344

  Fly   588 ELPEELSILLHCVYWKERDDVADMWYLLKQWPLISIERSLELLDYAYPDPAVRRFAI-RCLHFLK 651
            :.|:.|:..|..|.|....:|.....|:..|.||..|.:||||..|:..||||.::: |.|....
Worm   345 QFPKALNKYLRSVNWVHPQEVKTALALMNDWELIEAEDALELLSSAFTHPAVRAYSVSRLLEAAS 409

  Fly   652 DEDLLLYLLQLVQAIKHE------------------------------SYLE------------- 673
            .|.:||||.|||||:|:|                              ..||
Worm   410 PEQVLLYLPQLVQALKYEQGQQLPEEGNPVPVVSEEEGKIPSVATTPTEELEGRDMTVVTKKEAR 474

  Fly   674 ----SDLVVFLLERALRNQRIGHYFFWHLRSEMQT------------PSMQTRFGLLLEVYLK-- 720
                .||..||::.||.:.::.:|.:|||::|:::            .::|.|   |:|..:|
Worm   475 KAASGDLATFLIDYALASPKVSNYLYWHLKTEIESTKESKEEHSKMYQNIQDR---LMEALVKRP 536

  Fly   721 GCKHHVAPLRKQLHVLE---------KLKQGSLIAKKGSKEKVKTMLQDFLRDQRNSAVFQNIQN 776
            ..:..|..|.:|...:|         |.:.|.|...|.:  :.:|||.    ..::....:.:..
Worm   537 DTRAQVDSLHQQQIFVEDLIILMNEAKARGGRLNESKSA--EFRTMLS----RAKHMLDLKGVHL 595

  Fly   777 PLNPSFRCSGVTPDRCKVMDSKMRPLWVVFE------NADVNASDVH-IIFKNGDDLRQDMLTLQ 834
            ||:||||.|.|.||......|:|.|..:.|:      .||.|..:.: :|||.|||||||.|..|
Worm   596 PLDPSFRLSSVIPDTASFFKSEMMPAKISFKVLQPNGKADRNIPEEYTVIFKTGDDLRQDQLIQQ 660

  Fly   835 MLRVMDQLWKRDGMDFRMNIYNCISMEKSLGMIEVVRHAETIANIQKEKGMFSATSPFKKGSLLS 899
            |:|::|.:.|:..:|.::..|..:|.....|.::.:: ::.:..||::          .|...:.
Worm   661 MVRLIDIILKKGQLDLKLTPYLVLSTGVGQGFVQCIK-SKPLRAIQEQ----------YKAHKMD 714

  Fly   900 WLKEHNK---PAD-----KLNKAINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDFG 956
            .::|..|   |.|     :.| .|:.:..|.|||.|..|:||:.|||.||:::..||:|||:|||
Worm   715 CIREAMKELRPGDGPFGIEPN-VIDNYVRSLAGYSVIMYILGLGDRHLDNLLLCENGKLFHVDFG 778

  Fly   957 HILGHFKEKLGVRRERVPFVLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLILSL 1021
            .|||...:.:     ..|..||.:.|.|:    ...:||:|..|.:..:.|:.:||:|..::|:|
Worm   779 FILGRDPKPM-----PPPMKLTSEMVQVM----GGVKSKQFLEFVQHVDSAYRILRRHSNVLLNL 834

  Fly  1022 FSMMISTGLPELSSEKD--LDYLRETLVLDYTEEKAREHFRAKFSEALANSWKTSLNWASHNFSK 1084
            ||:|:..|:|::::|.|  :..:.:.|.||.::|.|.:|...:...:| |:....::...|.:.:
Worm   835 FSLMLDAGIPDIAAEPDKAIFKIEQRLRLDLSDEAATKHIFTQIESSL-NAKMAMISDIIHAYKQ 898

  Fly  1085 N 1085
            |
Worm   899 N 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322
		PI3K_rbd	200..307	CDD:197540
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	33/207 (16%)
		PI3Ka_I	552..723	CDD:238444	60/232 (26%)
		PI3Kc_I	727..1084	CDD:270709	111/382 (29%)
vps-34	NP_491741.1	C2_PI3K_class_III	21..193	CDD:176042	27/140 (19%)
		PI3Ka_III	303..509	CDD:238442	59/210 (28%)
		PI3Kc_III	543..898	CDD:270628	111/382 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920