DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi3K92E and Pik3ca

DIOPT Version :9

Sequence 1:NP_001262770.1 Gene:Pi3K92E / 42446 FlyBaseID:FBgn0015279 Length:1088 Species:Drosophila melanogaster
Sequence 2:NP_596890.2 Gene:Pik3ca / 170911 RGDID:620916 Length:1068 Species:Rattus norvegicus


Alignment Length:1122 Identity:391/1122 - (34%)
Similarity:612/1122 - (54%) Gaps:115/1122 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 PPEEAEPPCMRFSVNLWKNEMLNWVDLI-CLLPNGFLLELRVNPANTIQVIKVEMVNQAKQMPLG 84
            ||..:       |..||...::....|: ||||||.::.|......|:..||.|:..:|::.||.
  Rat     2 PPRPS-------SGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFKEARKYPLH 59

  Fly    85 YVIKEACEYQVYGIS-TFNIEPYTDETKRLSEV---QPYFGILS-LGERTDTTSFSSDYELTKMV 144
            .::::...|....:: ....|.:.|||:||.::   ||:..::. :|.|.:           |::
  Rat    60 QLLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREE-----------KIL 113

  Fly   145 NGMIG-------TTFDHNRTHGSPEIDDFRLYMTQTCDNIELERSAYTWQQRLLYEHPLRLANST 202
            |..||       ..||..:   .||:.|||..:...|......|...:...|.:|.:|..:.:|.
  Rat   114 NREIGFVIGMPVCEFDMVK---DPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSP 175

  Fly   203 KMPELIRERHPTRTFLIV----VKNENDQSTFTLSVNEQDTPFSLTESTLQKMNRSQMKMNDR-- 261
            ::|:.|..:......::|    |...||:..:||.:|....|..:....::|..||.:..:::  
  Rat   176 ELPKHIYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK 240

  Fly   262 ------TSDYILKVSGRDEYLLGDYPLIQFLYIQEMLSDSAVPNVVL---QSVYR---LESYINH 314
                  ...|||||.|.|||.|..|||.|:.||:..:....:||::|   :|:|.   ::|:...
  Rat   241 LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPIDSFTMP 305

  Fly   315 HNEQAMVTKRPLPKKRTVHLHKSISSLWDMGNYFQLTLHSISNVNFDKTRALKVGVHVCLYHGDK 379
            ...:.:.|..|.....|     :..|||.:.:..::.:...:.||.:.....|:.|...:|||.:
  Rat   306 SYSRRISTATPYMNGET-----ATKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGE 365

  Fly   380 KLCAQRSTD---SPNGNFDTFLFNDLVMDFDIQMRNLPRMTRLCIVIFEVTKMSRSKKSSNNKDI 441
            .||...:|.   ..|..::.:|      ::||.:.:|||..|||:.|..|    :.:|.:..:..
  Rat   366 PLCDNVNTQRVPCSNPRWNEWL------NYDIYIPDLPRAARLCLSICSV----KGRKGAKEEHC 420

  Fly   442 ALKDVPYNKNPLAWVNTTIFDHKDILRTGRHTLYTWTYADDIQSVEVFHPLGTIEPNPRKE-ECA 505
                      ||||.|..:||:.|.|.:|:..|..|.....::  ::.:|:|....||.|| .|.
  Rat   421 ----------PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLE--DLLNPIGVTGSNPNKETPCL 473

  Fly   506 LVDLTFLSSGTGTVRYPSEEVVLQYA---ADREQ---------VNRLQRQLAGPEKPIKELKELM 558
            .::..:.||   .|::|...|:.::|   ..||.         .|||.|.....|...::|:.|.
  Rat   474 ELEFDWFSS---VVKFPDMSVIEEHANWSVSREAGFSYSHTGLSNRLARDNELRENDKEQLRALC 535

