DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pi3K92E and Sh3pxd2a

DIOPT Version :9

Sequence 1:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_032044.2	Gene:	Sh3pxd2a / 14218	MGIID:	1298393	Length:	1124	Species:	Mus musculus

Alignment Length:	241	Identity:	45/241 - (18%)
Similarity:	80/241 - (33%)	Gaps:	75/241 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 QAKQMPLGYVIKEACEYQVYGISTFNIEPYTDETKRLSEVQPYFGILSLGERTDTTSFSSDYELT 141
            :|::.|:|     |||.|...:.....||..|        .|.||            |.|:.|:.
Mouse   532 EAEENPVG-----ACESQGSPLKVKYEEPEYD--------VPAFG------------FDSEPEMN 571

  Fly   142 KMVNGMIGTTFDH----NRTHGSPEIDDFRLYMTQTCDNIELERSAYTWQQRLLYEH-------- 194
            :..:|..|:...|    .|...:..:......:.::.:::.||       :..:||:
Mouse   572 EEPSGDRGSGDKHPAQPRRISPASSLQRAHFKVGESSEDVALE-------EETIYENEGFRPYTE 629

  Fly   195 --------------------PLRLANSTKMPELIRERHPTRTFLIVVKNENDQSTFTLSVNEQDT 239
                                .|.:.||.|...      |..:.|:.:|.|.:... .|..|:.:.
Mouse   630 DTLSARGSSGDSDSPGSSSLSLAVKNSPKSDS------PKSSSLLKLKAEKNAQA-ELGKNQSNI 687

  Fly   240 PF--SLTESTLQKMNRSQMKMNDRTSDYILKVSGRDEYLLGDYPLI 283
            .|  |:|.||....:.|...::....|  ||.....:..:.|.|.:
Mouse   688 SFSSSVTISTTCSSSSSSSSLSKNNGD--LKPRSASDAGIRDTPKV 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322	13/54 (24%)
		PI3K_rbd	200..307	CDD:197540	20/86 (23%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075
		PI3Ka_I	552..723	CDD:238444
		PI3Kc_I	727..1084	CDD:270709
Sh3pxd2a	NP_032044.2	PX_FISH	6..124	CDD:132798
		SH3_Tks5_1	170..222	CDD:213007
		SH3_Tks5_2	269..322	CDD:213010
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	414..443
		SH3_Tks5_3	450..503	CDD:213012
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..672		30/177 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	692..830		10/42 (24%)
		SH3_Tks5_4	838..888	CDD:212952
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	886..952
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1020..1050
		SH3_Tks5_5	1067..1123	CDD:212953
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900