  Fly   559 ANYTGLDKIYEMVDQDRNAIWERRNDILRELPEELSILLHCVYWKERDDVADMWYLLKQWPLISI 623
            ..    |.:.|:.:|:::.:|..|:..: .:||.|..||..|.|..||:||.|:.|:|.||.|..
  Rat   536 TR----DPLSEITEQEKDFLWSHRHYCV-TIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKP 595

  Fly   624 ERSLELLDYAYPDPAVRRFAIRCLH-FLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLERALRN 687
            |:::||||..||||.||.||:|||. :|.|:.|..||:||||.:|:|.||::.||.|||::||.|
  Rat   596 EQAMELLDCNYPDPMVRSFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN 660

  Fly   688 QRIGHYFFWHLRSEMQTPSMQTRFGLLLEVYLKGCKHHVAPLRKQLHVLEKLKQGSLIAKKGSKE 752
            |||||:|||||:|||...::..|||||||.|.:.|..::..|.:|:..:|||...:.|.|:..|:
  Rat   661 QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEKKD 725

  Fly   753 KVKTMLQDFLRDQRNSAVF----QNIQNPLNPSFRCSGVTPDRCKVMDSKMRPLWVVFENADVNA 813
            :.:.:...||.:|.....|    |...:||||:.:...:..:.|::|.|..||||:.:||.|:.:
  Rat   726 ETQKVQMKFLVEQMRQPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMS 790

  Fly   814 ----SDVHIIFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCISMEKSLGMIEVVRHAE 874
                .:..|||||||||||||||||::|:|:.:|:..|:|.||..|.|:|:...:|:|||||::.
  Rat   791 ELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSH 855

  Fly   875 TIANIQKEKGMFSATSPFKKGSLLSWLKEHNKPADKLNKAINEFTLSCAGYCVATYVLGVADRHS 939
            ||..||.:.|:..|.. |...:|..|||:.|| .:..:.||:.||.|||||||||::||:.|||:
  Rat   856 TIMQIQCKGGLKGALQ-FNSHTLHQWLKDKNK-GEIYDAAIDLFTRSCAGYCVATFILGIGDRHN 918

  Fly   940 DNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPFVLTHDFVYVINKGFND-RESKEFCHFQEL 1003
            .|||||.:||||||||||.|.|.|:|.|.:|||||||||.||:.||:||..: .:::||..|||:
  Rat   919 SNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQEYTKTREFERFQEM 983

  Fly  1004 CERAFLVLRKHGCLILSLFSMMISTGLPELSSEKDLDYLRETLVLDYTEEKAREHFRAKFSEALA 1068
            |.:|:|.:|:|..|.::|||||:.:|:|||.|..|:.|:|:||.||.||::|.|:|..:.::|..
  Rat   984 CYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFTKQMNDAHH 1048

  Fly  1069 NSWKTSLNWASHNFSKN 1085
            ..|.|.::|..|...::
  Rat  1049 GGWTTKMDWIFHTIKQH 1065

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi3K92ENP_001262770.1 PI3K_p85B 56..132 CDD:295322 19/80 (24%)
PI3K_rbd 200..307 CDD:197540 34/121 (28%)
C2_PI3K_class_I_beta_delta 339..517 CDD:176075 47/181 (26%)
PI3Ka_I 552..723 CDD:238444 82/171 (48%)
PI3Kc_I 727..1084 CDD:270709 164/365 (45%)
Pik3caNP_596890.2 PI3K_p85B 31..108 CDD:197539 18/76 (24%)
PI3K_rbd 173..292 CDD:197540 33/118 (28%)
C2_PI3K_class_I_alpha 325..484 CDD:176043 47/183 (26%)
PI3Ka_I 525..696 CDD:238444 83/175 (47%)
PI3Kc_IA_alpha 695..1064 CDD:270719 165/370 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 165 1.000 Domainoid score I3821
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D204282at2759
OrthoFinder 1 1.000 - - FOG0001201
OrthoInspector 1 1.000 - - otm63531
orthoMCL 1 0.900 - - OOG6_100986
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X531
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
87.820

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